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1
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85030917267
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FTC-301 study team: Characterization of baseline and treatment-emergent resistance mutations following one year of therapy on an entirely once a day regimen including emtricitabine.
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June 10-14; Los Cabos, Mexico: Abstract 7
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Borroto-Esoda K, Waters J, Quinn, JB, Shaw A, Hinkle J, Rousseau F, FTC-301 study team: Characterization of baseline and treatment-emergent resistance mutations following one year of therapy on an entirely once a day regimen including emtricitabine. In Proceedings of the XII International HIV Drug Resistant Workshop: 2003 June 10-14; Los Cabos, Mexico: Abstract 7.
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Borroto-Esoda, K.1
Waters, J.2
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2
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0037076708
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Genotypic and phenotypic analyses of HIV-1 in antiretroviral-experienced patients treated with tenofavir DF
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Margot N.A., Isaacson E., McGowan I., Cheng A.K., Schooley R.T., Miller M.D. Genotypic and phenotypic analyses of HIV-1 in antiretroviral-experienced patients treated with tenofavir DF. AIDS. 16:2002;1227-1235.
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0344645030
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Nucleoside analog toxicity insidiously impairs cell energy production.
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Gilden D: Nucleoside analog toxicity insidiously impairs cell energy production. American Foundation for AIDS Res 2000:1-11.
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3943090858
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Lopinavir/ritonavir in antiretroviral-naïve HIV-infected patients: Five-year follow up.
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Sep 14-17; Chicago: Abstract H-844
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Eron J, Da Silva B, King M, Gulick R, Benson C, White AC, Glesby M, Thompson M, Albrecht M, Wolfe P et al.: Lopinavir/ritonavir in antiretroviral-naïve HIV-infected patients: five-year follow up. In Proceedings of the 43rd Interscience Conference on Antiretroviral agents and Chemotherapy: 2003 Sep 14-17; Chicago: Abstract H-844.
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Eron, J.1
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White, A.C.6
Glesby, M.7
Thompson, M.8
Albrecht, M.9
Wolfe, P.10
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7
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2942540524
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Compares an atazanavir-containing regimen with LPV/r: the atazanavir-containing regimen was inferior to the LPV/r-containing regimen
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Reyataz: (Atazanavir) package insert. URL: http://www.BMS.com Compares an atazanavir-containing regimen with LPV/r: the atazanavir-containing regimen was inferior to the LPV/r-containing regimen.
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(Atazanavir) Package Insert
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Reyataz1
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8
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85030917924
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Pantaleo, and the BMS-008 International trial group: Comparative results: BMS-232632, stavudin, lamivudin as HAART in treatment-naïve patients.
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Dec 16-19; Chicago: Abstract I-667
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Sanne I, Cahn P, Percival L, Phanuphaak P, Kelleher T, Wellens I, Giordano M: Pantaleo, and the BMS-008 International trial group: Comparative results: BMS-232632, stavudin, lamivudin as HAART in treatment-naïve patients. In Proceedings of the 4Ist Interscience Conference on Antiretroviral agents and Chemotherapy: 2001, Dec 16-19; Chicago: Abstract I-667.
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Sanne, I.1
Cahn, P.2
Percival, L.3
Phanuphaak, P.4
Kelleher, T.5
Wellens, I.6
Giordano, M.7
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9
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0037055025
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Antiretroviral treatment for adult HIV infection in 2002: Updated recommendations of the international AIDS society-USA panel
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Yeni P.G., Hammer S.M., Carpenter C.C., Cooper D.A., Fischl M.A., Gatell J.M., Gazzard B.G., Hirsch M.S., Jacobsen D.M., Katzenstein D.A.et al. Antiretroviral treatment for adult HIV infection in 2002: updated recommendations of the international AIDS society-USA panel. JAMA. 288:2002;222-235.
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Gatell, J.M.6
Gazzard, B.G.7
Hirsch, M.S.8
Jacobsen, D.M.9
Katzenstein, D.A.10
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10
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0032988176
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Combination therapy containing ritonavir plus saquinavir has superior short-term antiretroviral efficacy: A randomized trials
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Kirk O., Katzenstein T.L., Gerstoft J., Mathiesen L., Nielsen H., Pedersen C., Lundgren J.D. Combination therapy containing ritonavir plus saquinavir has superior short-term antiretroviral efficacy: a randomized trials. AIDS. 13:1999;F9-16.
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Kirk, O.1
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Pedersen, C.6
Lundgren, J.D.7
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11
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0037471311
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A phase II clinical study of the long-term safety and antiviral activity of enfuvirtide-based antiretroviral therapy
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Lalezari J.P., Eron J.J., Carlson M., Cohen C., Dejesus E., Arduino R.C., Gallant J.E., Volberding P., Murphy R.L., Valentine F.et al. A phase II clinical study of the long-term safety and antiviral activity of enfuvirtide-based antiretroviral therapy. AIDS. 17:2003;691-698.
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Lalezari, J.P.1
Eron, J.J.2
Carlson, M.3
Cohen, C.4
Dejesus, E.5
Arduino, R.C.6
Gallant, J.E.7
Volberding, P.8
Murphy, R.L.9
Valentine, F.10
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13
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85030916230
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The identification of active site mutations that confer resistance to structurally diverse inhibitors of HIV-1 integrase strand transfer supports a general mechanism of phosphotransferase inhibiton.
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Jun 10-14; Cabo San Lucas, Mexico: Abstract 10.
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Hazuda DJ, and the MRL HIV-1 drug discovery team: The identification of active site mutations that confer resistance to structurally diverse inhibitors of HIV-1 integrase strand transfer supports a general mechanism of phosphotransferase inhibiton. In Proceedings of the XII International Drug Resistance Workshop: Basic principles and clinical implications, Antiviral Therapy: 2003 Jun 10-14; Cabo San Lucas, Mexico: Abstract 10.
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Hazuda, D.J.1
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14
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0037664057
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The discovery of BILN 2061-an orally bioavailable small molecule inhibitor of the HCV serine protease and a promising antiviral for treatment of hepatitis C.
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Nov 1-5; Boston: Abstract 464
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rd Annual Meeting: 2002 Nov 1-5; Boston: Abstract 464.
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(2002)
rd Annual Meeting
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Lamarre, D.1
Bailey, M.2
Bolger, G.3
Cameron, D.4
Cartier, M.5
Faucher, A.-M.6
Goudreau, N.7
Kukolj, G.8
Lagace, L.9
Pause, A.10
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15
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0000674684
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Safety, tolerability and antiviral effect of BILN 2061, a novel HCV serine protease inhibitor, after oral treatment over 2 days in patients with chronic hepatitis C, genotype 1, with advanced liver fibrosis.
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Nov 1-5; Boston: Abstract 563.
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rd Annual Meeting: 2002 Nov 1-5; Boston: Abstract 563.
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(2002)
rd Annual Meeting
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Benhamou, Y.1
Hinrichsen, H.2
Sentjens, R.3
Reiser, R.4
Manns, M.5
Forns, X.6
Avendano, C.7
Cronlein, J.8
Nehmiz, G.9
Steinmann, G.10
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16
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85030925197
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Press release
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Idnex Pharmaceuticals Inc: NM283 shows promise. 2003; Press release. URL: http://www.idinix.com.
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(2003)
NM283 Shows Promise.
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17
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0037809239
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Inhibition of hepatitis C virus RNA replication by 2′-modified nucleoside analogs
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Carroll S.S., Tomassini J.E., Bosserman M., Getty K., Stahlhutt M.W., Eldrup A.B., Bhat B., Hall D., Simcoe A.L., LaFemina R.et al. Inhibition of hepatitis C virus RNA replication by 2′-modified nucleoside analogs. J. Biol. Chem. 278:2003;11979-11984.
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Carroll, S.S.1
Tomassini, J.E.2
Bosserman, M.3
Getty, K.4
Stahlhutt, M.W.5
Eldrup, A.B.6
Bhat, B.7
Hall, D.8
Simcoe, A.L.9
Lafemina, R.10
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18
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0344375829
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First clinical results on antiretroviral activity, pharmacokinetics, and safety of TMC114, an HIV protease inhibitor, in multiple PI-experienced patients.
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Feb 10-14; Boston: Abstract 8
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th Conference on Retroviruses and Opportunistic Infections: 2003 Feb 10-14; Boston: Abstract 8.
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(2003)
th Conference on Retroviruses and Opportunistic Infections
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Arastec, K.1
Clumeck, N.2
Pozniak, A.3
Jaeger, H.4
De Pauw, M.5
Muller, H.6
Peeters, M.7
Hotelmans, R.8
De Meyer, S.9
Van Der Sandt, I.10
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19
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0042450392
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Tipranavit/ritonavir demonstrates potent efficacy in multiple protease inhibitor experienced patients: BI 118252.
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Feb 10-14; Boston: Abstract 179
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th Conference on Retroviruses and Opportunistic Infections: 2003 Feb 10-14; Boston: Abstract 179.
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(2003)
th Conference on Retroviruses and Opportunistic Infections
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Gathe, J.1
Kohlbrenner, V.M.2
Pierone, G.3
Arasteh, K.4
Rubio, R.5
Lalonde, R.6
Piliero, P.7
McCallister, S.8
Garfinkel, S.9
Et Al., C.R.10
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20
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85030915362
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SM-309515: A novel and promising HIV protease inhibitor with favorable pharmacokinetics and resistance profiles.
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Sep 14-17; Chicago: Abstract H-873.
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Mimoto T, Nojima S, Terashima K, Takaku H, Chiba N, Shintani M, Yamaoka T, Hayashi H: SM-309515: a novel and promising HIV protease inhibitor with favorable pharmacokinetics and resistance profiles. In Proceedings of the 43rd Interscience Conference on Antiretroviral agents and Chemotherapy: 2003 Sep 14-17; Chicago: Abstract H-873.
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(2003)
Proceedings of the 43rd Interscience Conference on Antiretroviral Agents and Chemotherapy
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Mimoto, T.1
Nojima, S.2
Terashima, K.3
Takaku, H.4
Chiba, N.5
Shintani, M.6
Yamaoka, T.7
Hayashi, H.8
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23
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33644928012
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Interspecies pharmacokinetics and scalling of GW8248, a novel non-nucleoside HIV reverse transcriptase inhibitor and its prodrug GW5634.
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Sep 14-17; Chicago: Abstract F-1837.
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Burnette TC, Marr H, Owens B, Wheelan P, Moore K: Interspecies pharmacokinetics and scalling of GW8248, a novel non-nucleoside HIV reverse transcriptase inhibitor and its prodrug GW5634. In Proceedings of the 43rd Interscience Conference on Antiretroviral agents and Chemotherapy: 2003 Sep 14-17; Chicago: Abstract F-1837.
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(2003)
Proceedings of the 43rd Interscience Conference on Antiretroviral Agents and Chemotherapy
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Burnette, T.C.1
Marr, H.2
Owens, B.3
Wheelan, P.4
Moore, K.5
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24
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85030934362
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Characterization of the anti-HIV activity of GW8248 in combination with other antiretroviral drugs and in vitro selection of resistance.
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Sep 14-17; Chicago: Abstract H-445.
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Hazen RJ, Harvey R, Ferris R, Creech K, Clair M, Romines K, Freeman G, Schaller L, Chan J, Dornsife R, et al.: Characterization of the anti-HIV activity of GW8248 in combination with other antiretroviral drugs and in vitro selection of resistance. In Proceedings of the 43rd Interscience Conference on Antiretroviral agents and Chemotherapy: 2003 Sep 14-17; Chicago: Abstract H-445.
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Proceedings of the 43rd Interscience Conference on Antiretroviral Agents and Chemotherapy
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Hazen, R.J.1
Harvey, R.2
Ferris, R.3
Creech, K.4
Clair, M.5
Romines, K.6
Freeman, G.7
Schaller, L.8
Chan, J.9
Dornsife, R.10
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25
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33644911417
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Long-term virologic response to capravirin in HIV infected NNRTI-experienced patients.
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Sep 14-17; Chicago: Abstract H-871.
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Hammond JL, Amantea M, Raber S, Grettenberger H, Shetty B, Pesano R, Patick AK, Hawley P: Long-term virologic response to capravirin in HIV infected NNRTI-experienced patients. In Proceedings of the 43rd Interscience Conference on Antiretroviral agents and Chemotherapy: 2003 Sep 14-17; Chicago: Abstract H-871.
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Proceedings of the 43rd Interscience Conference on Antiretroviral Agents and Chemotherapy
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Hammond, J.L.1
Amantea, M.2
Raber, S.3
Grettenberger, H.4
Shetty, B.5
Pesano, R.6
Patick, A.K.7
Hawley, P.8
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26
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0011343037
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TMC125, a next generation NNRTI, demonstrates high potency after 7 days therapy in treatment-experienced HIV-1 infected individuals with phenotypic NNRTI resistance.
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Feb 24-28; Seattle: Abstract 4.
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th Conference on Retroviruses and Opportunistic Infections: 2002 Feb 24-28; Seattle: Abstract 4.
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(2002)
th Conference on Retroviruses and Opportunistic Infections
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Gazzard, B.1
Pozniak, A.2
Arasteh, K.3
Staszewski, S.4
Rozenbaum, W.5
Yeni, P.6
Van'T Klooster, G.7
De Dier, K.8
Peeters, M.9
De Bethune, M.P.10
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27
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0003259264
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Study DPC 083-023, a phase II comparison of 100 and 200 mg once daily DPC 083 and 2 NRTIs in patients failing a NNRTI containing regimen.
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Feb 24-28; Seattle: Abstract 6.
-
th Conference on Retroviruses and Opportunistic Infections: 2002 Feb 24-28; Seattle: Abstract 6.
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(2002)
th Conference on Retroviruses and Opportunistic Infections
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Ruiz, N.1
Nusrat, R.2
Lauenroth-Mai, E.3
Berger, D.4
Walworth, C.5
Bacheler, L.T.6
Ploughman, L.7
Tsang, P.8
Labriola, D.9
Echols, R.10
Levy, R.11
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28
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2942575632
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Final analysis of T1249-102: T-1249 retains potent short-term antiviral activity in patients who have failed a regimen containing enfuvirtide (ENF).
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Sep 14-17; Chicago: Abstract H-444
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Lalezari JP, Bellos N, Richmond G, Sathasivam K, Cohen C, Myers R, Henry D, Raskino C, Zhang Y, Spence B et al.: Final analysis of T1249-102: T-1249 retains potent short-term antiviral activity in patients who have failed a regimen containing enfuvirtide (ENF). In Proceedings of the 43rd Interscience Conference on Antiretroviral agents and Chemotherapy: 2003 Sep 14-17; Chicago: Abstract H-444.
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(2003)
Proceedings of the 43rd Interscience Conference on Antiretroviral Agents and Chemotherapy
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Lalezari, J.P.1
Bellos, N.2
Richmond, G.3
Sathasivam, K.4
Cohen, C.5
Myers, R.6
Henry, D.7
Raskino, C.8
Zhang, Y.9
Et Al., S.B.10
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29
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85030928026
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Viral resistance and pharmacokinetic analysis of phase I/II study patients treated with HIV-1 entry inhibitor PRO542.
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Feb 10-14; Boston: Abstract 561.
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th Conference on Retroviruses and Opportunistic Infections: 2003 Feb 10-14; Boston: Abstract 561.
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(2003)
th Conference on Retroviruses and Opportunistic Infections
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Olson, W.1
Israel, R.2
Jacobson, J.3
Vassilatos, L.4
Tran, D.5
Stambler, N.6
Barish, M.7
O'Hara, B.8
Ketas, T.9
Et Al., S.B.10
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30
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4544371685
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Multiple dose study to investigate the safety of UK-427,857 (100 mg or 300 mg) BID for 28 days in healthy males and females.
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Sep 14-17; Chicago: Abstract H-874.
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Russell D, Bakhtyari A, Jazrawi RP, Whitlock L, Ridgway C, Mchale M, Abel S: Multiple dose study to investigate the safety of UK-427,857 (100 mg or 300 mg) BID for 28 days in healthy males and females. In Proceedings of the 43rd Interscience Conference on Antiretroviral agents and Chemotherapy: 2003 Sep 14-17; Chicago: Abstract H-874.
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Proceedings of the 43rd Interscience Conference on Antiretroviral Agents and Chemotherapy
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Russell, D.1
Bakhtyari, A.2
Jazrawi, R.P.3
Whitlock, L.4
Ridgway, C.5
McHale, M.6
Abel, S.7
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31
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3042802956
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Effect of short-term monotherapy with UK-427,857 on viral load in HIV infected patients.
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Sep 14-17; Chicago: Abstract H-443.
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Pozniak AL, Fatkenheuer G, Johnson M, Hoepelman IM, Rockstroh J, Goebel F, Abel S, James I, Rosario M, Medhurst C et al.: Effect of short-term monotherapy with UK-427,857 on viral load in HIV infected patients. In Proceedings of the 43rd Interscience Conference on Antiretroviral agents and Chemotherapy: 2003 Sep 14-17; Chicago: Abstract H-443.
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(2003)
Proceedings of the 43rd Interscience Conference on Antiretroviral Agents and Chemotherapy
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Pozniak, A.L.1
Fatkenheuer, G.2
Johnson, M.3
Hoepelman, I.M.4
Rockstroh, J.5
Goebel, F.6
Abel, S.7
James, I.8
Rosario, M.9
Et Al., M.C.10
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34
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0041631007
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Characterization of resistant HIV variants generated by in vitro passage with lopinavir/ritonavir
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Describes the in vitro resistance profile of LPV selected during passage with LPV alone or in combination with LPV and ritonavir.
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Mo H., Lu L., Dekhtyar T., Stewart K.D., Sun E., Kempf D.J., Molla A. Characterization of resistant HIV variants generated by in vitro passage with lopinavir/ritonavir. Antiviral Res. 59:2003;173-180 Describes the in vitro resistance profile of LPV selected during passage with LPV alone or in combination with LPV and ritonavir.
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Antiviral Res.
, vol.59
, pp. 173-180
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Mo, H.1
Lu, L.2
Dekhtyar, T.3
Stewart, K.D.4
Sun, E.5
Kempf, D.J.6
Molla, A.7
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35
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0034909925
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Identification of genotypic changes in human immunodeficiency virus protease that correlate with reduced susceptibility to the protease inhibitor lopinavir among viral isolates from protease inhibitor-experienced patients
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Describes the relationship between protease mutations and susceptibility to the HIV protease inhibitor lopinavir.
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Kempf D.J., Isaacson J.D., King M., Brun S.C., Xu Y., Real K., Bernstein B.M., Japour A.J., Sun E., Rode R.A. Identification of genotypic changes in human immunodeficiency virus protease that correlate with reduced susceptibility to the protease inhibitor lopinavir among viral isolates from protease inhibitor-experienced patients. J. Virol. 75:2001;7462-7469 Describes the relationship between protease mutations and susceptibility to the HIV protease inhibitor lopinavir.
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J. Virol.
, vol.75
, pp. 7462-7469
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Kempf, D.J.1
Isaacson, J.D.2
King, M.3
Brun, S.C.4
Xu, Y.5
Real, K.6
Bernstein, B.M.7
Japour, A.J.8
Sun, E.9
Rode, R.A.10
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36
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0038555736
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Improving lopinavir genotype algorithm through phenotype correlations: Novel mutation patterns and amprenavir cross-resistance
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Parkin N.T., Chappey C., Petropoulos C.J. Improving lopinavir genotype algorithm through phenotype correlations: novel mutation patterns and amprenavir cross-resistance. AIDS. 17:2003;955-961.
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AIDS
, vol.17
, pp. 955-961
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Parkin, N.T.1
Chappey, C.2
Petropoulos, C.J.3
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37
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0037379517
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Activities of atazanavir (BMS-232632) against a large panel of human immunodeficiency virus type 1 clinical isolates resistant to one or more approved protease inhibitors
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Describes the cross-resistance profile of the new protease inhibitor atazanavir to a large panel of clinical isolates exhibiting a wide array of protease inhibitor resistance profiles.
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Colonno R.J., Thiry A., Limoli K., Parkin N. Activities of atazanavir (BMS-232632) against a large panel of human immunodeficiency virus type 1 clinical isolates resistant to one or more approved protease inhibitors. Antimicrob. Agents Chemother. 47:2003;1324-1333 Describes the cross-resistance profile of the new protease inhibitor atazanavir to a large panel of clinical isolates exhibiting a wide array of protease inhibitor resistance profiles.
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Antimicrob. Agents Chemother.
, vol.47
, pp. 1324-1333
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Colonno, R.J.1
Thiry, A.2
Limoli, K.3
Parkin, N.4
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