Hookworm cathepsin D aspartic proteases: Contributing roles in the host-specific degradation of serum proteins and skin macromolecules

Parasitology

Volumn 126, Issue 2, 2003, Pages 179-185

  Williamson, A L ^a,b   Brindley, P J ^c   Loukas, A ^a,b  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b GEORGE WASHINGTON UNIVERSITY MEDICAL CENTER   (United States)

^c TULANE UNIVERSITY   (United States)

Author keywords

Albumin; Aspartic protease; Collagen; Haemoglobin; Hookworm; Host specificity

Indexed keywords

ANTISERUM; ASPARTIC PROTEINASE; ASPARTIC PROTEINASE 1; CATHEPSIN D; COLLAGEN TYPE 1; COLLAGEN TYPE 3; COLLAGEN TYPE 4; COLLAGEN TYPE 5; FIBRINOGEN; HUMAN SERUM ALBUMIN; UNCLASSIFIED DRUG;

ANCYLOSTOMA CANINUM; ARTICLE; ASSAY; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME INHIBITION; HAMSTER; HOST; IN VITRO STUDY; MACROMOLECULE; MOLECULAR MODEL; NECATOR AMERICANUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN ISOLATION;

ANCYLOSTOMA; ANIMALS; ASPARTIC ENDOPEPTIDASES; BIODEGRADATION, ENVIRONMENTAL; BLOOD PROTEINS; CATHEPSIN D; COLLAGEN; FIBRINOGEN; HOST-PARASITE RELATIONS; NECATOR AMERICANUS; RECOMBINANT PROTEINS; SKIN; SPECIES SPECIFICITY;

ANCYLOSTOMA; ANCYLOSTOMA CANINUM; ANCYLOSTOMATOIDEA; CANIS FAMILIARIS; CRICETINAE; NECATOR AMERICANUS; NEMATODA;

EID: 0345118193     PISSN: 00311820     EISSN: None     Source Type: Journal    
DOI: 10.1017/S0031182002002706     Document Type: Article

References (28)

1. BALDWIN, E. T., BHAT, T. N., GULNIK, S., HOSUR, M. V., SOWDER, R. C., CACHAU, R. E., COLLINS, J., SILVA, A. M. & ERICKSON, J. W. (1993). Crystal structures of native and inhibited forms of human cathepsin D: implications for lysosomal targeting and drug design. Proceedings of the National Academy of Sciences, USA 90, 6796-6800.
2. BRINDLEY, P. J., KALINNA, B. H., DALTON, J. P., DAY, S. R., WONG, J. Y., SMYTHE, M. L. & McMANUS, D. P. (1997). Proteolytic degradation of host hemoglobin by schistosomes. Molecular and Biochemical Parasitology 89, 1-9.
3. BRINDLEY, P. J., KALINNA, B. H., WONG, J. Y., BOGITSH, B. J., KING, L. T., SMYTH, D. J., VERITY, C. K., ABBENANTE, G., BRINKWORTH, R. I., FAIRLIE, D. P., SMYTHE, M. L., MILBURN, P. J., BIELEFELDT-OHMANN, H., ZHENG, Y. & McMANUS, D. P. (2001). Proteolysis of human hemoglobin by schistosome cathepsin D. Molecular and Biochemical Parasitology 112, 103-112.
4. BRINKWORTH, R. I., PROCIV, P., LOUKAS, A. & BRINDLEY, P. J. (2000). Host specificity in blood feeding parasites: a defining contribution by haemoglobin-degrading enzymes? International Journal for Parasitology 30, 785-790.
5. BROWN, A., BURLEIGH, J. M., BILLETT, E. E. & PRITCHARD, D. I. (1995). An initial characterization of the proteolytic enzymes secreted by the adult stage of the human hookworm Necator americanus. Parasitology 110, 555-563.
6. BROWN, A., GIROD, N., BILLETT, E. E. & PRITCHARD, D. I. (1999). Necator americanus (human hookworm) aspartyl proteinases and digestion of skin macromolecules during skin penetration. American Journal of Tropical Medicine and Hygiene 60, 840-847.
7. CLEGG, J. A. & SMITHERS, S. R. (1972). The effects of immune rhesus monkey serum on schistosomula of Schistosoma mansoni during cultivation in vitro. International Journal for Parasitology 2, 79-98.
8. CROMPTON, D. W. (1999). How much human helminthiasis is there in the world? Journal of Parasitology 85, 397-403.
9. DOWD, A. J., DALTON, J. P., LOUKAS, A. C., PROCIV, P. & BRINDLEY, P. J. (1994). Secretion of cysteine proteinase activity by the zoonotic hookworm Ancylostoma caninum. American Journal of Tropical Medicine and Hygiene 51, 341-347.
10. FRANCIS, S. E., SULLIVAN, D. J. JR. & GOLDBERG, D. E. (1997). Hemoglobin metabolism in the malaria parasite Plasmodium falciparum. Annual Review of Microbiology 51, 97-123.
11. GAMBLE, H. R., PURCELL, J. P. & FETTERER, R. H. (1989). Purification of a 44 kilodalton protease which mediates the ecdysis of infective Haemonchus contortus larvae. Molecular and Biochemical Parasitology 33, 49-58.
12. GEIER, G., BANAJ, H. J., HEID, H., BINI, L., PALLINI, V. & ZWILLING, R. (1999). Aspartyl proteases in Caenorhabditis elegans. Isolation, identification and characterization by a combined use of affinity chromatography, two-dimensional gel electrophoresis, microsequencing and databank analysis. European Journal of Biochemistry 264, 872-879.
13. HARROP, S. A., PROCIV, P. & BRINDLEY, P. J. (1996). Acasp, a gene encoding a cathepsin D-like aspartic protease from the hookworm Ancylostoma caninum. Biochemical and Biophysical Research Communications 227, 294-302.
14. HAWDON, J. M. & HOTEZ, P. J. (1996). Hookworm: developmental biology of the infectious process. Current Opinions in Genetic Development 6, 618-623.
15. HAWDON, J. M., JONES, B. F., PERREGAUX, M. A. & HOTEZ, P. J. (1995). Ancylostoma caninum: metalloprotease release coincides with activation of infective larvae in vitro. Experimental Parasitology 80, 205-211.
16. HONG, X., BOUVIER, J., WONG, M. M., YAMAGATA, G. Y. & McKERROW, J. H. (1993). Brugia pahangi: identification and characterization of an aminopeptidase associated with larval molting. Experimental Parasitology 76, 127-133.
17. HOTEZ, P., HAGGERTY, J., HAWDON, J., MILSTONE, L., GAMBLE, H. R., SCHAD, G. & RICHARDS, F. (1990). Metalloproteases of infective Ancylostoma hookworm larvae and their possible functions in tissue invasion and ecdysis. Infection and Immunity 58, 3883-3892.
18. HOTEZ, P. J., NARASIMHAN, S., HAGGERTY, J., MILSTONE, L., BHOPALE, V., SCHAD, G. A. & RICHARDS, F. F. (1992). Hyaluronidase from infective Ancylostoma hookworm larvae and its possible function as a virulence factor in tissue invasion and in cutaneous larva migrans. Infection and Immunity 60, 1018-1023.
19. LIPPS, G., FULLKRUG, R. & BECK, E. (1996). Cathepsin B of Schistosoma mansoni. Purification and activation of the recombinant proenzyme secreted by Saccharomyces cerevisiae. Journal of Biological Chemistry 271, 1717-1725.
20. O'NEILL, S. M., MILLS, K. H. & DALTON, J. P. (2001). Fasciola hepatica cathepsin L cysteine proteinase suppresses Bordetella pertussis-specific interferon-gamma production in vivo. Parasite Immunology 23, 541-547.
21. PROCIV, P. & CROESE, J. (1990). Human eosinophilic enteritis caused by dog hookworm Ancylostoma caninum. Lancet 335, 1299-1302.
22. PROWSE, R. K., CHAPLIN, P., ROBINSON, H. C. & SPITHILL, T. W. (2002). Fasciola hepatica cathepsin L suppresses sheep lymphocyte proliferation in vitro and modulates surface CD4 expression on human and ovine T cells. Parasite Immunology 24, 57-66.
23. SALTER, J. P., LIM, K. C., HANSELL, E., HSIEH, I. & McKERROW, J. H. (2000). Schistosome invasion of human skin and degradation of dermal elastin are mediated by a single serine protease. Journal of Biological Chemistry 275, 38667-38673.
24. SILVA, F. P. JR., RIBEIRO, F., KATZ, N. & GIOVANNI-DE-SIMONE, S. (2002). Exploring the subsite specificity of Schistosoma mansoni aspartyl hemoglobinase through comparative molecular modelling. FEBS Letters 514, 141-148.
25. VERITY, C. K., LOUKAS, A., McMANUS, D. P. & BRINDLEY, P. J. (2001). Schistosoma japonicum cathepsin D aspartic protease cleaves human IgG and other serum components. Parasitology 122, 415-421.
26. WILLIAMSON, A. L., BRINDLEY, P. J., ABBENANTE, G., PROCIV, P., BERRY, C., GIRDWOOD, K., PRITCHARD, D. I., FAIRLIE, D. P., HOTEZ, P. J., DALTON, J. P. & LOUKAS, A. (2002). Cleavage of hemoglobin by hookworm cathepsin D aspartic proteases and its potential contribution to host-specificity. The FASEB Journal 16, 1458-1460.
27. YOSHIDA, Y., OKAMOTO, K., HIGO, A. & IMAI, K. (1960). Studies on the development of Necator americanus in young dogs. Japanese Journal of Parasitology 9, 735-743.
28. ZHAN, B., YAN, W., HOTEZ, P. J. & HAWDON, J. M. (2002). A developmentally regulated metalloprotease secreted by host-stimulated Ancylostoma caninum third-stage infective larvae is a member of the astacin family of proteases. Molecular and Biochemical Parasitology 120, 291-296.