Serum protein binding of histamine H1-antagonists A comparative study on the serum protein binding of a sedating (3Hmepyramine) and a non-sedating H1-antagonist ([3H]loratadine)

European Journal of Pharmaceutical Sciences

Volumn 4, Issue 5, 1996, Pages 307-319

  Ter Laak, A M ^a   Bijloo, G J ^a   Fischer, M J E ^b   Donne G M ^a   Kelder, Op Den ^a   Wilting, J ^b   Timmerman, H ^a  

^a VU UNIVERSITY AMSTERDAM   (Netherlands)

^b UTRECHT UNIVERSITY   (Netherlands)

Author keywords

Blood brain barrier; Central nervous system; Histamine h1 receptor antagonist; Human serum albumin (usa); Loratadine; Mepyramine; Sedation

Indexed keywords

ASTEMIZOLE; AZATADINE; CHLORPHENIRAMINE; DESLORATADINE; DIMETINDENE; DIPHENHYDRAMINE; HISTAMINE H1 RECEPTOR ANTAGONIST; HUMAN SERUM ALBUMIN; IMIPRAMINE; LORATADINE; MEPYRAMINE; TEMELASTINE; TERFENADINE; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; BLOOD BRAIN BARRIER; DRUG PROTEIN BINDING; LIPOPHILICITY; PRIORITY JOURNAL; PROTON TRANSPORT; SEDATION;

EID: 0029858418     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/0928-0987(96)00172-8     Document Type: Article

References (3)

1. Barnett, A., Iorio, L.C., Kreutner, W., Tozzi, S., Ahn, H.S. and Bulbenkian, A. (1984) Evaluation of the CNS properties of SCH29851, a potential non-sedating antihistamine. Agents Actions 14, 590-597.
2. Bos, O.J.M., Labro, J.F.A., Fischer, M.J.E., Wilting, J. and Janssen, L.H.M. (1989) The molecular mechanism of the neutral-to-base transition of human serum albumin. J. Biol. Chem. 264, 953-959.
3. 1-acid glycoprotein in man and other species. Biochem. Pharmacol. 33, 2065-2069.