Immunomodulatory activity of resveratrol: Discrepant in vitro and in vivo immunological effects

Biochemical Pharmacology

Volumn 66, Issue 12, 2003, Pages 2427-2435

  Gao, Xiaohua ^a   Deeb, Dorrah ^a   Media, Joseph ^a   Divine, George ^b   Jiang, Hao ^c   Chapman, Robert A ^a   Gautam, Subhash C ^a  

^a HENRY FORD HEALTH SYSTEM   (United States)

^b Dept Biostatist Res Epidemiol ^*  (United States)

^c HENRY FORD HOSPITAL   (United States)

Author keywords

Cell mediated cytotoxicity; Colony forming units; Cytokines; Immunomodulation; Lymphocyte proliferation; Resveratrol

Indexed keywords

ALLOANTIGEN; ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; CONCANAVALIN A; GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 2; MITOGENIC AGENT; RESVERATROL; TUMOR NECROSIS FACTOR ALPHA;

ALLOTYPE SUPPRESSION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD TOXICITY; BODY WEIGHT; BONE MARROW CELL; CELLULAR IMMUNITY; COLONY FORMING UNIT; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXIC T LYMPHOCYTE; ERYTHROCYTE COUNT; IMMUNOMODULATION; INTERMETHOD COMPARISON; LEUKOCYTE COUNT; LYMPH NODE; LYMPHOCYTE PROLIFERATION; LYMPHOKINE ACTIVATED KILLER CELL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPLEEN CELL; T LYMPHOCYTE; THROMBOCYTE COUNT; TREATMENT FAILURE; WEIGHT GAIN;

EID: 0345016867     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2003.08.008     Document Type: Article

References (41)

1. Block G., Patterson B., Subar A. Fruit, vegetables, and cancer prevention: a review of the epidemiological evidence. Nutr. Cancer. 18:1992;1-29.
2. Willett W.C. Diet and health: what should we eat? Science. 264:1994;532-537.
3. Miller A.B. Diet and cancer: a review. Rev. Oncol. 3:1990;87-95.
4. Wattenberg L.W. Inhibition of carcinogenesis by minor dietary constituents. Cancer Res. 52(Suppl.):1992;2085-2091.
5. Hu F.B., Stampfer M.J., Manson J.E., Rimm E., Colditz G.A., Rosner B.A., Hennekens C.H., Willett W.C. Dietary fat intake and the risk of coronary heart disease in women. N. Engl. J. Med. 337:1997;1491-1499.
6. Kuo S.M. Dietary flavonoid and cancer prevention: evidence and potential mechanism. Crit. Rev. Oncol. 8:1997;47-69.
7. Surh Y. Molecular mechanisms of chemopreventive effects of selected dietary and medicinal phenolic substances. Mutat. Res. 428:1999;305-327.
8. Constant J. Alcohol, ischemic heart disease, and the French paradox. Coron. Artery Dis. 8:1997;645-649.
9. Renaud S., Lorgeril M. Wine, alcohol, platelets, and the French paradox for coronary heart disease. Lancet. 339:1992;1523-1526.
10. Gronbaek M., Deis A., Sorensen T.I., Becker U., Schonhr P., Jensen G. Mortality associated with moderate intakes of wine, bear, or spirits. Br. Med. J. 310:1995;1165-1169.
11. Belguendouz L., Fremont L., Gozzelino M.-T. Interaction of transresveratrol with plasma lipoproteins. Biochem. Pharmacol. 55:1998;811-816.
12. Frankel E.N., Waterhouse A.L., Kinsella J.E. Inhibition of human LDL oxidation by resveratrol. Lancet. 341:1993;1103-1104.
13. Pace-Asciak C.R., Hahn S., Diamandis E.P., Soleas G., Goldberg D.M. The red wine phenolics trans-resveratrol and quercetin block human platelet aggregation and eicosanoid synthesis: implication for protection against coronary heart disease. Clin. Chim. Acta. 235:1995;207-219.
14. Rotondo S., Rajtar G., Manarini S., Celardo A., Rotilio D., de Gaetano G., Evangelista V., Cerletti C. Effects of trans-resveratrol, a natural polyphenolic compound, on human polymorphonuclear leukocyte function. Br. J. Pharmacol. 123:1998;1691-1699.
15. Kimura Y., Okuda H., Arichi S. Effects of stilbenes on arachidonate metabolism in leukocytes. Biochim. Biophys. Acta. 834:1985;275-278.
16. Belguendouz L., Fremont L., Linard A. Resveratrol inhibits metal ion dependent and independent peroxidation of porcine low density lipoproteins. Biochem. Pharmacol. 53:1997;1347-1355.
17. Bertelli A.A., Giovannini L., Bernini W., Migliori M., Fregoni M., Bavaresco L., Bertelli A. Antiplatelet activity of cis resveratrol. Drugs Exp. Clin. Res. 22:1996;61-63.
18. Jang M., Cai L., Udeani G.O., Slowing K.V., Thomas C.F., Beecher C.W.W., Fong H.H.S., Farnsworth N.R., Kinghorn A.D., Mehta R.G., Moon R.C., Pezzuto J.M. Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science. 275:1997;218-220.
19. Mgbonyebi O.P., Russo J., Russo I.H. Antiproliferative effect of synthetic resveratrol on human breast epithelial cells. Int. J. Oncol. 12:1998;865-869.
20. Lu R., Serrero G. Resveratrol, a natural product derived from grape, exhibits antiestrogenic activity and inhibits the growth of human breast cancer cells. J. Cell Physiol. 179:1999;297-304.
21. Chan M.Y., Mattiacci J.A., Hwang H.S., Shah A., Fong D. Synergy between ethanol and grape polyphenols, quercetin, and resveratrol, in the inhibition of the inducible nitric oxide synthase pathway. Biochem. Pharmacol. 60:2000;1539-1548.
22. Moreno J.J. Resveratrol modulates arachidonic acid release, prostaglandin synthesis, and 3T6 fibroblast growth factor. J. Pharmacol. Exp. Ther. 294:2000;333-338.
23. Hsieh T.-C., Wu J.M. Differential effects on growth, cell cycle arrest, and induction of apoptosis by resveratrol in human prostrate cancer cell lines. Exp. Cell Res. 249:1999;109-115.
24. Schneider Y., Vincent F., Duranton B., Badolo L., Gosse F., Bergmannm C., Seiler N., Raul F. Anti-proliferative effect of resveratrol, a natural component of grapes, wine, on human colonic cancer cells. Cancer Lett. 158:2000;85-91.
25. Hung L.-M., Chen J.-K., Huang S.-S., Lee R.-S., Su M.-J. Cardioprotective effect of resveratrol, a natural antioxidant derived from grapes. Cardiovasc. Res. 47:2000;549-555.
26. Virgili M., Contestabile A. Partial neuroprotection of in vivo excitotoxic brain damage by chronic administration of the red wine antioxidant agent, trans-resveratrol in rats. Neurosci. Lett. 281:2000;123-126.
27. Gautam S.C., Xu Y.X., Dumaguin M., Janakiraman N., Chapman R.A. Resveratrol selectively inhibits leukemia cells: a prospective agent for ex vivo bone marrow purging. Bone Marrow Transplant. 25:2000;639-645.
28. Gao X., Xu Y.X., Janakiraman N., Chapman R.A., Gautam S.C. Immunomodulatory activity of resveratrol: suppression of lymphocyte proliferation, development of cell-mediated cytotoxicity, and cytokine production. Biochem. Pharmacol. 62:2001;1299-1308.
29. Goldberg D.M., Hahn S.E., Parkes J.G. Beyond alcohol: beverage consumption and cardiovascular mortality. Clin. Chim. Acta. 237:1995;155-187.
30. Langcake P., Pryce R.J. The production of resveratrol by Vitis vinifera and other members of the Vitaceae as a response to infection and injury. Physiol. Plant Pathol. 9:1976;77-86.
31. Juan M.E., Vinardell M.P., Planas J.M. The daily administration of high doses of trans-resveratrol to rats for 28 days is not harmful. J. Nutr. 132:2002;257-260.
32. Fontcave M., Lepoivre M., Elleingand E., Gerez C., Guittet O. Resveratrol, a remarkable inhibitor of ribonucleotide reductase. FEBS Lett. 421:1997;277-279.
33. Sun N.J., Woo S.H., Cassady J.M., Snapka R.M. DNA polymerase and topoisomerase II inhibitors from Psoralea corylifolia. J. Nat. Prod. 61:1998;362-366.
34. Ragione F.D., Cucciolla V., Borriello A., Pietra V.D., Racioppi L., Soldati G., Manna C., Galletti P., Zappia V. Resveratrol arrests the cell division cycle at S/G2 phase transition. Biochem. Biophys. Res. Commun. 250:1998;53-58.
35. De la Fuente M., Victor V.M. Antioxidants as modulators of immune response. Immunol. Cell Biol. 78:2000;49-54.
36. Falchetti R., Fuggetta M.P., Lanzilli G., Tricarico M., Ravagnan G. Effects of resveratrol on human immune cell function. Life Sci. 70:2001;81-96.
37. Schneider R., Duranton B., Gosse F., Schleiffer R., Seiler N., Raul F. Resveratrol inhibits intestinal tumorigenesis and modulates host-defense- related gene expression in an animal model of human familial adenomatous polyposis. Nutr. Cancer. 39:2001;102-107.
38. Soleas G.J., Angelini M., Grass L., Diamandis E.P., Goldberg D.M. Absorption of trans-resveratrol in rats. Methods Enzymol. 335:2001;145-154.
39. Marier J.-F., Vachon P., Gritsas A., Zhang J., Moreau J.-P., Ducharme M.P. Metabolism ans disposition of resveratrol in rats: extent of absorption, glucuronidation, and enterohepatic recirculation evidenced by a linked-rat model. J. Pharmacol. Exp. Ther. 302:2002;369-373.
40. Yu C., Shin Y.G., Chow A., Li Y., Kosmeder J.W., Lee Y.S., Hirschelman W.H., Pezzuto J.M., Mehta R.G., van Breemen R.B. Human, rat, and mouse metabolism of resveratrol. Pharm. Res. 19:2002;1907-1914.
41. Asensi M., Medina I., Ortega A., Carretero J., Bano M.C., Obrador E., Estrela J.M. Inhibition of cancer growth by resveratrol is related to its low bioavailability. Free Radic. Biol. Med. 33:2002;387-398.