The IDDM-associated solitary retroviral promoters DQ-LTR3 and DQ-LTR13 have a distinct impact on the expression of selected DQB1 genes in different cell lines in vitro

Immunogenetics

Volumn 55, Issue 8, 2003, Pages 521-529

  Krach, Katrin ^a   Badenhoop, Klaus ^b   Tönjes, Ralf R ^a  

^a PAUL EHRLICH INSTITUT   (Germany)

^b UNIVERSITY HOSPITAL FRANKFURT   (Germany)

Author keywords

HERV; HLA DQB1; Insulin dependent diabetes mellitus; LTR

Indexed keywords

HLA DQ ANTIGEN; HLA DQB1 ANTIGEN;

ANTIGEN EXPRESSION; ARTICLE; B LYMPHOCYTE; GENE; GENE ACTIVITY; HLA DQ LTR13 GENE; HLA DQ LTR3 GENE; HLA DQBI1 GENE; HUMAN; HUMAN CELL; LONG TERMINAL REPEAT; LYMPHOBLASTOID CELL LINE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; RETROVIRUS; T LYMPHOCYTE;

BASE SEQUENCE; CELL LINE; DIABETES MELLITUS, TYPE 1; ENDOGENOUS RETROVIRUSES; GENETIC PREDISPOSITION TO DISEASE; HLA-DQ ANTIGENS; HUMANS; MOLECULAR SEQUENCE DATA; PROMOTER REGIONS (GENETICS); TERMINAL REPEAT SEQUENCES;

UNIDENTIFIED RETROVIRUS;

EID: 0344944123     PISSN: 00937711     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00251-003-0614-5     Document Type: Article

References (35)

1. Andersen LC, Beaty JS, Nettles JW, Seyfried CE, Nepom GT, Nepoom BS (1991) Allelic polymorphism in transcriptional regulatory regions of HLA-DQB genes. J Exp Med 173:181-192
2. Banatvala JE, Bryant J, Schernthaner G, Borkenstein M, Schober E, Brown D, De SL, Menser MA, Silink M (1985) Coxsackie B, mumps, rubella, and cytomegalovirus specific IgM responses in patients with juvenile-onset insulin-dependent diabetes mellitus in Britain, Austria, and Australia. Lancet 1:1409-1412
3. Beaty JS, West KA, Nepom GT (1995) Functional effects of a natural polymorphism in the transcriptional regulatory sequence of HLA-DQB1. Mol Cell Biol 15:4771-4782
4. Benoist C, Mathis D (1990) Regulation of major histocompatibility complex class-II genes: X, Y and other letters of the alphabet. Annu Rev Immunol 8:681-715
5. Bieda K, Pani MA, van Der AB, Seidl C, Tönjes RR, Gorus F, Usadel KH, Badenhoop K (2002) A retroviral long terminal repeat adjacent to the HLA DQB1 gene (DQ-LTR13) modifies Type I diabetes susceptibility on high risk DQ haplotypes. Diabetologia 45:443-447
6. Blackwood EM, Kadonaga JT (1998) Going the distance: a current view of enhancer action. Science 281:61-63
7. Domansky AN, Kopantzev EP, Snezhkov EV, Lebedev YB, Leib-Mösch C, Sverdlov ED (2000) Solitary HERV-K LTRs possess bi-directional promoter activity and contain a negative regulatory element in the U5 region. FEBS Lett 472:191-195
8. Donner H, Tönjes RR, Bontrop RE, Kurth R, Usadel KH, Badenhoop K (1999a) Intronic sequence motifs of HLA-DQB1 are shared between humans, apes and Old World monkeys, but a retroviral LTR element (DQLTR3) is human specific. Tissue Antigens 53:551-558
9. Donner H, Tönjes RR, Van der Auwera B, Siegmund T, Braun J, Weets I, Herwig J, Kurth R, Usadel KH, Badenhoop K (1999b) The presence or absence of a retroviral long terminal repeat influences the genetic risk for type 1 diabetes conferred by human leukocyte antigen DQ haplotypes. Belgian Diabetes Registry. J Clin Endocrinol Metab 84:1404-1408
10. Donner H, Tönjes RR, Bontrop RE, Kurth R, Usadel KH, Badenhoop K (2000) MHC diversity in Caucasians, investigated using highly heterogeneous noncoding sequence motifs at the DQB1 locus including a retroviral long terminal repeat element, and its comparison to nonhuman primate homologues. Immunogenetics 51:898-904
11. Ginsberg-Fellner F, Witt ME, Yagihashi S, Dobersen MJ, Taub F, Fedun B, McEvoy RC, Roman SH, Davies RG, Cooper LZ (1984) Congenital rubella syndrome as a model for type 1 (insulin-dependent) diabetes mellitus: increased prevalence of islet cell surface antibodies. Diabetologia [Suppl] 27:87-89
12. Glimcher LH, Kara CJ (1992) Sequences and factors: a guide to MHC class-II transcription. Annu Rev Immunol 10:13-49
13. Horn GT, Bugawan TL, Long CM, Erlich HA (1988) Allelic sequence variation of the HLA-DQ loci: relationship to serology and to insulin-dependent diabetes susceptibility. Proc Natl Acad Sci USA 85:6012-6016
14. Kambhu S, Falldorf P, Lee JS (1990) Endogenous retroviral long terminal repeats within the HLA-DQ locus. Proc Natl Acad Sci USA 87:4927-4931
15. King ML, Shaikh A, Bidwell D, Voller A, Banatvala JE (1983) Coxsackie-B-virus-specific IgM responses in children with insulin-dependent (juvenile-onset; type I) diabetes mellitus. Lancet 1:1397-1399
16. Lander ES, Linton LM, Birren B, Nusbaum C, Zody MC, Baldwin J, Devon K, Dewar K, Doyle M, FitzHugh W, Funke R, Gage D, Harris K, Heaford A, Howland J, Kann L, Lehoczky J, LeVine R, McEwan P, McKernan K et al (2001) Initial sequencing and analysis of the human genome. Nature 409:860-921
17. Leib-Mösch C, Brack-Werner R, Werner T, Bachmann M, Faff O, Erfle V, Hehlmann R (1990) Endogenous retroviral elements in human DNA. Cancer Res 50:536S-542S
18. Leib-Mösch C, Haltmeier M, Werner T, Geigl EM, Brack-Werner R, Francke U, Erfle V, Hehlmann R (1993) Genomic distribution and transcription of solitary HERV-K LTRs. Genomics 18:261-269
19. Liao D, Pavelitz T, Weiner AM (1998) Characterization of a novel class of interspersed LTR elements in primate genomes: structure, genomic distribution, and evolution. J Mol Evol 46:649-660
20. Löwer R, Löwer J, Frank H, Harzmann R, Kurth R (1984) Human teratocarcinomas cultured in vitro produce unique retrovirus-like viruses. J Gen Virol 65:887-898
21. Ono M, Yasunaga T, Miyata T, Ushikubo H (1986) Nucleotide sequence of human endogenous retrovirus genome related to the mouse mammary tumor virus genome. J Virol 60:589-598
22. Pak CY, Eun HM, McArthur RG, Yoon JW (1988) Association of cytomegalovirus infection with autoimmune type 1 diabetes. Lancet 2:1-4
23. Pascual M, Martin J, Nieto A, Giphart MJ, van der Slik AR, De VR, Zanelli E (2001) Distribution of HERV-LTR elements in the 5′-flanking region of HLA-DQB1 and association with autoimmunity. Immunogenetics 53:114-118
24. Quandt K, Frech K, Karas H, Wingender E, Werner T (1995) MatInd and MatInspector: new fast and versatile tools for detection of consensus matches in nucleotide sequence data. Nucleic Acids Res 23:4878-4884
25. Reichstetter S, Krellner PH, Meenzen CM, Kalden JR, Wassmuth R (1994) Comparative analysis of sequence variability in the upstream regulatory region of the HLA-DQB1 gene. Immunogenetics 39:207-212
26. Ridgway WM, Fathman CG (1998) The association of MHC with autoimmune diseases: understanding the pathogenesis of autoimmune diabetes. Clin Immunol Immunopathol 86:3-10
27. Steinman L (1996) A few autoreactive cells in an autoimmune infiltrate control a vast population of nonspecific cells: a tale of smart bombs and the infantry. Proc Natl Acad Sci USA 93:2253-2256
28. Sverdlov ED (1998) Perpetually mobile footprints of ancient infections in human genome. FEBS Lett 428:1-6
29. Temin HM (1993) A proposal for a new approach to a preventive vaccine against human immunodeficiency virus type 1. Proc Natl Acad Sci USA 90:4419-4420
30. Thorsby E (1997) Invited anniversary review: HLA associated diseases. Hum Immunol 53:1-11
31. Tisch R, McDevitt H (1996) Insulin-dependent diabetes mellitus. Cell 85:291-297
32. Todd JA, Bell JI, McDevitt HO (1987) HLA-DQ beta gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus. Nature 329:599-604
33. Tönjes RR, Löwer R, Boller K, Denner J, Hasenmaier B, Kirsch H, König H, Korbmacher C, Limbach C, Lugert R, Phelps RC, Scherer J, Thelen K, Lower J, Kurth R (1996) HERV-K: the biologically most active human endogenous retrovirus family. J Acquir Immune Defic Syndr Hum Retrovirol 13 [Suppl. 1]:S261-S267
34. Tönjes RR, Czauderna F, Kurth R (1999) Genome-wide screening, cloning, chromosomal assignment, and expression of full-length human endogenous retrovirus type K. J Virol 73:9187-9195
35. Vogetseder W, Dumfahrt A, Mayersbach P, Schonitzer D, Dierich MP (1993) Antibodies in human sera recognizing a recombinant outer membrane protein encoded by the envelope gene of the human endogenous retrovirus K. AIDS Res. Hum Retrovir 9:687-694