O6-Alkylguanine-DNA Alkyltransferases Repair O 6-Methylguanine in DNA with Michaelis-Menten-like Kinetics

Chemical Research in Toxicology

Volumn 16, Issue 11, 2003, Pages 1405-1409

  Meyer, Aviva S ^a   McCain, Melodie D ^a   Fang, Qingming ^b   Pegg, Anthony E ^b   Spratt, Thomas E ^a  

^a AMERICAN HEALTH FOUNDATION   (United States)

^b PENN STATE MILTON S HERSHEY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6 O ALKYLGUANINE DNA ALKYLTRANSFERASE; 6 O METHYLGUANINE; COMPLEMENTARY DNA; CYSTEINE; DNA; METHYL GROUP; OLIGODEOXYNUCLEOTIDE; PHOSPHORUS 32; SODIUM HYDROXIDE; DRUG DERIVATIVE; GUANINE; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; O (6) METHYLGUANINE; O-(6)-METHYLGUANINE; OLIGODEOXYRIBONUCLEOTIDE; PHOSPHORUS; POLYDEOXYRIBONUCLEOTIDE SYNTHASE;

ARTICLE; CHEMICAL REACTION KINETICS; DISSOCIATION CONSTANT; DNA MODIFICATION; DNA REPAIR; DNA SEQUENCE; ENZYME SUBSTRATE COMPLEX; GEL MOBILITY SHIFT ASSAY; GENETIC COMPLEMENTATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ION EXCHANGE CHROMATOGRAPHY; ISOTOPE LABELING; MATHEMATICAL ANALYSIS; MICHAELIS MENTEN KINETICS; MOLECULAR INTERACTION; PROTEIN DNA BINDING; PROTEIN DNA INTERACTION; RADIOASSAY; TEMPERATURE; TIME; DNA DAMAGE; DOSE RESPONSE; DRUG EFFECT; ENZYME SPECIFICITY; KINETICS; METABOLISM; METHODOLOGY; METHYLATION; PHYSIOLOGY; POLYACRYLAMIDE GEL ELECTROPHORESIS;

KOBUS;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DNA DAMAGE; DNA REPAIR; DNA REPAIR ENZYMES; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHORESIS, POLYACRYLAMIDE GEL; GUANINE; KINETICS; METHYLATION; O(6)-METHYLGUANINE-DNA METHYLTRANSFERASE; OLIGODEOXYRIBONUCLEOTIDES; PHOSPHORUS RADIOISOTOPES; SUBSTRATE SPECIFICITY; TEMPERATURE; TIME FACTORS;

EID: 0344851845     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx0341254     Document Type: Article

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