Nitric oxide of neuronal origin is involved in cerebral blood flow increase during seizures induced by kainate

Journal of Cerebral Blood Flow and Metabolism

Volumn 17, Issue 1, 1997, Pages 94-99

  Montécot, Céline ^a   Borredon, Josiane ^a   Seylaz, Jacques ^a   Pinard, Elisabeth ^a,b  

^a CNRS   (France)

^b UFR Lariboisiere S Louis Paris VII   (France)

Author keywords

Cerebral blood flow; Kainate; Nitric oxide; Seizures

Indexed keywords

KAINIC ACID; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN BLOOD FLOW; BRAIN BLOOD VESSEL; CONTROLLED STUDY; ELECTROENCEPHALOGRAM; ENZYME ACTIVITY; LASER DOPPLER FLOWMETRY; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PRIORITY JOURNAL; RAT; SEIZURE; VASODILATATION;

EID: 0343247820     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004647-199701000-00012     Document Type: Article

References (41)

1. Babbedge RC, Bland-Ward PA, Hart SL, Moore PK (1993) Inhibition of rat cerebellar nitric oxide synthase by 7-nitro indazole and related substituted indazoles. Br J Pharmacol 110:225-228
2. Balcioglu A, Maher TJ (1993) Determination of kainic acid-induced release of nitric oxide using a novel hemoglobin trapping technique with microdialysis. J Neurochem 61:2311-2313
3. Bonvento G, Charbonné R, Corrèze JL, Borredon J, Seylaz J, Lacombe P (1994) Is α-chioralose plus halothane induction a suitable anesthetic regimen for cerebrovascular research? Brain Res 665:213-221
4. Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254
5. Bredt DS, Snyder SH (1989) Nitric oxide mediates glutamate-linked enhancement of cGMP levels in the cerebellum. Proc Natl Acad Sci USA 86:9030-9033
6. Bredt DS, Hwang PM, Snyder SH (1990) Localization of nitric oxide synthase indicating a neural role for nitric oxide. Nature 347:768-770
7. Carla V, Moroni F (1992) General anaesthetics inhibit the responses induced by glutamate receptor agonists in the mouse cortex. Neurosci Lett 146:21-24
8. Clavier N, Tobin J, Kirsch JR, Izuta M, Traystman RJ (1994) Brain nitric oxide synthase activity in normal, hypertensive, and stroke prone rats. Stroke 25:1674-1678
9. East SJ, Garthwaite J (1991) NMDA receptor activation in rat hippocampus induces cyclic GMP formation through the L-arginine-nitric oxide pathway. Neurosci Lett 123:17-19
10. Faraci FM, Breese KR (1993) Nitric oxide mediates vasodilatation in response to activation of N-methyl-D-aspartate receptors in brain. Circ Res 72:476-480
11. Faraci FM, Breese KR, Heistad DD (1993) Nitric oxide contributes to dilatation of cerebral arterioles during seizures. Am J Physiol 265:H2209-H2212
12. Faraci FM, Breese KR, Heistad DD (1994) Responses of cerebral arterioles to kainate. Stroke 25:2080-2084
13. Faraci FM, Brian JE (1995) 7-Nitroindazole inhibits brain nitric oxide synthase and cerebral vasodilatation to N-methyl-D-aspartate. Stroke 26:2172-2176
14. Ferkany JW, Coyle JT (1983) Kainic acid selectively stimulates the release of endogenous excitatory amino acids. J Pharmacol Exp Ther 225:399-406
15. Garthwaite J, Charles SL, Chess-Williams R (1988) Endothelium-derived relaxing factor release on activation of NMDA receptors suggests role as intercellular messenger in the brain. Nature 336: 385-388
16. Garthwaite J, Southam E, Anderton M (1989) A kainate receptor linked to nitric oxide synthesis from arginine. J Neurochem 53:1952-1954
17. Goldman H, Sapirstein LA (1973) Brain blood flow in the conscious and anesthetized rat. Am J Physiol 224:122-126
18. Hart JL, Jing M, Bina S, Freas W, Van Dyke RA, Muldoon SM (1993) Effects of halothane on EDRF/cGMP-mediated vascular smooth muscle relaxations. Anesthesiology 79:323-331
19. Iadecola C, Beitz AJ, Renno W, Xu X, Mayer B, Zhang F (1993) Nitric-oxide synthase-containing neural processes on large cerebral arteries and cerebral microvessels. Brain Res 606:148-155
20. Iadecola C, Pelligrino DA, Moskowitz MA, Lassen NA (1994) Nitric oxide synthase and cerebrovascular regulation. J Cereb Blood Flow Metab 14:175-192
21. Kelly PAT, Ritchie IM, Arbuthnott GW (1995) Inhibition of neuronal nitric oxide synthase by 7-nitroindazole: effects upon local cerebral blood flow and glucose use in the rat. J Cereb Blood Flow Metab 15:766-773
22. Klatt P, Schmid M, Leopold E, Schmidt K, Werner ER, Mayer B (1994) The pteridine binding site of brain nitric oxide synthase. J Biol Chem 269:13861-13866
23. Kovach AGB, Marczis J, Lohinai Z, Balla I, Vasas G, Reivich M (1995) Effect of neural NO-synthase inhibition on regional cerebral blood flow and MCA reactivity in the cat. J Cereb Blood Flow Metab 15(suppl. 1):S469
24. Lasbennes F, Gayet J (1984) Capacity for energy metabolism in microvessels isolated from rat brain. Neurochem Res 9:1-10
25. Lindauer U, Villringer A, Dirnagl U (1993) Characterization of CBF response to somatosensory stimulation: model and influence of anesthetics. Am J Physiol 254:H1223-H1228
26. Mackenzie GM, Rose S, Bland-Ward PA, Moore PK, Jenner P, Marsden CD (1994) Time course of inhibition of brain nitric oxide synthase by 7-nitro indazole. Neuroreport 5:1993-1996
27. Maggio R, Fumagalli F, Donati E, Barbier P, Racagni G, Corsini GU, Riva M (1995) Inhibition of nitric oxide synthase dramatically potentiates seizures induced by kainic acid and pilocarpine in rats. Brain Res 679:184-187
28. Moore PK, Wallace P, Gaffen Z, Hart SL, Babbedge RC (1993) Characterization of the novel nitric oxide synthase inhibitor 7-nitro indazole and related indazoles: antinociceptive and cardiovascular effects. Br J Pharmacol 110:219-224
29. Mülsch A, Busse R, Mordvintcev PI, Vanin AF, Nielsen EO, Scheel-Krüger J, Olesen SP (1994) Nitric oxide promotes seizure activity in kainate-treated rats. Neuroreport 5:2325-2328
30. Nathan C, Xie QW (1994) Nitric oxide synthases: roles, tolls and controls. Cell 78:915-918
31. Nozaki K, Moskowitz MA, Maynard KI, Koketsu N, Dawson TM, Bredt DS, Snyder SH (1993) Possible origins and distribution of immunoreactive nitric oxide synthase-containing nerve fibers in cerebral arteries. J Cereb Blood Flow Metab 13:70-79
32. Penix LP, Davis W, Subramaniam S (1994) Inhibition of NO synthase increases the severity of kainic acid-induced seizures in rodents. Epilepsy Res 18:177-184
33. Pereira de Vasconcelos A, Baldwin RA, Wasterlain CG (1995) Nitric oxide mediates the increase in local cerebral blood flow during focal seizures. Proc Natl Acad Sci USA 92:3175-3179
34. Pinard E, Rigaud AS, Riche D, Naquet R, Seylaz J (1987) Continuous determination of the cerebrovascular changes induced by bicuculline and kainic acid in unanaesthetized spontaneously breathing rats. Neuroscience 23:943-952
35. Rigaud-Monnet AS, Pinard E, Borredon J, Seylaz J (1994) Blockade of NO synthesis inhibits hippocampal hyperemia in kainic-induced seizures. J Cereb Blood Flow Metab 14:581-590
36. Tobin JR, Martin LD, Breslow MJ, Traystman RJ (1994) Selective anesthetic inhibition of brain nitric oxide synthase. Anesthesiology 81:1264-1269
37. 3H]kainic acid binding sites in the rat forebrain. Eur J Pharmacol 86:361-371
38. Wang Q, Theard MA, Pelligrino DA, Baughman VL, Hoffman WE, Albrecht RF, Cwik M, Paulson OB, Lassen NA (1994) Nitric oxide (NO) is an endogenous anticonvulsant but not a mediator of the increase in cerebral blood flow accompanying bicuculline-induced seizures in rats. Brain Res 658:192-198
39. Wang Q, Pelligrino DA, Baughman VL, Koenig HM, Albrecht RF (1995) The role of neuronal nitric oxide synthase in regulation of cerebral blood flow in normocapnia and hypercapnia in rats. J Cereb Blood Flow Metab 15:774-778
40. G-nitro-L-arginine by halothane. J Cardiovasc Pharmacol 22:571-578
41. Wood J, Garthwaite J (1994) Models of the diffusional spread of nitric-oxide: implications for neural nitric oxide signalling and its pharmacological properties. Neuropharmacology 33:1235-1244