Disulfide connectivity in cerebroside sulfate activator is not necessary for biological activity or α-helical content but is necessary for trypsin resistance and strong ligand binding

Archives of Biochemistry and Biophysics

Volumn 376, Issue 2, 2000, Pages 266-274

  Faull, Kym F ^a   Higginson, Jason ^a   Waring, Alan J ^b   Johnson, Jeffrey ^c   To, Trang ^c   Whitelegge, Julian P ^a   Stevens, Richard L ^a   Fluharty, Claire B ^c   Fluharty, Arvan L ^c  

^a Neuropsychiatric Institute   (United States)

^b CHARLES R DREW UNIVERSITY OF MEDICINE AND SCIENCE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

4 vinylpyridine; Arylsulfatase A; Cerebroside sulfate; Cerebroside sulfate activator protein; Circular dichroism; Disulfide connectivity; Disulfide reduction; Electrospray mass spectrometry; Hydrogen deuterium exchange; Saposin B; Sulfohydrolyase; Trypsin sensitivity

Indexed keywords

4 VINYLPYRIDINE; CEREBROSIDE SULFATASE; DEUTERIUM; HYDROGEN; LIGAND; SPHINGOLIPID ACTIVATOR PROTEIN; SPHINGOLIPID ACTIVATOR PROTEIN 1; SULFATASE; TRYPSIN;

ALPHA HELIX; ANIMAL TISSUE; ARTICLE; CATALYSIS; CIRCULAR DICHROISM; DISULFIDE BOND; GEL PERMEATION CHROMATOGRAPHY; HYDROLYSIS; ION EXCHANGE; LIGAND BINDING; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN PURIFICATION; PROTEIN STABILITY; PROTEIN STRUCTURE; PROTEIN SYNTHESIS; STRUCTURE ACTIVITY RELATION; SWINE;

ANIMALIA; SUS SCROFA;

EID: 0034655952     PISSN: 00039861     EISSN: None     Source Type: Journal    
DOI: 10.1006/abbi.2000.1714     Document Type: Article

References (35)

1. Mehl E., Jatzkewitz H. Hoppe-Seyler's Z. Physiol. Chem. 331:1963;292-294.
2. Mehl E., Jatzkewitz H. Hoppe-Seyler's Z. Physiol. Chem. 339:1964;260-276.
3. Fluharty A. L., Katona Z., Meek W. E., Frei K., Fowler A. V. Biochem. Med. Metab. Biol. 47:1992;66-85.
4. Hiraiwa M., Soeda S., Martin B. M., Fluharty A. L., Hirabayashi Y., O'Brien J. S., Kishimoto Y. Arch. Biochem. Biophys. 303:1993;326-331.
5. Inui K., Wenger D. A. Arch. Biochem. Biophys. 233:1984;556-564.
6. Conzelmann E., Sandhoff K. Methods Enzymol. 138:1987;792.
7. O'Brien J. S., Kishimoto Y. FASEB J. 5:1991;301-308.
8. Fürst W., Sandhoff K. Biochem. Biophys. Acta. 1126:1992;1-16.
9. Sandhoff K., Harzer K., Fürst W. Scriver C. R., Beaudet A. L., Sly W. S., Valle D. The Metabolic and Molecular Bases of Inherited Disease. 1995;2427-2441 McGraw-Hill, New York.
10. Fluharty A. L. Trends Glycosci. Glycotechnol. 7:1995;167-189.
11. Mraz W., Fischer G., Jatzkewitz H. Hoppe-Seyler's Z. Physiol. Chem. 357:1976;1181-1191.
12. Tamaru T., Fujibayashi S., Brown W. R., Wenger D. A. Histochemistry. 86:1985;195-200.
13. Stevens R. L., Faull K. F., Conklin K. A., Green B. N., Fluharty A. L. Biochemistry. 32:1993;4051-4059.
14. Faull K. F., Whitelegge J. P., Higginson J., Waring A. J., To T., Stevens R. L., Fluharty C., Fluharty A. L. J. Mass Spectrom. 34:1999;1040-1054.
15. Vaccaro A. M., Salvioli R., Barca A., Tatti M., Ciaffoni F., Maras B., Siciliano R., Zappacosta F., Amoresano A., Pucci P. J. Biol. Chem. 270:1995;9953-9960.
16. Waring A. J., Chen Y., Faull K. F., Stevens R. L., Sherman M. A., Fluharty A. L. Mol. Genet. Metab. 63:1998;14-25.
17. Faull, K. F, Higginson, J, Waring, A.J, To, T, Whitelegge, J. P, Stevens, R. L, Fluharty, C, and, Fluharty, A. L. in press, J. Mass Spectrom.
18. Whitelegge, J. P, Penn, B, To, T, Waring, A. J, Sherman, M, Stevens, R. L, Fluharty, C, Fluharty, A. L, and, Faull, K. F, Submitted for publication.
19. Munford R. S., Sheppard P. O., O'Hara P. J. J. Lipid Res. 36:1995;1653-1663.
20. Liepinsh E., Andersson M., Ruysschaert J. M., Otting G. Nat. Struct. Biol. 4:1997;793-795.
21. Ponting C. P., Russell R. B. Trends Biochem. Sci. 20:1995;179-180.
22. Vaccaro A. M., Salvioli R., Tatti M., Ciaffoni F. Neurochem. Res. 24:1999;307-314.
23. Fluharty A. I., Davis M. L., Kihara H., Kritchevsky G. Lipids. 9:1974;865-869.
24. Sarafian T., Fluharty A. L., Kihara H., Helfand G., Edmond J. J. Appl. Biochem. 4:1982;126-132.
25. Chen Y. H., Yang J. T, Chau K. H. Biochemistry. 13:1993;3350-3359.
26. Lee T. D., Shively J. E. Methods Enzymol. 193:1990;361-373.
27. Fluharty A. L., Meek W. E., Katona Z., Tsay K. K. Biochem. Med. Metab. Biol. 47:1992;86-96.
28. Glasgow B. J., Abduragimov A. R., Yusifov T. N., Gassymov O. K., Horwitz J., Hubbell W. L., Faull K. F. Biochemistry. 37:1998;2215-2225.
29. Lee T. D., Vemuri S. Biomed. Environ. Mass Spectrom. 19:1990;639-645.
30. Barrett A. J. Segal H. L., Doyle D. J. Protein Turnover and Lysosome Function. 1978;295-304 Academic Press, New York.
31. Taniike M., Inui K., Shinoda K., Okada S., Shiotani Y., Yabuuchi H. Acta Histochem. Cytochem. 21:1988;565-573.
32. Ryle A. P., Sanger F., Smith L. F., Kitai R. Biochem. J. 60:1955;541-556.
33. Smyth D. G., Stein W. H., Moore S. J. Biol. Chem. 238:1963;227-234.
34. Steinman H. M., Naik V. R., Abernathy J. L., Hill R. L. J. Biol. Chem. 249:1974;7326-7333.
35. Hirayama K., Ahashi S., Furuya M., Fukuhara K-i. Biochem. Biophys. Res. Commun. 173:1990;639-646.