Identification of an amino acid residue important for binding of methiothepin and sumatriptan to the human 5-HT(1B) receptor

European Journal of Pharmacology

Volumn 380, Issue 2-3, 1999, Pages 171-181

  Grånäs, Charlotta ^a   Larhammar, Dan ^a  

^a UPPSALA UNIVERSITY   (Sweden)

Author keywords

5 HT(1B) receptor; 5 Nonyloxytryptamine; CGS12066; GR125743; GR127935; GR55562; L 694,247; Methiothepin; Site directed mutagenesis; Sumatriptan

Indexed keywords

3 (3 DIMETHYLAMINOPROPYL) 4 HYDROXY N [4 (4 PYRIDINYL)PHENYL]BENZAMIDE; 4 (4 METHYL 1 PIPERAZINYL) 7 TRIFLUOROMETHYLPYRROLO[1,2 A]QUINOXALINE; AMINO ACID; METITEPINE; N [4 [5 [3 (2 AMINOETHYL) 1H INDOL 5 YL] 1,2,4 OXADIAZOL 3 YL]BENZYL]METHANESULFONAMIDE; N [4 METHOXY 3 (4 METHYL 1 PIPERAZINYL)PHENYL] 2' METHYL 4' (5 METHYL 1,2,4 OXADIAZOL 3 YL)[1,1' BIPHENYL] 4 CARBOXAMIDE; N [4 METHOXY 3 (4 METHYL 1 PIPERAZINYL)PHENYL] 3 METHYL 4 (4 PYRIDYL)BENZAMIDE; SEROTONIN 1B RECEPTOR; SUMATRIPTAN; UNCLASSIFIED DRUG;

ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; HUMAN; LIGAND BINDING; MIGRAINE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RADIOASSAY; RECEPTOR BINDING; SITE DIRECTED MUTAGENESIS;

AMINO ACID SEQUENCE; AMINO ACIDS; ANIMALS; BENZAMIDES; BINDING SITES; BINDING, COMPETITIVE; CHO CELLS; CRICETINAE; DOSE-RESPONSE RELATIONSHIP, DRUG; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); HUMANS; METHIOTHEPIN; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN BINDING; PYRIDINES; RADIOLIGAND ASSAY; RECEPTOR, SEROTONIN, 5-HT1B; RECEPTORS, SEROTONIN; SEQUENCE HOMOLOGY, AMINO ACID; SEROTONIN AGONISTS; SEROTONIN ANTAGONISTS; SODIUM; SUMATRIPTAN; TRITIUM;

EID: 0344631772     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(99)00520-8     Document Type: Article

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