Induction of donor-type chimerism and transplantation tolerance across major histocompatibility barriers in sublethally irradiated mice by Sca- 1+Lin- Bone marrow progenitor cells: Synergism with non-alloreactive (host x donor) F1 T cells

Blood

Volumn 94, Issue 9, 1999, Pages 3212-3221

  Bachar Lustig, Esther ^a   Li, Hong Wei ^a   Gur, Hilit ^a   Krauthgamer, Rita ^a   Marcus, Hadar ^a   Reisner, Yair ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOIMMUNITY; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BONE MARROW CELL; BONE MARROW TRANSPLANTATION; CONTROLLED STUDY; FEMALE; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HOST RESISTANCE; IMMUNOLOGICAL TOLERANCE; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NONHUMAN; PRIORITY JOURNAL; RADIATION CHIMERA; STEM CELL; T LYMPHOCYTE; WHOLE BODY RADIATION;

EID: 0344631763     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v94.9.3212.421k29_3212_3221     Document Type: Article

References (36)

1. Qin S, Cobbold SP, Pope H, Elliott J, Kioussis D, Davies J, Waldmann H: "Infectious" transplantation tolerance. Science 259:974, 1993
2. Wood K, Sachs DH: Chimerism and transplantation tolerance: Cause and effect. Immunol Today 17:584, 1996
3. Greenstein JL, Sachs DH: The use of tolerance for transplantation across xenogeneic barriers. Nat Biotechnol 15:235, 1997
4. Reisner Y: Chimerism, hematopoietic, in Roitt IM, Delves PJ (eds): Encyclopedia of Immunology. London, UK, Academic, 1992, p 332
5. Bachar-Lustig E, Rachamim N, Li HW, Lan F, Reisner Y: Megadose of T cell-depleted bone marrow overcomes MHC barriers in sublethally irradiated mice. Nat Med 1:1268, 1995
6. Sykes M, Szot GL, Swenson KA, Pearson DA: Induction of high levels of allogeneic hematopoietic reconstitution and donor-specific tolerance without myelosuppressive conditioning. Nat Med 3:783, 1997
7. Cobbold SP, Martin G, Qin S, Waldmann H: Monoclonal antibodies to promote marrow engraftment and tissue graft tolerance. Nature 323:164, 1986
8. Strober S, Palathumpat V, Schwadron R, Hertel-Wulff B: Cloned natural suppressor cells prevent lethal graft-vs-host disease. J Immunol 138:699, 1987
9. Kikuya S, Inaba M, Ogata H, Yasumizu R, Inaba K: Wheat germ agglutinin-positive cells in a stem cell-enriched fraction of mouse bone marrow have potent natural suppressor activity. Proc Natl Acad Sci USA 85:4824, 1988
10. Tscherning T, Claesson M: Veto-like down regulation of T helper cell reactivity in vivo by injection of semi-allogeneic spleen cells. Immunol Letters 29:223, 1991
11. Kiyoshi H, Hiruma K, Nakamura H, Henkart P, Cress R: Clonal deletion of postthymic T cells: Veto cells kill precursor cytotoxic T lymphocytes. J Exp Med 175:863, 1992
12. Kaufman CL, Colson YL, Wren SM, Watkins S, Simmons RL, Ildstad ST: Phenotypic characterization of a novel bone marrow-derived cell that facilitates engraftment of allogeneic bone marrow stem cells. Blood 84:2436, 1994
13. Pierce GE, Watts LM: Do donor cells function as veto cells in the induction and maintenance of tolerance across an MHC disparity in mixed lymphoid radiation chimeras? Transplantation 55:882, 1993
14. Pierce GE, Watts LM: Thy 1+ donor cells function as veto cells in the maintenance of tolerance across a major histocompatibility complex disparity in mixed-lymphoid radiation chimeras. Transplant Proc 25:331, 1993
15. Sambhara SR, Miller RG: Programmed cell death of T cells signaled by the T cell receptor and the alpha 3 domain of class I MHC. Science 252:1424, 1991
16. Thomas JM, Carver FM, Cunningham PR, Olson LC, Thomas FT: Kidney allograft tolerance in primates without chronic immunosuppression - The role of veto cells. Transplantation 51:198, 1991
17. Qi Y, Berg R, Singleton MA, Debrick JE, Staerz DU: Hybrid antibody mediated veto of cytotoxic T lymphocyte responses. J Exp Med 183:1973, 1996
18. Aversa F, Tabilio A, Terenzi A, Velardi A, Falzetti F, Giannoni C, lacucci R, Zei T, Martelli MP, Gambelunghe C, Rossetti M, Caputo P, Latini P, Aristei C, Raymondi C, Reisner Y, Martelli MF: Successful engraftment of T-cell-depleted haploidentical "three-loci" incompatible transplants in leukemia patients by addition of recombinant human granulocyte colony-stimulating factor-mobilized peripheral blood progenitor cells to bone marrow inoculum. Blood 84:3948, 1994
19. Reisner Y, Martelli MF: Bone marrow transplantation across HLA barriers by increasing the number of transplanted cells. Immunol Today 16:437, 1995
20. Aversa F, Tabilio A, Velardi A, Cunningham I, Terenzi A, Falzetti F, Ruggeri L, Barbabietola G, Aristei C, Latini P, Reisner Y, Martelli MF: Transplantation of high-risk acute leukemia with T-cell-depleted stem cells from related donor with one fully mismatched HLA haplotype. N Engl J Med 339:1186, 1998
21. Rachamim N, Gan Y, Segal H, Marcus H, Berrrebi A, Krauthgamer R, Martelli MF, Reisner Y: Potential role of CD34 stem cells in tolerance induction. Transplant Proc 29:1935, 1997
22. Rachamim N, Gan J, Segall H, Krauthgamer R, Marcus H, Berrrebi A, Martelli M, Reisner Y: Tolerance induction by "megadose" hematopoietic transplants: Donor-type human CD34 stem cells induce potent specific reduction of host anti-donor cytotoxic T lymphocyte precursors in mixed lymphocyte culture. Transplantation 65:1386, 1998
23. + thymocytes. Blood 80:2406, 1992
24. Levite M, Meshorer A, Reisner Y: A rapid method for obtaining murine bone marrow cells in high yield. Bone Marrow Transpl 8:1, 1991
25. Spangrude GJ, Scollay R: A simplified method for enrichment of mouse hematopoietic stem cells. Exp Hematol 18:920, 1990
26. Reisner Y, Linker-Israel M, Sharon N: Separation of mouse thymocytes into two subpopulations by the use of peanut agglutinin. Cell Immunol 25:129, 1976
27. Baharov E, Lider O, Margalit M, Cohen IR: A modified technique for experimental skin grafting. J Immunol Methods 90:143, 1986
28. Ryser JE, MacDonald HR: Limiting dilution analysis of alloantigen-reactive T lymphocytes. I. Comparison of precursor frequencies for proliferative and cytolytic responses. J Immunol 122:1691, 1979
29. Sentman CL, Kumar V, Koo G, Bennett M: Effector cell expression of NK1.1, a murine natural killer cell-specific molecule, and ability of mice to reject bone marrow allografts. J Immunol 142:1847, 1989
30. Lapidot T, Lubin I, Terenzi A, Faktorowich Y, Erlich P, Reisner Y: Enhancement of bone marrow allografts from nude mice into mismatched recipients by T cells void of graft-versus-host activity. Proc Natl Acad Sci USA 87:4595, 1990
31. Lapidot T, Terenzi A, Singer TS, Salomon O, Reisner Y: Enhancement by dimethyl myleran of donor type chimerism in murine recipients of bone marrow allografts. Blood 73:2025, 1989
32. Stewart FM, Zhong S, Wuu J, Hsieh C, Nilsson SK, Quesenberry PJ: Lymphohematopoietic engraftment in minimally myeloablated hosts. Blood 86:924, 1995
33. Uchida N, Tsukamoto A, He D, Friera AM, Scollay R, Weissman IL: High doses of purified stem cells cause early hematopoietic recovery in syngeneic and allogeneic hosts. J Clin Invest 101:961, 1998
34. Cavazzana Calvo M, Stephan JL, Sarnacki S, Chevret S, Fromont C, De Coene C, Le Deist F, Guy Grand D, Fischer A: Attenuation of graft-versus-host disease and graft rejection by ex vivo immunotoxin elimination of alloreactive T cells in an H-2 haplotype disparate mouse combination. Blood 83:288, 1994
35. Boussiotis VA, Gribben JG, Freeman GJ, Nadler LM: Blockade of the CD28 co-stimulatory pathway: A means to induce tolerance. Curr Opin Immunol 6:797, 1994
36. Gribben JG, Guinan EC, Boussiotis VA, Ke XY, Linsley L, Sieff C, Gray GS, Freeman GJ, Nadler LM: Complete blockade of B7 family-mediated costimulation is necessary to induce human alloantigen-specific anergy: A method to ameliorate graft-versus-host disease and extend the donor pool. Blood 87:4887, 1996