Hybrid antibody mediated veto of cytotoxic T lymphocyte responses

Journal of Experimental Medicine

Volumn 183, Issue 5, 1996, Pages 1973-1980

  Qi, Yan ^a   Berg, Rance ^a,b   Singleton, Michael A ^a   Debrick, J Eric ^a   Staerz, Uwe D ^a,b  

^a NATIONAL JEWISH MEDICAL AND RESEARCH CENTER   (United States)

^b UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; CD8 ANTIGEN; HYBRID PROTEIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1;

ADOLESCENT; ALLOGRAFT; ANIMAL CELL; ANTIBODY SPECIFICITY; ARTICLE; CYTOTOXIC T LYMPHOCYTE; FEMALE; IMMUNOLOGICAL TOLERANCE; MAJOR HISTOCOMPATIBILITY COMPLEX RESTRICTION; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTIBODIES; CHO CELLS; CRICETINAE; CYTOTOXICITY, IMMUNOLOGIC; FEMALE; HUMANS; IMMUNE TOLERANCE; ISOANTIBODIES; LYMPHOCYTE CULTURE TEST, MIXED; MAJOR HISTOCOMPATIBILITY COMPLEX; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, INBRED DBA; MODELS, IMMUNOLOGICAL; PROTEIN HYBRIDIZATION; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; RECOMBINANT PROTEINS; SPLEEN; T-LYMPHOCYTES, CYTOTOXIC; TRANSFECTION;

EID: 0029980866     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.183.5.1973     Document Type: Article

References (35)

1. Miller, R.G. 1980. An immunological suppressor cell inactivating cytotoxic T lymphocyte precursor cells recognizing it. Nature (Lond.). 287:544-546.
2. + T cells of stimulator strain origin. Eur. J. Immunol. 12:930-934.
3. Fink, P.J., I.L. Weissman, and M.J. Bevan. 1983. Haplotype specific suppression of cytotoxic T cell induction by antigen inappropriately presented on T cells. J. Exp. Med. 157:141-154.
4. Rammensee, H.-G., A. Juretic, Z.A. Nagy, and J. Klein. 1984. Class I-restricted interaction between suppressor and cytolytic cells in the response to minor histocompatibility antigens. J. Immunol. 132:668-672.
5. Muraoka, S., and R.G. Miller. 1980. Cells in bone marrow and in T cell colonies grown from bone marrow can suppress generation of cytotoxic T lymphocytes directed against their self antigens. J. Exp. Med. 152:54-71.
6. Rammensee, H.-G. 1989. Veto function in vitro and in vivo. Int. Rev. Immunol. 4:175-191.
7. Fink, P.J., R.P. Shimonkevitz, and M.J. Bevan. 1988. Veto cells. Annu. Rev. Immunol. 6:115-137.
8. Zhang, L., J. Shannon, J. Sheldon, H.-S. Teh, T.W. Mak, and R.G. Miller. 1994. Role of infused CD8+ cells in the induction of peripheral tolerance. J. Immunol. 152:2222-2228.
9. Martin, D.R., and R.G. Miller. 1989. In vivo administration of histocompatibility lymphocytes leads to rapid functional deletion of cytotoxic T lymphocyte precursors. J. Exp. Med. 170:679-690.
10. Johnson, L.L. 1987. Prolonged minor allograft survival of intravenously primed mice - a test of the veto hypothesis. Transplantation. 44:92-97.
11. Thomas, J.M., F.M. Carver, P.R. Cunningham, L.C. Olson, and F.T. Thomas. 1991. Kidney allograft tolerance in primates without chronic immunosuppression. Transplant. Proc. 51:198-207.
12. Takahashi, T., and T. Maki. 1991. Prolongation of mouse skin allograft survival by cloned veto suppressor cells. Transplant. Proc. 23:192-193.
13. Hiruma, K., H. Nakamura, P.A. Henkart, and R.E. Gress. 1992. Clonal deletion of post-thymic T cells: Veto cells kill precursor cytotoxic T lymphocytes. J. Exp. Med. 175:863-868.
14. Thomas, J.M., F.M. Carver, J. Kasten-Jolly, C.E. Haisch, L.M. Rebellato, U. Gross, S.J. Vore, and F.T. Thomans. 1994. Further studies of veto activity in rhesus monkey bone marrow in relation to allograft tolerance and chimerism. Transplantation. 57:101-115.
15. Hambor, J.E., M.C. Weber, M.L. Tykocinski, and D.R. Kaplan. 1990. Regulation of allogeneic responses by expression of CD8 α-chain on stimulator cells. Intern. Immunol. 2:879-883.
16. Swain, S.L. 1981. Significance of Lyt phenotype: Lyt-2 antibodies block activities of T cells that recognize class I major histocompatibility complex antigens regardless of their function. Proc. Natl. Acad. Sci. USA. 78:7101-7105.
17. Connolly, J.M., T.H. Hansen, A.L. Ingold, and T.A. Potter. 1990. Recognition by CD8 on cytotoxic T lymphocytes is ablated by several substitutions in the class I alpha 3 domain: CD8 and the T cell receptor recognize the same class I MHC molecule. Proc. Natl. Acad. Sci. USA. 87:2137-2141.
18. Smith, D.M., J.A. Bluestone, M.K. Newberg, V.H. Englehard, J.R. Thistlethwite, Jr., and E.S. Woode. 1994. Inhibition of T cell activity by a monoclonal antibody directed against the alpha 3 domain of the MHC class I molecule. J. Immunol. 153:1054-1067.
19. Cobbold, S.P., S. Qin, L.W. Leong, G. Martin, and H. Waldmann. 1992. Reprogramming the immune system for peripheral tolerance with CD4 and CD8 monoclonal antibodies. Immunol. Rev. 129:165-201.
20. Krensky, A.M., S.C. Lyu, P. Pouletty, R. Benjamin, P. Parham, and C. Clayberger. 1993. Peptides corresponding to the CD8 binding region of HLA class I block differentiation of cytotoxic T lymphocyte precursors. Transplant. Proc. 25:483-484.
21. Sambhara, S., and R.G. Miller. 1991. Programmed cell death of T cells signaled by the T cell receptor and the α3 domain of class I MHC. Science (Wash. DC). 252:1424-1427.
22. Sha, W.C., C.A. Nelson, R.D. Newberry, D.M. Kranz, J.H. Russel, and D.Y. Loh. 1988. Positive and negative selection of an antigen receptor on T cells in transgenic mice. Nature (Lond.). 336:73-76.
23. Leahy, D.J., R. Axel, and W.A. Hendrickson. 1992. Crystal structure of a soluble form of the human T cell co-receptor CD8 at 2.6 A resolution. Cell 68:1145-1162.
24. Ozato, K., N. Mayer, and D.H. Sachs. 1980. Hybridoma cell lines secreting monoclonal antibodies to mouse H-2 and Ia antigens. J. Immunol. 124:533-540.
25. Staerz, U.D., O. Kanagawa, and M.J. Sevan. 1983. Hybrid antibodies can target sites for attack by T cells. Nature (Lond.). 314:628-631.
26. Pawlowski, T., J.D. Elliott, D.Y. Loh, and U.D. Staerz. 1993. Positive selection of T lymphocytes on fibroblasts. Nature (Lond.). 364:642-645.
27. Staerz, U.D., and M.J. Bevan. 1986. Hybrid hybridoma producing a bispecific monoclonal antibody which can focus T cell activity. Proc. Natl. Acad. Sci. USA. 83:1453-1457.
28. Staerz, U.D., J.W. Yewdell, and M.J. Bevan. 1987. Hybrid antibody mediated lysis of virus infected cells. Eur. J. Immunol. 17:571-574.
29. Zepp, F., and U.D. Staerz. 1988. Hybrid antibodies induce selection processes in the thymus. Nature (Lond.). 336:473-475.
30. Newberg, N.M., J.P. Ridge, D.R. Vining, R. Salter, and V.H. Englehard. 1992. Species specificity in the interaction of CD8 with the alpha 3 domain of MHC class I molecules. J. Immunol. 149:136-142.
31. Hurme, M. 1986. Genetic variation in the in vitro veto actvity of bone marrow cells. Scand. J. Immunol. 23:389-392.
32. Rotzschke, O., K. Falk, S. Faath, and H.-G. Rammensee. 1991. On the nature of peptides involved in T cell alloreactivity. J. Exp. Med. 174:1059-1071.
33. Matis, L.A., S.B. Sorger, D.L. McElligott, P.J. Fink, and S.M. Hedrick. 1987. The molecular basis of alloreactivity in antigen-specific, major histocompatibility complex-restricted T cell clones. Cell. 51:59-69.
34. Liu, Z., Y.K. sun, Y.P. Xi, A. Maffei, E. Reed, P. Harris, and N. Sociu-Foca. 1994. Contribution of direct and indirect recognition pathways to T cell alloreactivity. J. Exp. Med. 177:1643-1650.
35. Fangmann, J., R. Dalchau, and J.W. Fabre. 1992. Rejection of skin allografts by indirect allorecognition of donor class I histocompatibility complex peptides. J. Exp. Med. 175:1521-1529.