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Volumn 132, Issue 3, 2003, Pages 196-209

Viral RNA and p24 antigen as markers of HIV disease and antiretroviral treatment success

Author keywords

Antiretroviral treatment monitoring; HIV infection; HIV RNA; p24 antigen; Viral load

Indexed keywords

ANTIBODY; ANTIGEN P24; ANTIVIRUS AGENT; BIOLOGICAL MARKER; BUFFER; CD4 ANTIGEN; INDINAVIR; ISOPROPAMIDE IODIDE; VIRUS PROTEIN; VIRUS RNA;

EID: 0344629362     PISSN: 10182438     EISSN: None     Source Type: Journal    
DOI: 10.1159/000074552     Document Type: Review
Times cited : (44)

References (68)
  • 1
    • 0030058515 scopus 로고    scopus 로고
    • Changes in plasma HIV-1 RNA and CD4+ lymphocyte counts and the risk of progression to AIDS
    • Veterans Affairs Cooperative Study Group on AIDS
    • O'Brien WA, Hartigan PM, Martin D, et al: Changes in plasma HIV-1 RNA and CD4+ lymphocyte counts and the risk of progression to AIDS. Veterans Affairs Cooperative Study Group on AIDS. N Engl J Med 1996;334:426-431.
    • (1996) N Engl J Med , vol.334 , pp. 426-431
    • O'Brien, W.A.1    Hartigan, P.M.2    Martin, D.3
  • 2
    • 9844238154 scopus 로고    scopus 로고
    • Impact of new antiretroviral combination therapies in HIV infected patients in Switzerland: Prospective multicentre study. Swiss HIV Cohort Study
    • Egger M, Hirschel B, Francioli P, et al: Impact of new antiretroviral combination therapies in HIV infected patients in Switzerland: Prospective multicentre study. Swiss HIV Cohort Study. BMJ 1997;315:1194-1199.
    • (1997) BMJ , vol.315 , pp. 1194-1199
    • Egger, M.1    Hirschel, B.2    Francioli, P.3
  • 3
    • 2642709177 scopus 로고    scopus 로고
    • Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection
    • HIV Outpatient Study Investigators
    • Palella FJ Jr, Delaney KM, Moorman AC, et al: Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators. N Engl J Med 1998;338:853-860.
    • (1998) N Engl J Med , vol.338 , pp. 853-860
    • Palella Jr., F.J.1    Delaney, K.M.2    Moorman, A.C.3
  • 4
    • 0032968454 scopus 로고    scopus 로고
    • Determinants of sustainable CD4 lymphocyte count increases in response to antiretroviral therapy
    • Staszewski S, Miller V, Sabin C, et al: Determinants of sustainable CD4 lymphocyte count increases in response to antiretroviral therapy. AIDS 1999;13:951-956
    • (1999) AIDS , vol.13 , pp. 951-956
    • Staszewski, S.1    Miller, V.2    Sabin, C.3
  • 5
    • 0030868897 scopus 로고    scopus 로고
    • Positive effects of combined antiretroviral therapy on CD4+ T cell homeostasis and function in advanced HIV disease
    • Autran B, Carcelain G, Li TS, et al: Positive effects of combined antiretroviral therapy on CD4+ T cell homeostasis and function in advanced HIV disease. Science 1997;277:112-116
    • (1997) Science , vol.277 , pp. 112-116
    • Autran, B.1    Carcelain, G.2    Li, T.S.3
  • 6
    • 0031882434 scopus 로고    scopus 로고
    • Biphasic kinetics of peripheral blood T cells after triple combination therapy in HIV-1 infection: A composite of redistribution and proliferation
    • Pakker NG, Notermans DW, de Boer RJ, et al: Biphasic kinetics of peripheral blood T cells after triple combination therapy in HIV-1 infection: A composite of redistribution and proliferation. Nat Med 1998;4:208-214.
    • (1998) Nat Med , vol.4 , pp. 208-214
    • Pakker, N.G.1    Notermans, D.W.2    De Boer, R.J.3
  • 7
    • 0031907427 scopus 로고    scopus 로고
    • Perturbation of CD4+ and CD8+ T-cell repertoires during progression to AIDS and regulation of the CD4+ repertoire during antiviral therapy
    • Gorochov G, Neumann AU, Kereveur A, et al: Perturbation of CD4+ and CD8+ T-cell repertoires during progression to AIDS and regulation of the CD4+ repertoire during antiviral therapy. Nat Med 1998;4:215-221.
    • (1998) Nat Med , vol.4 , pp. 215-221
    • Gorochov, G.1    Neumann, A.U.2    Kereveur, A.3
  • 8
    • 0032104145 scopus 로고    scopus 로고
    • High prevalence of thymic tissue in adults with human immunodeficiency virus-1 infection
    • McCune JM, Loftus R, Schmidt DK, et al: High prevalence of thymic tissue in adults with human immunodeficiency virus-1 infection. J Clin Invest 1998;101:2301-2308.
    • (1998) J Clin Invest , vol.101 , pp. 2301-2308
    • McCune, J.M.1    Loftus, R.2    Schmidt, D.K.3
  • 9
    • 17444372347 scopus 로고    scopus 로고
    • Changes in thymic function with age and during the treatment of HIV infection
    • Douek DC, McFarland RD, Keiser PH, et al: Changes in thymic function with age and during the treatment of HIV infection. Nature 1998;396:690-695.
    • (1998) Nature , vol.396 , pp. 690-695
    • Douek, D.C.1    McFarland, R.D.2    Keiser, P.H.3
  • 10
    • 0028811974 scopus 로고
    • Viral dynamics in human immunodeficiency virus type 1 infection
    • Wei X, Ghosh SK, Taylor ME, et al: Viral dynamics in human immunodeficiency virus type 1 infection. Nature 1995;373:117-122.
    • (1995) Nature , vol.373 , pp. 117-122
    • Wei, X.1    Ghosh, S.K.2    Taylor, M.E.3
  • 11
    • 0032991492 scopus 로고    scopus 로고
    • HIV-1 rebound during interruption of highly active antiretroviral therapy has no deleterious effect on reinitiated treatment
    • Neumann AU, Tubiana R, Calvez V, et al: HIV-1 rebound during interruption of highly active antiretroviral therapy has no deleterious effect on reinitiated treatment. AIDS 1999;13:677-683.
    • (1999) AIDS , vol.13 , pp. 677-683
    • Neumann, A.U.1    Tubiana, R.2    Calvez, V.3
  • 12
    • 0027410369 scopus 로고
    • High levels of HIV-1 in plasma during all stages of infection determined by competitive PCR
    • Piatak M Jr, Saag MS, Yang LC, et al: High levels of HIV-1 in plasma during all stages of infection determined by competitive PCR. Science 1993;259:1749-1754
    • (1993) Science , vol.259 , pp. 1749-1754
    • Piatak Jr., M.1    Saag, M.S.2    Yang, L.C.3
  • 15
    • 0029683640 scopus 로고    scopus 로고
    • Serum HIV-1 RNA levels and time to development of AIDS in the Multicenter Hemophilia Cohort Study
    • O'Brien TR, Blattner WA, Waters D, et al: Serum HIV-1 RNA levels and time to development of AIDS in the Multicenter Hemophilia Cohort Study. JAMA 1996;276:105-110.
    • (1996) JAMA , vol.276 , pp. 105-110
    • O'Brien, T.R.1    Blattner, W.A.2    Waters, D.3
  • 16
    • 10144260003 scopus 로고    scopus 로고
    • Association of plasma human immunodeficiency virus type 1 RNA level with risk of clinical progression in patients with advanced infection
    • AIDS Clinical Trials Group (ACTG) 116B/117 Study Team. ACTG Virology Committee Resistance and HIV-1 RNA Working Groups
    • Coombs RW, Welles SL, Hooper C, et al: Association of plasma human immunodeficiency virus type 1 RNA level with risk of clinical progression in patients with advanced infection. AIDS Clinical Trials Group (ACTG) 116B/117 Study Team. ACTG Virology Committee Resistance and HIV-1 RNA Working Groups. J Infect Dis 1996;174:704-712.
    • (1996) J Infect Dis , vol.174 , pp. 704-712
    • Coombs, R.W.1    Welles, S.L.2    Hooper, C.3
  • 17
    • 1842266562 scopus 로고    scopus 로고
    • HIV viral load markers in clinical practice
    • Saag MS, Holodniy M, Kuritzkes DR, et al: HIV viral load markers in clinical practice. Nat Med 1996;2:625-629.
    • (1996) Nat Med , vol.2 , pp. 625-629
    • Saag, M.S.1    Holodniy, M.2    Kuritzkes, D.R.3
  • 18
    • 0031006111 scopus 로고    scopus 로고
    • Changes in plasma HIV RNA levels and CD4+ lymphocyte counts predict both response to antiretroviral therapy and therapeutic failure
    • VA Cooperative Study Group on AIDS
    • O'Brien WA, Hartigan PM, Daar ES, Simberkoff MS, Hamilton JD: Changes in plasma HIV RNA levels and CD4+ lymphocyte counts predict both response to antiretroviral therapy and therapeutic failure. VA Cooperative Study Group on AIDS. Ann Intern Med 1997;126: 939-945.
    • (1997) Ann Intern Med , vol.126 , pp. 939-945
    • O'Brien, W.A.1    Hartigan, P.M.2    Daar, E.S.3    Simberkoff, M.S.4    Hamilton, J.D.5
  • 20
    • 0029081506 scopus 로고
    • Natural history of HIV-1 cell-free viremia
    • Henrard DR, Phillips JF, Muenz LR, et al: Natural history of HIV-1 cell-free viremia. JAMA 1995;274:554-558.
    • (1995) JAMA , vol.274 , pp. 554-558
    • Henrard, D.R.1    Phillips, J.F.2    Muenz, L.R.3
  • 21
    • 17344371054 scopus 로고    scopus 로고
    • Variability and prognostic values of virologic and CD4 cell measures in human immunodeficiency virus type 1-infected patients with 200-500 CD4 cells/mm(3) (ACTG 175)
    • AIDS Clinical Trials Group Protocol 175 Team
    • Lathey JL, Hughes MD, Fiscus SA, et al: Variability and prognostic values of virologic and CD4 cell measures in human immunodeficiency virus type 1-infected patients with 200-500 CD4 cells/mm(3) (ACTG 175). AIDS Clinical Trials Group Protocol 175 Team. J Infect Dis 1998;177:617-624.
    • (1998) J Infect Dis , vol.177 , pp. 617-624
    • Lathey, J.L.1    Hughes, M.D.2    Fiscus, S.A.3
  • 22
    • 0032498578 scopus 로고    scopus 로고
    • A critical assessment of the prognostic value of HIV-1 RNA levels and CD4+ cell counts in HIV-infected patients. The Swiss HIV Cohort Study
    • Yerly S, Perneger TV, Hirschel B, et al: A critical assessment of the prognostic value of HIV-1 RNA levels and CD4+ cell counts in HIV-infected patients. The Swiss HIV Cohort Study. Arch Intern Med 1998;158:247-252.
    • (1998) Arch Intern Med , vol.158 , pp. 247-252
    • Yerly, S.1    Perneger, T.V.2    Hirschel, B.3
  • 23
    • 0023546646 scopus 로고
    • Viral gene expression, antibody production and immune complex formation in human immunodeficiency virus infection
    • Lange JM, Paul DA, de Wolf F, Coutinho RA, Goudsmit J: Viral gene expression, antibody production and immune complex formation in human immunodeficiency virus infection. AIDS 1987;1:15-20.
    • (1987) AIDS , vol.1 , pp. 15-20
    • Lange, J.M.1    Paul, D.A.2    De Wolf, F.3    Coutinho, R.A.4    Goudsmit, J.5
  • 24
    • 0023251026 scopus 로고
    • Risk of AIDS related complex and AIDS in homosexual men with persistent HIV antigenaemia
    • de Wolf F, Goudsmit J, Paul DA, et al: Risk of AIDS related complex and AIDS in homosexual men with persistent HIV antigenaemia. Br Med J (Clin Res Ed) 1987;295:569-572.
    • (1987) Br Med J (Clin Res Ed) , vol.295 , pp. 569-572
    • De Wolf, F.1    Goudsmit, J.2    Paul, D.A.3
  • 25
    • 0023177259 scopus 로고
    • Temporal relation of antigenaemia and loss of antibodies to core antigens to development of clinical disease in HIV infection
    • Pedersen C, Nielsen CM, Vestergaard BF, Gerstoft J, Krogsgaard K, Nielsen JO: Temporal relation of antigenaemia and loss of antibodies to core antigens to development of clinical disease in HIV infection. Br Med J (Clin Res Ed) 1987;295:567-569.
    • (1987) Br Med J (Clin Res Ed) , vol.295 , pp. 567-569
    • Pedersen, C.1    Nielsen, C.M.2    Vestergaard, B.F.3    Gerstoft, J.4    Krogsgaard, K.5    Nielsen, J.O.6
  • 26
    • 0029830201 scopus 로고    scopus 로고
    • Advances in antiretroviral therapy and viral load monitoring
    • Hammer SM: Advances in antiretroviral therapy and viral load monitoring. AIDS 1996;10: S1-11.
    • (1996) AIDS , vol.10
    • Hammer, S.M.1
  • 27
    • 0027434448 scopus 로고
    • Rapid serologic testing with immune-complex-dissociated HIV p24 antigen for early detection of HIV infection in neonates. Southern California Pediatric AIDS Consortium
    • Miles SA, Balden E, Magpantay L, et al: Rapid serologic testing with immune-complex-dissociated HIV p24 antigen for early detection of HIV infection in neonates. Southern California Pediatric AIDS Consortium. N Engl J Med 1993;328:297-302.
    • (1993) N Engl J Med , vol.328 , pp. 297-302
    • Miles, S.A.1    Balden, E.2    Magpantay, L.3
  • 28
    • 0029206245 scopus 로고
    • Enhancement of HIV antigen detection after acid dissociation of immune complexes is associated with loss of specificity
    • Gutierrez M, Vallejo A, Soriano V: Enhancement of HIV antigen detection after acid dissociation of immune complexes is associated with loss of specificity. Vox Sang 1995;68:132-133.
    • (1995) Vox Sang , vol.68 , pp. 132-133
    • Gutierrez, M.1    Vallejo, A.2    Soriano, V.3
  • 29
    • 0027244063 scopus 로고
    • Quantitative and sensitive detection of immune-complexed and free HIV antigen after boiling of serum
    • Schupbach J, Boni J: Quantitative and sensitive detection of immune-complexed and free HIV antigen after boiling of serum. J Virol Methods 1993;43:247-256.
    • (1993) J Virol Methods , vol.43 , pp. 247-256
    • Schupbach, J.1    Boni, J.2
  • 30
    • 0032144234 scopus 로고    scopus 로고
    • A simple and robust method for the complete dissociation of Hiv-1 P24 and other antigens from immune complexes in serum and plasma samples
    • Steindl F, Armbruster C, Pierer K, Purtscher M, Katinger HWD: A simple and robust method for the complete dissociation of Hiv-1 P24 and other antigens from immune complexes in serum and plasma samples. J Immunol Methods 1998;217:143-151.
    • (1998) J Immunol Methods , vol.217 , pp. 143-151
    • Steindl, F.1    Armbruster, C.2    Pierer, K.3    Purtscher, M.4    Katinger, H.W.D.5
  • 32
    • 0028234401 scopus 로고
    • Sensitive detection and early prognostic significance of p24 antigen in heat-denatured plasma of human immunodeficiency virus type 1-infected infants
    • Swiss Neonatal HIV Study Group
    • Schupbach J, Boni J, Tomasik Z, Jendis J, Seger R, Kind C: Sensitive detection and early prognostic significance of p24 antigen in heat-denatured plasma of human immunodeficiency virus type 1-infected infants. Swiss Neonatal HIV Study Group. J Infect Dis 1994;170:318-324.
    • (1994) J Infect Dis , vol.170 , pp. 318-324
    • Schupbach, J.1    Boni, J.2    Tomasik, Z.3    Jendis, J.4    Seger, R.5    Kind, C.6
  • 33
    • 0028032975 scopus 로고
    • Rapid increases in load of human immunodeficiency virus correlate with early disease progression and loss of CD4 cells in vertically infected infants
    • Dickover RE, Dillon M, Gillette SG, et al: Rapid increases in load of human immunodeficiency virus correlate with early disease progression and loss of CD4 cells in vertically infected infants. J Infect Dis 1994;170:1279-1284.
    • (1994) J Infect Dis , vol.170 , pp. 1279-1284
    • Dickover, R.E.1    Dillon, M.2    Gillette, S.G.3
  • 34
    • 0024852342 scopus 로고
    • Catalyzed reporter deposition, a novel method of signal amplification. Application to immunoassays
    • Bobrow MN, Harris TD, Shaughnessy KJ, Litt GJ: Catalyzed reporter deposition, a novel method of signal amplification. Application to immunoassays. J Immunol Methods 1989;125:279-285.
    • (1989) J Immunol Methods , vol.125 , pp. 279-285
    • Bobrow, M.N.1    Harris, T.D.2    Shaughnessy, K.J.3    Litt, G.J.4
  • 35
    • 0029830936 scopus 로고    scopus 로고
    • Heat-mediated immune complex dissociation and enzyme-linked immunosorbent assay signal amplification render p24 antigen detection in plasma as sensitive as HIV-1 RNA detection by polymerase chain reaction
    • Schupbach J, Flepp M, Pontelli D, Tomasik Z, Luthy R, Boni J: Heat-mediated immune complex dissociation and enzyme-linked immunosorbent assay signal amplification render p24 antigen detection in plasma as sensitive as HIV-1 RNA detection by polymerase chain reaction. AIDS 1996;10:1085-1090.
    • (1996) AIDS , vol.10 , pp. 1085-1090
    • Schupbach, J.1    Flepp, M.2    Pontelli, D.3    Tomasik, Z.4    Luthy, R.5    Boni, J.6
  • 36
    • 17144445063 scopus 로고    scopus 로고
    • HIV-1 p24 antigen is a significant inverse correlate of CD4 T-cell change in patients with suppressed viremia under long-term antiretroviral therapy
    • Schupbach J, Boni J, Bisset LR, et al: HIV-1 p24 antigen is a significant inverse correlate of CD4 T-cell change in patients with suppressed viremia under long-term antiretroviral therapy. J Acquir Immune Defic Syndr 2003;33:292-299.
    • (2003) J Acquir Immune Defic Syndr , vol.33 , pp. 292-299
    • Schupbach, J.1    Boni, J.2    Bisset, L.R.3
  • 38
    • 0003358914 scopus 로고    scopus 로고
    • Retroviridae: The viruses and their replication
    • Fields BN, Knipe DM, Howley PM (eds). Philadelphia, Lippincott-Raven
    • Coffin JM: Retroviridae: The viruses and their replication; in Fields BN, Knipe DM, Howley PM (eds): Virology, ed 3. Philadelphia, Lippincott-Raven, 1996, pp 1767-1847.
    • (1996) Virology, Ed 3 , pp. 1767-1847
    • Coffin, J.M.1
  • 39
    • 0030935706 scopus 로고    scopus 로고
    • Simple monitoring of antiretroviral therapy with a signal-amplification- boosted HIV-1 P24 antigen assay with heat-denatured plasma
    • Boni J, Opravil M, Tomasik Z, et al: Simple monitoring of antiretroviral therapy with a signal-amplification-boosted HIV-1 P24 antigen assay with heat-denatured plasma. AIDS 1997;11:F47-F52.
    • (1997) AIDS , vol.11
    • Boni, J.1    Opravil, M.2    Tomasik, Z.3
  • 40
    • 0033387317 scopus 로고    scopus 로고
    • Prospective evaluation of amplification-boosted ELISA for heat-denatured p24 antigen for diagnosis and monitoring of pediatric HIV-1 infection
    • Nadal D, Böni J, Kind C, et al: Prospective evaluation of amplification-boosted ELISA for heat-denatured p24 antigen for diagnosis and monitoring of pediatric HIV-1 infection. J Infect Dis 1999;180:1089-1095.
    • (1999) J Infect Dis , vol.180 , pp. 1089-1095
    • Nadal, D.1    Böni, J.2    Kind, C.3
  • 41
    • 0034024945 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 p24 concentration measured by boosted ELISA of heat-denatured plasma correlates with decline in CD4 cells, progression to AIDS, and survival: Comparison with viral RNA measurement
    • Ledergerber B, Flepp M, Boni J, et al: Human immunodeficiency virus type 1 p24 concentration measured by boosted ELISA of heat-denatured plasma correlates with decline in CD4 cells, progression to AIDS, and survival: Comparison with viral RNA measurement. J Infect Dis 2000;181:1280-1288.
    • (2000) J Infect Dis , vol.181 , pp. 1280-1288
    • Ledergerber, B.1    Flepp, M.2    Boni, J.3
  • 42
    • 0034860989 scopus 로고    scopus 로고
    • Antiretroviral treatment monitoring with an improved HIV-1 p24 antigen test: An inexpensive alternative to tests for viral RNA
    • Schüpbach J, Boni J, Flepp M, Tomasik Z, Joller H, Opravil M: Antiretroviral treatment monitoring with an improved HIV-1 p24 antigen test: An inexpensive alternative to tests for viral RNA. J Med Virol 2001;65:225-232.
    • (2001) J Med Virol , vol.65 , pp. 225-232
    • Schüpbach, J.1    Boni, J.2    Flepp, M.3    Tomasik, Z.4    Joller, H.5    Opravil, M.6
  • 43
    • 0037108665 scopus 로고    scopus 로고
    • Prognostic value of heat-denatured HIV-1 p24 antigen and correlation with plasma HIV-1 viral load and CD4+ T-lymphocyte level in adults
    • Sterling TR, Hoover DR, Astemborski J, Vlahov D, Bartlett JG, Schupbach J: Prognostic value of heat-denatured HIV-1 p24 antigen and correlation with plasma HIV-1 viral load and CD4+ T-lymphocyte level in adults. J Infect Dis 2002;186:1181-1185.
    • (2002) J Infect Dis , vol.186 , pp. 1181-1185
    • Sterling, T.R.1    Hoover, D.R.2    Astemborski, J.3    Vlahov, D.4    Bartlett, J.G.5    Schupbach, J.6
  • 44
    • 0036308862 scopus 로고    scopus 로고
    • Comparison of an assay using signal amplification of the heat-dissociated p24 antigen with the Roche Monitor human immunodeficiency virus RNA assay
    • Pascual A, Cachafeiro A, Funk ML, Fiscus SA: Comparison of an assay using signal amplification of the heat-dissociated p24 antigen with the Roche Monitor human immunodeficiency virus RNA assay. J Clin Microbiol 2002;40:2472-2475.
    • (2002) J Clin Microbiol , vol.40 , pp. 2472-2475
    • Pascual, A.1    Cachafeiro, A.2    Funk, M.L.3    Fiscus, S.A.4
  • 45
    • 0142091697 scopus 로고    scopus 로고
    • Performance of a quantitative human immunodeficiency virus type 1 p24 antigen assay on various HIV-1 subtypes for the follow-up of human immunodeficiency type 1 seropositive individuals
    • Ribas SG, Ondoa P, Schupbach J, van der Groen G, Fransen K: Performance of a quantitative human immunodeficiency virus type 1 p24 antigen assay on various HIV-1 subtypes for the follow-up of human immunodeficiency type 1 seropositive individuals. J Virol Methods 2003;113:29-34.
    • (2003) J Virol Methods , vol.113 , pp. 29-34
    • Ribas, S.G.1    Ondoa, P.2    Schupbach, J.3    Van Der Groen, G.4    Fransen, K.5
  • 46
    • 0025761245 scopus 로고
    • High titers of cytopathic virus in plasma of patients with symptomatic primary HIV-1 infection
    • Clark SJ, Saag MS, Decker WD, et al: High titers of cytopathic virus in plasma of patients with symptomatic primary HIV-1 infection. N Engl J Med 1991;324:954-960.
    • (1991) N Engl J Med , vol.324 , pp. 954-960
    • Clark, S.J.1    Saag, M.S.2    Decker, W.D.3
  • 47
    • 0025735965 scopus 로고
    • Transient high levels of viremia in patients with primary human immunodeficiency virus type 1 infection
    • Daar ES, Moudgil T, Meyer RD, Ho DD: Transient high levels of viremia in patients with primary human immunodeficiency virus type 1 infection. N Engl J Med 1991;324:961-964.
    • (1991) N Engl J Med , vol.324 , pp. 961-964
    • Daar, E.S.1    Moudgil, T.2    Meyer, R.D.3    Ho, D.D.4
  • 48
    • 0027182022 scopus 로고
    • Kinetics of human immunodeficiency virus type 1 (HIV-1) DNA and RNA synthesis during primary HIV-1 infection
    • Graziosi C, Pantaleo G, Butini L, et al: Kinetics of human immunodeficiency virus type 1 (HIV-1) DNA and RNA synthesis during primary HIV-1 infection. Proc Natl Acad Sci USA 1993;90:6405-6409
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 6405-6409
    • Graziosi, C.1    Pantaleo, G.2    Butini, L.3
  • 49
    • 0028337166 scopus 로고
    • Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome
    • Koup RA, Safrit JT, Cao Y, et al: Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome. J Virol 1994;68:4650-4655.
    • (1994) J Virol , vol.68 , pp. 4650-4655
    • Koup, R.A.1    Safrit, J.T.2    Cao, Y.3
  • 51
    • 0041828179 scopus 로고    scopus 로고
    • Dynamics of HIV viremia and antibody seroconversion in plasma donors: Implications for diagnosis and staging of primary HIV infection
    • Fiebig EW, Wright DJ, Rawal BD, et al: Dynamics of HIV viremia and antibody seroconversion in plasma donors: Implications for diagnosis and staging of primary HIV infection. AIDS 2003;17:1871-1879.
    • (2003) AIDS , vol.17 , pp. 1871-1879
    • Fiebig, E.W.1    Wright, D.J.2    Rawal, B.D.3
  • 52
    • 0027516822 scopus 로고
    • Massive covert infection of helper T lymphocytes and macrophages by HIV during the incubation period of AIDS
    • Embretson J, Zupancic M, Ribas JL, et al: Massive covert infection of helper T lymphocytes and macrophages by HIV during the incubation period of AIDS. Nature 1993;362:359-362.
    • (1993) Nature , vol.362 , pp. 359-362
    • Embretson, J.1    Zupancic, M.2    Ribas, J.L.3
  • 53
    • 0027538456 scopus 로고
    • HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of disease
    • Pantaleo G, Graziosi C, Demarest JF, et al: HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of disease. Nature 1993;362:355-358.
    • (1993) Nature , vol.362 , pp. 355-358
    • Pantaleo, G.1    Graziosi, C.2    Demarest, J.F.3
  • 54
    • 0028825476 scopus 로고
    • Follicular dendritic cells and human immunodeficiency virus infectivity
    • Heath SL, Tew JG, Tew JG, Szakal AK, Burton GF: Follicular dendritic cells and human immunodeficiency virus infectivity. Nature 1995;377:740-744.
    • (1995) Nature , vol.377 , pp. 740-744
    • Heath, S.L.1    Tew, J.G.2    Tew, J.G.3    Szakal, A.K.4    Burton, G.F.5
  • 55
    • 0030952479 scopus 로고    scopus 로고
    • Decay characteristics of HIV-1-infected compartments during combination therapy
    • Perelson AS, Essunger P, Cao YZ, et al: Decay characteristics of HIV-1-infected compartments during combination therapy. Nature 1997;387:188-191.
    • (1997) Nature , vol.387 , pp. 188-191
    • Perelson, A.S.1    Essunger, P.2    Cao, Y.Z.3
  • 56
    • 0032889275 scopus 로고    scopus 로고
    • Rapid clearance of simian immunodeficiency virus particles from plasma of rhesus macaques
    • Zhang LQ, Dailey PJ, He T, et al: Rapid clearance of simian immunodeficiency virus particles from plasma of rhesus macaques. J Virol 1999;73:855-860.
    • (1999) J Virol , vol.73 , pp. 855-860
    • Zhang, L.Q.1    Dailey, P.J.2    He, T.3
  • 57
    • 18144435424 scopus 로고    scopus 로고
    • Evolutionary pattern of human immunodeficiency virus (HIV) replication and distribution in lymph nodes following primary infection - Implications for antiviral therapy
    • Pantaleo G, Cohen OJ, Schacker T, et al: Evolutionary pattern of human immunodeficiency virus (HIV) replication and distribution in lymph nodes following primary infection - Implications for antiviral therapy. Nat Med 1998;4:341-345.
    • (1998) Nat Med , vol.4 , pp. 341-345
    • Pantaleo, G.1    Cohen, O.J.2    Schacker, T.3
  • 58
    • 0028024718 scopus 로고
    • The natural history of HIV-1 infection: Virus load and virus phenotype independent determinants of clinical course?
    • Jurriaans S, Van Gemen B, Weverling GJ, et al: The natural history of HIV-1 infection: Virus load and virus phenotype independent determinants of clinical course? Virology 1994;204:223-233.
    • (1994) Virology , vol.204 , pp. 223-233
    • Jurriaans, S.1    Van Gemen, B.2    Weverling, G.J.3
  • 59
    • 0027692154 scopus 로고
    • Multifactorial nature of human immunodeficiency virus disease: Implications for therapy
    • Fauci AS: Multifactorial nature of human immunodeficiency virus disease: Implications for therapy. Science 1993;262:1011-1018.
    • (1993) Science , vol.262 , pp. 1011-1018
    • Fauci, A.S.1
  • 60
    • 0029704332 scopus 로고    scopus 로고
    • PCR detection of HIV
    • Boni J: PCR detection of HIV. Methods Mol Biol 1996;50:93-107.
    • (1996) Methods Mol Biol , vol.50 , pp. 93-107
    • Boni, J.1
  • 61
    • 9344259105 scopus 로고    scopus 로고
    • Performance of a modified HIV-1 p24 antigen assay for early diagnosis of HIV-1 infection in infants and prediction of mother-to-infant transmission of HIV-1 in Dar es Salaam, Tanzania
    • Lyamuya E, Bredberg-Raden U, Massawe A, et al: Performance of a modified HIV-1 p24 antigen assay for early diagnosis of HIV-1 infection in infants and prediction of mother-to-infant transmission of HIV-1 in Dar es Salaam, Tanzania. J Acquir Immune Defic Syndr 1996;12:421-426.
    • (1996) J Acquir Immune Defic Syndr , vol.12 , pp. 421-426
    • Lyamuya, E.1    Bredberg-Raden, U.2    Massawe, A.3
  • 62
    • 1542533854 scopus 로고    scopus 로고
    • Quantification of HIV-1 RNA in plasma: Comparable results with the NASBA HIV-1 RNA QT and the AMPLICOR HIV monitor test
    • Vandamme AM, Schmit JC, Van Dooren S, et al: Quantification of HIV-1 RNA in plasma: Comparable results with the NASBA HIV-1 RNA QT and the AMPLICOR HIV monitor test. J Acquir Immune Defic Syndr 1996;13:127-139.
    • (1996) J Acquir Immune Defic Syndr , vol.13 , pp. 127-139
    • Vandamme, A.M.1    Schmit, J.C.2    Van Dooren, S.3
  • 63
    • 0034860989 scopus 로고    scopus 로고
    • Antiretroviral treatment monitoring with an improved HIV-1 p24 antigen test: An inexpensive alternative to tests for viral RNA
    • Schupbach J, Boni J, Flepp M, Tomasik Z, Joller H, Opravil M: Antiretroviral treatment monitoring with an improved HIV-1 p24 antigen test: An inexpensive alternative to tests for viral RNA. J Med Virol 2001;65:225-232.
    • (2001) J Med Virol , vol.65 , pp. 225-232
    • Schupbach, J.1    Boni, J.2    Flepp, M.3    Tomasik, Z.4    Joller, H.5    Opravil, M.6
  • 64
    • 12944250984 scopus 로고    scopus 로고
    • Performance of five different assays for the quantification of viral load in subjects infected with various subtypes of HIV-1
    • Bürgisser P, Vernazza P, Flepp M, et al: Performance of five different assays for the quantification of viral load in subjects infected with various subtypes of HIV-1. J Acquir Immune Defic Syndr 2000;23:138-144.
    • (2000) J Acquir Immune Defic Syndr , vol.23 , pp. 138-144
    • Bürgisser, P.1    Vernazza, P.2    Flepp, M.3
  • 65
    • 0028091322 scopus 로고
    • Ultrasensitive retrovirus detection by a reverse transcriptase assay based on product enhancement
    • Pyra H, Boni J, Schupbach J: Ultrasensitive retrovirus detection by a reverse transcriptase assay based on product enhancement. Proc Natl Acad Sci USA 1994;91:1544-1548.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 1544-1548
    • Pyra, H.1    Boni, J.2    Schupbach, J.3
  • 66
    • 0037335643 scopus 로고    scopus 로고
    • p24 antigen detection assay modified with a booster step for diagnosis and monitoring of human immunodeficiency virus type 1 infection
    • Sutthent R, Gaudart N, Chokpaibulkit K, Tanliang N, Kanoksinsombath C, Chaisilwatana P: p24 antigen detection assay modified with a booster step for diagnosis and monitoring of human immunodeficiency virus type 1 infection. J Clin Microbiol 2003;41:1016-1022.
    • (2003) J Clin Microbiol , vol.41 , pp. 1016-1022
    • Sutthent, R.1    Gaudart, N.2    Chokpaibulkit, K.3    Tanliang, N.4    Kanoksinsombath, C.5    Chaisilwatana, P.6
  • 67
    • 0000884527 scopus 로고    scopus 로고
    • Human imunodeficiency viruses
    • Murray PR, Baron EJ, Pfaller MA, Tenover FC, Yolken RH (eds). Washington, ASM Press
    • Schüpbach J: Human imunodeficiency viruses; in Murray PR, Baron EJ, Pfaller MA, Tenover FC, Yolken RH (eds): Manual of Clinical Microbiology. Washington, ASM Press, 1999, pp 847-870.
    • (1999) Manual of Clinical Microbiology , pp. 847-870
    • Schüpbach, J.1
  • 68
    • 0033675843 scopus 로고    scopus 로고
    • Use of HIV-1 p24 as a sensitive, precise and inexpensive marker for infection, disease progression and treatment failure
    • Schüpbach J, Tomasik Z, Nadal D, et al: Use of HIV-1 p24 as a sensitive, precise and inexpensive marker for infection, disease progression and treatment failure. Int J Antimicrob Agents 2000;16:441-445.
    • (2000) Int J Antimicrob Agents , vol.16 , pp. 441-445
    • Schüpbach, J.1    Tomasik, Z.2    Nadal, D.3


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