Investigations into the stabilisation of drugs by sugar glasses: II: Delivery of an inulin-stabilised alkaline phosphatase in the intestinal lumen via the oral route

International Journal of Pharmaceutics

Volumn 257, Issue 1-2, 2003, Pages 273-281

  Eriksson, H J C ^a   Verweij, W R ^a   Poelstra, K ^a   Hinrichs, W L J ^a   De Jong, G J ^b   Somsen, G W ^b   Frijlink, H W ^a  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

^b UTRECHT UNIVERSITY   (Netherlands)

Author keywords

Oral administration; Proteins; Sugar glass

Indexed keywords

ACID; ALKALINE PHOSPHATASE; CHLORIDE; ENDOTOXIN; INULIN; SUGAR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CATTLE; CONCEPT FORMATION; DISEASE SEVERITY; DRUG ACTIVITY; DRUG COATING; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG RELEASE; DRUG SCREENING; DRUG STABILITY; ENTERIC COATED TABLET; ENZYME ACTIVITY; FREEZE DRYING; IN VITRO STUDY; IN VIVO STUDY; INTESTINE; MALE; NONHUMAN; PH; PRIORITY JOURNAL; RAT; SENSITIVITY ANALYSIS; SEPSIS; STOMACH; TABLET COMPRESSION; TABLET DISINTEGRATION TIME; TABLET FORMULATION; TABLET FRIABILITY; TABLET PROPERTY; WEIGHT;

EID: 0344519688     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(03)00152-2     Document Type: Article

References (23)

1. Bentala, H., Verweij, W.R., Huizinga-van der Vla, A., van Loenen-Weemaes, A.M., Meijer, D.K.F., Poelstra, K., 2002. Removal of phosphate from lipid A as a strategy to detoxify lipopolysaccharide. Shock (submitted for publication).
2. Butterworth P.J. The reversible inactivation of pig kidney alkaline phosphatase at low pH. Biochem. J. 108:1968;243-246.
3. Cardona S., Schebor C., Buera M.P., Karel M., Chirife J. Thermal stability of invertase in reduced-moisture amorphous matrices in relation to glassy state and trehalose crystallization. J. Food Sci. 62:1997;105-112.
4. Cleland J.L., Daugherty A., Mrsny R. Emerging protein delivery methods. Curr. Opin. Biotechnol. 12:2001;212-219.
5. Colaco C.A.L.S., Smith C.J.S., Sen S., Roser D.H., Newman Y., Ring S., Roser B.J. Chemistry of protein stabilization by trehalose. Am. Chem. Soc. Symp. Ser. 567:1994;222-240.
6. Craig D.B., Wong J.C.Y., Dovichi N.J. Detection of attomolar concentrations of alkaline phosphatase by capillary electrophoresis using laser-induced fluorescence detection. Anal. Chem. 68:1996;697-700.
7. Crowe L.M., Reid D.S., Crowe J.H. Is trehalose special for preserving dry biomaterials? Biophys. J. 71:1996;2087-2093.
8. Eriksson H.J., Somsen G.W., Hinrichs W.L., Frijlink H.W., de Jong G.J. Characterization of human placental alkaline phosphatase by activity and protein assays, capillary electrophoresis and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. J. Chromatogr. B. 755:2001;311-319.
9. Eriksson H.J.C., Hinrichs W.L.J., van Veen B., de Jong G.J., Somsen G.W., Frijlink H.W. Investigations into the stabilisation of drugs by sugar glasses: I. Tablets prepared from stabilised alkaline phosphatase. Int. J. Pharm. 249:2002;59-70.
10. Ford A.W., Allahiary Z. The adverse effect of glycation of human serum albumin on its preservative activity in the freeze-drying and accelerated degradation of alkaline phosphatase. J. Pharm. Pharmacol. 45:1993;900-906.
11. Ford A.W., Dawson P.J. The effect of carbohydrate additives in the freeze-drying of alkaline phosphatase. J. Pharm. Pharmacol. 45:1993;86-93.
12. Hatley R.H.M., Blair J.A. Stabilisation and delivery of labile materials by amorphous carbohydrates and their derivatives. J. Mol. Catal. B. 7:1999;11-19.
13. Hinrichs W.L., Prinsen M.G., Frijlink H.W. Inulin glasses for the stabilization of therapeutic proteins. Int. J. Pharm. 215:2001;163-174.
14. Irino T., Matsushita M., Sakagishi Y., Komoda T. Phosphorylcholine as a unique substrate for human intestinal alkaline phosphatase. Int. J. Biochem. 26:1994;273-277.
15. Izutsu K., Yoshioka S., Terao T. Stabilization of β-galactosidase by amphiphilic additives during freeze-drying. Int. J. Pharm. 90:1993;187-194.
16. Lowry O.H., Roseborough N.J., Farr A.L., Randall R.J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193:1951;265-275.
17. Mazzobre M.F., del Pilar M., Chirife J. Protective role of trehalose on thermal stability of lactase in relation to its glass and crystal forming properties and effect of delaying crystallization. Lebensm. Wiss. u Technol. 30:1997;324-329.
18. Millqvist-Fureby A., Malmsten M., Bergenstahl B. Surface characterization of freeze-dried protein/carbohydrate mixtures. Int. J. Pharm. 191:1999;103-114.
19. Poelstra K., Bakker W.W., Klok P.A., Hardonk M.J., Meijer D.K.F. A physiologic function for alkaline phosphatase: endotoxin detoxification. Lab. Invest. 76:1997;319-327.
20. Schebor C., Burin L., Buera M.P., Aguilera J.M., Chirife J. Glassy state and thermal inactivation of invertase and lactase in dried amorphous matrices. Biotechnol. Prog. 13:1997;857-863.
21. Scott T.A., Melvin E.H. Determination of dextran with anthrone. Anal. Chem. 25:1953;1656-1661.
22. Scutt P.B., Moss D.W. Reversible inactivation of alkaline phosphatase in acid solution. Enzymology. 35:1968;157-167.
23. Xie G., Timasheff S.N. The thermodynamic mechanism of protein stabilization by trehalose. Biophys. Chem. 64:1997;25-43.