High glucose induced NF-κB DNA-binding activity in HAEC is maintained under low shear stress but inhibited under high shear stress: Role of nitric oxide

Atherosclerosis

Volumn 171, Issue 2, 2003, Pages 225-234

  Mohan, Sumathy ^a   Hamuro, Masao ^a   Koyoma, Koichi ^a   Sorescu, George P ^c   Jo, Hanjoong ^c   Natarajan, Mohan ^b  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^b UNIVERSITY OF TEXAS AT SAN ANTONIO   (United States)

^c Emory University   (United States)

Author keywords

Accelerated atherosclerosis; Diabetes mellitus; eNOS; Hemodynamics

Indexed keywords

GLUCOSE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR;

ANIMAL CELL; AORTA; ARTICLE; CATTLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA BINDING; ENDOTHELIUM CELL; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REGULATORY MECHANISM; SHEAR STRESS; SIGNAL TRANSDUCTION;

EID: 0344464839     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2003.08.023     Document Type: Article

References (29)

1. Feener E.P., King G.L. Vascular dysfunction in diabetes mellitus. Lancet. 350:1997;SI9-S13.
2. Asakura T., Karino T. Flow patterns and spatial distribution of atherosclerotic lesions in human coronary arteries. Circ. Res. 66:1990;1045-1066.
3. Hajra L, Evans AI, Chen M, Hyduk SJ, Collins T, Cybulsky MI. The NF-kappa B signal transduction pathway in aortic endothelial cells is primed for activation in regions predisposed to atherosclerotic lesion formation, vol. 97. PNAS 2000; 97: 9052-57.
4. Berliner J.A., Navab M., Fogelman A.M., Frank J.S., Demer L.L., Edwards P.A., et al. Atherosclerosis: basic mechanisms, oxidation. Inflamm. Genet. 91:1995;2488-2496.
5. Mohan S., Mohan N., Sprague E.A. Differential activation of NF-kappa B in human aortic endothelial cells conditioned to specific flow environments. Am. J. Physiol. 273:1997;C572-C578.
6. Ghosh S., May M.J., Kopp E.B. NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses. Annu. Rev. Immunol. 16:1998;225-260.
7. Verma I.M., Stevenson J.K., Schwarz E.M., Van Antwerp D., Miyamoto S. Rel/NF-kappa B/I kappa B family: Intimate tales of association and dissociation. Genes Develop. 9:1995;2723-2735.
8. Pieper G.M., Riazul H. Activation of nuclear factor-kappa B in cultured endothelial cells by increased glucose concentration: prevention by calphostin C. J. Cardiovasc. Pharmacol. 30:1997;528-532.
9. Bao X., Lu C., Frangos J.A. Temporal gradient in shear but not steady shear stress induces PDGFA and MCP-1 expression in endothelial cells: role of NO, NF kappa B, and egr-1. Arterioscler. Thromb. Vasc. Biol. 19:1999;996-1003.
10. Nagel T., Resnick N., Dewey C.F. Jr., Gimbrone M.A. Jr. Vascular endothelial cells respond to spatial gradients in fluid shear stress by enhanced activation of transcription factors. Arterioscler. Thromb. Vasc. Biol. 19:1999;1825-1834.
11. Mohan S., Mohan N., Valente A.J., Sprague E.A. Regulation of low shear flow-induced HAEC VCAM-1 expression and monocyte adhesion. Am. J. Physiol. 276:1999;C1100-C1107.
12. Boo Y.C., Sorescu G., Boyd N., Shiojima I., Walsh K., Du J., et al. Shear stress stimulates phosphorylation of endothelial nitric oxide synthase at Ser 1179 by Akt-independent mechanisms: role of protein kinase A. J. Biol. Chem. 277:2002;3388-3396.
13. Hamuro M., Polan J., Natarajan M., Mohan S. High glucose induced nuclear factor kappa B mediated inhibition of endothelial cell migration. Atherosclerosis. 162:2002;277-287.
14. Xiao Z, Zhang Z, Ranjan V, Diamond SL. Shear stress induction of the endothelial nitric oxide synthase gene is calcium-dependent but not calcium-activated. J Cell Physiol 1997;171:205-11 [published Erratum appeared in J Cell Physiol Jan 1998;174(1):144].
15. Du X.L., Edelstein D., Dimmeler S., Ju Q., Sui C., Brownlee M. Hyperglycemia inhibits endothelial nitric oxide synthase activity by post-translational modification at the Akt site. J. Clin. Invest. 108:2001;1341-1348.
16. Ming-Hui Z., Chaomei S., Richard A.C. High glucose via peroxynitrite causes tyrosine nitration and inactivation of prostacyclin synthase that is associated with thromboxane/prostaglandin H2 receptor mediated apoptosis and adhesion molecule expression in cultured human aortic endothelial cells. Diabetes. 51:2002;198-203.
17. Inoguchi T., Li P., Umeda F., Yu H.Y., Kakimot M., Imamura M., et al. High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C-dependent activation of NAD(P)H oxidase in cultured vascular cells. Diabetes. 49:2000;1939-1945.
18. Chakravarthy U., Hayes R.G., Stitt A.W., McAuley E., Archer D.B. Constitutive nitric oxide synthase expression in retinal vascular endothelial cells is suppressed by high glucose and advanced glycation end products. Diabetes. 47:1998;945-952.
19. Noyman I., Marikovsky M., Sasson S., Stark A.H., Bernath K., Seger R., et al. Hyperglycemia reduces nitric oxide synthase and glycogen synthase activity in endothelial cells. Nitric oxide. 7:2002;187-193.
20. Malek AM, Izumo S, Alper SL. Modulation by pathophysiological stimuli of the shear stress-induced up-regulation of endothelial nitric oxide synthase expression in endothelial cells. Neurosurgery 1999;45:334-45.
21. Ranjan V., Xiao Z., Diamond S.L. Constitutive NOS expression in cultured endothelial cells is elevated by fluid shear stress. Am. J. Physiol. 269:1995;H550-H555.
22. Ziegler T., Silacci P., Harrison V.J., Hayoz D. Nitric oxide synthase expression in endothelial cells exposed to mechanical forces. Hypertension. 32(2):1998;351-355.
23. Channon K.M., Qian H., George S.E. Nitric oxide synthase in atherosclerosis and vascular injury: insights from experimental gene therapy. Arterioscler. Thromb. Vasc. Biol. 20:2000;1873-1881.
24. Dimmeler S., Fleming I., Fisslthaler B., Hermann C., Busse R., Zeiher A.M. Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation. Nature. 399:1999;601-605.
25. Spiecker M., Peng H.B., Liao J.K. Inhibition of endothelial vascular cell adhesion molecule-1 expression by nitric oxide involves the induction and nuclear translocation of IkappaB-alpha. J. Biol. Chem. 272:1997;30969-30974.
26. Peng H.B., Libby P., Liao J.K. Induction and stabilization of I kappa B alpha by nitric oxide mediates inhibition of NF-kappa B. J. Biol. Chem. 270:1995;14214-14219.
27. DelaTorre A., Schroeder R.A., Punzalan C., Kuo P.C. Endotoxin-mediated S-nitrosylation of p50 alters NF-kappa B-dependent gene transcription in ANA-1 murine macrophages. J. Immunol. 162:1999;4101-4108.
28. Matthews J.R., Botting C.H., Panico M., Morris H.R., Hay R.T. Inhibition of NF-kappaB DNA binding by nitric oxide. Nucl. Acid Res. 24:1996;236-2242.
29. Wei Z., Costa K., Al-Mehdi A.B., Dodia C., Muzykanto V., Fisher A.B. Simulated Ischemia in flow-adapted endothelial cells leads to generation of reactive oxygen species and cell signaling. Circ Res. 85:1999;682-689.