Further evidence for the participation of primary carbon-centered free radicals in the antimalarial action of the qinghaosu (artemisinin) series of compounds

Journal of the Chemical Society. Perkin Transactions 1

Volumn , Issue 6, 2001, Pages 605-609

  Wang, Dong Ye ^a   Wu, Yu Lin ^a   Wu, Yikang ^a   Liang, Jie ^a   Li, Ying ^a  

^a SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYLATION; AROMATIC HYDROCARBONS; CARBON; COLUMN CHROMATOGRAPHY; IONS; SOLUTIONS;

ANTIMALARIAL ACTIVITIES;

FREE RADICALS;

EID: 0035925869     PISSN: 14727781     EISSN: None     Source Type: Journal    
DOI: 10.1039/b008145k     Document Type: Article

References (17)

1. (a) J.-M. Liu, M.-Y. Ni, Y.-F. Fan, Y.-Y. Tu, Z.-H. Wu, Y.-L. Wu and W.-S. Chou, Huaxue Xuebao, 1979, 37, 2, 129.
2. (b) D.L. Klayman, Science, 1985, 228, 1049.
3. (c) A.R. Butler and Y.-L. Wu, Chem. Soc. Rev., 1992, 85.
4. (a) S.R. Meshnick, Med. Trop. (Marseille), 1998, 58, 3S, 13; and references cited therein.
5. (b) A. Robert and B. Meunier, Chem. Soc. Rev., 1998, 27, 273.
6. (c) A. Robert and B. Meunier, J. Am. Chem. Soc., 1997, 119, 5968.
7. (a) J.N. Cumming, P. Ploypradith and G.H. Posner, Adv. Pharmacol., 1997, 37, 253.
8. (b) W.-M. Wu, Z.-J. Yao, Y.-L. Wu, K. Jiang, Y.-F. Wang, H.-B. Chen, F. Shan and Y. Li, Chem. Commun., 1996, 18, 2213.
9. (c) W.-M. Wu, Y.-K. Wu, Y.-L. Wu, Z.-J. Yao, C.-M. Zhou, Y. Li and F. Shan, J. Am. Chem. Soc., 1998, 120, 14, 3316; and references cited therein.
10. (d) A.R. Butler, B.C. Gilbert, P. Hulme and L.R. Irvine, Free Radical Res., 1998, 28, 471.
11. Y.-K. Wu, Z.-Y. Yue and Y.-L. Wu, Angew. Chem., Int. Ed., 1999, 38, 17, 2580.
12. S.E. Fracis, D.J. Sullivan Jr. and D.E. Goldberg, Annu. Rev. Microbiol., 1997, 51, 97.
13. Y.Z. Yang, W. Asawamahasakda and S.R. Meshnick, Biochem. Pharmacol., 1993, 46, 336.
14. D.-Y. Wang, Y.-K. Wu, Y.-L. Wu, Y. Li and F. Shan, J. Chem. Soc., Perkin Trans. 1, 1999, 13, 1827.
15. Y. Li, P.-L. Yu, Y.-X. Chen, L.-Q. Li, Y.-Z. Gai, D.-S. Wang and Y.-P. Zheng, Yaoxue Xuebao, 1981, 16, 6, 429 (Chem. Abstr., 1983, 97, 92245n).
16. G.H. Posner, M.H. Parker, J. Northrop, J.S. Elias, P. Ploypradith, S.-J. Xie and T.A. Shapiro, J. Med. Chem., 1999, 42, 300.
17. For the method of antimalarial assay in vivo see: Y. Li, Y.-M. Zhu, H.-J. Jiang, J.-P. Pan, G.-S. Wu and J.-M. Wu, J. Med. Chem., 2000, 43, 1635.