Trypanosoma cruzi glycosomal glyceraldehyde-3-phosphate dehydrogenase: Structure, catalytic mechanism and targeted inhibitor design

FEBS Letters

Volumn 424, Issue 3, 1998, Pages 131-135

  Souza, D H F ^a   Garratt, R C ^a   Araujo A P U ^a   Guimaraes B G ^a   Jesus, W D P ^a   Michels, P A M ^b   Hannaert, V ^b   Oliva, G ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b DE DUVE INSTITUTE   (Belgium)

Author keywords

Catalytic mechanism; Conformational change; Crystal structure; Glyceraldehyde 3 phosphate dehydrogenase; Trypanosoma cruzi

Indexed keywords

GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; OXIDOREDUCTASE;

ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG TARGETING; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME STRUCTURE, FUNCTION AND VARIABILITY; NONHUMAN; PRIORITY JOURNAL; REACTION ANALYSIS; TRYPANOSOMA CRUZI;

ANIMALS; DRUG DESIGN; ENZYME INHIBITORS; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASES; HUMANS; MODELS, MOLECULAR; NAD; PHOSPHATES; PROTEIN CONFORMATION; SULFATES; TRYPANOSOMA CRUZI;

MAMMALIA; PROTOZOA; TRYPANOSOMA; TRYPANOSOMA CRUZI;

EID: 0032513293     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-5793(98)00154-9     Document Type: Article

References (33)

1. World Health Organisation Statistical Information System Website, at http://www.who.ch./whosis/whosis.htm.
2. Kirchhoff L.V. New Engl. J. Med. 329:1993;639-644.
3. Opperdoes F.R. Annu. Rev. Microbiol. 41:1987;127-151.
4. Wierenga R.K., Noble M.E.M., Vriend G., Nauche S., Hol W.G.J. J. Mol. Biol. 220:1991;995-1015.
5. Vellieux F.M.D., Hajdu J., Verlinde C.L.M.J., Groendijk H., Read R.J., Greenhough T.J., Campbell J.W., Kalk K.H., Littlechild J.A., Watson H.C., Hol W.G.J. Proc. Natl. Acad. Sci. USA. 20:1993;2355-2359.
6. Bernstein B.E., Michels P.A.M., Hol W.G.J. Nature. 385:1997;275-278.
7. Verlinde C.L.M., Callens M., Van Calenbergh S., Van Aerschot A., Herdewijn P., Hannaert V., Michels P.A.M., Opperdoes F.R., Hol W.G.J. J. Med. Chem. 37:1994;3605-3613.
8. Verlinde C.L.M.J., Merrit T.E.A., Van Den Akker F., Kim H., Feil I., Delboni L.F., Mamde S.C., Sarfaty S., Petra P.H., Hol W.G.J. Protein Sci. 3:1994;1670-1686.
9. Engel J.C., Franke de Cazzulo B.M., Stoppani A.O., Cannatta J.J., Cazzullo J.J. Mol. Biochem. Parasitol. 26:1987;1-10.
10. Seydoux F., Bernhard S., Pfenninger O., Payne M., Malhota O.P. Biochemistry. 12:1973;4290-4300.
11. Duggleby R.G., Dennis D.T. J. Biol. Chem. 249:1974;167-174.
12. Harrigan P.J., Trentham D.R. Biochem. J. 135:1973;695-703.
13. Segal H.L., Boyer P.D. J. Biol. Chem. 204:1953;265-281.
14. Moras D., Olsen K.W., Sabesan M.N., Buehner M., Ford G.C., Rossmann M.G. J. Biol. Chem. 250:1975;9137-9162.
15. Watson H.C., Duee E., Mercer W.D. Nature New Biol. 240:1972;130.
16. Skarzynski T., Moody P.C.E., Wonacott A.J. J. Mol. Biol. 193:1987;171-187.
17. Korndörfer I., Steipe B., Huber R., Tornschy A., Jaenicke R. J. Mol. Biol. 246:1995;511-521.
18. Tanner, J., Hecht, R.M., Pisegna, M., Seth, D.M. and Krause, K.L. (1994) Acta Crystallogr. D50, 744-748; PDB access code 1CER.
19. Duée E., Olivier-Deyris L., Fanchon E., Corbier C., Branlant G., Dideberg O. J. Mol. Biol. 257:1996;814-838.
20. Barbosa, V.M. (1996) PhD Thesis, University of São Paulo.
21. Kim H., Feil I.K., Verlinde C.L.M., Petra P.H., Hol W.G.J. Biochemistry. 34:1995;14975-14986.
22. Hannaert V., Opperdoes F.R., Michels P.A.M. Protein Express. Purif. 6:1995;244-250.
23. Matheus B.W. J. Mol. Biol. 33:1968;491-497.
24. Process Program, Instruction Manual of R-AXIS IIC.
25. Navaza J. Acta Crystallogr. A50:1994;157-163.
26. Brunger, A.T. (1992) X-PLOR, A System for X-ray Crystallography and NMR, Version 3.1, Yale University Press, New Haven, CT.
27. Kleywegt, G.J. and Jones, T.A. (1994) Manual do programa MAMA, University of Uppsala.
28. CCP4 Program Suite Rotation Function-ALMN (1994) User Documentation, Daresbury Laboratory.
29. Kleywegt, G.J. and Jones, T.A. (1994) RAVE, The Manual, Uppsala.
30. Jones, T.A. and Kjeldgaard, M. (1993) 'O', The Manual, Version 5.9, Uppsala.
31. Kleywegt G.J., Jones T.A. Structure. 3:1995;535-540.
32. Laskowski R.A., MacArthur M.W., Thornton J.M. J. Appl. Crystallogr. 26:1993;283-291.
33. Kraulis P.J. J. Appl. Crystallogr. 24:1991;946-950.