Somatostatin Receptor Subtypes in Human Pheochromocytoma: Subcellular Expression Pattern and Functional Relevance for Octreotide Scintigraphy

Journal of Clinical Endocrinology and Metabolism

Volumn 88, Issue 11, 2003, Pages 5150-5157

  Mundschenk, Jochen ^a   Unger, Nicole ^a   Schulz, Stefan ^a   Höllt, Volker ^a   Schulz, Solveig ^a   Steinke, Rainer ^a   Lehnert, Hendrik ^a,b  

^a OTTO VON GUERICKE UNIVERSITY   (Germany)

^b UNIVERSITY HOSPITAL MAGDEBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

MONOCLONAL ANTIBODY; OCTREOTIDE; PENTETREOTIDE IN 111; POLYCLONAL ANTIBODY; RECEPTOR SUBTYPE; SOMATOSTATIN RECEPTOR;

ARTICLE; CELLULAR DISTRIBUTION; COMPARATIVE STUDY; CONTROLLED STUDY; CYTOSOL; HUMAN; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; IMMUNOSCINTIGRAPHY; MAJOR CLINICAL STUDY; PATIENT SELECTION; PHEOCHROMOCYTOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; TUMOR LOCALIZATION; TUMOR VOLUME;

ADRENAL GLAND NEOPLASMS; ANTIBODY SPECIFICITY; EVALUATION STUDIES; HUMANS; IMMUNOHISTOCHEMISTRY; INDIUM RADIOISOTOPES; MEMBRANE PROTEINS; OCTREOTIDE; PHEOCHROMOCYTOMA; RANDOM ALLOCATION; RECEPTORS, SOMATOSTATIN;

EID: 0344442675     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.2003-030262     Document Type: Article

References (32)

1. Patel YC 1992 General aspects of the biology and function of somatostatin. In: Weil C, Muller EE, Thorner MO, eds. Basic and clinical aspects of neuroscience. Berlin: Springer-Verlag; 4:1-16
2. Weckbecker G, Raulf F, Stolz B, Bruns C 1993 Somatostatin analogs for diagnosis and treatment of cancer. Pharmacol Ther 60:245-264
3. Patel YC 1999 Somatostatin and ist receptor family. Front Neuroendocrinol 20:157-198
4. Vanetti M, Vogt G, Hoellt V 1993 The two isoforms of the mouse somatostatin receptor (mSSTR2A and mSSTR2B) differ in coupling efficiency to adenylate cyclase and in agonist-induced receptor desensitization. FEBS Lett 311:260-266
5. Arnold R, Trautmann ME, Creutzfeldt W, Benning R, Benning M, Neuhaus C, Juergensen, R, Stein, K, Schaefer H, Bruns C, Dennler HJ 1996 Somatostatin analogue octreotide and inhibition of tumour growth in metastatic endocrine gastroenteropancreatic tumours. Gut 38:430-438
6. Casnici C, Lattuada D, Perego C, Franco P, Marelli O 1997 Inhibitory effect of somatostatin on human T lymphocytes proliferation. Int J Immunopharmacol 19:721-727
7. 111In- DTPA-octreotide. Eur J Nucl Med 28:1743-1750
8. Lamberts SWL, Krenning EP, Reubi JC 1991 The role of somatostatin and its analogs in the diagnosis and treatment of tumors. Endocr Rev 12:450-482
9. Mundschenk J, Lehnert H 1998 Malignant pheochromocytoma. Exp Clin Endocrinol Diabetes 106:373-376
10. Tenenbaum F, Lumbroso J, Schlumberger M, Mure A, Plouin, PF, Caillou B, Parmentier C 1995 Comparison of radiolabeled octreotide and meta- iodobenzylguanidine (MIBG) scintigraphy in malignant pheochromocytoma. J Nucl Med 36:1-6
11. Kopf D, Bockisch A, Steinert H, Hahn K, Beyer J, Neumann HPH, Hensen J, Lehnert H 1997 Octreotide scintigraphy and catecholamine response to an octreotide challenge in malignant phaeochromocytoma. Clin Endocrinol 46: 39-44
12. van der Harst E, de Herder WW, Bruining HA, Bonjer HJ, de Krijger RR, Lamberts SWJ, van de Meiracker AH, Boomsma F, Stijnen T, Krenning EP, Bosman FT, Kwekkeboom DJ 2000 123[I]Metaiodobenzylguanidine and 111[In]octreotide uptake in benign and malignant pheochromocytomas. J Clin Endocrinol Metab 86:685-693
13. Pacak K, Eisenhofer G, Carrasquillo JA, Chen CC, Li ST, Goldstein DS 2001 6-[18F]Fluorodopamine positron emission tomogtaphic (PET) scanning for diagnostic localization of pheochromocytoma. Hypertension 38:6-8
14. Kopf D, Goretzki PE, Lehnert H 2001 Clinical management of malignant adrenal tumors. J Cancer Res Clin Oncol 127:143-155
15. Bravo EL 1994 Evolving concepts in the pathophysiology, diagnosis, and treatment of pheochromocytoma. Endocr Rev 15:356-368
16. 3 in paraffin-embedded breast cancer tissue using subtype-specific antibodies. Clin Cancer Res 4:2047-2052
17. 2A. Clin Cancer Res 6:2047-2052
18. Pfeiffer M, Koch T, Schroeder H, Klutzny M, Kirscht S, Kreienkamp HJ, Hollt V, Schulz S 2001 Homo- and heterodimerization of somatostatin receptor subtypes. Inactivation of sst3 receptor function by hetreodimerization with sst2A. J Biol Chem 276:14027-14036
19. Schulz S, Schmitt J, Quednow C, Roessner A, Weise W 2002 Immunohistochemical detection of somatostatin receptors in human ovarian tumors. Gynaecol Oncol 84:235-240
20. Kulaksiz H, Eissele R, Rossler D, Schulz S, Höllt V, Cetin Y, Arnold R 2002 Identification of somatostatin receptor subtypes 1, 2A, 3 and 5 in neuroendocrine tumours with subtype specific antibodies. Gut 50:52-60
21. 2A in human somatostatin receptor positive tumors. J Clin Endocrinol Metab 84:775-780
22. Reubi JC, Waser B, Khosla S, Kvols L, Goellner JR, Krenning E, Lamberts S 1992 In vitro and in vivo detection of somatostatin receptors in pheochromocytoma and paraganglioma. J Clin Endocrinol Metab 74:1082-1089
23. Reubi JC, Waser B, Qisheng L, Laissue JA, Schonbrunn A 2000 Subcellular distribution of somatostatin sst2A receptors in human tumors of the nervous and neuroendocrine systems: membranous versus intracellular location. J Clin Endocrinol Metab 85:3882-3891
24. Hukovic N, Panetta R, Kumar U, Patel YC 1996 Agonist-depending regulation of cloned human somatostatin receptor types 1-5 (hSSTR1-5): subtype selective internalization or upregulation. Endocrinology 137:4046-4049
25. Janson ET, Stridberg M, Gobl A, Westlin J-E, Oberg K 1998 Determination of somatostatin receptor subtype 2 in carcinoid tumors by immunohistochemical investigation with somatostatin receptor 2 antibodies. Cancer Res 58:2375-2378
26. Kimura N, Pilichowska M, Date F, Kimura I, Schindler M 1999 Immunohistochemical expression of somatostatin type 2A receptor in neuroendocrine tumors. Clin Cancer Res 5:3483-3487
27. Ferone D, van Hagen MP, Kwekkeboom DJ, van Koetsveld PM, Mooy DM, Lichtenauer-Kaligis, E, Schonbrunn A, Coloa A, Lamberts SWJ, Hofland L 2000 Somatostatin receptor subtypes in human thymoma and inhibition of cell proliferation by octreotide in vitro. J Clin Endocrinol Metab 85:1719-1726
28. Spier AD, de Lecea L 2000 Cortistatin: a member of the somatostatin neuropeptide family with distinct physiological functions. Brain Res Brain Res Rev 33:228-241
29. B receptor subunits mediate intracellular trafficking but are not required for receptor signaling. J Neurosci 21:1203-1210
30. B receptors. J Neurosci 21:1189-1202
31. 2 dopamine receptor promotes endoplasmic reticulum disruption. J Cell Sci 114:3517-3527
32. Sharma K, Patel YC, Srikant, CB 1996 Subtype-selective induction of wild-type p53 and apoptosis, but not cell cycle arrest, by human somatostatin receptor 3. Mol Endocrinol 10:1688-1696