Noviose mimics of the coumarin inhibitors of gyrase B

Tetrahedron Letters

Volumn 44, Issue 52, 2003, Pages 9259-9262

  Musicki, Branislav ^a   Periers, Anne Marie ^a   Piombo, Laurent ^a   Laurin, Patrick ^a   Klich, Michel ^a   Dupuis Hamelin, Claudine ^a   Lassaigne, Patrice ^a   Bonnefoy, Alain ^a  

^a SANOFI   (France)

Author keywords

Antibiotics; Coumarin; Noviose; Structure activity

Indexed keywords

5',5' DIMETHYLCYCLOHEXANE; ANTIBIOTIC AGENT; COUMARIN DERIVATIVE; GYRASE INHIBITOR; PIPERIDINE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; DRUG ACTIVITY; DRUG DESIGN; DRUG SYNTHESIS;

EID: 0344441317     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2003.10.076     Document Type: Article

References (20)

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2. Klich, M.; Laurin, P.; Musicki, B.; Schio, L. WO 9747634, 1998; Chem. Abstr. 1998, 128, 75634 Chartreaux, F.; Klich, M.; Schio, L. EP 894805, 1999; Chem. Abstr. 1999, 130, 125344.
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6. For a review of DNA gyrase structure and function, see: (a) Reece, R. J. ; Maxwell, A. Crit. Rev. Biochem. Mol. Biol. 1991, 26, 335-375; (b) Levine, C.; Hiasa, H.; Marians, K. J. Biochim. Biophys. Acta 1998, 1400, 29-43; (c) Berger, J. M. Biochim. Biophys. Acta 1998, 1400, 3-18; (d) Maxwell, A. Biochem. Soc. Trans. 1999, 27, 48-53.
7. For a review of DNA gyrase structure and function, see: (a) Reece, R. J. ; Maxwell, A. Crit. Rev. Biochem. Mol. Biol. 1991, 26, 335-375; (b) Levine, C.; Hiasa, H.; Marians, K. J. Biochim. Biophys. Acta 1998, 1400, 29-43; (c) Berger, J. M. Biochim. Biophys. Acta 1998, 1400, 3-18; (d) Maxwell, A. Biochem. Soc. Trans. 1999, 27, 48-53.
8. For a review of DNA gyrase structure and function, see: (a) Reece, R. J. ; Maxwell, A. Crit. Rev. Biochem. Mol. Biol. 1991, 26, 335-375; (b) Levine, C.; Hiasa, H.; Marians, K. J. Biochim. Biophys. Acta 1998, 1400, 29-43; (c) Berger, J. M. Biochim. Biophys. Acta 1998, 1400, 3-18; (d) Maxwell, A. Biochem. Soc. Trans. 1999, 27, 48-53.
9. For a review of DNA gyrase structure and function, see: (a) Reece, R. J. ; Maxwell, A. Crit. Rev. Biochem. Mol. Biol. 1991, 26, 335-375; (b) Levine, C.; Hiasa, H.; Marians, K. J. Biochim. Biophys. Acta 1998, 1400, 29-43; (c) Berger, J. M. Biochim. Biophys. Acta 1998, 1400, 3-18; (d) Maxwell, A. Biochem. Soc. Trans. 1999, 27, 48-53.
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20. Recently, we accomplished the synthesis of a 4′-desmethoxy analogue of RU79115 and the results of its biological activity confirmed the importance of this group in conferring a good inhibitory potency to the analogues. These findings will be published in due course.