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Volumn 5, Issue 1, 2003, Pages 77-84

HIV-1 fitness and replication capacity: What are they and can they help in patient management?

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; EFAVIRENZ; PROTEIN INHIBITOR; RITONAVIR; RNA DIRECTED DNA POLYMERASE INHIBITOR; VIRUS PROTEIN;

EID: 0344426568     PISSN: 15233847     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11908-003-0068-9     Document Type: Review
Times cited : (4)

References (43)
  • 1
    • 0034565934 scopus 로고    scopus 로고
    • HIV-1 drug resistance and viral fitness
    • Clavel F, Race E, Mammano F: HIV-1 drug resistance and viral fitness. Adv Pharmacol 2000, 49:41-66.
    • (2000) Adv. Pharmacol. , vol.49 , pp. 41-66
    • Clavel, F.1    Race, E.2    Mammano, F.3
  • 2
    • 0035141001 scopus 로고    scopus 로고
    • Implications of antiretroviral resistance on viral fitness
    • Nijhuis M, Deeks S, Boucher C: Implications of antiretroviral resistance on viral fitness. Curr Opin Infect Dis 2001, 14:23-28.
    • (2001) Curr. Opin. Infect. Dis. , vol.14 , pp. 23-28
    • Nijhuis, M.1    Deeks, S.2    Boucher, C.3
  • 3
    • 0001769435 scopus 로고    scopus 로고
    • HIV-1 fitness: Implications for drug resistance, disease progression, and global epidemic evolution
    • Los Alamos, NM: Theoretical Biology and Biophysics Group, Los Alamos National Laboratory
    • Quiñones-Mateu M, Arts EJ: HIV-1 fitness: implications for drug resistance, disease progression, and global epidemic evolution. In HIV-1 Sequence Compendium 2001. Los Alamos, NM: Theoretical Biology and Biophysics Group, Los Alamos National Laboratory; 2001:134-170.
    • (2001) HIV-1 Sequence Compendium 2001 , pp. 134-170
    • Quiñones-Mateu, M.1    Arts, E.J.2
  • 5
    • 0034564274 scopus 로고    scopus 로고
    • HIV-1 accessory proteins: Multifunctional components of a complex system
    • Bour S, Strebel K: HIV-1 accessory proteins: multifunctional components of a complex system. Adv Pharmacol 2000, 48:75-120.
    • (2000) Adv. Pharmacol. , vol.48 , pp. 75-120
    • Bour, S.1    Strebel, K.2
  • 6
    • 0030769354 scopus 로고    scopus 로고
    • Drug resistance during indinavir therapy is caused by mutations in the protease gene and in its Gag substrate cleavage sites
    • Zhang YM, Imamichi H, Imamichi T, et al.: Drug resistance during indinavir therapy is caused by mutations in the protease gene and in its Gag substrate cleavage sites. J Virol 1997, 71:6662-6670.
    • (1997) J. Virol. , vol.71 , pp. 6662-6670
    • Zhang, Y.M.1    Imamichi, H.2    Imamichi, T.3
  • 7
    • 0034469260 scopus 로고    scopus 로고
    • Estimating relative fitness in viral competition experiments
    • Maree AF, Keulen W, Boucher CA, De Boer RJ: Estimating relative fitness in viral competition experiments. J Virol 2000, 74:11067-11072.
    • (2000) J. Virol. , vol.74 , pp. 11067-11072
    • Maree, A.F.1    Keulen, W.2    Boucher, C.A.3    De Boer, R.J.4
  • 8
    • 0035102156 scopus 로고    scopus 로고
    • Transition between stochastic evolution and deterministic evolution in the presence of selection: General theory and application to virology
    • Rouzine IM, Rodrigo A, Coffin JM: Transition between stochastic evolution and deterministic evolution in the presence of selection: general theory and application to virology. Microbiol Mol Biol Rev 2001, 65:151-185.
    • (2001) Microbiol. Mol. Biol. Rev. , vol.65 , pp. 151-185
    • Rouzine, I.M.1    Rodrigo, A.2    Coffin, J.M.3
  • 9
    • 0036901603 scopus 로고    scopus 로고
    • Mathematical models of HIV-1pathogenesis and treatment
    • Wodarz D, Nowak MA: Mathematical models of HIV-1pathogenesis and treatment. Bioessays 2002, 24:1178-1187.
    • (2002) Bioessays , vol.24 , pp. 1178-1187
    • Wodarz, D.1    Nowak, M.A.2
  • 11
    • 0033863985 scopus 로고    scopus 로고
    • Retracing the evolutionary pathways of human immunodeficiency virus type 1 resistance to protease inhibitors: Virus fitness in the absence and in the presence of drug
    • Mammano F, Trouplin V, Zennou V, Clavel F: Retracing the evolutionary pathways of human immunodeficiency virus type 1 resistance to protease inhibitors: virus fitness in the absence and in the presence of drug. J Virol 2000, 74:8524-8531.
    • (2000) J. Virol. , vol.74 , pp. 8524-8531
    • Mammano, F.1    Trouplin, V.2    Zennou, V.3    Clavel, F.4
  • 12
    • 0033064963 scopus 로고    scopus 로고
    • Comparative fitness of multi-dideoxynucleoside-resistant human immunodeficiency virus type 1 (HIV-1) in an In vitro competitive HIV-1 replication assay
    • Kosalaraksa P, Kavlick MF, Maroun V, et al.: Comparative fitness of multi-dideoxynucleoside-resistant human immunodeficiency virus type 1 (HIV-1) in an In vitro competitive HIV-1 replication assay. J Virol 1999, 73:5356-6533.
    • (1999) J. Virol. , vol.73 , pp. 5356-6533
    • Kosalaraksa, P.1    Kavlick, M.F.2    Maroun, V.3
  • 13
    • 0031948662 scopus 로고    scopus 로고
    • Altered drug sensitivity, fitness, and evolution of human immunodeficiency virus type 1 with pol gene mutations conferring multi-dideoxynucleoside resistance
    • Maeda Y, Venzon DJ, Mitsuya H: Altered drug sensitivity, fitness, and evolution of human immunodeficiency virus type 1 with pol gene mutations conferring multi-dideoxynucleoside resistance. J Infect Dis 1998, 177:1207-1213.
    • (1998) J. Infect. Dis. , vol.177 , pp. 1207-1213
    • Maeda, Y.1    Venzon, D.J.2    Mitsuya, H.3
  • 14
    • 0028874043 scopus 로고
    • Retroviral recombination can lead to linkage of reverse transcriptase mutations that confer increased zidovudine resistance
    • Kellam P, Larder BA: Retroviral recombination can lead to linkage of reverse transcriptase mutations that confer increased zidovudine resistance. J Virol 1995, 69:669-674.
    • (1995) J. Virol. , vol.69 , pp. 669-674
    • Kellam, P.1    Larder, B.A.2
  • 15
    • 0035330599 scopus 로고    scopus 로고
    • A novel recombinant marker virus assay for comparing the relative fitness of hiv-1 reverse transcriptase variants
    • Lu J, Kuritzkes DR: A novel recombinant marker virus assay for comparing the relative fitness of hiv-1 reverse transcriptase variants. J Acquir Immune Defic Syndr 2001, 27:7-13.
    • (2001) J. Acquir. Immune Defic. Syndr. , vol.27 , pp. 7-13
    • Lu, J.1    Kuritzkes, D.R.2
  • 16
    • 0032928065 scopus 로고    scopus 로고
    • Replicative fitness of protease inhibitor-resistant mutants of human immunodeficiency virus type 1
    • Martinez-Picado J, Savara AV, Sutton L, D'Aquila RT: Replicative fitness of protease inhibitor-resistant mutants of human immunodeficiency virus type 1. J Virol 1999, 7:3744-3752.
    • (1999) J. Virol. , vol.7 , pp. 3744-3752
    • Martinez-Picado, J.1    Savara, A.V.2    Sutton, L.3    D'Aquila, R.T.4
  • 17
    • 0034734783 scopus 로고    scopus 로고
    • Fitness of human immunodeficiency virus type 1 protease inhibitor-selected single mutants
    • Martinez-Picado J, Savara AV, Shi L, et al.: Fitness of human immunodeficiency virus type 1 protease inhibitor-selected single mutants. Virology 2000, 275:318-322.
    • (2000) Virology , vol.275 , pp. 318-322
    • Martinez-Picado, J.1    Savara, A.V.2    Shi, L.3
  • 18
    • 0031958266 scopus 로고    scopus 로고
    • Relative replicative fitness of zidovudine-resistant human immunodeficiency virus type 1 isolates in vitro
    • Harrigan PR, Bloor S, Larder BA: Relative replicative fitness of zidovudine-resistant human immunodeficiency virus type 1 isolates in vitro. J Virol 1998, 72:3773-3778.
    • (1998) J. Virol. , vol.72 , pp. 3773-3778
    • Harrigan, P.R.1    Bloor, S.2    Larder, B.A.3
  • 19
    • 0033946764 scopus 로고    scopus 로고
    • Evolution of lamivudine resistance in human immunodeficiency virus type 1-infected individuals: The relative roles of drift and selection
    • Frost SD, Nijhuis M, Schuurman R, et al.: Evolution of lamivudine resistance in human immunodeficiency virus type 1-infected individuals: the relative roles of drift and selection. J Virol 2000, 74:6262-6268.
    • (2000) J. Virol. , vol.74 , pp. 6262-6268
    • Frost, S.D.1    Nijhuis, M.2    Schuurman, R.3
  • 20
    • 0036786425 scopus 로고    scopus 로고
    • Insertions in the reverse transcriptase increase both drug resistance and viral fitness in a human immunodeficiency virus type 1 isolate harboring the multi-nucleoside reverse transcriptase inhibitor resistance 69 insertion complex mutation
    • Quinones-Mateu ME, Tadele M, Parera M, et al.: Insertions in the reverse transcriptase increase both drug resistance and viral fitness in a human immunodeficiency virus type 1 isolate harboring the multi-nucleoside reverse transcriptase inhibitor resistance 69 insertion complex mutation. J Virol 2002, 76:10546-10552.
    • (2002) J. Virol. , vol.76 , pp. 10546-10552
    • Quinones-Mateu, M.E.1    Tadele, M.2    Parera, M.3
  • 21
    • 0033863784 scopus 로고    scopus 로고
    • Mutants of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase resistant to nonnucleoside reverse transcriptase inhibitors demonstrate altered rates of RNase H cleavage that correlate with HIV-1 replication fitness in cell culture
    • Archer RH, Dykes C, Gerondelis P, et al.: Mutants of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase resistant to nonnucleoside reverse transcriptase inhibitors demonstrate altered rates of RNase H cleavage that correlate with HIV-1 replication fitness in cell culture. J Virol 2000, 74:8390-8401.
    • (2000) J. Virol. , vol.74 , pp. 8390-8401
    • Archer, R.H.1    Dykes, C.2    Gerondelis, P.3
  • 22
    • 0035811838 scopus 로고    scopus 로고
    • Impact of clinical reverse transcriptase sequences on the replication capacity of HIV-1 drug-resistant mutants
    • Dykes C, Fox K, Lloyd A, et al.: Impact of clinical reverse transcriptase sequences on the replication capacity of HIV-1 drug-resistant mutants. Virology 2001, 285:193-203.
    • (2001) Virology , vol.285 , pp. 193-203
    • Dykes, C.1    Fox, K.2    Lloyd, A.3
  • 23
    • 0033794835 scopus 로고    scopus 로고
    • The replicative capacity of rhesus macaque peripheral blood mononuclear cells for simian immunodeficiency virus in vitro is predictive of the rate of progression to AIDS in vivo
    • Seman AL, Pewen WF, Fresh LF et al.: The replicative capacity of rhesus macaque peripheral blood mononuclear cells for simian immunodeficiency virus in vitro is predictive of the rate of progression to AIDS in vivo. J Gen Virol 2000, 81(Pt 10):2441-2449.
    • (2000) J. Gen. Virol. , vol.81 , Issue.PART 10 , pp. 2441-2449
    • Seman, A.L.1    Pewen, W.F.2    Fresh, L.F.3
  • 24
    • 0035890105 scopus 로고    scopus 로고
    • Effects of reverse-transcriptase mutations M184V and E89G on simian immunodeficiency virus in Rhesus monkeys
    • Newstein MC, Desrosiers RC: Effects of reverse-transcriptase mutations M184V and E89G on simian immunodeficiency virus in Rhesus monkeys. J Infect Dis 2001, 184:1262-1267.
    • (2001) J. Infect. Dis. , vol.184 , pp. 1262-1267
    • Newstein, M.C.1    Desrosiers, R.C.2
  • 25
    • 0036113511 scopus 로고    scopus 로고
    • Virulence and reduced fitness of simian immunodeficiency virus with the M184V mutation in reverse transcriptase
    • Van Rompay KK, Matthews TB, Higgins J, et al.: Virulence and reduced fitness of simian immunodeficiency virus with the M184V mutation in reverse transcriptase. J Virol 2002, 76:6083-6092.
    • (2002) J. Virol. , vol.76 , pp. 6083-6092
    • Van Rompay, K.K.1    Matthews, T.B.2    Higgins, J.3
  • 26
    • 0032907674 scopus 로고    scopus 로고
    • Neutralizing antibody directed against the HIV-1 envelope glycoprotein can completely block HIV-1/SIV chimeric virus infections of macaque monkeys
    • Shibata R, Igarashi T, Haigwood N, et al.: Neutralizing antibody directed against the HIV-1 envelope glycoprotein can completely block HIV-1/SIV chimeric virus infections of macaque monkeys. Nat Med 1999, 5:204-210.
    • (1999) Nat. Med. , vol.5 , pp. 204-210
    • Shibata, R.1    Igarashi, T.2    Haigwood, N.3
  • 27
    • 0036092061 scopus 로고    scopus 로고
    • A nucleotide substitution in the tRNA(Lys) primer binding site dramatically increases replication of recombinant simian immunodeficiency virus containing a human immunodeficiency virus type 1 reverse transcriptase
    • Soderberg K, Denekamp L, Nikiforow S, et al.: A nucleotide substitution in the tRNA(Lys) primer binding site dramatically increases replication of recombinant simian immunodeficiency virus containing a human immunodeficiency virus type 1 reverse transcriptase. J Virol 2002, 76:5803-5806.
    • (2002) J. Virol. , vol.76 , pp. 5803-5806
    • Soderberg, K.1    Denekamp, L.2    Nikiforow, S.3
  • 28
    • 85039526405 scopus 로고    scopus 로고
    • A new reverse transcriptase-SHIV-1to study HIV-1 non-nucleoside reverse transcriptase inihibitor-resistance in pigtailed macaques
    • Ambrose Z, Hughes SH, Kewal-Ramani VN: A new reverse transcriptase-SHIV-1to study HIV-1 non-nucleoside reverse transcriptase inihibitor-resistance in pigtailed macaques. Antiviral Ther 2002, 7:S44.
    • (2002) Antiviral Ther. , vol.7
    • Ambrose, Z.1    Hughes, S.H.2    Kewal-Ramani, V.N.3
  • 29
    • 0029670763 scopus 로고    scopus 로고
    • Replication and pathogenicity of human immunodeficiency virus type 1 accessory gene mutants in SCID-hu mice
    • Aldrovandi GM, Zack JA: Replication and pathogenicity of human immunodeficiency virus type 1 accessory gene mutants in SCID-hu mice. J Virol 1996, 70:1505-1511.
    • (1996) J. Virol. , vol.70 , pp. 1505-1511
    • Aldrovandi, G.M.1    Zack, J.A.2
  • 30
    • 0034948377 scopus 로고    scopus 로고
    • Impaired replication of protease inhibitor-resistant HIV-1 in human thymus
    • Stoddart CA, Liegler TJ, Mammano F, et al.: Impaired replication of protease inhibitor-resistant HIV-1 in human thymus. Nat Med 2001, 7:712-718.
    • (2001) Nat. Med. , vol.7 , pp. 712-718
    • Stoddart, C.A.1    Liegler, T.J.2    Mammano, F.3
  • 31
    • 0034914207 scopus 로고    scopus 로고
    • Primary and recombinant HIV-1 type 1 strains resistant to protease inhibitors are pathogenic in mature human lymphoid tissues
    • Penn ML, Myers M, Eckstein DA, et al.: Primary and recombinant HIV-1 type 1 strains resistant to protease inhibitors are pathogenic in mature human lymphoid tissues. AIDS Res Hum Retroviruses 2001, 17:517-523.
    • (2001) AIDS Res. Hum. Retroviruses , vol.17 , pp. 517-523
    • Penn, M.L.1    Myers, M.2    Eckstein, D.A.3
  • 32
    • 0034492631 scopus 로고    scopus 로고
    • Altered viral fitness of HIV-1 following failure of protease inhibitor-based therapy
    • Picchio GR, Valdez H, Sabbe R, et al.: Altered viral fitness of HIV-1 following failure of protease inhibitor-based therapy. J Acquir Immune Defic Syndr 2000, 25:289-295.
    • (2000) J. Acquir. Immune Defic. Syndr. , vol.25 , pp. 289-295
    • Picchio, G.R.1    Valdez, H.2    Sabbe, R.3
  • 33
    • 0034019566 scopus 로고    scopus 로고
    • A novel phenotypic drug susceptibility assay for human immunodeficiency virus type 1
    • Petropoulos CJ, Parkin NT, Limoli KL, et al.: A novel phenotypic drug susceptibility assay for human immunodeficiency virus type 1. Antimicrob Agents Chemother 2000, 44:920-928.
    • (2000) Antimicrob. Agents Chemother. , vol.44 , pp. 920-928
    • Petropoulos, C.J.1    Parkin, N.T.2    Limoli, K.L.3
  • 34
    • 0034948070 scopus 로고    scopus 로고
    • Correlation between viral resistance to zidovudine and resistance at the reverse transcriptase level for a panel of human immunodeficiency virus type 1 mutants
    • Lennerstrand J, Hertogs K, Stammers DK, Larder BA: Correlation between viral resistance to zidovudine and resistance at the reverse transcriptase level for a panel of human immunodeficiency virus type 1 mutants. J Virol 2001, 75:7202-7205.
    • (2001) J. Virol. , vol.75 , pp. 7202-7205
    • Lennerstrand, J.1    Hertogs, K.2    Stammers, D.K.3    Larder, B.A.4
  • 35
    • 0034616958 scopus 로고    scopus 로고
    • The role of steric hindrance in 3TC resistance of human immunodeficiency virus type-1 reverse transcriptase
    • Gao HQ, Boyer PL, Sarafianos SG, et al.: The role of steric hindrance in 3TC resistance of human immunodeficiency virus type-1 reverse transcriptase. J Mol Biol 2000, 300:403-418.
    • (2000) J. Mol. Biol. , vol.300 , pp. 403-418
    • Gao, H.Q.1    Boyer, P.L.2    Sarafianos, S.G.3
  • 36
    • 0036803368 scopus 로고    scopus 로고
    • Rapid phenotypic assay for human immunodeficiency virus type 1 protease using in vitro translation
    • Iga M, Matsuda Z, Okayama A, et al.: Rapid phenotypic assay for human immunodeficiency virus type 1 protease using in vitro translation. J Virol Method 2002, 106:25-37.
    • (2002) J. Virol. Method , vol.106 , pp. 25-37
    • Iga, M.1    Matsuda, Z.2    Okayama, A.3
  • 37
    • 0035864943 scopus 로고    scopus 로고
    • Virologic and immunologic consequences of discontinuing combination antiretroviral-drug therapy in HIV-infected patients with detectable viremia
    • Deeks SG, Wrin T, Liegler T, et al.: Virologic and immunologic consequences of discontinuing combination antiretroviral-drug therapy in HIV-infected patients with detectable viremia. N Engl J Med 2001, 344:472-480.
    • (2001) N. Engl. J. Med. , vol.344 , pp. 472-480
    • Deeks, S.G.1    Wrin, T.2    Liegler, T.3
  • 38
    • 0032804864 scopus 로고    scopus 로고
    • Increased fitness of drug resistant HIV-1 protease as a result of acquisition of compensatory mutations during suboptimal therapy
    • Nijhuis M, Schuurman R, dejong D, et al.: Increased fitness of drug resistant HIV-1 protease as a result of acquisition of compensatory mutations during suboptimal therapy. AIDS 1999, 13:2349-2359.
    • (1999) AIDS , vol.13 , pp. 2349-2359
    • Nijhuis, M.1    Schuurman, R.2    deJong, D.3
  • 39
    • 0031846317 scopus 로고    scopus 로고
    • Resistance-associated loss of viral fitness in human immunodeficiency virus type 1: Phenotypic analysis of protease and gag coevolution in protease inhibitor-treated patients
    • Mammano F, Petit C, Clavel F: Resistance-associated loss of viral fitness in human immunodeficiency virus type 1: phenotypic analysis of protease and gag coevolution in protease inhibitor-treated patients. J Virol 1998, 72:7632-7637.
    • (1998) J. Virol. , vol.72 , pp. 7632-7637
    • Mammano, F.1    Petit, C.2    Clavel, F.3
  • 40
    • 0036838224 scopus 로고    scopus 로고
    • Evolution of phenotypic drug susceptibility and viral replication capacity during long-term virologic failure of protease inhibitor therapy in human immunodeficiency virus-infected adults
    • Barbour JD, Wrin T, Grant RM, et al.: Evolution of phenotypic drug susceptibility and viral replication capacity during long-term virologic failure of protease inhibitor therapy in human immunodeficiency virus-infected adults. J Virol 2002, 76:11104-11112.
    • (2002) J. Virol. , vol.76 , pp. 11104-11112
    • Barbour, J.D.1    Wrin, T.2    Grant, R.M.3
  • 41
    • 0347117650 scopus 로고    scopus 로고
    • Transmission of Drug Resistant HIV-1 exhibiting lower replication capacity is associated with higher CD4 counts
    • Grant RM, Barbour JD, Wrin T, et al.: Transmission of Drug Resistant HIV-1 exhibiting lower replication capacity is associated with higher CD4 counts. Antiviral Ther 2002, 7:S41.
    • (2002) Antiviral Ther. , vol.7
    • Grant, R.M.1    Barbour, J.D.2    Wrin, T.3
  • 42
    • 0036149707 scopus 로고    scopus 로고
    • Persistence and fitness of multidrug-resistant human immunodeficiency virus type 1 acquired in primary infection
    • Brenner BG, Routy JP, Petrella M, et al.: Persistence and fitness of multidrug-resistant human immunodeficiency virus type 1 acquired in primary infection. J Virol 2002, 76:1753-1761.
    • (2002) J. Virol. , vol.76 , pp. 1753-1761
    • Brenner, B.G.1    Routy, J.P.2    Petrella, M.3
  • 43
    • 0035313472 scopus 로고    scopus 로고
    • Discordant increases in CD4+ T cells in human immunodeficiency virus-infected patients experiencing virologic treatment failure: Role of changes in thymic output and T cell death
    • Lecossier D, Bouchonnet F, Schneider P, et al.: Discordant increases in CD4+ T cells in human immunodeficiency virus-infected patients experiencing virologic treatment failure: role of changes in thymic output and T cell death. J Infect Dis 2001, 183:1009-1016.
    • (2001) J. Infect. Dis. , vol.183 , pp. 1009-1016
    • Lecossier, D.1    Bouchonnet, F.2    Schneider, P.3


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