Apoptotic response to TGF-β in fetal hepatocytes depends upon their state of differentiation

Experimental Cell Research

Volumn 252, Issue 2, 1999, Pages 281-291

  Sanchez A ^a   Alvarez A M ^b   Lopez Pedrosa J M ^c   Roncero, C ^a   Benito, M ^a   Fabregat, I ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^b UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^c ABBOTT LABORATORIES   (Spain)

Author keywords

Apoptosis; Differentiation; Hepatocarcinogenesis; Hepatocyte; TGF

Indexed keywords

TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DIFFERENTIATION; CELL SURVIVAL; CONTROLLED STUDY; DNA BINDING; FETUS; GENE EXPRESSION; LIVER CANCER; LIVER CARCINOGENESIS; LIVER CELL; NONHUMAN; PRIORITY JOURNAL; PROTO ONCOGENE; RAT; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 0344390889     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1006/excr.1999.4624     Document Type: Article

References (45)

1. Schulte-Hermann R., Bursch W., Low-ßaselli A., Wagner A., Grasl-Kraupp B. Apoptosis in the liver and its role in hepatocarcinogenesis. Cell Biol. Toxicol. 13:1997;339-448.
2. Pitot H. C. Hepatocyte death in hepatocarcinogenesis. Hepatology. 28:1998;1-5.
3. Fabregat I., Sánchez A., Alvarez A. M., Nakamura T., Benito M. Epidermal growth factor, but not hepatocyte growth factor, suppresses the apoptosis induced by transforming growth factor-β in fetal hepatocytes in primary culture. FEBS Lett. 384:1996;14-18.
4. Kosai K., Matsumoto K., Nagata S., Tsujimoto Y., Nakamura T. Abrogation of Fas-induced fulminant hepatic failure in mice by hepatocyte growth factor. Biochem. Biophys. Res. Commun. 244:1998;683-690.
5. Senaldi G., Shaklee C. L., Simon B., Rowan C. G., Lacey D. L., Hartung T. Keratinocyte growth factor protects murine hepatocytes from tumor necrosis factor-induced apoptosis in vivo and in vitro. Hepatology. 27:1998;1584-1591.
6. Grasl-Kraupp B., Ruttkay-Nedecky B., Mullauer L., Taper H., Huber W., Bursch W., Schulte-Hermann R. Inherent increase of apoptosis in liver tumors: Implications for carcinogenesis and tumor repression. Hepatology. 25:1997;906-912.
7. Massague J. TGFβ signal transduction. Annu. Rev. Biochem. 67:1998;753-791.
8. Wollenberg G. K., Semple E., Quinn B. A., Hayes M. A. Inhibition of proliferation of normal, preneoplastic and neoplastic rat hepatocytes by transforming growth-β Cancer Res. 47:1987;6595-6599.
9. Serra R., Carbonetto S., Lord M., Isom H. C. Transforming growth factor β1 suppresses transformation in hepatocytes by regulating α1β1 integrin expression. Cell Growth Differ. 5:1994;509-517.
10. Reeder M. K., Isom H. C. Effect of transforming growth factor beta on rat hepatocyte cell lines depends upon the state of tumorigenic progression. Cell Growth Differ. 7:1996;449-460.
11. Oberhammer F., Bursch W., Parzefall W., Breit P., Erber E., Stadler M. Effect of transforming growth factor β on cell death of cultured rat hepatocytes. Cancer Res. 51:1991;2478-2485.
12. Thorgeirsson S. S., Teramoto T., Factor V. M. Dysregulation of apoptosis in hepatocellular carcinoma. Semin. Liver Dis. 18:1998;115-122.
13. Ito N., Kawata S., Tamura S., Takaishi K., Shirai Y., Kiso S., Yabuuchi I., Matsuda Y., Nishioka M., Tarui S. Elevated levels of transforming growth factor beta messenger RNA and its polypeptide in human hepatocellular carcinoma. Cancer Res. 51:1991;4080-4083.
14. Tsai J. F., Jeng J. E., Chuang L. Y., Yang M. L., Ho M. S., Chang W. Y., Hsich M. Y., Lin Z. Y., Tsai J. H. Elevated urinary transforming growth factor-β1 level as a tumour marker and predictor of poor survival in cirrhotic hepatocellular carcinoma. Br. J. Cancer. 76:1997;244-250.
15. Factor V. M., Kao C. Y., Santoni-Rugiu E., Woitach J. T., Jensen M. R., Thorgeirsson S. S. Constitutive expression of mature transforming growth factor beta1 in liver accelerates hepatocarcinogenesis in transgenic mice. Cancer Res. 57:1997;2089-2095.
16. Zhang X., Wang T., Batist G., Tsao M. S. Transforming growth factor beta 1 promotes spontaneous transformation of cultured rat liver epithelial cells. Cancer Res. 54:1994;6122-6128.
17. Sánchez A., Álvarez A. M., Benito M., Fabregat I. Transforming growth factor β modulates growth and differentiation of fetal hepatocytes in primary culture. J. Cell. Physiol. 165:1995;398-405.
18. Sánchez A., Pagan R., Álvarez A. M., Roncero C., Vilaró S., Benito M., Fabregat I. Transforming growth factor-β (TGF-β) and EGF promote cord-like structures that indicate terminal differentiation of fetal hepatocytes in primary culture. Exp. Cell Res. 242:1998;27-37.
19. Sánchez A., Álvarez A. M., Benito M., Fabregat I. Apoptosis induced by transforming growth factor-β in fetal hepatocyte primary cultures. J. Biol. Chem. 271:1996;7416-7422.
20. Sánchez A., Álvarez A. M., Benito M., Fabregat I. Cycloheximide prevents apoptosis, reactive oxygen species production and glutathione depletion induced by transforming growth factor β in fetal rat hepatocytes in primary culture. Hepatology. 26:1997;935-943.
21. Roncero C., Lorenzo M., Fabregat I., Benito M. Rates of lipogenesis in fetal hepatocytes in suspension and in primary culture: Hormonal effects. Biochim. Biophys. Acta. 1012:1989;320-324.
22. De Juan C., Benito M., Álvarez A., Fabregat I. Differential proliferative response of cultured fetal and regenerating hepatocytes to growth factors and hormones. Exp. Cell Res. 202:1992;495-500.
23. Chomczynski P., Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:1987;156-159.
24. Roncero C., Ventura J.-J., Sánchez A., Bois-Joyeux B., Mesa M. L., Thomassin H., Danan J.-L., Benito M., Fabregat I. Phorbol esters down-regulate alpha-fetoprotein gene expression without affecting growth in fetal hepatocytes in primary culture. Biochim. Biophys. Acta. 1402:1998;151-164.
25. Wen P., Locker J. A novel hepatocytic transcription factor that binds the α-fetoprotein promoter-linked coupling element. Mol. Cell. Biol. 14:1994;6616-6626.
26. Schibler U., Hagenbuchle O., Wellauer P. K., Pitte A. C. Two promoters of different strengths control the transcription of the mouse alpha-amylase gene Amy-1a in the parotid gland and the liver. Cell. 33:1983;501-508.
27. Linial M., Gunderson N., Groudine M. Enhanced transcription of c-myc in bursal lymphoma cells requires continuous protein synthesis. Science. 230:1985;1126-1132.
28. Pagan R., Llobera M., Vilaró S. Epithelial-mesenchymal transition in cultured neonatal hepatocytes. Hepatology. 25:1995;820-831.
29. Pagan R., Martín I., Llobera M., Vilaró S. Epithelial-mesenchymal transition of cultured rat neonatal hepatocytes is differentially regulated in response to epidermal growth factor and dimethylsulfoxide. Hepatology. 25:1997;598-606.
30. Arsura M., Fitzgerald M. J., Fausto N., Sonesnshein G. E. Nuclear factor-kappaB/Rel blocks transforming growth factor beta 1-induced apoptosis of murine hepatocyte cell lines. Cell Growth Differ. 8:1997;1049-1059.
31. Barnard J. A., Lyons R. M., Moses H. L. The cell biology of transforming growth factor β Biochim. Biophys. Acta. 1032:1990;79-87.
32. De Juan C., Benito M., Fabregat I. Regulation of albumin expression in fetal rat hepatocytes cultured under proliferative conditions: Role of epidermal growth factor and hormones. J. Cell. Physiol. 152:1992;95-101.
33. Birchmeier C., Birchmeier W. Molecular aspects of mesenchymal-epithelial interactions. Annu. Rev. Cell Biol. 9:1993;511-540.
34. Birchmeier W., Birchmeier C. Epithelial-mesenchymal transitions in development and tumor progression. Goldberg I. D., Rosen E. M. Epithelial-Mesenchymal Interactions in Cancer. 1995;Birkhauser Verlag, Basel.
35. Caulín C., Scholl F. G., Frontelo P., Gamallo C., Quintanilla M. Chronic exposure of cultured transformed mouse epidermal cells to transforming growth factor-β1 induces an epithelial-mesenchymal transdifferentiation and a spincle tumoral phenotype. Cell Growth Differ. 6:1995;1027-1035.
36. Miettinen P. J., Ebner R., Lopez A. R., Derynck R. TGF-beta induced transdifferentiation of mammary epithelial cells to mesenchymal cells: Involvement of type I receptors. J. Cell Biol. 127:1994;2021-2036.
37. Cui W., Fowlis D. J., Bryson S., Duffie E., Ireland H., Balmain A., Akrust J. TGFβ1 inhibits the formation of benign skin tumors, but enhances progression to invasive spindle carcinomas in transgenic mice. Cell. 86:1996;531-542.
38. Frontelo P., González-Garrigues M., Vilaró S., Gamallo C., Fabra A., Quintanilla M. Transforming growth factor β1 induces squamous carcinoma cell variants with increased metastatic abilities and a disorganized cytoskeleton. Exp. Cell Res. 244:1998;420-432.
39. Yanagisawa K., Osada H., Masuda A., Kondo M., Saito T., Yatabe Y., Takagi K., Takahashi T., Takahashi T. Induction of apoptosis by Smad3 and down-regulation of Smad3 expression in response to TGF-beta in human normal lung epithelial cells. Oncogene. 17:1998;1743-1747.
40. Brown T. L., Patil S., Basnett R. K., Howe P. H. Caspase inhibitor BD-fmk distinguishes transforming growth factor beta-induced apoptosis from growth inhibition. Cell Growth Differ. 9:1998;869-875.
41. Hay E. D., Zuk A. Transformations between epithelium and mesenchyme: Normal, pathological and experimentally induced. Am. J. Kidney Dis. 26:1995;678-690.
42. Houck K. A., Michalopoulos G. K., Strom S. C. Introduction of a Ha-ras oncogene into rat liver epithelial cells and parenchymal hepatocytes confers resistance to the growth-inhibitory effects of TGF-β Oncogene. 4:1989;19-25.
43. Huggett A., Ellis P. A., Ford C. P., Hampton L. L., Rimoldi D., Thorgeirsson S. S. Development of resistance to the growth-inhibitory effects of transforming growth factor β1 promotes spontaneous transformation of rat liver epithelial cells. Cancer Res. 51:1991;5929-5936.
44. Gressner A. M., Lahme B., Mannherz H. G., Polzar B. TGF-beta-mediated hepatocellular apoptosis by rat and human hepatoma cells and primary rat hepatocytes. J. Hepatol. 26:1997;1079-1092.
45. Arrick B. A., Lopez A. R., Elfman F., Ebner R., Damsky C. H., Derynck R. Altered metabolic and adhesive properties and increased tumorigenesis associated with increased expression of transforming growth factor β1. J. Cell Biol. 118:1992;715-726.