Contribution of oxidative stress to radiosensitization by a combination of 2-DG and 6-AN in human cancer cell line

Indian Journal of Experimental Biology

Volumn 41, Issue 12, 2003, Pages 1384-1391

  Varshney, R ^a   Adhikari, J S ^a   Dwarakanath, B S ^a  

^a INSTITUTE OF NUCLEAR MEDICINE AND ALLIED SCIENCES   (India)

Author keywords

2 Deoxy D glucose; 6 Aminonicotinamide; Metabolic stress; Oxidative stress; Radiosensitization

Indexed keywords

FREE RADICALS; IONIZING RADIATION; OXIDATION; TUMORS;

APOPTOSIS;

CELLS;

6 AMINONICOTINAMIDE; DEOXYGLUCOSE; RADIOSENSITIZING AGENT;

ARTICLE; HUMAN; OXIDATIVE STRESS; TUMOR CELL LINE;

6-AMINONICOTINAMIDE; CELL LINE, TUMOR; DEOXYGLUCOSE; HUMANS; OXIDATIVE STRESS; RADIATION-SENSITIZING AGENTS;

EID: 0344304427     PISSN: 00195189     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. Ward J F, DNA damage produced by ionizing radiation in mammalian cells: Identities, mechanisms of formation and reparability, Prog Nucl Acid Res Mol Biol, 25 (1988) 95.
2. Maity A, Kao G D, Muschel R J & Mckenna W G, Potential molecular targets for manipulating the radiation response, Int J Radiat Oncol Biol Phys, 37 (1997) 639.
3. Jain V K, Kalia V, Sharma K, Maharajan R V &Menon M, Effects of 2-deoxy-D glucose on glycolysis, proliferation kinetics and radiation response on human cancer cells, Int J Radiat Oncol Biol Phys, 11 (1985) 943.
4. Dwarakanath B S & Jain V K, Energy linked modification of radiation response in a human cerebral glioma cell line, Int J Radiat Oncol Biol Phys, 17 (1989) 1033.
5. Dwarakanath B S, Zolzer F, Chandana S, Bauch T, Adhikari J S, Muller W, Streffer C & Jain V, Heterogeneity in 2-deoxy-D-glucose induced modification of radiation of radiation response in human tumor cell line, Int J Radiat Oncol Biol Phys, 50 (2001) 1051.
6. Dwarakanath B S, Adhikari J S & Jain V, Hematoporphyin derivatives potentiate the radiosensitizing effects of 2-deoxy-D glucose in cancer cells, Int J Radiat Oncol Biol Phys, 43 (1999) 1125.
7. Varshney R, Dwarakanath B S, Mathew T L & Jain V, Radiomodifying effects of 6-Aminonicotinamide and 2-deoxy-D glucose in human cancer cell lines, Paper presented to Radiobiology 2000, Trivandrum, India 17-19 February 2000.
8. Spitz D R, Sim J E, Ridnour L A, Galoforo S S & Lee Y J, Glucose deprivation -induced oxidative stress in human tumor cells, Ann N Y Acad Sci, 899 (2000) 349.
9. Lehninger A L, Biochemistry (Worth Publishers Inc., New York) 1976 245, 467.
10. Dwarakanath B S, Energy metabolism and repair of radiation induced damage in brain tumors,Ph.D. thesis, Bangalore University, 1988.
11. Hissin P J & Hilf R A, Fluorometric method for determination of oxidized and reduced glutathione in tissues, Anal Biochem, 74 (1976) 214.
12. Madesh M & Balasubramanian K A, A microtitre plate assay for superoxide using MTT reduction method, Ind J Biochem Biophys, 35 (1997) 535.
13. Vermes I, Haanen C, Steffens-Nakken H & Reutelingsoerger C, A novel assay for apoptosis: Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labeled detection, J Immunol Meth, 184 (1995) 39.
14. Steck K, McDonnell T, Sneige N & El-Naggar A K, Flow cytometric analysis of apoptosis and Bcl-2 in primary breast carcinomas; clinical and biological inplications. Cytometry, 24(1996) 116.
15. Jianping G, Barbara A, Frank T & Zbigniew D, Unscheduled expression of Cyclin B1 & Cyclin E in several leukemic and solid tumor cell lines, Can Res, 54 (1994) 4285.
16. Korsmeyer S J, Yin Xiao-Ming, Oltvai, Z N, Veis-NovacK D J & Linette G P, Reactive oxygen species and regulation of cell death by Bcl-2 gene family, Biochim Biophys Acta, 1271 (1995) 63.
17. Hockenbery D, Nunez G, Milliman C, Schreiber R D & Koresmeyer S J, Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death, Nature, 348 (1990) 334.
18. Cai J, Yang J & Jones D P, Mitochondrial control of apoptosis: The role of cytochrome C, Biochim Biophys Acta, 1366 (1998) 139.
19. 2 checkpoint through cyclin B1, Proc Natl Acad Sci, 96 (1999) 2147.
20. 2 in vitro and in vivo and reduced menadione-induced DNA injury and cytotoxicity, Am J Physiol, 268 (1995) C227.
21. Tuttle S, Stamato T, Perez M L & Biaglow J, Glucose-6-phosphate dehydrogenase and the oxidative pentose phosphate cycle protect cells against apoptosis induced by low doses of ionizing radiation, Radiat Res, 153 (2000) 781.
22. Finkel T & Holbrook N J, Oxidants, oxidative stress and the biology of ageing. Nature, 408 (2000) 239.
23. Bump E, Cerce B A, Sarraf R A, Pierce S M & Koch C J, Radioprotection of DNA in isolated Nuclei by naturally occurring thiols at intermediate oxygen tension, Radiat Res, 132 (1992) 94.
24. Mitchell J B & Rusoo A, The role of glutathione in radiation and drug induced cyotoxicity, Br J Cancer Suppl. VIII, 55 (1987), 96.
25. Liu B & Hannun Y A, Inhibition of neutral magnesium - dependent sphingomyelinase by glutathione, J Biol Chem, 272 (1997) 16281.
26. Miller A C, Gafner J, Clark E P & Samid D, Post transcriptional down regulation of ras oncogene expression by inhibitors of cellular glutathione, Mol Cell Biol, 13 (1993) 4416.
27. Single B, Leist M & Pierluigi N, Differential effects of Bcl-2 on cell death triggered under ATP depleting conditions, Exp Cell Res, 262 (2001) 8.
28. Vlachaki M T & Meyn R E, The role of Bcl-2 and glutathione in an antioxidant pathway to prevent radiation induced apoptosis, Int J Radiat Oncol Biol Phys, 42 (1998) 185.
29. Voehringer D W, McConkey D J, McDonnell T J, Brisbay S & Meyn R E, Bcl-2 expression causes redistribution of glutathione to the nucleus, Proc Natl Acad Sci USA, 95 (1998) 2956.
30. Rudoltz M, Kao G, Blank K R, Muschel R J & McKenna G M, Molecular biology of the cell cycle: Potential for therapeutic applications in radiation biology, Sem Radiat Oncol, 6 (1996) 284.
31. Terzoudi G I, Jung T, Hain J, Vrouvas K, Margaritis K, Donta-Bakoyianni C, Makropopulas V, Angelakis P H & Pantelias G E, increased G2 chromosomal radiosensitivity in cancer patients: Role of cdk1/cyclin-B activity level in the mechanism involved, Int J Radiat Biol, 76 (2000) 607.
32. Russo T, Zambrano N, Esposito F, Ammendola R, Cimino F, Fiscella M, Jackman J, O'Connor P M & Anderson C W, A p53-indepenedent pathway for activation of WAF1/CIP1 expression following oxidative stress, J Biol Chem, 270 (1995) 29386.
33. 2/M arrest after DNA damage, J Biol Chem, 276 (2001) 42971.
34. Waga S, Hannon G J, Beach D & Stillman B, The p21 inhibitor of cyclin dependent kinases controls DNA replication by interaction with PCNA, Nature, 369 (1994) 574.
35. EL Deiry W, Harper J W, O'Conmor P M, Velchelescu V E, Canman C E, Jackman J, Pietenpol J A, Burrell M, Hill D E, Wang Y, Wiman K G, Mercer W E, Kastan M B, Khon K W, Elledge S J, Kinzler K W & Vogelstein B, WAFI/CIPI is induced by p53-mediated G1 arrest and apoptosis, Cancer Res, 54 (1994) 1169.
36. H alldorsson H, Gray D A & Shall S, Poly(ADP-ribose) polymerase activity in nucleotide permeable cells, FEBS Lett, 85 (1978) 349.
37. Hunting D, Gowans B & Henderson F, Effects of 6-aminonicotinamide on cell growth, poly (ADP-ribose) synthesis and nucleotide metabolism, Biochem Pharmacol, 34 (1985) 3999.