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Volumn 36, Issue 1, 1999, Pages 59-79

Cyclodextrins in ophthalmic drug delivery

Author keywords

Corneal permeability; Eye; Ocular absorption; Ocular irritation; Penetration enhancer; Solubility; Stability; Topical administration; Water soluble polymer

Indexed keywords

DERIVATIVES; DRUG INFUSION; DRUG PRODUCTS; OPHTHALMOLOGY; SOLUBILITY; SOLUTIONS;

EID: 0344286485     PISSN: 0169409X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-409X(98)00055-6     Document Type: Review
Times cited : (284)

References (122)
  • 1
    • 0343907824 scopus 로고    scopus 로고
    • Effect of cyclodextrins on topical drug delivery to the eye
    • I. Loftsson, E. Stefánsson, Effect of cyclodextrins on topical drug delivery to the eye, Drug Devel. Ind. Pharm. 23 (1997) 473-481.
    • (1997) Drug Devel. Ind. Pharm. , vol.23 , pp. 473-481
    • Loftsson, I.1    Stefánsson, E.2
  • 2
    • 0029852699 scopus 로고    scopus 로고
    • Pharmaceutical applications of cyclodextrins. 2. In vivo drug delivery
    • R.A. Rajewski, V.J. Stella, Pharmaceutical applications of cyclodextrins. 2. In vivo drug delivery, J. Pharm. Sci. 85 (1996) 1142-1168.
    • (1996) J. Pharm. Sci. , vol.85 , pp. 1142-1168
    • Rajewski, R.A.1    Stella, V.J.2
  • 3
    • 0027282446 scopus 로고
    • Interaction between cyclodextrins and ophthalmic drugs
    • H. van Dorne, Interaction between cyclodextrins and ophthalmic drugs, Eur. J. Pharm. Biopharm. 39 (1993) 133-139.
    • (1993) Eur. J. Pharm. Biopharm. , vol.39 , pp. 133-139
    • Van Dorne, H.1
  • 4
    • 8244248457 scopus 로고    scopus 로고
    • Cyclodextrins: Their future in drug formulation and delivery
    • V.J. Stella, R.A. Rajewski, Cyclodextrins: their future in drug formulation and delivery, Pharm. Res. 14 (1997) 556-567.
    • (1997) Pharm. Res. , vol.14 , pp. 556-567
    • Stella, V.J.1    Rajewski, R.A.2
  • 5
    • 0018778644 scopus 로고
    • Mechanistic and quantitative evaluation of precorneal pilocarpine disposition in albino rabbits
    • V.H.L. Lee, J.R. Robinson, Mechanistic and quantitative evaluation of precorneal pilocarpine disposition in albino rabbits, J. Pharm. Sci. 68 (1979) 673-684.
    • (1979) J. Pharm. Sci. , vol.68 , pp. 673-684
    • Lee, V.H.L.1    Robinson, J.R.2
  • 6
    • 0022852854 scopus 로고
    • Topical ocular drug delivery: Recent developments and future challenges
    • V.H.L. Lee, J.R. Robinson, Topical ocular drug delivery: recent developments and future challenges, J. Ocul. Pharmacol. 2 (1986) 67-108.
    • (1986) J. Ocul. Pharmacol. , vol.2 , pp. 67-108
    • Lee, V.H.L.1    Robinson, J.R.2
  • 7
    • 0002611505 scopus 로고
    • Ocular pharmacokinetics
    • M.C Sears (Ed.), Springer-Verlag, Berlin-Heidelberg
    • D.M. Maurice, S. Mishima, Ocular pharmacokinetics, in: M.C Sears (Ed.), Handbook of Experimental Pharmacology, vol. 69, Springer-Verlag, Berlin-Heidelberg, 1984, pp. 19-116.
    • (1984) Handbook of Experimental Pharmacology , vol.69 , pp. 19-116
    • Maurice, D.M.1    Mishima, S.2
  • 9
    • 0027252620 scopus 로고
    • Minimizing systemic absorption of topically administered ophthalmic drugs
    • A. Urtti, L. Salminen, Minimizing systemic absorption of topically administered ophthalmic drugs, Surv. Ophthalmol. 37 (1993) 435-456.
    • (1993) Surv. Ophthalmol. , vol.37 , pp. 435-456
    • Urtti, A.1    Salminen, L.2
  • 11
    • 0016424489 scopus 로고
    • Influence of topical anesthesia on tear dynamics and ocular drug bioavailability in albino rabbits
    • T.F. Patton, J.R. Robinson, Influence of topical anesthesia on tear dynamics and ocular drug bioavailability in albino rabbits, J. Pharm. Sci. 64 (1975) 267-271.
    • (1975) J. Pharm. Sci. , vol.64 , pp. 267-271
    • Patton, T.F.1    Robinson, J.R.2
  • 12
    • 0017140815 scopus 로고
    • Quantitative precorneal disposition of topically applied pilocarpine nitrate in rabbit eyes
    • T.F. Patton, J.R. Robinson, Quantitative precorneal disposition of topically applied pilocarpine nitrate in rabbit eyes, J. Pharm. Sci. 65 (1976) 1295-1301.
    • (1976) J. Pharm. Sci. , vol.65 , pp. 1295-1301
    • Patton, T.F.1    Robinson, J.R.2
  • 14
    • 0022533978 scopus 로고
    • A comparison of the effect of viscosity on the precomeal residence of solutions in rabbit and man
    • I. Zaki, P. Fitzgerald, J.G. Hardy, C.G. Wilson, A comparison of the effect of viscosity on the precomeal residence of solutions in rabbit and man, J. Pharm. Pharmacol. 38 (1986) 463-466.
    • (1986) J. Pharm. Pharmacol. , vol.38 , pp. 463-466
    • Zaki, I.1    Fitzgerald, P.2    Hardy, J.G.3    Wilson, C.G.4
  • 15
    • 0024409346 scopus 로고
    • The evaluation of viscous ophthalmic vehicles by slit lamp fluorophotometry in humans
    • A. Ludwig, M. Van Ooteghem, The evaluation of viscous ophthalmic vehicles by slit lamp fluorophotometry in humans, Int. J. Pharm. 54 (1989) 95-102.
    • (1989) Int. J. Pharm. , vol.54 , pp. 95-102
    • Ludwig, A.1    Van Ooteghem, M.2
  • 16
    • 0025371137 scopus 로고
    • Evaluation of viscous ophthalmic vehicles containing carbomer by slit-lamp fluorophotometry in humans
    • A. Ludwig, N. LJnIu, M. Van Ooteghem, Evaluation of viscous ophthalmic vehicles containing carbomer by slit-lamp fluorophotometry in humans, Int. J. Pharm. 61 (1990) 15-25.
    • (1990) Int. J. Pharm. , vol.61 , pp. 15-25
    • Ludwig, A.1    LJnIu, N.2    Van Ooteghem, M.3
  • 17
    • 0024390449 scopus 로고
    • The pharmacology of antiglaucoma drugs
    • M.F. Sugrue, The pharmacology of antiglaucoma drugs, Pharm. Ther. 43 (1989) 91-138.
    • (1989) Pharm. Ther. , vol.43 , pp. 91-138
    • Sugrue, M.F.1
  • 18
    • 0023918338 scopus 로고
    • Comparison of conjunctival and corneal surface areas in rabbit and human
    • M.A. Watsky, M.M. Jablonski, H.F. Edelhauser, Comparison of conjunctival and corneal surface areas in rabbit and human, Curr. Eye Res. 7 (1988) 483-486.
    • (1988) Curr. Eye Res. , vol.7 , pp. 483-486
    • Watsky, M.A.1    Jablonski, M.M.2    Edelhauser, H.F.3
  • 19
    • 0023553501 scopus 로고
    • Physicochemical determinants of drug diffusion across the conjunctiva, sclera, and cornea
    • I. Ahmed, R.D. Gokhale, MV. Shah, T.F. Patton, Physicochemical determinants of drug diffusion across the conjunctiva, sclera, and cornea, J. Pharm. Sci. 76 (1987) 583-586.
    • (1987) J. Pharm. Sci. , vol.76 , pp. 583-586
    • Ahmed, I.1    Gokhale, R.D.2    Shah, M.V.3    Patton, T.F.4
  • 20
    • 0025775370 scopus 로고
    • Lipophilicity influence on conjunctival drug penetration in the pigmented rabbit: A comparison with corneal penetration
    • W. Wang, H. Sasaki, D.-S. Chien, V.H.L. Lee, Lipophilicity influence on conjunctival drug penetration in the pigmented rabbit: a comparison with corneal penetration, Curr. Eye Res. 10 (1991) 571-579.
    • (1991) Curr. Eye Res. , vol.10 , pp. 571-579
    • Wang, W.1    Sasaki, H.2    Chien, D.-S.3    Lee, V.H.L.4
  • 21
    • 0017872741 scopus 로고
    • Penetration routes of topically applied eye medication
    • M.G. Doane, A.D. Jensen, C.H. Dohlman, Penetration routes of topically applied eye medication, Am. J. Ophthalmol. 85 (1978) 383-386.
    • (1978) Am. J. Ophthalmol. , vol.85 , pp. 383-386
    • Doane, M.G.1    Jensen, A.D.2    Dohlman, C.H.3
  • 22
    • 0025767277 scopus 로고
    • Formulation influence on conjunctival penetration of four beta-blockers in the pigmented rabbit: A comparison with corneal penetration
    • P. Ashton, S.K. Podder, V.H.L. Lee, Formulation influence on conjunctival penetration of four beta-blockers in the pigmented rabbit: a comparison with corneal penetration, Pharm. Res. 8 (1991) 1166-1174.
    • (1991) Pharm. Res. , vol.8 , pp. 1166-1174
    • Ashton, P.1    Podder, S.K.2    Lee, V.H.L.3
  • 23
    • 0026666843 scopus 로고
    • The transport barrier of epithelia: A comparative study on membrane permeability and charge selectivity in the rabbit
    • Y. Rojanasakul, L.-Y. Wang, M. Bhat, D.D. Glover, C.J. Malanga, J.K.H. Ma, The transport barrier of epithelia: a comparative study on membrane permeability and charge selectivity in the rabbit, Pharm. Res. 9 (1992) 1029-1034.
    • (1992) Pharm. Res. , vol.9 , pp. 1029-1034
    • Rojanasakul, Y.1    Wang, L.-Y.2    Bhat, M.3    Glover, D.D.4    Malanga, C.J.5    Ma, J.K.H.6
  • 24
    • 0021072511 scopus 로고
    • Corneal penetration behavior of beta-blocking agents II: Assessment of barrier contributions
    • H.-S. Huang, R.D. Schoenwald, J.L. Lach, Corneal penetration behavior of beta-blocking agents II: assessment of barrier contributions, J. Pharm. Sci. 72 (1983) 1272-1286.
    • (1983) J. Pharm. Sci. , vol.72 , pp. 1272-1286
    • Huang, H.-S.1    Schoenwald, R.D.2    Lach, J.L.3
  • 26
    • 0021052458 scopus 로고
    • Corneal penetration behaviour of β-blocking agents. I: Physicochemical factors
    • R.D. Schoenwald, H.-S. Huang, Corneal penetration behaviour of β-blocking agents. I: physicochemical factors, J. Pharm. Sci. 72 (1983) 1266-1272.
    • (1983) J. Pharm. Sci. , vol.72 , pp. 1266-1272
    • Schoenwald, R.D.1    Huang, H.-S.2
  • 27
    • 0017806197 scopus 로고
    • Relationship between steroid permeability across excited rabbit cornea and octanol-water partition coefficients
    • R.D. Schoenwald, R. Ward, Relationship between steroid permeability across excited rabbit cornea and octanol-water partition coefficients, J. Pharm. Sci. 67 (1978) 786-788.
    • (1978) J. Pharm. Sci. , vol.67 , pp. 786-788
    • Schoenwald, R.D.1    Ward, R.2
  • 28
    • 0017641743 scopus 로고
    • Vehicle effects on ocular drug bioavailability II: Evaluation of pilocarpine
    • J.W. Sieg, J.R. Robinson, Vehicle effects on ocular drug bioavailability II: evaluation of pilocarpine, J. Pharm. Sci. 66 (1977) 1222-1228.
    • (1977) J. Pharm. Sci. , vol.66 , pp. 1222-1228
    • Sieg, J.W.1    Robinson, J.R.2
  • 29
    • 0026746696 scopus 로고
    • The effect of polyethylene glycol molecular weight on corneal transport and the related influence of penetration enhancers
    • J. Liaw, J.R. Robinson, The effect of polyethylene glycol molecular weight on corneal transport and the related influence of penetration enhancers, Int. J. Pharm. 88 (1992) 125-140.
    • (1992) Int. J. Pharm. , vol.88 , pp. 125-140
    • Liaw, J.1    Robinson, J.R.2
  • 30
    • 0026685311 scopus 로고
    • The effect of drug charge type and charge density on corneal transport
    • J. Liaw, Y. Rojanasakul, J.R. Robinson, The effect of drug charge type and charge density on corneal transport, Int. J. Pharm. 88 (1992) 111-124.
    • (1992) Int. J. Pharm. , vol.88 , pp. 111-124
    • Liaw, J.1    Rojanasakul, Y.2    Robinson, J.R.3
  • 31
    • 0022415335 scopus 로고
    • Ocular pharmacology of sulfonamides: The cornea as barrier and depot
    • T.H. Maren, L. Jankowska, Ocular pharmacology of sulfonamides: the cornea as barrier and depot, Curr. Eye Res. 4 (1985) 399-408.
    • (1985) Curr. Eye Res. , vol.4 , pp. 399-408
    • Maren, T.H.1    Jankowska, L.2
  • 32
    • 0027216970 scopus 로고
    • pH and drug ionization affects ocular pressure lowering of topical carbonic anhydrase inhibitors
    • W.F. Brechue, T.H. Maren, pH and drug ionization affects ocular pressure lowering of topical carbonic anhydrase inhibitors, Invest. Ophthalmol. Vis. Sci. 34 (1993) 2581-2587.
    • (1993) Invest. Ophthalmol. Vis. Sci. , vol.34 , pp. 2581-2587
    • Brechue, W.F.1    Maren, T.H.2
  • 33
    • 0018341629 scopus 로고
    • Human tear buffering capacity
    • L.G. Carney, R.M. Hill, Human tear buffering capacity, Arch. Ophthalmol. 97 (1979) 951-952.
    • (1979) Arch. Ophthalmol. , vol.97 , pp. 951-952
    • Carney, L.G.1    Hill, R.M.2
  • 34
    • 0017131017 scopus 로고
    • Effect of topically applied pilocarpineon tear film pH
    • A. Longwell, S. Birss, N. Keller, D. Moore, Effect of topically applied pilocarpineon tear film pH, J. Pharm. Sci. 65 (1976) 1654-1657.
    • (1976) J. Pharm. Sci. , vol.65 , pp. 1654-1657
    • Longwell, A.1    Birss, S.2    Keller, N.3    Moore, D.4
  • 35
    • 0021330357 scopus 로고
    • Effect of pH and buffer on the precorneal disposition and ocular penetration of pilocarpine in rabbits
    • I. Ahmed, T. Patton, Effect of pH and buffer on the precorneal disposition and ocular penetration of pilocarpine in rabbits, Int. J. Pharm. 19 (1984) 215-227.
    • (1984) Int. J. Pharm. , vol.19 , pp. 215-227
    • Ahmed, I.1    Patton, T.2
  • 36
    • 0016367531 scopus 로고
    • Permeability of the cornea to topically applied drugs
    • H. Benson, P. Alto, Permeability of the cornea to topically applied drugs, Arch. Ophthalmol. 91 (1974) 313-327.
    • (1974) Arch. Ophthalmol. , vol.91 , pp. 313-327
    • Benson, H.1    Alto, P.2
  • 37
    • 0031054513 scopus 로고    scopus 로고
    • Pharmaceutical applications of cyclodextrins. III. Toxicological issues and safety evaluation
    • T. Irie, K. Uekama, Pharmaceutical applications of cyclodextrins. III. Toxicological issues and safety evaluation, J. Pharm. Sci. 86 (1997) 147-162.
    • (1997) J. Pharm. Sci. , vol.86 , pp. 147-162
    • Irie, T.1    Uekama, K.2
  • 38
    • 0031042310 scopus 로고    scopus 로고
    • Cyclodextrins-enabling excipients: Their present and future use in pharmaceuticals
    • T.O. Thompson, Cyclodextrins-enabling excipients: their present and future use in pharmaceuticals, Crit. Rev. Ther. Drug Carrier Syst. 14 (1997) 1-104.
    • (1997) Crit. Rev. Ther. Drug Carrier Syst. , vol.14 , pp. 1-104
    • Thompson, T.O.1
  • 39
    • 0031036821 scopus 로고    scopus 로고
    • Intestinal safety of water-soluble β-cycIodextrins in paediatric oral solutions of spironolactone: Effects on human intestinal epithelial Caco-2 cells
    • A.M. Totterman, N.G. Schipper, D.O. Thompson, J.P. Mannermaa, Intestinal safety of water-soluble β-cycIodextrins in paediatric oral solutions of spironolactone: effects on human intestinal epithelial Caco-2 cells, J. Pharm. Pharmacol. 49 (1997) 43-48.
    • (1997) J. Pharm. Pharmacol. , vol.49 , pp. 43-48
    • Totterman, A.M.1    Schipper, N.G.2    Thompson, D.O.3    Mannermaa, J.P.4
  • 40
    • 0025542154 scopus 로고
    • Beta-cyclodextrins as vehicles in eye-drop formulation: An evaluation of their effects on rabbit corneal epithelium
    • T. Jansen, B. Xhonneux, J. Mesens, M. Borgers, Beta-cyclodextrins as vehicles in eye-drop formulation: an evaluation of their effects on rabbit corneal epithelium, Lens Eye Toxicity Res. 7 (1990) 459-468.
    • (1990) Lens Eye Toxicity Res. , vol.7 , pp. 459-468
    • Jansen, T.1    Xhonneux, B.2    Mesens, J.3    Borgers, M.4
  • 41
    • 0344968886 scopus 로고    scopus 로고
    • Topical Compositions for the Eye Comprising a Beta-Cyclodextrin Derivative and a Carbonic Anhydrase Inhibitor, International Patent Application No. WO 94/15582, 1994
    • J.C. Javitt, N.B. Javitt, P. McDonnell, Topical Compositions for the Eye Comprising a Beta-Cyclodextrin Derivative and a Carbonic Anhydrase Inhibitor, International Patent Application No. WO 94/15582, 1994.
    • Javitt, J.C.1    Javitt, N.B.2    McDonnell, P.3
  • 42
    • 0029943654 scopus 로고    scopus 로고
    • Cyclodextrin-inediated removal of sterols from monolayers: Effects of sterol structure and phospholipids on desorption rate
    • H. Ohvo, J.P. Slotte, Cyclodextrin-inediated removal of sterols from monolayers: effects of sterol structure and phospholipids on desorption rate, Biochemistry 35 (1996) 8018-8024.
    • (1996) Biochemistry , vol.35 , pp. 8018-8024
    • Ohvo, H.1    Slotte, J.P.2
  • 43
    • 0030927460 scopus 로고    scopus 로고
    • Influence of α-cyclodextrin and hydroxyalkylated β-cyclodextrin derivatives on the in vitro corneal uptake and permeation of aqueous pilocarpine-HCl solutions
    • B. Siefert, S. Keipert, Influence of α-cyclodextrin and hydroxyalkylated β-cyclodextrin derivatives on the in vitro corneal uptake and permeation of aqueous pilocarpine-HCl solutions, J. Pharm. Sci. 86 (1997) 716-720.
    • (1997) J. Pharm. Sci. , vol.86 , pp. 716-720
    • Siefert, B.1    Keipert, S.2
  • 46
    • 0029060183 scopus 로고
    • Sulfobutyl ether β-cyclodextrin (SBE-β-CyD) in eye drops improves the tolerability of a topically applied pilocarpine prodrug in rabbits
    • T. Jarvinen, K. Jarvinen, A. Urtti, D. Thompson, V.J. Stella, Sulfobutyl ether β-cyclodextrin (SBE-β-CyD) in eye drops improves the tolerability of a topically applied pilocarpine prodrug in rabbits, J. Ocul. Pharmacol. Ther. 11 (1995) 95-106.
    • (1995) J. Ocul. Pharmacol. Ther. , vol.11 , pp. 95-106
    • Jarvinen, T.1    Jarvinen, K.2    Urtti, A.3    Thompson, D.4    Stella, V.J.5
  • 47
    • 0030001340 scopus 로고    scopus 로고
    • Modified β-cyclodextrin (SBE7-β-CyD) with viscous vehicle improves the ocular delivery and tolerability of pilocarpine prodrug in rabbits
    • P. Jarho, K. Järvinen, A. Urtti, V.J. Stella, T. Jarvinen, Modified β-cyclodextrin (SBE7-β-CyD) with viscous vehicle improves the ocular delivery and tolerability of pilocarpine prodrug in rabbits, J. Pharm. Pharmacol. 48 (1996) 264-270.
    • (1996) J. Pharm. Pharmacol. , vol.48 , pp. 264-270
    • Jarho, P.1    Järvinen, K.2    Urtti, A.3    Stella, V.J.4    Jarvinen, T.5
  • 49
    • 0031687944 scopus 로고    scopus 로고
    • Evaluation of cytotoxicity of various ophthalmic drugs, eye drop excipients and Cyclodextrins in an immortalized human corneal epithelium cell line
    • P. Saarinen-Savolainen, T. Järvinen, K. Araki-Sasaki, H. Watanabe, A. Urtti, Evaluation of cytotoxicity of various ophthalmic drugs, eye drop excipients and Cyclodextrins in an immortalized human corneal epithelium cell line, Pharm. Res. 15 (1998) 1275-1280.
    • (1998) Pharm. Res. , vol.15 , pp. 1275-1280
    • Saarinen-Savolainen, P.1    Järvinen, T.2    Araki-Sasaki, K.3    Watanabe, H.4    Urtti, A.5
  • 50
    • 0028271662 scopus 로고
    • Delivery of antiglaucoma drugs: Ocular vs systemic absorption
    • A. Urtti, Delivery of antiglaucoma drugs: ocular vs systemic absorption, J. Ocular Pharmacol. 10 (1994) 349-357.
    • (1994) J. Ocular Pharmacol. , vol.10 , pp. 349-357
    • Urtti, A.1
  • 53
    • 0002938796 scopus 로고
    • The effect of cyclodextrins on percutaneous transport of drugs
    • E.W. Smith, H.I. Maibach (Eds.), CRC Press, Boca Raton, Florida
    • T. Loftsson, N. Bodor, The effect of cyclodextrins on percutaneous transport of drugs. In: E.W. Smith, H.I. Maibach (Eds.), Percutaneous Penetration Enhancers. CRC Press, Boca Raton, Florida, 1995, pp. 335-342.
    • (1995) Percutaneous Penetration Enhancers , pp. 335-342
    • Loftsson, T.1    Bodor, N.2
  • 55
    • 0005175113 scopus 로고    scopus 로고
    • The effect of SBE7-β-cyclodextrin with viscous vehicle on ocular delivery of pilocarpine prodrug in rabbits
    • J. Szejtli, L. Szente, (Eds.), Kluwer Academic Publishers, Dordrecht
    • P. Jarho, K. Jarvinen, A. Urtti, V.J. Stella, T. Jarvinen, The effect of SBE7-β-cyclodextrin with viscous vehicle on ocular delivery of pilocarpine prodrug in rabbits, in: J. Szejtli, L. Szente, (Eds.), The Eigth International Symposium on Cyclodextrins, Kluwer Academic Publishers, Dordrecht, 1997, pp. 299-402.
    • (1997) The Eigth International Symposium on Cyclodextrins , pp. 299-402
    • Jarho, P.1    Jarvinen, K.2    Urtti, A.3    Stella, V.J.4    Jarvinen, T.5
  • 56
    • 0030604721 scopus 로고    scopus 로고
    • Increase in aqueous solubility, stability and in vitro corneal permeability of anandamide by hydroxypropyl-β-cyclodextrin
    • P. Jarho, A. Urtti, D.W. Pate, P. Suhonen, T. Järvinen, Increase in aqueous solubility, stability and in vitro corneal permeability of anandamide by hydroxypropyl-β-cyclodextrin, Int. J. Pharm. 137 (1996) 209-217.
    • (1996) Int. J. Pharm. , vol.137 , pp. 209-217
    • Jarho, P.1    Urtti, A.2    Pate, D.W.3    Suhonen, P.4    Järvinen, T.5
  • 57
    • 0029564835 scopus 로고
    • The effect of polyvinylpyrrolidone on cyclodextrin complexation of hydrocortisone and its diffusion through hairless mouse skin
    • A.M. Sigurdardottir, T. Loftsson, The effect of polyvinylpyrrolidone on cyclodextrin complexation of hydrocortisone and its diffusion through hairless mouse skin, Int. J. Pharm. 126 (1995) 73-78.
    • (1995) Int. J. Pharm. , vol.126 , pp. 73-78
    • Sigurdardottir, A.M.1    Loftsson, T.2
  • 58
    • 0029851441 scopus 로고    scopus 로고
    • Nasal absorption of 17β-estradiol from different cyclodextrin inclusion formulations in sheep
    • H. Kublik, T.K. Bock, H. Schreier, B.W. Müller, Nasal absorption of 17β-estradiol from different cyclodextrin inclusion formulations in sheep, Eur. J. Pharm. Biopharm. 42 (1996) 320-324.
    • (1996) Eur. J. Pharm. Biopharm. , vol.42 , pp. 320-324
    • Kublik, H.1    Bock, T.K.2    Schreier, H.3    Müller, B.W.4
  • 59
    • 85052564875 scopus 로고    scopus 로고
    • Pharmaceutical and medical applications of cyclodextrins
    • S. Dumitriu (Ed.), Marcel Dekker, New York
    • D. Duchêne, D. Wouessidjewe, Pharmaceutical and medical applications of cyclodextrins, in: S. Dumitriu (Ed.), Polysaccharides In Medical Applications, Marcel Dekker, New York, 1996, pp. 575-602.
    • (1996) Polysaccharides in Medical Applications , pp. 575-602
    • Duchêne, D.1    Wouessidjewe, D.2
  • 60
    • 4244141057 scopus 로고    scopus 로고
    • How do cyclodextrins enhance drug permeability through biological membranes?
    • J.J. Torres-Labandeira. (Ed.), Santiago de Compostela, Kluwer Academic Publishers, Dordrecht, in print
    • M. Másson, T. Loftsson, E. Stefánsson, How do cyclodextrins enhance drug permeability through biological membranes? in: J.J. Torres-Labandeira. (Ed.), Ninth International Symposium on Cyclodextrins, Santiago de Compostela, Kluwer Academic Publishers, Dordrecht, 1998 in print.
    • (1998) Ninth International Symposium on Cyclodextrins
    • Másson, M.1    Loftsson, T.2    Stefánsson, E.3
  • 61
    • 0002086622 scopus 로고
    • Physical chemical analysis of percutaneous absorption process from creams and ointments
    • T. Higuchi, Physical chemical analysis of percutaneous absorption process from creams and ointments, J. Soc. Cosmetic Chemists 11 (1960) 85-97.
    • (1960) J. Soc. Cosmetic Chemists , vol.11 , pp. 85-97
    • Higuchi, T.1
  • 62
    • 0025732982 scopus 로고
    • Reduction in the ulcerogenicity of naproxen by complexation with β-cyclodextrin
    • F.J. Otero Espinar, S. Anguiano, M.J. Blanco, J.J.L. Vila, Reduction in the ulcerogenicity of naproxen by complexation with β-cyclodextrin, Int. J. Pharm. 70 (1991) 35-41.
    • (1991) Int. J. Pharm. , vol.70 , pp. 35-41
    • Otero Espinar, F.J.1    Anguiano, S.2    Blanco, M.J.3    Vila, J.J.L.4
  • 63
    • 0028324016 scopus 로고
    • In vivo evaluation of indomnethacin/cyclodextrin complexes gastrointestinal tolerance and dermal anti-inflammatory activity
    • S.-L. Lin, D. Wouessidjewe, M.-C. Poelman, D. Duchêne, In vivo evaluation of indomnethacin/cyclodextrin complexes gastrointestinal tolerance and dermal anti-inflammatory activity, Int. J. Pharm. 106 (1994) 63-67.
    • (1994) Int. J. Pharm. , vol.106 , pp. 63-67
    • Lin, S.-L.1    Wouessidjewe, D.2    Poelman, M.-C.3    Duchêne, D.4
  • 64
    • 0024391429 scopus 로고
    • Comparison of faecal blood loss, upper gastrointestinal mucosal integrity and symptoms after piroxicam beta-cyclodextrin, pyroxicam and placebo administration
    • L. Patoia, G. Clausi, F. Farroni, P. Alberti, P. Fugiani, L. Bufalino, Comparison of faecal blood loss, upper gastrointestinal mucosal integrity and symptoms after piroxicam beta-cyclodextrin, pyroxicam and placebo administration, Eur. J. Clin. Pharmacol. 36 (1989) 599-604.
    • (1989) Eur. J. Clin. Pharmacol. , vol.36 , pp. 599-604
    • Patoia, L.1    Clausi, G.2    Farroni, F.3    Alberti, P.4    Fugiani, P.5    Bufalino, L.6
  • 65
    • 0025831715 scopus 로고
    • Enhancement of 4-biphenylacetic acid bioavailability in rats by its β-cyclodextrin complex after oral administration
    • G. Puglisi, N.A. Santagati, C.A. Ventura, R. Pignatello, A. Panico, Enhancement of 4-biphenylacetic acid bioavailability in rats by its β-cyclodextrin complex after oral administration, J. Pharm. Pharmacol. 43 (1991) 430-432.
    • (1991) J. Pharm. Pharmacol. , vol.43 , pp. 430-432
    • Puglisi, G.1    Santagati, N.A.2    Ventura, C.A.3    Pignatello, R.4    Panico, A.5
  • 66
    • 0025236395 scopus 로고
    • Utility of 2-hydroxypropyl-β-cyclodextrin in an intramuscular injectable preparation of nimodipine
    • A. Yoshida, M. Yamamoto, T. Itoh, T. Irie, F. Hirayama, K. Uekama, Utility of 2-hydroxypropyl-β-cyclodextrin in an intramuscular injectable preparation of nimodipine, Chem. Pharm. Bull. 38 (1990) 176-179.
    • (1990) Chem. Pharm. Bull. , vol.38 , pp. 176-179
    • Yoshida, A.1    Yamamoto, M.2    Itoh, T.3    Irie, T.4    Hirayama, F.5    Uekama, K.6
  • 67
    • 0029048935 scopus 로고
    • The effect of SBE4-β-CD on i.m. prednisolone pharmacokinetics and tissue damage in rabbits: Comparison to a co-solvent solution and a water-soluble prodrug
    • V.J. Stella, H.K. Lee, D.O. Thompson, The effect of SBE4-β-CD on i.m. prednisolone pharmacokinetics and tissue damage in rabbits: comparison to a co-solvent solution and a water-soluble prodrug, Int. J. Pharm. 120 (1995) 197-204.
    • (1995) Int. J. Pharm. , vol.120 , pp. 197-204
    • Stella, V.J.1    Lee, H.K.2    Thompson, D.O.3
  • 68
    • 0025917222 scopus 로고
    • O,O′-(1,4-xylylene)bispilocarpic acid esters as new potential double prodrugs of pilocarpine for improvement of ocular delivery. II. Physochemical properties, stability, solubility and enzymatic hydrolysis
    • T. Järvinen, P. Suhonen, A. Urtti, P. Peura, O,O′-(1,4-xylylene)bispilocarpic acid esters as new potential double prodrugs of pilocarpine for improvement of ocular delivery. II. Physochemical properties, stability, solubility and enzymatic hydrolysis, Int. J. Pharm. 75 (1991) 259-269.
    • (1991) Int. J. Pharm. , vol.75 , pp. 259-269
    • Järvinen, T.1    Suhonen, P.2    Urtti, A.3    Peura, P.4
  • 70
    • 0028930838 scopus 로고
    • Ocular absorption and irritation of pilocarpine prodrug is modified with buffer, polymer, and cyclodextrin in the eyedrop
    • P. Suhonen, T. Järvinen, K. Lehmussaari, T. Reunamäki, A. Urtti, Ocular absorption and irritation of pilocarpine prodrug is modified with buffer, polymer, and cyclodextrin in the eyedrop, Pharm. Res. 12 (1995) 529-533.
    • (1995) Pharm. Res. , vol.12 , pp. 529-533
    • Suhonen, P.1    Järvinen, T.2    Lehmussaari, K.3    Reunamäki, T.4    Urtti, A.5
  • 71
    • 0024595698 scopus 로고
    • Effect of the interaction of drug-β-cyclodextrin complex with bile salts on the drug absorption from rat small intestinal lumen
    • K. Nakanishi, M. Masada, T. Nadai, K. Miyajima, Effect of the interaction of drug-β-cyclodextrin complex with bile salts on the drug absorption from rat small intestinal lumen, Chem. Pharm. Bull. 37 (1989) 211-214.
    • (1989) Chem. Pharm. Bull. , vol.37 , pp. 211-214
    • Nakanishi, K.1    Masada, M.2    Nadai, T.3    Miyajima, K.4
  • 72
    • 0025259927 scopus 로고
    • The effect of cyclodextrins on drug absorption. II. In vivo observation
    • H.W. Frijlink, A.C. Eissens, A.J.M. Schoonen, C.F. Lerk, The effect of cyclodextrins on drug absorption. II. In vivo observation, Int. J. Pharm. 64 (1990) 195-205.
    • (1990) Int. J. Pharm. , vol.64 , pp. 195-205
    • Frijlink, H.W.1    Eissens, A.C.2    Schoonen, A.J.M.3    Lerk, C.F.4
  • 73
    • 0344968879 scopus 로고    scopus 로고
    • Antiallergic Composition for Ophthalmic or Nasal Use, Eur. Pat. Appl. 1 605 203 A3, 1994
    • Y. Ikejiri, F. Tokomochi, S. Sameshima, M. Kimura, Antiallergic Composition for Ophthalmic or Nasal Use, Eur. Pat. Appl. 1 605 203 A3, 1994.
    • Ikejiri, Y.1    Tokomochi, F.2    Sameshima, S.3    Kimura, M.4
  • 74
    • 0344968878 scopus 로고    scopus 로고
    • Composition for Eyedrops. Eur. Pat. Appl. No. 0472 327 A1, 1992
    • K. Ushio, Y. Ikejiri Y, Composition for Eyedrops. Eur. Pat. Appl. No. 0472 327 A1, 1992.
    • Ushio, K.1    Ikejiri Y, Y.2
  • 75
    • 0002262216 scopus 로고
    • Effects of cyclodextrins on the chemical stability of drugs in aqueous solutions
    • T. Loftsson, Effects of cyclodextrins on the chemical stability of drugs in aqueous solutions, Drug Stability 1 (1995) 22-33.
    • (1995) Drug Stability , vol.1 , pp. 22-33
    • Loftsson, T.1
  • 76
    • 0029819323 scopus 로고    scopus 로고
    • Pharmaceutical applications of cyclodextrins. 1. Drug solubilization and stabilization
    • T. Loftsson, M.E. Brewster, Pharmaceutical applications of cyclodextrins. 1. Drug solubilization and stabilization, J. Pharm. Sci. 85 (1996) 1017-1025.
    • (1996) J. Pharm. Sci. , vol.85 , pp. 1017-1025
    • Loftsson, T.1    Brewster, M.E.2
  • 78
  • 79
    • 0029885804 scopus 로고    scopus 로고
    • Photochemical stability of the inclusion complexes of nicardipine with α-, γ-cyclodextrin, methyl-β-cyclodextrin and hydroxypropyl-β-cyclodextrin in solid state and in solution
    • J. Mielcarek, Photochemical stability of the inclusion complexes of nicardipine with α-, γ-cyclodextrin, methyl-β-cyclodextrin and hydroxypropyl-β-cyclodextrin in solid state and in solution, Pharmazie 51 (1996) 477-479.
    • (1996) Pharmazie , vol.51 , pp. 477-479
    • Mielcarek, J.1
  • 80
    • 0024448580 scopus 로고
    • Epimerization and racemization of some chiral drugs in the presence of cyclodextrin and lipopsomes
    • Y. Aso, S. Yoshioka, Y. Takeda, Epimerization and racemization of some chiral drugs in the presence of cyclodextrin and lipopsomes, Chem. Pharm. Bull. 37 (1989) 2786-2789.
    • (1989) Chem. Pharm. Bull. , vol.37 , pp. 2786-2789
    • Aso, Y.1    Yoshioka, S.2    Takeda, Y.3
  • 81
    • 0026098307 scopus 로고
    • Cyclodextrin-accelerated degradation of β-lactam antibiotics in aqueous solutions
    • T. Loftsson, B.J. Ólafsdóttir, Cyclodextrin-accelerated degradation of β-lactam antibiotics in aqueous solutions, Int. J. Pharm. 67 (1991) R5-R7.
    • (1991) Int. J. Pharm. , vol.67
    • Loftsson, T.1    Ólafsdóttir, B.J.2
  • 82
    • 0025874523 scopus 로고
    • Interaction of NSA with Cyclodextrins and hydroxypropyl cyclodextrin derivatives
    • T. Backensfeld, B. Müller, K. Kolter, Interaction of NSA with Cyclodextrins and hydroxypropyl cyclodextrin derivatives, Int. J. Pharm. 74 (1991) 85-93.
    • (1991) Int. J. Pharm. , vol.74 , pp. 85-93
    • Backensfeld, T.1    Müller, B.2    Kolter, K.3
  • 83
    • 0027510058 scopus 로고
    • Kinetics of aspirin hydrolysis and stabilization in presence of 2-hydroxypropyl-β-cyclodextrin
    • S. Choundry, A.K. Mitra, Kinetics of aspirin hydrolysis and stabilization in presence of 2-hydroxypropyl-β-cyclodextrin, Pharm. Res. 10 (1993) 156-159.
    • (1993) Pharm. Res. , vol.10 , pp. 156-159
    • Choundry, S.1    Mitra, A.K.2
  • 84
    • 0026595332 scopus 로고
    • Cyclodextrin/weak-electrolyte complexation: Interpretation and estimation of association constants from phase solubility diagrams
    • F. Liu, D.O. Kildsig, A.K. Mitra, cyclodextrin/weak-electrolyte complexation: interpretation and estimation of association constants from phase solubility diagrams, Pharm. Res. 9 (1992) 1671-1672.
    • (1992) Pharm. Res. , vol.9 , pp. 1671-1672
    • Liu, F.1    Kildsig, D.O.2    Mitra, A.K.3
  • 85
    • 0030575716 scopus 로고    scopus 로고
    • Characterization and in vitro dissolution behaviour of ketakonazole/β- and 2-hydroxypropyl-β-cyclodextrin inclusion compounds
    • M.T. Esclusa-Diaz, M. Guimaraens-Mendez, M.B. Perez-Marcos, Characterization and in vitro dissolution behaviour of ketakonazole/β- and 2-hydroxypropyl-β-cyclodextrin inclusion compounds, Int. J. Pharm. 143 (1996) 203-210.
    • (1996) Int. J. Pharm. , vol.143 , pp. 203-210
    • Esclusa-Diaz, M.T.1    Guimaraens-Mendez, M.2    Perez-Marcos, M.B.3
  • 86
    • 0030053698 scopus 로고    scopus 로고
    • The interaction of charged and uncharged drugs with neutral (HP-β-CD) and anionically charged (SBE7-β-CD) β-cyclodextrins
    • K. Okimoto, R.A. Rajewski, K. Uekama, J.A. Jona, V.J. Stella, The interaction of charged and uncharged drugs with neutral (HP-β-CD) and anionically charged (SBE7-β-CD) β-cyclodextrins, Pharm. Res. 13 (1996) 256-264.
    • (1996) Pharm. Res. , vol.13 , pp. 256-264
    • Okimoto, K.1    Rajewski, R.A.2    Uekama, K.3    Jona, J.A.4    Stella, V.J.5
  • 87
    • 0017137343 scopus 로고
    • Prodrug approaches to enhancement of physicochemical properties of drugs. IV: Novel epinephrine prodrug
    • A. Hussain, J.E. Truelove, Prodrug approaches to enhancement of physicochemical properties of drugs. IV: novel epinephrine prodrug, J. Pharm. Sci. 72 (1976) 1510-1512.
    • (1976) J. Pharm. Sci. , vol.72 , pp. 1510-1512
    • Hussain, A.1    Truelove, J.E.2
  • 88
    • 0017940245 scopus 로고
    • Dipivalyl epinephrine: A new prodrug in the treatment of glaucoma
    • A.I. Mandell, F. Stentz, Dipivalyl epinephrine: a new prodrug in the treatment of glaucoma, Ophthalmol. 85 (1978) 268-275.
    • (1978) Ophthalmol. , vol.85 , pp. 268-275
    • Mandell, A.I.1    Stentz, F.2
  • 92
    • 0028584251 scopus 로고
    • The effect of modified β-cyclodextrin, SBE4-β-CD, on the aqueous solubility and ocular absorption of pilocarpine
    • K. Järvinen, T. Järvinen, D.O. Thompson, V. Stella, The effect of modified β-cyclodextrin, SBE4-β-CD, on the aqueous solubility and ocular absorption of pilocarpine, Curr. Eye Res. 13 (1994) 891-905.
    • (1994) Curr. Eye Res. , vol.13 , pp. 891-905
    • Järvinen, K.1    Järvinen, T.2    Thompson, D.O.3    Stella, V.4
  • 93
    • 0030847658 scopus 로고    scopus 로고
    • Evaluation of a hydrocortisone/hydroxypropyl-β-cyclodextrin solution for ocular drug delivery
    • N.M. Davies, G. Wang, I.G. Tucker, Evaluation of a hydrocortisone/hydroxypropyl-β-cyclodextrin solution for ocular drug delivery, Int. J. Pharm. 156 (1997) 201-209.
    • (1997) Int. J. Pharm. , vol.156 , pp. 201-209
    • Davies, N.M.1    Wang, G.2    Tucker, I.G.3
  • 94
    • 0025930845 scopus 로고
    • Effect of 2-hydroxypropyl-β-cyclodextrin on the ocular absorbtion of dexamethazone and dexamethazoneacetat
    • A. Usayapant, A.H. Karara, M.M. Narurkar, Effect of 2-hydroxypropyl-β-cyclodextrin on the ocular absorbtion of dexamethazone and dexamethazoneacetat, Pharm. Res. 12 (1991) 1495-1499.
    • (1991) Pharm. Res. , vol.12 , pp. 1495-1499
    • Usayapant, A.1    Karara, A.H.2    Narurkar, M.M.3
  • 95
    • 0029133967 scopus 로고
    • Ophthalmic arachidonylethanolamide decreases intraocular pressure in normotensive rabbits
    • D.W. Pate, K. Järvinen, A. Urtti, P. Jarho, T. Järvinen, Ophthalmic arachidonylethanolamide decreases intraocular pressure in normotensive rabbits, Curr. Eye Res. 14 (1995) 791-797.
    • (1995) Curr. Eye Res. , vol.14 , pp. 791-797
    • Pate, D.W.1    Järvinen, K.2    Urtti, A.3    Jarho, P.4    Järvinen, T.5
  • 97
    • 0031413704 scopus 로고    scopus 로고
    • Effects of topical alpha-substituted anandamide on intraocular pressure in normotensive rabbits
    • D.W. Pate, K. Jarvinen, A. Urtti, P. Jarho, F. Mette, V. Mahadevan, T. Järvinen, Effects of topical alpha-substituted anandamide on intraocular pressure in normotensive rabbits, Pharm. Res. 14 (1996) 1738-1743.
    • (1996) Pharm. Res. , vol.14 , pp. 1738-1743
    • Pate, D.W.1    Jarvinen, K.2    Urtti, A.3    Jarho, P.4    Mette, F.5    Mahadevan, V.6    Järvinen, T.7
  • 99
    • 0344588867 scopus 로고    scopus 로고
    • The effect of water-soluble polymers on the aqueous solubility and complexing abilities of β-cyclodextrin
    • T. Loftsson, H. Fridriksdóttir, The effect of water-soluble polymers on the aqueous solubility and complexing abilities of β-cyclodextrin, Int. J. Pharm. 163 (1998) 115-121.
    • (1998) Int. J. Pharm. , vol.163 , pp. 115-121
    • Loftsson, T.1    Fridriksdóttir, H.2
  • 103
    • 4744341349 scopus 로고
    • Polymer-micelle interactions: Physical organic aspects
    • J.C. Brackman, J.B.F.N. Engberts, Polymer-micelle interactions: physical organic aspects. Chem. Soc. Rev. (1993) 85-92.
    • (1993) Chem. Soc. Rev. , pp. 85-92
    • Brackman, J.C.1    Engberts, J.B.F.N.2
  • 105
    • 0026663460 scopus 로고
    • Influence of vehicle and anterior chamber protein concentration on cyclosporin penetration through the isolated rabbit cornea
    • L. Cheeks, R.L. Kaswan, K. Green, Influence of vehicle and anterior chamber protein concentration on cyclosporin penetration through the isolated rabbit cornea, Curr. Eye Res. 11 (1992) 641-649.
    • (1992) Curr. Eye Res. , vol.11 , pp. 641-649
    • Cheeks, L.1    Kaswan, R.L.2    Green, K.3
  • 106
    • 0028265697 scopus 로고
    • The effect of hydroxypropyl methylcellulose on release of dexamethazone from aqueous 2-hydroxypropyl-β-cyclodextrin formulations
    • T. Loftsson, H. Fridriksdottir, S. Thorisdottir, E. Stefansson, The effect of hydroxypropyl methylcellulose on release of dexamethazone from aqueous 2-hydroxypropyl-β-cyclodextrin formulations, Int. J. Pharm. 104 (1994) 181-184.
    • (1994) Int. J. Pharm. , vol.104 , pp. 181-184
    • Loftsson, T.1    Fridriksdottir, H.2    Thorisdottir, S.3    Stefansson, E.4
  • 107
    • 0027931257 scopus 로고
    • In vitro corneal permeability of diclofenac sodium in formulations containing cyclodextrins compared to commercial product voltaren ophtha
    • O. Reer, T.K. Bock, B.W. Müller, In vitro corneal permeability of diclofenac sodium in formulations containing cyclodextrins compared to commercial product voltaren ophtha, J. Pharm. Sci. 83 (1994) 1345-1349.
    • (1994) J. Pharm. Sci. , vol.83 , pp. 1345-1349
    • Reer, O.1    Bock, T.K.2    Müller, B.W.3
  • 108
    • 0027260909 scopus 로고
    • Beta-cyclodextrins enhance biovailability of pilocarpine
    • K.A. Freedman, J.W. Klein, C.E. Crosson, Beta-cyclodextrins enhance biovailability of pilocarpine, Curr. Eye Res. 12 (1993) 641.
    • (1993) Curr. Eye Res. , vol.12 , pp. 641
    • Freedman, K.A.1    Klein, J.W.2    Crosson, C.E.3
  • 109
    • 0030580131 scopus 로고    scopus 로고
    • Interactions between Cyclodextrins and pilocarpine-as an example of a hydrophilic drug
    • S. Keipert, J. Fedder, A. Bohm, B. Hanke, Interactions between Cyclodextrins and pilocarpine-as an example of a hydrophilic drug, Int. J. Pharm. 142 (1996) 153-162.
    • (1996) Int. J. Pharm. , vol.142 , pp. 153-162
    • Keipert, S.1    Fedder, J.2    Bohm, A.3    Hanke, B.4
  • 110
    • 0345400240 scopus 로고    scopus 로고
    • The use of inclusion complexes of prostaglandins with Cyclodextrins in the treatment of ocular hypertension, Eur. Pat. No. 0435 682 A3, 1991
    • L.A. Wheeler, The use of inclusion complexes of prostaglandins with Cyclodextrins in the treatment of ocular hypertension, Eur. Pat. No. 0435 682 A3, 1991.
    • Wheeler, L.A.1
  • 111
    • 0016696997 scopus 로고
    • Pilocarpine levels in the eyes of rabbits following topical application
    • R. Lazare, M. Horlington, Pilocarpine levels in the eyes of rabbits following topical application, Exp. Eye Res. 21 (1975) 281-287.
    • (1975) Exp. Eye Res. , vol.21 , pp. 281-287
    • Lazare, R.1    Horlington, M.2
  • 112
    • 0024552652 scopus 로고
    • Formulation studies on pilocarpine nitrate ophthalmic solutions
    • N. Unlü, M. Sumnu, A.A. Hincal, Formulation studies on pilocarpine nitrate ophthalmic solutions, Acta Pharm. Technol. 35 (1989) 38-43.
    • (1989) Acta Pharm. Technol. , vol.35 , pp. 38-43
    • Unlü, N.1    Sumnu, M.2    Hincal, A.A.3
  • 114
    • 0028288534 scopus 로고
    • Effect of hydroxypropyl-β-cyclodextrin on the antimicrobial action of preservatives
    • S.J. Lehner, B.W. Müller, J.K. Seydel, Effect of hydroxypropyl-β-cyclodextrin on the antimicrobial action of preservatives, J. Pharm. Pharmacol. 46 (1994) 186-191.
    • (1994) J. Pharm. Pharmacol. , vol.46 , pp. 186-191
    • Lehner, S.J.1    Müller, B.W.2    Seydel, J.K.3
  • 116
    • 0027241706 scopus 로고
    • Interactions between p-hydroxybenzoic acid esters and hydroxypropyl-β-Cyclodextrins and their antimicrobial effect against Candida albicans
    • S.J. Lehner, B.W. Müller, J.K. Seydel, Interactions between p-hydroxybenzoic acid esters and hydroxypropyl-β-Cyclodextrins and their antimicrobial effect against Candida albicans, Int. J. Pharm. 93 (1993) 201-208.
    • (1993) Int. J. Pharm. , vol.93 , pp. 201-208
    • Lehner, S.J.1    Müller, B.W.2    Seydel, J.K.3
  • 117
    • 0344968863 scopus 로고    scopus 로고
    • Ophthalmic compositions containing Cyclodextrins and quaternary ammonium compounds, Int. Pat. Appl. No. WO 97/10805, 1997
    • G.L. Kis, A. Fetz, C. Schoch, Ophthalmic compositions containing Cyclodextrins and quaternary ammonium compounds, Int. Pat. Appl. No. WO 97/10805, 1997.
    • Kis, G.L.1    Fetz, A.2    Schoch, C.3
  • 118
    • 0027435328 scopus 로고
    • Inclusion complexation of p-hydroxybenzoic acid esters with 2-hydroxypropyl-β-cyclodextrin. on changes in solubility and antimicrobial activity
    • H. Matsuda, K. Ito, Y. Sato, D. Yoshizava, M. Tanaka, A. Taki, H. Suiniyoshi, T. Utsuki, F. Hirayama, K. Uekama, Inclusion complexation of p-hydroxybenzoic acid esters with 2-hydroxypropyl-β-cyclodextrin. On changes in solubility and antimicrobial activity, Chem. Pharm. Bull. 41 (1993) 1448-1452.
    • (1993) Chem. Pharm. Bull. , vol.41 , pp. 1448-1452
    • Matsuda, H.1    Ito, K.2    Sato, Y.3    Yoshizava, D.4    Tanaka, M.5    Taki, A.6    Suiniyoshi, H.7    Utsuki, T.8    Hirayama, F.9    Uekama, K.10
  • 119
    • 0344106372 scopus 로고    scopus 로고
    • Process for reducing intraocular pressure, United States Patent No. 4,619,939, 1986, p. 6
    • T.H. Maren, Process for reducing intraocular pressure, United States Patent No. 4,619,939, 1986, p. 6.
    • Maren, T.H.1
  • 121
    • 0027515720 scopus 로고
    • Four-week safety and efficacy study of Dorzolamide, a novel, active topical carbonic anhydrase inhibitor
    • M. Wilkerson, M. Cyrlin, E. Lippa, Four-week safety and efficacy study of Dorzolamide, a novel, active topical carbonic anhydrase inhibitor, Arch. Ophtalmol. 111 (1993) 1343-1350.
    • (1993) Arch. Ophtalmol. , vol.111 , pp. 1343-1350
    • Wilkerson, M.1    Cyrlin, M.2    Lippa, E.3
  • 122
    • 0037871611 scopus 로고    scopus 로고
    • Acute and Chronic Postoperative Inflammatory Reactions after Cateract Extraction and Intraocular Lens Implantation
    • K.M. Saari, H. Jyrkkiö, H. Seppa, T. Loftsson, E. Stefansson, Acute and Chronic Postoperative Inflammatory Reactions after Cateract Extraction and Intraocular Lens Implantation, Excerta Medica International Congress, 1998, p. 1158.
    • (1998) Excerta Medica International Congress , pp. 1158
    • Saari, K.M.1    Jyrkkiö, H.2    Seppa, H.3    Loftsson, T.4    Stefansson, E.5


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