Decreased nitric oxide synthase activity in platelets from IDDM and NIDDM patients

Diabetologia

Volumn 41, Issue 1, 1998, Pages 101-104

  Rabini, R A ^a   Staffolani, R ^b   Fumelli, P ^a   Mutus, B ^c   Curatola, G ^b   Mazzanti, L ^b  

^a INRCA   (Italy)

^b UNIVERSITÀ POLITECNICA DELLE MARCHE   (Italy)

^c UNIVERSITY OF WINDSOR   (Canada)

Author keywords

Diabetes mellitus; HbA(1c); Na+ K+ ATPase; Nitric oxide synthase; Platelet

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); CYCLIC GMP; HEMOGLOBIN A1C; METHEMOGLOBIN; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; OXYHEMOGLOBIN;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; DIABETIC ANGIOPATHY; ENZYME ACTIVITY; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN CELL; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; MALE; METABOLIC REGULATION; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; SPECTROPHOTOMETRY; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION; THROMBOCYTE MEMBRANE;

ADULT; BLOOD PLATELETS; CELL MEMBRANE; DIABETES MELLITUS, TYPE 1; DIABETES MELLITUS, TYPE 2; FEMALE; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; MALE; MIDDLE AGED; NA(+)-K(+)-EXCHANGING ATPASE; NITRIC OXIDE SYNTHASE; REFERENCE VALUES; REGRESSION ANALYSIS;

EID: 0031882609     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001250050873     Document Type: Article

References (19)

1. Radomsky MW, Palmer RMJ, Moncada S (1990) An L-arginine/nitric oxide pathway present in human platelets regulates aggregation. Proc Natl Acad Sci USA 87: 5193-5197
2. Mellio BT, Ignarro LJ, Ohlstein EH, Pontecorvo EG, Hyman AL, Kadowitz PJ (1981) Evidence for the inhibitory role of guanosine-3',5'-cyclic monophosphate in ADP-induced human platelet aggregation in the presence of nitric oxide and related vasodilators. Blood 57: 946-955
3. Trovati M, Massucco P, Mattiello L, Piretto V, Cavalot F, Mularoni E, Anfossi G (1996) The insulin-induced increase of guanosine-3',5'-cyclic monophosphate in human platelets is mediated by nitric oxide. Diabetes 45: 768-770
4. Muragandam A, Mutus B (1994) Isolation of nitric oxide synthase from human platelets. Biochim Biophys Acta 1200: 1-6
5. Amado JA, Salas E, Botana MA, Poveda JJ, Berrazueta JR (1993) Low levels of intraplatelet cGMP in IDDM. Diabetes Care 16: 809-811
6. + - ATPase activity in rabbit aorta by hyperglycemia. Possible role of endothelium-derived nitric oxide. J Clin Invest 90: 727-732
7. Akai T (1982) On the measurement of glycosylated hemoglobin In: Baba S, Okuda K (eds) Vensonic Seminar, Proceedings 1. Kyoto Daiichi Kagaku Co, Kobe, Tokyo pp 1117-1125
8. Rabini RA, Ferretti G, Galassi R et al. (1994) Modified fluidity and lipid composition in lipoproteins and platelet membranes from diabetic patients. Clin Biochem 27: 381-385
9. Kitao T, Hattori K (1983) Inhibition of erythrocyte ATPase activity by aclacinomycin and reverse effect of ascorbate on ATPase activity. Experientia 39: 1362-1364
10. Mazzanti L, Staffolani R, Rabini RA et al. (1992) Modifications in platelet membrane transport functions in insulin-dependent diabetes mellitus and in gestational diabetes. Biochim Biophys Acta 1139: 65-69
11. Fiske C, Subbarow Y (1925) The colorimetric determination of phosphorus. J Biol Chem 66: 375-400
12. Lowry OH, Rosenbrough NJ, Farr AL, Randall RT (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 192: 265-275
13. Moncada S, Palmer RMJ, Higgs EA (1991) Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol Rev 43: 109-141
14. Durante W, Sen AK, Sunahara FA (1988) Impairment of endothelium dependent relaxation in aortae from spontaneously diabetic rats. Br J Pharmacol 94: 463-468
15. Saenz de Tejada I, Goldstein I, Azadzoi K, Krane R, Cohen R (1989) Impaired neurogenic and endothelium-dependent relaxation of human penile smooth muscle: the pathophysiological basis for impotence in diabetes. N Engl J Med 320: 1025-1030
16. Colwell JA, Lopez-Virella MF (1988) A review of the development of large vessel disease in diabetes mellitus. Am J Med 85 [Suppl 5A]:113-118
17. Baynes JW (1991) Perspectives in diabetes: role of oxidative stress in development of complications in diabetes. Diabetes 40: 405-412
18. Francescutti D, Baldwin J, Lee L, Mutus B (1996) Peroxynitrite modifications of glutathione reductase: modeling studies and kinetic evidence suggest the modification of tyrosines at the glutathione disulfide binding site. Protein Engineering 9: 189-194
19. Mazzanti L, Rabini RA, Faloia E, Fumelli P, Bertoli E, De Pirro R (1990) Altered cellular calcium and sodium transport in diabetes mellitus. Diabetes 39: 850-854