Secretory immunoglobulin A: From mucosal protection to vaccine development

Biological Chemistry

Volumn 380, Issue 11, 1999, Pages 1251-1262

  Corthésy, Blaise ^a   Spertini, François ^a  

^a LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

Author keywords

Mucosal immunity; Recombinant immunoglobulins; Secretory IgA; Vaccine

Indexed keywords

IMMUNOGLOBULIN A; SECRETORY IMMUNOGLOBULIN; VACCINE;

BACTERIAL INFECTION; EPITHELIUM; IMMUNIZATION; IMMUNOGLOBULIN STRUCTURE; MUCOSAL IMMUNITY; OPSONIZATION; PRIORITY JOURNAL; REVIEW; VIRUS INFECTION;

BACTERIA (MICROORGANISMS);

EID: 0344182437     PISSN: 14316730     EISSN: None     Source Type: Journal    
DOI: 10.1515/BC.1999.160     Document Type: Review

References (128)

1. Abu-Ghazaleh, R.I., Fujisawa, T., Mestecky, J., Kyle, R.A., and Gleich, G.J. (1989). IgA-induced eosinophil degranulation. J. Immunol. 142, 2393-2400.
2. Apter, F.M., Michetti, P., Winner, L.S., Mack, J.A., Mekalanos, J.J., and Neutra, M.R. (1993). Analysis of the roles of anti-lipopolysaccharide and anti-cholera toxin immunoglobulin A (IgA) antibodies in protection against Vibrio cholerae and cholera toxin by use of monoclonal IgA antibodies in vivo. Infect. Immun. 61, 5279-5285.
3. Araneo, B.A., Woods II, M.L., and Daynes, R.A. (1993). Reversal of the immunosenescent phenotype by dehydroepiandrosterone: hormone treatment provides an adjuvant effect on the immunization of aged mice with recombinant hepatitis B surface antigen. J. Infect. Dis. 167, 830-840.
4. Atkin, J.D., Pleass, R.J., Owens, R.J., and Woof, J.M. (1996). Mutagenesis of the human IgA1 heavy chain tailpiece that prevents dimer assembly. J. Immunol. 157, 156-159.
5. Bakos, M.A., Kurosky, A., and Goldblum, R.M. (1991). Characterization of a critical binding site for human polymeric Ig on secretory component. J. Immunol. 147, 3419-3426.
6. Beagley, K.W., and Elson, C.O. (1992). Cells and cytokines inmucosal immunity and inflammation. Gastroenterol. Clin. N. Am. 21, 347-366.
7. Berdoz, J., Monath, T.P., and Kraehenbuhl, J.P. (1995). Specific amplification of rearranged genomic variable regions of immunoglobulin genes from mouse hybridoma cells by the polymerase chain reaction. PCR Meth. Appl. 4, 256-264.
8. Berdoz, J., Tallichet Blanc, C., Reinhardt, M., Kraehenbuhl, J.P., and Corthésy, B. (1999). In vitro comparison of the antigen-binding and stability properties of the various molecular forms of IgA antibodies assembled and produced in CHO cells. Proc. Natl. Acad. Sci. USA 96, 3029-3034.
9. Biesbrock, A.R., Reddy, M.S., and Levine, M.J. (1991). Interaction of a salivary mucin-secretory immunoglobulin A complex with mucosal pathogens. Infect. Immun. 59, 3492-3497.
10. Blanchard, T.G., Czinn, S.J., Maurer, R., Thomas, W.D., Soman, G., and Nedrud, J.G. (1995). Urease-specific monoclonal antibodies prevent Helicobacter felis infection in mice. Infect. Immun. 63, 1394-1399.
11. Bogstedt, A.K., Nava, S., Wadström, T., and Hammarström, L. (1996). Helicobacter pylori infections in IgA deficiency: lack of role for the secretory immune system. Clin. Exp. Immunol. 105, 202-204.
12. Brandtzaeg, P. (1995). Molecular and cellular aspects of the secretory immunoglobulin system. APMIS. 103, 1-19.
13. Brandtzaeg, P., Halstensen, T.S., Huitfeldt, H.S., Krajci, P., Kvale, D., Scott, H., and Thrane, P.S. (1992). Epithelial expression of HLA, secretory component (poly-Ig receptor), and adhesion molecules in the human alimentary tract. Ann. NY Acad. Sci. 664, 157-179.
14. Burns, J.W., Siadatpajouh, M., Krishnaney, A.A., and Greenberg, H.B. (1996). Protective effect of rotavirus VP6-specific IgA monoclonal antibodies that lack neutralizing activity. Science 272, 104-107.
15. Carayannopoulos, L., Max, E.E., and Capra, J.D. (1994). Recombinant human IgA expressed in insect cells. Proc. Natl. Acad. Sci. USA 91, 8348-8352.
16. Chintalacharuvu, K.R., and Morrison, S.L. (1997). Production of secretory immunoglobulin A by a single mammalian cell. Proc. Natl. Acad. Sci. USA 94, 6364-6368.
17. Chintalacharuvu, S.R., and Emancipator, S.N. (1997). The glycosylation of IgA produced by murine B cells is altered by Th2 cytokines. J. Immunol. 159, 2327-2333.
18. Chuang, P.D., and Morrison, S.L. (1997). Elimination of N-linked glycosylation sites from the human IgA1 constant region: effects on structure and function. J. Immunol. 158, 724-732.
19. Corthésy, B., and Kraehenbuhl, J.P. (1999). Antibody-mediated protection of mucosal surfaces. Curr. Top. Microbiol. Immunol. 236, 93-111.
20. Corthésy, B., Kaufmann, M., Phalipon, A., Peitsch, M., Neutra, M.R., and Kraehenbuhl, J.P. (1996). A pathogen-specific epitope inserted into recombinant secretory immunoglobulin A is immunogenic by the oral route. J. Biol. Chem. 271, 33670-33677.
21. Corthésy-Theulaz, I., Hopkins, S., Bachmann, D., Saldinger, P.F., Porta, N., Haas, R., Zheng-Xin, Y., Meyer, T., Bouzourène, H., Blum, A.L., and Kraehenbuhl, J.P. (1998). Mice are protected from Helicobacter pylori infection by nasal immunization with attenuated Salmonella typhimurium phoPc expressing urease A and B subunits. Infect. Immun. 66, 581-586.
22. Cottet, S., and Corthésy, B. (1997). Cellular processing limits the heterologous expression of secretory component in mammalian cells. Eur. J. Biochem. 246, 23-31.
23. 2: A possible implication for mucosal defense. J. Immunol. 161, 5445-5453.
24. Crottet, P., and Corthésy, B. (1999). Mapping the interaction between murine IgA and murine secretory component carrying epitope substitutions reveals a role of domains II and III in covalent binding to IgA. J. Biol. Chem., in press.
25. Crottet, P., Cottet, S., and Corthésy, B. (1999). Expression, purification and biochemical characterization of recombinant murine secretory component: a novel tool in mucosal immunology. Biochem. J. 341, 299-306.
26. Coyne, R.S., Siebrecht, M., Peitsch, M.C., and Casanova, J.E. (1994). Mutational analysis of polymeric immunoglobulin receptor/ligand interactions. Evidence for the involvement of multiple complementary determining region (CDR)-like loops in receptor domain I. J. Biol. Chem. 269, 31620-31625.
27. Davis, N.L., Brown, K.W., and Johnston, R.E. (1996). A viral vaccine vector that expresses foreign genes in lymph nodes and protects against mucosal challenge. J. Virol. 70, 3781-3787.
28. Daynes, R.A., Enioutina, E.Y., Butler, S., Mu, H.H., McGee, Z.A., and Araneo, B.A. (1996). Induction of common mucosal immunity by hormonally immunomodulated peripheral immunization. Infect. Immun. 64, 1100-1109.
29. Di Tommaso, A., Saletti, G., Pizza, M., Rappuoli, R., Dougan, G., Abrignani S., Douce, G., De Magistris, M.T. (1996). Induction of antigen-specific antibodies in vaginal secretions by using a nontoxic mutant of heat-labile enterotoxin as a mucosal adjuvant. Infect. Immun. 64, 974-979.
30. Duque, N., Gomez-Guerrero, C., and Egido, J. (1997). Interaction of IgA with Fc alpha receptors of human mesangial cells activates transcription factor nuclear factor-kappa B and induces expression and synthesis of monocyte chemoattractant protein-1, IL-8, and IFN-inducible protein 10. J. Immunol. 159, 3474-3482.
31. Endo, T., Mestecky, J., Kulhavy, R., and Kobata, A. (1994).Carbohydrate heterogeneity of human myeloma proteins of the IgA1 and IgA2 subclasses. Mol. Immunol. 31, 1415-1422.
32. Estrada, A., McDermott, M.R., Underdown, B.J., and Snider, D.P. (1995). Intestinal immunization of mice with antigen conjugated to anti-MHC class II antibodies. Vaccine 13, 901-907.
33. Fallgreen-Gebauer, E., Gebauer, W., Bastian, A., Kratzin, H.D., Eiffert, H., Zimmermann, B., Karas, M., and Hilschmann, N. (1993). The covalent linkage of secretory component to IgA: structure of sIgA. Biol. Chem. Hoppe-Seyler 374, 1023-1028.
34. Flanagan, J.G., Lefranc, M.P. and Rabbitts, T.H. (1984). Mechanisms of divergence and convergence of the human immunoglobulin alpha 1 and alpha 2 constant region gene sequences. Cell 36, 681-688.
35. Frey, A. Lencer, W.I., Weltzin, R., Giannasca, K.T., Giannasca, P.J., and Neutra, M.R. (1996). Role of the glycolalyx in regulating access of microparticles to apical plasma membranes of intestinal epithelial cells: implications for microbial attachment and oral vaccine targeting. J. Exp. Med. 184, 1045-1060.
36. Frütiger, S., Hughes, G.J., Fonck, C., and Jaton, J.C. (1987). High and low molecular weight rabbit secretory components. J. Biol. Chem. 262, 1712-1715.
37. Frütiger, S., Hughes, G.J., Paquet, N., Lüthi, R., and Jaton, J.C. (1992). Disulfide bond assignment in human J chain and its covalent pairing with immunoglobulin M. Biochemistry 31, 12643-12647.
38. Fujioka, H., Emancipator, S.N., Aikawa, M., Huang, D.S., Blatnik, F., Karban, T., DeFife, K., and Mazanec, M.B. (1998). Immunocytochemical colocalization of specific immunoglobulin A with sendaï virus protein in infected polarized epithelium. J. Exp. Med. 188, 1223-1229.
39. Gomez-Guerrero, C., Gonzalez, E., and Egido, J. (1993). Evidence for a specific IgA receptor in rat and human mesangial cells. J. Immunol. 151, 7172-7181.
40. Goodrich, M.E., and McGee, D.W. (1998). Regulation of mucosal B cell immunoglobulin secretion by intestinal epithelial-derived cytokines. Cytokine 10, 948-955.
41. + B cells. Immunol. Lett. 15, 11-14.
42. Grey, H.M., Abel, C.A., Yount, W.J., and Kunkel, H.G. (1968). A subclass of γA-globulins (γA2) which lacks the disulfide bonds linking heavy chain and light chains. J. Exp. Med. 128, 1223-1236.
43. Guzman, C.A., Molinari, G., Fountain, M.W., Rohde, M., Timmis, K.N., and Walker, M.J. (1993). Antibody responses in the serum and respiratory tract of mice following oral vaccination with liposomes coated with filamentous hemagglutinin and pertussis toxoid. Infect. Immun. 61, 573-579.
44. Hendrickson, B.A., Conner, D.A., Ladd, D.J., Kendall, D., Casanova, J.E., Corthésy, B., Max, E.E., Neutra, M.R., Seidman, C.E., and Seidman, J.G. (1995). Altered hepatic transport of immunoglobulin A in mice lacking the J chain. J. Exp. Med. 182, 1905-1911.
45. Hendrickson, B.A., Rindisbacher, L., Corthésy, B., Kendall, D., Waltz, D.A., Neutra, M.R., and Seidman, J.G. (1996). Lack of association of secretory component with IgA in J chain-deficient mice. J. Immunol. 157, 750-754.
46. Hopkins, S., Kraehenbuhl, J.P., Schodel, F., Potts, A., Peterson, D., de Grandi, P., and Nardelli-Haefliger, D. (1995). A recombinant Salmonella typhimurium vaccine induces local immunity by four different routes of immunization. Infect. Immun. 63, 3279-3286.
47. Hughes, G.J., Frütiger, S., Savoy, L.A., Reason, A.J., Morris, H.R., and Jaton, J.C. (1997). Human free secretory component is composed of the first 585 amino acid residues of the polymeric immunoglobulin receptor. FEBS Lett. 410, 443-446.
48. Hunkapiller, T., and Hood, L. (1989). Diversity of the immunoglobulin gene superfamily. Adv. Immunol. 44, 1-63.
49. Hurle, M.R., and Gross, M. (1994). Protein engineering techniques for antibody humanization. Curr. Opin. Biotechnol. 5, 428-433.
50. Iikura, M., Yamagushi, M., Jujisawa, T., Miyamasu, M., Takaishi, T., Morita, Y., Iwase, T., Moro, I., Yamamoto, K., and Hirai, K. (1998). Secretory IgA induces degranulation of II-3-primed basophils. J. Immunol. 161, 1510-1515.
51. Jarvis, G.A., and Griffiss, J.M. (1991). IgA1 blockade of IgG-initiated lysis of Neisseria meningitidis is a function of antigen-binding fragment binding to the polysaccharide capsule. J. Immunol. 147, 1962-1967.
52. Jones, D.H., McBride, B.W., Thornton, C., O'Hagan, D.T., Robinson, A., and Farrar, G.H. (1996). Orally administered microencapsulated Bordetella pertussis fimbriae protect mice from B. pertussis respiratory infection. Infect. Immun. 64, 489-494.
53. Kaetzel, C.S., Robinson, J.K., Chintalacharuvu, K.R., Vaerman, J.P., and Lamm, M.E. (1991). The polymeric immunoglobulin receptor (secretory component) mediates transport of immune complexes across epithelial cells: a local defense function for IgA. Proc. Natl. Acad. Sci. USA 88, 8796-8880.
54. Kato, T. (1990). A study of secretory immunoglobulin A on membranous epithelial cells (M cells) and adjacent absortive cells of rabbit Peyer's patches. Gastroenterol. J. 25, 15-23.
55. Kerr, M.A. (1990). The structure and function of human IgA. Biochem. J. 271, 285-296.
56. Killian, M., and Russell, M.W. (1994). Function of mucosal immunoglobulins. In: Handbook of Mucosal Immunology, P.L. Ogra, J. Mestecky, M.E. Lamm, W. Strober, J.R. McGhee, J. Bienenstock, eds. (Orlando, Florida, USA: Academic Press), pp. 127-137.
57. Kim, P.H., and Kagnoff, M.F. (1990). Transforming growth factor β1 is a costimulator of IgA production. J. Immunol. 144, 3411-3416.
58. Kita, H., Kato, M., Gleich, G.J., and Abraham, R.T. (1994). Tyrosine phosphorylation and inositol phosphate production: are early events in eosinophil activation stimulated by immobilized secretory IgA and IgG? J. Allergy Clin. Immunol. 94, 1272-1281.
59. Kragten, E.A., Bergwerff, A.A., vanOostrum, J., Müller, D.R., and Richter, W.J. (1995). Site-specific analysis of the N-glycans on murine polymeric immunoglobulin A using liquid chromatography/electrospray mass spectrometry. J. Mass Spectrom. 30, 1679-1686.
60. Krugmann, S., Pleass, R.J., Atkin, J.D., and Woof, J.M. (1997). Structural requirements for assembly of dimeric IgA1 probed by site-directed mutagenesis of J chain and a cysteine residue of the α-chain CH2 domain. J. Immunol. 159, 244-249.
61. Kvale, D., and Brandtzaeg, P. (1995). Constitutive and cytokine-induced expression of HLA molecules, secretory component, and intercellular adhesion molecule-1 is modulated by butyrate in the colonic epithelial cell line HT-29. Gut 36, 737-742.
62. Lamkhioued, B., Gounni, A.S., Gruart, V., Pierce, A., Capron, A., and Capron, M. (1995). Human eosinophils express a receptor for secretory component. Role in secretory IgA-dependent activation. Eur. J. Immunol. 25, 117-125.
63. Lamm, M.E. (1997). Interaction of antigens and antibodies at mucosal surfaces. Annu. Rev. Microbiol. 51, 311-340.
64. Launay, P., Patry, C., Lehuen, A., Pasquier, B., Blank, U., and Monteiro, R.C. (1999). Alternative endocytic pathway for immunglobulin A Fc receptors (CD89) depends on the lack of FcRgamma association and protects against degradation of bound ligand. J. Biol. Chem. 274, 7216-7225.
65. Leclerc, C., and Ronco, J. (1998). New approaches in vaccine development. Immunol. Today. 19, 300-302.
66. Lindh, E., and Björk, I. (1976). Binding of secretory component to dimers of immunoglobulin A in vitro. Mechanism of the covalent bond formation. Eur. J. Biochem. 62, 263-270.
67. Loman, S., Radl, J., Jansen, H.M., Out, T.A., and Lutter, R. (1997). Vectorial transcytosis of dimeric IgA by the Calu-3 human lung epithelial cell line: upregulation by IFN-γ. Am. J. Physiol. 272, L951-L958.
68. Lüllau, E., Heyse, S., Vogel, H., Marison, I.W., von Stockar, U., Kraehenbuhl, J.P., and Corthésy, B. (1996) Antigen binding properties of purified immunoglobulin A and reconstituted secretory immunoglobulin A antibodies. J. Biol. Chem. 271, 16300-16309.
69. Ma, J.K.-C., Hiatt, A., Hein, M., Vine, N.D., Wang, F., Stabila, P., van Dolleweerd, C., Mostov, K.E., and Lehner, T. (1995). Generation and assembly of secretory antibodies in plants. Science 268, 716-719.
70. Mach, J.-P. (1970). In vitro combination of human and bovine free secretory component with IgA of various species. Nature 228, 1278-1282.
71. Maliszewski, C.R., March, C.J., Schoenborn, M.A., Gimpel, S., and Shen, L. (1990). Expression cloning of a human Fc receptor for IgA. J. Exp. Med. 172, 1665-1672.
72. Matsumoto, R., Matsumoto, R., Mita, S., Hitoshi, Y., Adno, M., Araki, S., Yamagushi, N., Tominaga, A., and Takatsu, K. (1989). Interleukin-5 induces maturation but not class-switching of surface IgA-positive B cells into IgA-secreting cell. Immunology 66, 32-41.
73. Mattu, T.S., Pleass, R.J., Willis, A.C., Kilian, M., Wormald, M.R., Lellouch, A.C., Rudd, P.M., Woof, J.M., and Dwek, R.A. (1998). The glycosylation and structure of human serum IgA1, Fab, and Fc regions and the role of N-glycosylation on Fcα receptor interactions. J. Biol. Chem. 273, 2260-2272.
74. Mazanec, M.B., Nedrud, J.G., Kaetzel, C.S., and Lamm M.E. (1993). A three-tiered view of the role of IgA in mucosal defense. Immunol. Today. 14, 430-435.
75. McGhee, J.R., Mestecky, J., Dertzbaugh, M.T., Eldridge, J.H., Hirasawa, M., and Kiyono, H. (1992). The mucosal immune system: from fundamental concepts to vaccine development. Vaccine 10, 75-88.
76. McKinney, K.L., Dilwith, R., and Belfort, G. (1995). Optimizing antibody production in batch hybridoma cell culture. J. Biotechnol. 40, 31-48.
77. Mestecky, J., and McGhee, J.R. (1987). Immunoglobulin A (IgA): molecular and cellular reactions involved in IgA biosynthesis and immune responses. Adv. Immunol. 40, 153-245.
78. Michetti, P., Mahan, M.J., Slauch, J.M., Mekalanos, J.J., and Neutra, M.R. (1992). Monoclonal secretory immunoglobulin A protects mice against oral challenge with the invasive pathogen Salmonella typhimurium. Infect. Immun. 60, 1786-1792.
79. Mizogushi, A., Mizuochi, T., and Kobata, A. (1982). Structures of the carbohydrate moieties of secretory component purified from human milk. J. Biol. Chem. 157, 9612-9621.
80. Monica, T.J., Goochee, C.F., and Maiorella, B.L. (1993). Comparative biochemical characterization of a human IgM produced in both ascites and in vitro cell culture. Bio/Technology 11, 512-515.
81. Monteiro, R.C., Kubagawa, H. and Cooper, M.D. (1990). Cellular distribution, regulation, and biochemical nature of an Fc alpha receptor in humans. J. Exp. Med. 171, 597-613.
82. Monteiro, R.C., Cooper, M.D., and Kubagawa, H. (1993). Molecular heterogeneity of Fc alpha receptors detected by receptorspecific monoclonal antibodies. J. Immunol. 148, 1764-1770.
83. Monteiro, R.C., Hostoffer, R.W., Cooper, M.D., Bonner, J.R., Gartland, G.L., and Kubagawa, H. (1993). Definition of immunoglobulin A receptors on eosinophils and their enhanced expression in allergic individuals. J. Clin Invest. 92, 1681-1685.
84. Morton, H.C., Atkin, J.D., Owens, R.J., and Woof, J.M. (1993). Purification and characterization of chimeric human IgA1 and IgA2 expressed in COS and chinese hamster ovary cells. J. Immunol. 151, 4743-4752.
85. Morton, H.C., van Egmond M., and van de Winkel, J.G.J. (1996). Structure and function of human IgA Fc receptors (FcαR). Crit. Rev. Immunol. 16, 423-440.
86. Mostov, K.E. (1994). Transepithelial transport of immunoglobulins. Annu. Rev. Immunol. 12, 63-84.
87. Musil, L.S., and Baenziger, J.U. (1987). Cleavage of membrane secretory component to soluble secretory component occurs on the cell surface of rat hepatocyte monolayers. J. Cell. Biol. 104, 1725-1733.
88. Nardelli-Haefliger, D., Kraehenbuhl, J.P., Curtiss, R., Schodel, F., Potts, A., Kelly, S., and de Grandi, P. (1996). Oral and rectal immunization of adult female volunteers with a recombinant attenuated Salmonella typhi vaccine strain. Infect. Immun. 64, 5219-5224.
89. Neutra, M.R., and Kraehenbuhl, J.P. (1992). Molecular and cellular basis of immune protection of mucosal surfaces. Physiol. Rev. 72, 853-879.
90. Neutra, M.R., Pringault, E., and Kraehenbuhl, J.P. (1996). Antigen sampling across epithelial barriers and induction of mucosal immune responses. Annu. Rev. Immunol. 14, 275-300.
91. Nikolova, E.B., Tomana, M., and Russell, M.W. (1994). All forms of human IgA antibodies bound to antigen interfere with complement (C3) fixation induced by IgG or by antigen alone. Scand. J. Immunol. 39, 275-280.
92. + Th2 cells producing IL-6 and IL-10 are associated with mucosal IgA responses. Infect. Immun. 64, 1516-1525.
93. Patry, C., Herbelin, A., Lehuen, A., Bach, J.F., and Monteiro, R.C. (1995). Fc alpha receptors mediate release of tumor necrosis factor-alpha and interleukin-6 by human monocytes following receptor aggregation. Immunology 86, 1-5.
94. Pfefferkorn, L.C., and Yeaman, G.R. (1994). Association of IgA-Fc receptors (FcαR) with FcεRIγ2 subunits in U937 cells. Aggregation induces the tyrosine phosphorylation of gamma2. J. Immunol. 153, 3228-3236.
95. Phalipon, A., Kaufmann, M., Michetti, P., Cavaillon, J.M., Huerre, M., Sansonetti, P.J., and Kraehenbuhl, J.-P. (1995). Monoclonal immunoglobulin A antibody directed against serotype-specific epitope of Shigella flexneri lipopolysaccharide protects against murine experimental shigellosis. J. Exp. Med. 182, 769-778.
96. Pumphrey, R.S.H. (1986). Computer models of the human immunoglobulins. Binding sites and molecular interactions. Immunol. Today 7, 206-211.
97. Ramsay, A.J., Husband, A.J., Ramshaw, I.A., Bao, S., Matthaei, K.I., Koehler, G., and Kopf, M. (1994). The role of interleukin-6 in mucosal IgA antibody responses in vivo. Science 264, 561-563.
98. Renegar K.B., and Small, P.A. (1991). Passive transfer of local immunity to influenza virus infection by IgA antibody. J. Immunol. 146, 1972-1978.
99. Reterink, T.J.F., van Zandbergen, G., van Egmond, M., Morton, C.H., van de Winkel, J.G.J., and Daha, M.R. (1997). Size-dependent effect of IgA on the IgA Fc receptor (CD89). Eur. J. Immunol. 27, 2219-2224.
100. Rindisbacher, L., Cottet, S., Wittek, R., Kraehenbuhl, J.P., and Corthésy, B. (1995). Production of human secretory component with dimeric IgA binding capacity using viral expression vectors. J. Biol. Chem. 270, 14220-14228.
101. Roque-Barreira, M.C., and Campos-Nieto, A. (1985). Jacalin: an IgA-binding lectin. J. Immunol. 134, 1740-1743.
102. Rott, L.S., Briskin, M.J., Andrew, D.P., Berg, E.L., and Butcher, E.C. (1996). A fundamental subdivision of circulating lymphocytes defined by adhesion to mucosal addressin cell adhesion molecule-1. J. Immunol. 156, 3727-3736.
103. Roy, M.J., and Varvayanis, M. (1987). Development of dome epithelium in gut-associated lymphoid tissues: association of IgA with M cells. Cell Tissue Res. 248, 645-651.
104. Russell, M.W., Reinholdt, J., and Kilian, M. (1989). Anti-inflammatory activity of human IgA antibodies and their Fabα fragments: inhibition of IgG-mediated complement activation. Eur. J. Immunol. 19, 2243-2249.
105. Schneider, M., Marison, I.W., and von Stockar, U. (1996). The importance of ammonia in mammalian cell culture. J. Biotechnol. 46, 161-185.
106. Schweikart, F., Jones, R., Jaton, J.C., and Hughes, G.J. (1999). Rapid structural characterization of a murine IgA alpha chain: heterogeneity of the oligosaccharide structures at a specific site in samples produced in different bioreactor systems. J. Biotechnol. 62, 191-201.
107. Shen, L., (1992). Receptors for IgA on phagocytic cells. Immunol. Res. 11, 273-282.
108. Siebers, A., and Finlay, B.B. (1996). M cells and the pathogenesis of mucosal and systemic infections. Trends Microbiol. 4, 22-29.
109. 414 and the secretory tailpiece. J. Immunol. 162, 3448-3455.
110. Spada, S., Krebber, C., and Plückthun, A. (1997). Selectively infective phages (SIP). Biol. Chem. 378, 445-456.
111. Spieker-Polet, H., Yam, P.C., and Knight, K.L. (1993). Differential expression of 13 IgA-heavy chain genes in rabbit lymphoid tissues. J. Immunol. 150, 5457-5465.
112. Staats, H.F., Jackson, R.J., Marinaro, M., Takahashi, I., Kiyono, H., and McGhee, J.R. (1994). Mucosal immunity to infection with implication for vaccine development. Curr.Opin. Immunol. 6, 572-583.
113. Stoll, T.S., Muhletahler, K., von Stockar, U., and Marison, I.W. (1996). Systematic improvement of a chemically-defined protein-free medium for hybridoma growth and monoclonal antibody production. J. Biotechnol. 45, 111-123.
114. Taylor, A.K., and Wall, R. (1988). Selective removal of alpha heavy-chain glycosylation sites causes immunglobulin A degradation and reduced secretion. Mol. Cell. Biol. 8, 4197-4203.
115. Taylor, H.P., and Dimmock, N.J. (1985). Mechanisms of neutralization of influenza virus by secretory IgA is different from that of monomeric IgAor IgG. J. Exp. Med. 161, 198-209.
116. Terskikh, A., Couty, S., Pélegrin, A., Hardman, N., Hunziker, W., and Mach, J.P. (1994). Dimeric recombinant IgA directed against carcino-embryonic antigen, a novel tool for carcinoma localization. Mol. Immunol. 31, 1313-1319.
117. Trill, J.J., Shatzman, A.R., and Ganguly, S. (1995). Production of monoclonal antibodies in COS and CHO cells. Curr. Opin. Biotechnol. 6, 553-560.
118. Ueda, S., Matsuda, F., and Honjo, T. (1988). Multiple recombinational events in primate immunoglobulin epsilon and alpha genes suggest closer relationship of humans and chimpanzees than gorillas. J. Mol. Evol. 27, 77-83.
119. Vajdy, M., Kosco-Vilbois, M.H., Kopf, M., Köhler, G., and Licke, N. (1995). Impaired mucosal immune response in interleukin 4-targeted mice. J. Exp. Med. 181, 41-53.
120. van Dijk, T.B., Bracke, M., Caldenhoven, E., Raaijmakers, J.A., Lammers, J.W., Koenderman, L., and de Groot, R.P. (1996). Cloning and characterization of Fc alpha Rb, a novel Fc alpha receptor (CD89) isoform expressed in eosinophils and neutrophils. Blood 88, 4229-4238.
121. Weltzin, R., Lucia-Jandris, P., Michetti, P., Fields, B.N., Kraehenbuhl, J.P., and Neutra, M.R. (1989). Binding and transepithelial transport of immunoglobulins by intestinal M cells: demonstration using monoclonal IgA antibodies against enteric viral proteins. J. Cell. Biol. 108, 1673-1685.
122. Weltzin, R. Traina-Dorge, V., Soike, K., Zhang, J.Y., Mack, P., Soman, G., Drabik, G., and Monath, T.P. (1996). Intranasal monoclonal IgA antibody to respiratory syncytial virus protects rhesus monkeys against upper and lower respiratory infection. J. Infect. Dis. 174, 256-261.
123. Winner, L., Mack, J., Weltzin, R., Mekalanos, J.J., Kraehenbuhl, J.P., and Neutra, M.R. (1991). New model for analysis of mucosal immunity: Intestinal secretion of specific monoclonal immunoglobulin A from hybridoma tumors protects against Vibrio cholerae infection. Infect. Immun. 59, 977-982.
124. Williams, M.B., and Butcher, E.C. (1997). Homing of naive and memory T lymphocytes subsets to Peyer's patches, lymph nodes, and spleen. J. Immunol. 159, 1746-1752.
125. Williams, N.A., Hirst, T.R., and Nashar, T.O. (1999). Immune modulation by the cholera-like enterotoxins: from adjuvant to therapeutic. Immunol. Today 20, 95-101.
126. Wolf, H.M., Hauber, I., Guile, H., Samstag, A., Fischer, M.B., Ahmad, R.U., and Eibl, M.M. (1996). Anti-inflammatory properties of human serum IgA: induction of IL-1 receptor antagonist and Fc alpha R (CD89)-mediated down-regulation of tumor necrosis factor-alpha (TNF-alpha) and IL-6 in human monocytes. Clin. Exp. Immunol. 105, 537-543.
127. Youngman, K.R., Fiocchi, C., and Kaetzel, C.S. (1994). Inhibition of IFN-γ activity in supernatants from stimulated human intestinal mononuclear cells prevents upregulation of the polymeric Ig receptor in an intestinal epithelial cell line. J. Immunol. 153, 675-681.
128. Zhou, F., Kraehenbuhl, J.P., and Neutra, M.R. (1995). Mucosal IgA response to rectally administered antigen formulated in IgA-coated liposomes. Vaccine 23, 637-644.