Elimination of N-Linked Glycosylation Sites from the Human IgA1 Constant Region: Effects on Structure and Function

Journal of Immunology

Volumn 158, Issue 2, 1997, Pages 724-732

  Chuang, Philip D ^a   Morrison, Sherie L ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FC RECEPTOR; IMMUNOGLOBULIN A;

ARTICLE; BIOSYNTHESIS; COMPLEMENT ACTIVATION; DRUG EFFECT; GENE DELETION; GENETICS; GLYCOSYLATION; HUMAN; IMMUNOGLOBULIN CONSTANT REGION; IMMUNOLOGY; METABOLISM; PROTEIN BINDING; SITE DIRECTED MUTAGENESIS;

COMPLEMENT ACTIVATION; GLYCOSYLATION; HUMANS; IMMUNOGLOBULIN A; IMMUNOGLOBULIN CONSTANT REGIONS; MUTAGENESIS, SITE-DIRECTED; PROTEIN BINDING; RECEPTORS, FC; SEQUENCE DELETION;

EID: 0031567982     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. Kerr, M. A. 1990. The structure and function of human IgA. Biochem. J. 271:285.
2. Mazanec, M. B., J. G. Nedrud, C. S. Kaetzel, and M. E. Lamm. 1993. A three-tiered view of the role of IgA in mucosal defense, Immunol. Today 14:430.
3. Fanger, M. W., L. Shen, J. Pugh, and G. M. Bernier. 1980. Subpopulations of human peripheral granulocytes and monocytes express receptors for IgA. Proc. Natl. Acad. Sci. USA 77:3640.
4. 2 gene. J. Immunol. 152:5299.
5. Mulks, M. H., and A. G. Plaut. 1978. IgA protease production as a characteristic distinguishing pathogenic from harmless neisseriaceae. N. Engl. J. Med. 299:973.
6. Torano, A., Y. Tsuzukida, Y. S. Liu, and F. W. Putnam. 1977. Location and structural significance of the oligosaccharides in human Ig-A1 and IgA2 immunoglobulins. Proc. Natl. Acad. Sci. USA 74:2301.
7. Jefferis, R. 1993. The glycosylation of antibody molecules: functional significance. Glycoconj. J. 10:358.
8. Tao, M. H., and S. L. Morrison. 1989. Studies of aglycosylated chimeric mouse-human IgG: role of carbohydrate in the structure and effector functions mediated by the human IgG constant region. J. Immunol. 143:2595.
9. Bazin, R., A. Darveau, F. Martel, A. Pelletier, L. Piche, M. St-Laurent, L. Thibault, A. Demers, L. Boyer, G. Lemieux, and R. Lemieux. 1992. Increased avidity of mutant IgM antibodies caused by the absence of COOH-terminal glycosylation of the μ H chain. J. Immunol. 149:3889.
10. Shin, S. U., and S. L. Morrison. 1989. Production and properties of chimeric antibody molecules. Methods Enzymol. 178:459.
11. Wright, A., M. H. Tao, E. A. Kabat, and S. L. Morrison. 1991. Antibody variable region glycosylation: position effects on antigen binding and carbohydrate structure. EMBO J. 10:2717.
12. Tamer, C. M., M. E. Lamm, J. K. Robinson, J. F. Piskurich, and C. S. Kaetzel. 1995. Comparative studies of transcytosis and assembly of secretory IgA in Madin-Darby canine kidney cells expressing human polymeric Ig receptor. J. Immunol. 155:707.
13. Brown, W. R., and T. M. Kloppel. 1989. The role of the liver in translocation of IgA into the gastrointestinal tract. Immunol. Invest. 18:269.
14. Dooley, J. S., B. J. Potter, H. C. Thomas, and S. Sherlock. 1982. A comparative study of the biliary secretion of human dimeric and monomeric IgA in the rat and in man. Hepatology 2:323.
15. Schneiderman, R. D., T. F. Lint, and K. L. Knight. 1990. Activation of the alternative pathway of complement by twelve different rabbit-mouse chimeric transfectoma IgA isotypes. J. Immunol. 145:233.
16. Hobbs, S. M., L. E. Jackson, and J. Hoadley. 1992. Interaction of aglycosyl immunoglobulins with the IgG Fc transport receptor from neonatal rat gut: comparison of deglycosylation by tunicamycin treatment and genetic engineering. Mol. Immunol. 29:949.
17. Taylor, A. K., and R. Wall. 1988. Selective removal of alpha heavy-chain glycosylation sites causes immunoglobulin A degradation and reduced secretion. Mol. Cell. Biol. 8:4197.
18. Moldoveanu, Z., M. L. Egan, and J. Mestecky. 1984. Cellular origins of human polymeric and monomeric IgA: intracellular and secreted forms of IgA. J. Immunol. 133:3156.
19. Cann, G. M., A. Zaritsky, and M, E. Koshland. 1982. Primary structure of the immunoglobulin J chain from the mouse. Proc. Natl. Acad. Sci. USA 79:6656.
20. Mostov, K. E. 1994. Transepithelial transport of immunoglobulins. Annu. Rev. Immunol. 12:63.
21. Atkin, J. D., R. J. Pleass, R. J. Owens, and J. M. Woof. 1996. Mutagenesis of the human IgA1 heavy chain tailpiece that prevents dimer assembly. J. Immunol. 157:156.
22. Muraoka, S., and M. J. Shulman. 1989. Structural requirements for IgM assembly and cytolytic activity: effects of mutations in the oligosaccharide acceptor site at Asn402. J. Immunol. 142:695.
23. Tomana, M., R. Kulhavy, and J. Mestecky. 1988. Receptor-mediated binding and uptake of immunoglobulin A by human liver. Gastroenterology 94:762.
24. Lucisano Valim, Y. M., and P. J. Lachmann. 1991. The effect of antibody isotype and antigenic epitope density on the complement-fixing activity of immune complexes: a systematic study using chimaeric anti-NIP antibodies with human Fc regions. Clin. Exp. Immunol. 84:1.
25. Hiemstra, P. S., J. Biewenga, A. Gorter, M. E. Stuurman, A. Faber, L. A. van Es, and M. R. Daha. 1988. Activation of complement by human serum IgA, secretory IgA and IgA1 fragments. Mol. Immunol. 25:527.
26. Russell, M. W., J. Reinholdt, and M. Kilian. 1989. Anti-inflammatory activity of human IgA antibodies and their Fab alpha fragments: inhibition of IgG-mediated complement activation. Eur. J. Immunol. 19:2243.
27. Bogers, W. M., R. K. Stad, L. A. van Es, and M. R. Daha. 1991. Immunoglobulin A: interaction with complement, phagocytic cells and endothelial cells. Complement Inflamm. 8:347.
28. Nikolova, E. B., M. Tomana, and M. W. Russell. 1994. All forms of human IgA antibodies bound to antigen interfere with complement (C3) fixation induced by IgG or by antigen alone. Immunology 82:275.
29. Bruggemann, M., G. T. Williams, C. I. Bindon, M. R. Clark, M. R. Walker, R. Jefferis, H. Waldmann, and M. S. Neuberger. 1987. Comparison of the effector functions of human immunoglobulins using a matched set of chimeric antibodies. J. Exp. Med. 166:1351.
30. Russell, M. W., and B. Mansa. 1989. Complement-fixing properties of human IgA antibodies: alternative pathway complement activation by plastic-bound, but not specific antigen-bound, IgA. Scand. J. Immunol. 30:175.
31. Morton, H. C., J. D. Atkin, R. S. Owens, and J. M. Woof. 1993. Purification and characterization of chimeric human IgA1 and IgA2 expressed in COS and Chinese hamster ovary cells. J. Immunol. 151:4743.
32. Zhang, W., and P. J. Lachmann. 1994. Glycosylation of IgA is required for optimal activation of the alternative complement pathway by immune complexes. Immunology 81:137.
33. Imai, H., A. Chen, R. J. Wyatt. and A. Rifai. 1988. Lack of complement activation by human IgA immune complexes. Clin. Exp. Immunol. 73:479.
34. Griffiss, J. M., and D. K. Goroff. 1983. IgA blocks IgM and IgG-initiated immune lysis by separate molecular mechanisms. J. Immunol. 130:2882.
35. Jarvis, G. A., and J. M. Griffiss. 1991. Human IgA1 blockade of IgG-initiated lysis of Neisseria meningitidis is a function of antigen-binding fragment binding to the polysaccharide capsule. J. Immunol. 147:1962.