Natural phenylpropanoids protect endothelial cells against oxidized LDL-induced cytotoxicity

Planta Medica

Volumn 69, Issue 3, 2003, Pages 207-211

  Martin Nizard, Françoise ^a   Sahpaz, Sevser ^b   Furman, Christophe ^a   Fruchart, Jean Charles ^a   Duriez, Patrick ^a   Bailleul, François ^b  

^a INSTITUT PASTEUR DE LILLE   (France)

^b UNIV LILLE   (France)

Author keywords

Cytotoxicity; Oxidized LDL; Phenylpropanoids

Indexed keywords

2,2' AZOBIS(2 AMIDINOPROPANE); ACTEOSIDE; ALDEHYDE; ARENARIOSIDE; BALLOTETROSIDE; CAFFEOYL 1 MALIC ACID; COPPER ION; OXIDIZED LOW DENSITY LIPOPROTEIN; PHENYLPROPANOID; POLYPHENOL DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; ATHEROSCLEROSIS; CELL PROTECTION; CONTROLLED STUDY; CYTOTOXICITY; DRUG ISOLATION; DRUG MECHANISM; DRUG STRUCTURE; ENDOTHELIUM CELL; HUMAN; IN VITRO STUDY; LIPID PEROXIDATION; MARRUBIUM; NONHUMAN; NORMAL HUMAN; OXIDATION; PATHOGENESIS; REDUCTION; STRUCTURE ANALYSIS;

COPPER; ENDOTHELIUM, VASCULAR; FLAVONOIDS; HUMANS; LIPID PEROXIDATION; LIPOPROTEINS, LDL; MARRUBIUM; MITOCHONDRIA; PHENOLS; PHYTOTHERAPY; PLANT PREPARATIONS; POLYMERS; THIOBARBITURIC ACID REACTIVE SUBSTANCES;

ANIMALIA; BOVINAE; MARRUBIUM; MARRUBIUM VULGARE;

EID: 0344089373     PISSN: 00320943     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2003-38474     Document Type: Article

References (20)

1. Seidel V, Bailleul F, Tillequin F. Phenylpropanoid glycosides from Ballota nigra. Planta Medica 1996; 62: 186-7
2. Seidel V, Bailleul F, Libot F, Tillequin F. A phenylpropanoid glycoside from Ballota nigra. Phytochemistry 1997; 44: 691-3
3. Sahpaz S, Garbacki N, Tits M, Bailleul F. Isolation and pharmacological activity of phenylpropanoid esters from Marrubium vulgare. J Ethnopharmacol 2002; 79: 389-92
4. Steinberg D. Low density lipoprotein oxidation and its pathobiological significance. J Biol Chem 1997; 272: 20963-6
5. Duriez P, Fruchart JC. Free radicals and atherosclerosis. Free radical damage and its control. In: New comprehensive biochemistry series Neuberger AL, van Deenen LLM, editors. ; chapter 10 Elsevier, Amsterdam, London, New York, Tokyo: 1994: 257-80
6. Hayek T, Fuhrman B, Vaya J, Rosenblat M, Belinky P, Coleman R, Elis A, Aviram M. Reduced progression of atherosclerosis in apolipoprotein E-deficient mice following consumption of red wine, or its polyphenols quercetin or catechin, is associated with reduced susceptibility of LDL to oxidation and aggregation. Arterioscler Thromb Vasc Biol 1997; 17: 2744-52
7. Nigdikar SV, Williams NR, Griffin BA, Howard AN. Consumption of red wine polyphenols reduces the susceptibility of low-density lipoproteins to oxidation in vivo. Am J Clin Nutr 1998; 68: 258-65
8. 2+ ions: implications for their antioxidant properties. Biochem J 1998; 330: 1173-8
9. Jessup W, Rankin SM, De Whalley CV, Hoult JR, Leake DS. Alpha-tocopherol consumption during low-density-lipoprotein oxidation. Biochem J 1990; 265: 399-405
10. Van Acker SA, Van den Berg DJ, Tromp MN, Griffioen DHH, Van Bennekom WP, Van der Vijgh WJ, Bast A. Structural aspects of antioxidant activity of flavonoids. Free Radic Biol Med 1996; 20: 331-42
11. Seidel V, Verholle M, Malard Y, Tillequin F, Fruchart JC, Duriez P, Bailleul F, Teissier E. Phenylpropanoids from Ballota nigra L. inhibit in vitro LDL peroxidation. Phytother Res 2000; 14: 93-8
12. Esterbauer H, Wang G, Puhl H. Lipid peroxidation and its role in atherosclerosis. Br Med Bull 1993; 49: 566-76
13. Furman C, Martin-Nizard F, Fruchart JC, Duriez P, Teissier E. Differential toxicities of air (mOx-LDL) or copper-oxidized LDLs (Cu-LDL) toward endothelial cells. J Biochem Toxicol 1999; 13: 216-323
14. Havel RJ, Eder HA, Bragdon JH. The distribution and chemical composition of ultra-centrifugally separated lipoproteins in human serum. J Clin Invest 1955; 34: 1345-53
15. Peterson GA. Simplification of the protein assay method of Lowry which is more generally applicable. Anal Biochem 1977; 83: 346-56
16. Furman, Lebeau J, Fruchart JC, Bernier JL, Duriez P, Cotelle N, Teissier E. Di-tert-butylhydroxylated flavonoids protect endothelial cells against oxidized LDL-induced cytotoxicity. J Biochem Molecular Toxicology 2001; 15: 270-8
17. Morel DW, Hessler JR, Chisolm GM. Low density lipoprotein induced by free radical peroxidation of lipid. J Lip Res 1983; 24: 1070-6
18. Thomas JP, Geiger PG, Girotti AW. Lethal damage to endothelial cells by oxidized low density lipoprotein: role of selenoperoxidases in cytoprotection against lipid hydroperoxide- and iron-mediated reactions. J Lip Res 1993; 34: 479-90
19. Lebeau J, Furman C, Fruchart JC, Duriez P, Bernier JL, Teissier E, Cotelle N. Antioxidant properties of di-tert-butylhydroxylated flavonoids. Free Radic Biol Med 2000; 29: 900-12
20. Naito M, Kuzuya M, Iguchi A. Mechanisms of endothelial cell injury induced by oxidatively modified LDL. J Jap Atheroscl Soc 1994; 22: 257-62