Regulation of cell surface expression of Fas (CD95) ligand and susceptibility to Fas (CD95)-mediated apoptosis in activation-induced T cell death involves calcineurin and protein kinase C, respectively

European Journal of Immunology

Volumn 29, Issue 2, 1999, Pages 383-393

  Tóth, Réka ^a   Szegezdi, Éva ^a   Molnár, Gábor ^a   Lord, Janet M ^b   Fésüs, László ^a   Szondy, Zsuzsa ^a  

^a UNIVERSITY OF DEBRECEN   (Hungary)

^b UNIVERSITY DEPARTMENT OF MEDICINE   (United Kingdom)

Author keywords

Apoptosis; Fas; Fas ligand; Protein kinase C; T cell

Indexed keywords

12 (2 CYANOETHYL) 6,7,12,13 TETRAHYDRO 13 METHYL 5 OXOINDOLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE; 2 [1 (3 DIMETHYLAMINOPROPYL) 3 INDOLYL] 3 (3 INDOLYL)MALEIMIDE; CALCIMYCIN; CALCINEURIN; CD4 ANTIGEN; CYCLOSPORIN A; FAS ANTIGEN; FAS LIGAND; ISOENZYME; MEMBRANE ANTIGEN; MESSENGER RNA; PHORBOL DIBUTYRATE; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ANTIGEN EXPRESSION; APOPTOSIS; ARTICLE; CONTROLLED STUDY; ENZYME LOCALIZATION; HYBRIDOMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

ANIMALS; ANTIGENS, CD95; APOPTOSIS; CALCINEURIN; GENE EXPRESSION REGULATION; HYBRIDOMAS; LYMPHOCYTE ACTIVATION; MICE; PROTEIN KINASE C; SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

EID: 0344026230     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-4141(199902)29:02<383::AID-IMMU383>3.0.CO;2-A     Document Type: Article

References (39)

1. Smith, C. A., Williams, G. T., Kingston, R., Jenkinson, E. J. and Owen, J. J. T., Antibodies to CD3/T cell receptor complex induce death by apoptosis in immature T cells in thymic cultures. Nature 1989. 337: 181-184.
2. Kawabe, Y. and Ochi, A., Programmed cell death and extrathymic reduction of Vb8+ CD4+ T cells in mice tolerant to Stephylococcus aureus enterotoxin B. Nature 1991. 349: 245-248.
3. Gougeon, M., Does apoptosis contribute to CD4 T cell depletion in human immunodeficiency virus infection? Cell Death Differ. 1995. 2: 1-8.
4. Chan, A. C. and Shaw, A. S., Regulation of antigen signal transduction by protein tyrosine kinases. Curr. Opin. Immunol. 1996. 8: 394-401.
5. Wange, R. L. and Samelson, L. E., Complex complexes: signaling at the TCR. Immunity 1996. 5: 197-205.
6. Cantrell, D., The ral LAT steps forward. 1998. Trends Cell Biol., 8: 180-181.
7. Weiss, A. and Littman, D. R., Signal transduction by lymphocyte antigen receptors. Cell 1994. 76: 263-274.
8. Exley, M. and Varticovski, L., Evidence for phosphatidylinositol 3-kinase-dependent T cell antigen receptor (TCR) signal transduction. Mol. Immunol. 1997. 34: 221-226.
9. Izquierdo, M., Leevers, S. J., Marshall, C. J. and Cantrell, D., p21ras couples the T cell antigen receptor to extracellular signal-regulated kinase 2 in T lymphocytes. J. Exp. Med. 1994. 178: 1199-1208.
10. Rothenberg, E. V. and Ward, S. B., A dynamic assembly of diverse transcription factors integrates activation and cell-type information for interleukine 2 gene expression. Proc. Natl. Acad. Sci. USA 1996. 93: 9358-9365.
11. Nishibe, S., Wahl, M. I., Hernandez-Sotomayor, S. M., Tonks, N. K., Rhee, S. G. and Carpenter, G., Increase in the catalytic activity of phospholipase C-gamma 1 by tyrosine phosphorylation. Science 1990. 250: 1253-1256.
12. Nishizuka, Y., lntracellular signalling by hydrolysis of phospholipids and activation of protein kinase C. Science 1992. 258: 607-614.
13. Clapham, D. E., Calcium signaling. Cell 1995. 89: 259-268.
14. Clipstone, N. A. and Crabtree, G. R., Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation. Nature 1992. 357: 695-697.
15. Lenardo, M. J., The molecular regulation of lymphocyte apoptosis. Semin. Immunol. 1997. 9: 1-5.
16. Brunner, T., Mogil, R. J., LaFace, D., Yoo, N. J., Mahboubi, A., Echeverri, F., Martin, S. J., Force, W. R., Lynch, D. H., Ware, C. F. and Green, D. R., Cell-autonomous Fas(CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas. Nature 1995. 373: 441-444.
17. Lee-Way, J., Kayo, I. and Saitoh, T., Involvement of protein kinase C in activation-induced cell death in T-cell hybridoma. Cell. Immunol. 1992. 144: 217-227.
18. Shi, Y. F., Sahai, B. M. and Green, D. R., Cyclosporin A inhibits activation-induced cell death in T-cell hybridomas and thymocytes. Nature 1989. 339: 625-626.
19. Bissonette, R. P., Brunner, T., Lazarchik, S. B., Yoo, N. J., Boehm, M. F., Green, D. R. and Heyman, R. A., 9-cis retinoic acid inhibition of activation-induced apoptosis is mediated via regulation of fas ligand and requires retinoic acid receptor and retinoid X receptor activation. Mol. Cell. Biol. 1995. 15: 5576-7785.
20. Latinis, K. M., Carr, L. L., Peterson, E. J., Norian, L. A., Eliasin, S. L. and Koretsky, G. A., Regulation of CD95(Fas) ligand expression by TCR-mediated signaling events. J. Immunol. 1997. 158: 4602-4611.
21. Holtz-Heppelmann, C. J., Algeciras, A., Badley, A. D. and Paya, C. V., Transcriptional regulation of the human Fast promoter-enhancer region. J. Biol. Chem. 1998. 273: 4416-4423.
22. Brunner, T., Yoo, N. J., LaFace, D., Ware, C. F. and Green, D. R., Activaton-induced cell death in murine T cell hybridomas. Differential regulation of Fas (CD95) versus Fas ligand expression by cyclosporin A and FK 106. Int. Immunol. 1996. 8: 1017-1026.
23. Wong, B., Arron, J. and Choi, Y., T cell receptor signals enhance susceptibility to Fas-mediated apoptosis. J. Exp. Med. 1997. 186: 1939-1944.
24. Martinez-Lorenzo, M. J., Alava, M. A., Anel, A., Pineiro, A. and Naval, J., Release of preformed Fas ligand in soluble form is the major factor for activation-induced death of Jurkat T cells. Immunology 1996. 89: 511 -51.
25. Anal, A., Simon, A. K., Auphan, N., Buferne, M., Boyer, C., Golstein, P. and Schmitt-Verhulst, A. M., Two signaling pathways can lead to Fas ligand expression in CD8+ cytotoxic T lymphocyte clones. Eur J. Immunol. 1995. 25: 3381-3387.
26. Rajnavölgyi, E., Nagy, Z., Kurucz, I., Gogolák, P., Tóth, G. K., Váradi, G., Penke, B., Tigyi, Z., Hotlósi, M. and Gergely, J., T cell recognition of the posttranslationally cleaved intersubunit region of influenza virus haemagglutinin. Mol. Immunol. 1994. 31: 1403-1414.
27. Baron, M. G., Kazanietz, M. G., Mischak, H., Blumberg, P. M., Kochs, G., Hug, H., Marme, D. and Schachtele, C., Selective inhibition of protein kinase C isoenzymes by the indolocarbazole G̈ 6976. J. Biol. Chem. 1993. 268: 9194-9197.
28. Yano, H., Nakanishi, S., Kimura, K., Hanai, N., Saitoh, Y., Fukui, Y., Nonomura, Y. and Matsuad, Y., Inhibition of histamine secretion by wortmannin through the blockade of phosphatidylinositol 3-kinase in RBL-2H3 cells. J. Biol. Chem. 1993. 268: 25846-25856.
29. Peter, M. E., Kischkel, F. C., Scheuerpflug, C. G., Medema, J. P., Debatin, K. M. and Krammer, P. H., Resistance of cultured periperal T cells towards activation-induced cell death involves lack of recruitment of FLICE (MACH/caspase 8) to the CD95 death-inducing complex. Eur. J. Immunol. 1997. 27: 1207-1212.
30. Miyawaki, T., Uehara, T., Nibu, R., Tsuji, T., Yachie, A., Yonehara, S. and Taniguchi, N., Differential expression of apoptosis related Fas antigen on lymphocyte subpopulations in human peripheral blood. J. Immunol. 1992. 149: 3753-3758.
31. Szondy, Z., Lecoeur, H., Fesus, L. and Gougeon, M. L., All-trans retinoic acid inhibition of anti-CD3 induced T cell apoptosis in HIV-infection mostly concerns CD4+ T lymphocytes and is mediated via regulation of FasL expression. J. Infect. Dis. 1998. 178: 1288-1298.
32. Su, X., Cheng, J., Liu, W., Liu, C., Wang, Z., Zhou, T. and Mountz, J. D., Autocrine and paracrine apoptosis are mediated by differential regulation of Fas ligand activity in two distinct Jurkat T cell populations. J. Immu-nol. 1998. 160: 5288-5293.
33. Ghayur, T., Hugunin, M., Talanian, R. V., Ratnofsky, S., Quinlan, C., Emoto, Y., Pandey, P., Datta, R., Huang, Y., Kharbanda, S., Allen, H., Kamen, R., Wong, W. and Kufe, D., Proteolytic activation of protein kinase C delta by an ICE/CED 3-like protease induces characteristics of apoptosis. J. Exp. Med. 1996. 184: 2399-2404.
34. Genot, E. M., Parker, D. J. and Cantrell, D. A., Analysis of the role of protein kinase C-alpha, -epsilon and -zeta in T cell activation. J. Biol. Chem. 1995. 270: 9833-9839.
35. Rouvier, E., Luciani, M. F. and Golstein, P., Fas involvement in Ca(2+)-independent T cell-mediated cytotoxicity. J. Exp. Med. 1993. 177: 195-200.
36. Alley, M. C., Scudiero, D. A., Monks, A., Hursey, M. L., Czerwinski, M. J., Fine, D. L., Abbott, B. J., Mayo, J. G., Shoemaker, R. H. and Boyd, M. R., Freasibility of drug screening with panels of human tumor cell lines using microculture tetrazolium assay. Cancer Res. 1988. 46: 589-601.
37. Szondy, Z., Reichert, U., Bernardon, J. M., Michel, S., Tóth, R., Ancian, P. and Fésüs, L., Induction of apoptosis by retinoids and RARγ selective compounds in mouse thymocytes through a novel apoptosis pathway. Mol. Pharmacol. 1997. 51: 972-982.
38. Griffiths, G., Garrone, B., Deacon, E., Owen, P., Pongracz, J., Mead, G., Bradwell, A. and Lord, J. M., The polyether Bistratene A activates protein kinase C δ and induces growth arrest in HL-60 cells. Biochem. Biophys. Res. Comm. 1996. 222: 802-808.
39. Pongracz, J., Tuffley, W., Johnson G. D., Deacon E. M., Burnett, D., Stockley, R. A. and Lord, J. M., Changes in protein kinase C isoenzyme expression associated with apoptosis of U 937 myelomonocytic cells. Exp. Cell. Res. 1995. 218: 430-438.