Strong inhibition of estrone-3-sulfatase activity by pregnenolone 16α- carbonitrile but not by several analogs lacking a 16α-nitrile group

Steroids

Volumn 65, Issue 9, 2000, Pages 521-527

  Zhu, Bao Ting ^a   Kosh, Joseph W ^a   Fu, Jia Huey ^b   Cai, May Xiaoxin ^b   Xu, Shiyao ^b   Conney, Allan H ^b  

^a UNIVERSITY OF SOUTH CAROLINA   (United States)

^b Department of Chemical Biology and Pharmacognosy   (United States)

Author keywords

E1 3 Sulfatase activity; PCN

Indexed keywords

16ALPHA CYANOPREGNENOLONE; 16ALPHA HYDROXYPREGNENOLONE; 16ALPHA HYDROXYPROGESTERONE; ANDROSTERONE; DANAZOL; ESTRONE; PRASTERONE; PREGNENOLONE DERIVATIVE; PROGESTERONE; SULFATASE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG POTENCY; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME KINETICS; FEMALE; HUMAN; HUMAN TISSUE; LIVER MICROSOME; NONHUMAN; RAT; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; SULFATION;

ANIMALS; ANTINEOPLASTIC AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROSTATICS; ENZYME INHIBITORS; FEMALE; HUMANS; MICROSOMES, LIVER; MODELS, MOLECULAR; MOLECULAR CONFORMATION; NITRILES; PLACENTA; PREGNANCY; PREGNENOLONE CARBONITRILE; RATS; RATS, LONG-EVANS; RATS, SPRAGUE-DAWLEY; STRUCTURE-ACTIVITY RELATIONSHIP; SUBCELLULAR FRACTIONS; SULFATASES;

ANIMALIA;

EID: 0343389558     PISSN: 0039128X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0039-128X(00)00129-X     Document Type: Article

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