Isothiocyanatobenzyl imidazoline is an alkylating agent for I2-imidazoline binding sites in rat and rabbit tissues

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 357, Issue 3, 1998, Pages 351-355

  Boronat, M Assumpciö ^a   Olmos, Gabriel ^a   Miller, Duane D ^b   Patil, Popat N ^c   García Sevilla, Jesús A ^a  

^a UNIVERSITAT DE LES ILLES BALEARS   (Spain)

^b UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^c OHIO STATE UNIVERSITY   (United States)

Author keywords

3H 2 (2 benzofuranyl) 2 imidazoline ( 3H 2 BFI); I2 imidazoline binding sites; Isothiocyanatobenzyl imidazoline; Rabbit brain; Rat brain and liver

Indexed keywords

ALKYLATING AGENT; IMIDAZOLINE; ISOTHIOCYANATOBENZYLIMIDAZOLINE; TOLAZOLINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING SITE; BRAIN; BRAIN CORTEX; CONTROLLED STUDY; DRUG BINDING SITE; IN VITRO STUDY; LIVER; LIVER MEMBRANE; NONHUMAN; RABBIT; RAT;

AFFINITY LABELS; ANIMALS; BENZOFURANS; BINDING SITES; BRAIN; IMIDAZOLES; LIVER; MALE; RABBITS; RATS; RATS, SPRAGUE-DAWLEY; TOLAZOLINE;

EID: 0343068807     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/PL00005178     Document Type: Article

References (23)

1. 2 imidazoline-preferring receptors. Br J Pharmacol 114: 837-845
2. 3H]2-(2-benzofuranyl)-2-imidazoline (2-BFI) in rat brain and liver: characterization, regulation and relation to monoamine oxidase enzymes. Naunyn-Schmiedeberg's Arch Pharmacol 356: 39-47
3. Bousquet P (1995) Imidazoline receptors: from basic concepts to recent developments. J Cardiovasc Pharmacol 26: S1-S6
4. Brasili L, Giannella M, Melchiorre C, Belleau B, Benfey BG (1981) Structural requirements for adrenergic α-receptor covalent occupancy by chiral tetramine disulfides. Eur J Med Chem 16: 115-118
5. Diamant S, Eldar-Geva T, Atlas D (1992) Imidazoline binding sites in human placenta: evidence for heterogeneity and a search for physiological function. Br J Pharmacol 106: 101-108
6. 2 sites in the mammalian central nervous system. Pharmacol Ther 68: 175-208
7. Ishikawa H, Miller DD, Patil PN (1996) Irreversible agonist and antagonist properties of isothiocyanatobenzyl imidazoline in albino rabbit iris muscles. Naunyn-Schmiedeberg's Arch Pharmacol 354: 362-368
8. Lanier SM, Ivkovic B, Singh I, Neumeyer JL, Bakthavachalam V (1993) Visualization of multiple imidazoline/guanidinium-receptive sites. J Biol Chem 268: 16047-16051
9. 1-imidazoline receptor binding properties of 2-(4'-isothiocyanatobenz.yl) imi-dazoline analogs in vascular and brain tissues. Ann NY Acad Sci 763: 283-286
10. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193: 265-275
11. Meiler E, Goldstein M, Friedhorff AJ, Schweitzer JW (1988) N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ): a new tool to probe CNS receptor function. Adv Exp Med Biol 235: 121-136
12. 3H]RX821002 (2-methoxy idazoxan) in the human and rat brains. J Pharmacol Exp Ther 264: 1187-1197
13. 2-imidazoline sites in vitro and in vivo. J Neurochem 61: 1602-1610
14. Molderings GJ (1997) Imidazoline receptors: basic knowledge, recent advances and future prospects for therapy and diagnosis. Drugs Fut 22: 757-772
15. Munson PJ, Rodbard D (1980) LIGAND: a versatile computerized approach for the characterization of ligand binding systems. Anal Biochem 107: 220-239
16. Olmos G, Miralles A, Barturen F, García-Sevilla JA (1992) Characterization of brain imidazoline receptors in normotensive and hypertensive rats: differential regulation by chronic imidazoline drug treatment. J Pharmacol Exp Ther 260: 1000-1007
17. 3H]-idazoxan binding sites in the rat brain. Br J Pharmacol 108: 597-603
18. Olmos G, Ribera J, García-Sevilla JA (1996a) Imidazoli(di)ne compounds interact with the phencyclidine site of NMDA receptors in the rat brain. Eur J Pharmacol 310: 273-276
19. 2-imidazoline receptor subtypes. Naunyn-Schmiedeberg's Arch Pharmacol 354: 709-716
20. 2-imidazoline receptors in rat liver. Br J Pharmacol 121: 901-912
21. Regunathan S, Reis DJ (1996) Imidazoline receptors and their endogenous ligands. Annu Rev Pharmacol Toxicol 36: 511-544
22. Slavica M, Lei L, Patil PN, Kerezy A, Feller DR, Miller DD (1994) Synthesis and biological activities of a new set of irreversibly acting 2-(4′-isothiocyanatobenzyl) imidazoline analogs in rat thoracic aorta. J Med Chem 37: 1874-1881
23. 3H]idazoxan in the smooth muscle of rabbit urethra. Eur J Pharmacol 154: 209-212