Labelling of I(2B)-imidazoline receptors by [3H]2-(2-benzofuranyl)-2-imidazoline (2-BFI) in rat brain and liver: Characterization, regulation and relation to monoamine oxidase enzymes

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 356, Issue 1, 1997, Pages 39-47

  Alemany, Regina ^a,b   Olmos, Gabriel ^a   García Sevilla, Jesús A ^a  

^a UNIVERSITAT DE LES ILLES BALEARS   (Spain)

^b UNIVERSITY HOSPITAL ESSEN   (Germany)

Author keywords

3H 2 (2 benzofuranyl) 2 imidazoline ( 3H 2 BFI); I(2B) imidazoline receptor; Irreversible MAO inhibitors; MAO isoenzymes; Rat brain and liver

Indexed keywords

2 (1,4 BENZODIOXAN 2 YLAMINO) 2 IMIDAZOLINE; AGANODINE; AGMATINE; AMILORIDE; AMINE OXIDASE (FLAVIN CONTAINING); CIRAZOLINE; CLONIDINE; CLORGYLINE; EFAROXAN; IDAZOXAN; IMIDAZOLINE DERIVATIVE; IMIDAZOLINE I2 RECEPTOR; ISOENZYME; LAZABEMIDE; MONOAMINE OXIDASE INHIBITOR; MOXONIDINE; N (2 AMINOETHYL) 5 (3 FLUOROPHENYL) 4 THIAZOLECARBOXAMIDE; NAPHAZOLINE; PHENELZINE; PHENETHYLAMINE; 2 (2 BENZOFURANYL) 2 IMIDAZOLINE; 2-(2-BENZOFURANYL)-2-IMIDAZOLINE; BENZOFURAN DERIVATIVE; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; DRUG RECEPTOR; IMIDAZOLE DERIVATIVE; IMIDAZOLINE RECEPTORS; LIGAND;

ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CONTROLLED STUDY; DRUG RECEPTOR BINDING; LIVER MEMBRANE; MALE; NONHUMAN; RAT; AFFINITY LABELING; ANIMAL; BINDING COMPETITION; BRAIN; DRUG EFFECT; ENZYMOLOGY; IN VITRO STUDY; LIVER; METABOLISM; PROTEIN BINDING; SPRAGUE DAWLEY RAT;

ADRENERGIC BETA-ANTAGONISTS; AFFINITY LABELS; ANIMALS; BENZOFURANS; BINDING, COMPETITIVE; BRAIN; CEREBRAL CORTEX; IDAZOXAN; IMIDAZOLES; ISOENZYMES; LIGANDS; LIVER; MALE; MONOAMINE OXIDASE; MONOAMINE OXIDASE INHIBITORS; PHENELZINE; PROTEIN BINDING; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, DRUG;

EID: 0030611203     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/PL00005026     Document Type: Article

References (58)

1. 2 receptors, on glial fibrillary acidic protein concentration. Eur J Pharmacol 280: 205-210
2. 2 imidazoline-preferring receptors. Br J Pharmacol 114: 837-845
3. Bousquet P (1995) Imidazoline receptors: from basic concepts to recent developments. J Cardiovasc Pharmacol 26: S1-S6
4. Bricca G, Dontenwill M, Molines A, Feldman J, Belcourt A, Bousquet P (1988) Evidence for the existence of a homogeneous population of imidazoline receptors in the human brainstem. Eur J Pharmacol 150: 401-402
5. Bricca G, Dontenwill M, Molines A, Feldman J, Belcourt A, Bousquet P (1989) The imidazoline preferring receptor: binding studies in bovine, rat and human brainstem. Eur J Pharmacol 1962: 1-9
6. 2-adrenoceptor subtypes and imidazoline-like binding sites in the rat brain. Br J Pharmacol 99: 803-809
7. Bruns RF, Lawson-Wendling K, Pugsley TA (1983) A rapid filtration assay for soluble receptors using polyethylenimine-treated filters. Anal Biochem 132: 74-81
8. 2-imidazoline sites. J Pharmacol Exp Ther 272: 681-688
9. Diamant S, Eldar-Geva T, Atlas D (1992) Imidazoline binding sites in human placenta: evidence for heterogeneity and a search for physiological function. Br J Pharmacol 106: 101-108
10. Dunne M J (1991) Block of ATP-regulated potassium channels by phentolamine and other alpha-adrenoceptor antagonists. Br J Pharmacol 103: 1847-1850
11. Dyck LE, Durden DA, Boulton AA (1985) Formation of β-phenylethylamine from the antidepressant. β-phenylethylhydrazine. Biochem Pharmacol 34: 1925-1929
12. 2 subtypes. Fundam Clin Pharmacol 6 [Suppl 1]: 55s, P18
13. 2-adrenoceptors in the ventrolateral medulla. Eur J Pharmacol 143: 1-13
14. 1-imidazoline receptors. Definition, characterization, distribution, and trans-membrane signaling. Ann NY Acad Sci 763: 22-42
15. Escribá PV, Sastre M, Wang H, Regunathan S, Reis DJ, García-Sevilla JA (1994) Immunodetection of putative imidazoline receptor proteins in the human and rat brain and other tissues. Neurosci Lett 178: 81-84
16. 3H]-idazoxan binding sites. Br J Pharmacol 118: 2028-2036
17. 2 sites in the mammalian central nervous system. Pharmacol Ther 68: 175-208
18. 2-adrenoceptors alter manipulation of noradrenergic transmission in the rat. Eur J Pharmacol 164: 455-466
19. 2-sites). Br J Pharmacol 112: 320P
20. 2-sites). Br J Pharmacol 114: 411P
21. Ivkovic B, Bakthavachalam V, Zhang W, Parini A, Diz D, Bosch S, Neumeyer J, Lanier S (1994) Development of a high-affinity radioiodinated ligand for identification of imidazoline/guanidium receptive sites (IGRS): intratissue distribution of IGRS in liver, forebrain and kidney. Mol Pharmacol 46: 15-23
22. 2-adrenergic binding sites. Mol Pharmacol 37: 876-885
23. Li G, Regunathan S, Barrow CJ, Eshraghi J, Cooper R, Reis DJ (1994) Agmatine - an endogenous clonidine-displacing substance in the brain. Science 263: 966-969
24. 2 receptors. Eur J Pharmacol 304: 221-229
25. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193: 265-275
26. 1A autoreceptors modulating serotonin synthesis in the rat brain in vivo. Neurosci Lett 218: 111-114
27. 2) imidazoline affinity in rat kidney. Br J Pharmacol 115: 72P
28. 2 imidazoline receptors. Br J Pharmacol 116: 1729-1736
29. Mallard NJ, Hudson AL, Nutt DJ (1992) Characterization and autoradiographical localization of non-adrenoceptor binding sites in the rat brain. Br J Pharmacol 106: 1019-1027
30. McManus DJ, Mousseau DD, Paetsch PR, Wishart TB, Greenshaw AJ (1991) β-adrenoceptors and antidepressants: possible 2-phenylethylamine mediation of chronic phenelzine effects. Biol Psychiatry 30: 1122-1130
31. 2-imidazoline sites. Br J Pharmacol 111: 298P
32. Michel MC, Ernsberger P (1992) Keeping an eye on the I site: imidazoline-preferring receptors. Trends Pharmacol Sci 13: 369-370
33. 2-adrenergie drugs also bind with high affinity to a nonadrenergic site. Mol Pharmacol 35: 324-330
34. 3H]RX821002 (2-methoxy idazoxan) in the human and rat brains. J Pharmacol Exp Ther 264: 1187-1197
35. 2-imidazoline sites in vitro and in vivo. J Neurochem 61: 1602-1610
36. 2 binding sites. Naunyn-Schmiedeberg's Arch Pharmacol 354: 245-252
37. Munson PJ, Rodbard D (1980) LIGAND: a versatile computerized approach for the characterization of ligand binding systems. Anal Biochem 107: 220-239
38. Nutt DJ, French N, Handley S, Hudson A, Husbands S, Jackson H, Jordan S, Lalies MD, Lewis J, Lione L, Mallard N, Pratt J (1995) Functional studies of specific imidazoline-2 receptor ligands. Ann NY Acad Sci 763: 125-140
39. Olmos G, Miralles A, Barturen F, García-Sevilla JA (1992) Characterization of brain imidazoline receptors in normotensive and hypertensive rats: differential regulation by chronic imidazoline drug treatment. J Pharmacol Exp Ther 260: 1000-1007
40. 3H]-idazoxan binding sites in the rat brain. Br J Pharmacol 108: 597-603
41. Olmos G, Alemany R, Escribá PV, García-Sevilla JA (1994) The effects of chronic imidazoline drug treatment on glial fibrillary acidic protein concentrations in rat brain. Br J Pharmacol 111: 997-1002
42. 2-imidazoline receptor subtypes. Naunyn-Schmiedeberg's Arch Pharmacol 354: 709-716
43. Olmos G, Ribera J, García-Sevilla JA (1996b) Imidazoli(di)ne compounds interact with the phencyclidine site of NMDA receptors in the rat brain. Eur J Pharmacol 310: 273-276
44. 2-imidazoline receptors in rat liver. Br J Pharmacol (in press)
45. Paetsch PR, Baker GB, Greenshaw AJ (1993) Induction of functional down-regulation of β-adrenoceptors in rats by 2-phenylethylamine. J Pharm Sci 82: 22-24
46. Parini A, Moudanos CG, Pizzinat N, Lanier SM (1996) The elusive family of imidazoline binding sites. Trends Pharmacol Sci 17: 13-16
47. Paterson IA, Juorio AV, Boulton AA (1990) 2-phenylethylamine: a modulator of catecholamine transmission in the mammalian central nervous system? J Neurochem 55: 1827-1837
48. Paterson IA, Juorio AV, Berry MD , Zhu MY (1991) Inhibition of monoamine oxidase-B by (-)-deprenyl potentiates neuronal responses to dopamine agonists but does not inhibit dopamine catabolism in the rat striatum. J Pharmacol Exp Ther 258: 1019-1026
49. Raddatz R, Parini A, Lanier SM (1995) Imidazoline/guanidinium binding domains on monoamine oxidases. Relationship to subtypes of imidazoline-binding proteins and tissue-specific interaction of imidazoline ligands with monoamine oxidase B. J Biol Chem 270: 27961-27968
50. Regunathan S, Reis DJ (1996) Imidazoline receptors and their endogenous ligands. Annu Rev Pharmacol Toxicol 36: 511-544
51. Reis DJ, Bousquet P, Parini A (1995) The imidazoline receptor: pharmacology, functions, ligands, and relevance to biology and medecine. Ann NY Acad Sci 763: 1-707
52. 1-imidazoline receptors to diacylglyceride accumulation in PC 12 rat pheochromocytoma cells. Mol Pharmacol 49: 668-675
53. Swillens S, Wallbroeck M, Champeil P (1995) Does a radiolabelled ligand bind to a homogenous population of non-interacting receptor sites? Trends Pharmacol Sci 16: 151-155
54. 2-imidazoline binding sites on monoamine oxidases. J Biol Chem 270: 9856-9861
55. 2-Adrenoceptors: classification, localization, mechanims, and targets for drugs. J Med Chem 25: 1389-1400
56. Wikberg JES, Uhlén S (1990) Further characterization of the guinea pig cerebral cortex idazoxan receptor: solubilization, distinction from the imidazole site, and demonstration of cirazoline as an idazoxan receptor selective drug. J Neurochem 55: 192-203
57. 3H]-idazoxan binding sites (I-receptors) occurs to interacting or interconvertible affinity forms of the receptor. Pharmacol Toxicol 70: 208-219
58. 2-adrenoceptor? Eur J Pharmacol 190: 203-215