Hyperoxia upregulates the NO pathway in alveolar macrophages in vitro: Role of AP-1 and NF-κB

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 280, Issue 5 25-5, 2001, Pages

  Pepperl, Sonja ^a   Dörger, Martina ^a   Ringel, Florian ^a   Kupatt, Christian ^a   Krombach, Fritz ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

Activator protein 1; Antioxidants; Inducible nitric oxide synthase; Nuclear factor B; Oxygen toxicity; Reactive oxygen species; Transcription factors

Indexed keywords

ACETYLCYSTEINE; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; NITROUS OXIDE; PYRROLIDINE DITHIOCARBAMATE; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR AP 1;

ANIMAL CELL; ARTICLE; BREATHING; CONTROLLED STUDY; ENZYME REGULATION; HYPEROXIA; LUNG ALVEOLUS MACROPHAGE; LUNG INJURY; MALE; NONHUMAN; OXYGEN TOXICITY; PRIORITY JOURNAL; PROTEIN BINDING; RAT;

EID: 0342960835     PISSN: 10400605     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajplung.2001.280.5.l905     Document Type: Article

References (50)

1. Albakri QA and Stuehr DJ. Intracellular assembly of inducible NO synthase is limited by nitric oxide-mediated changes in heme insertion and availability. J Biol Chem 271: 5414-5421, 1996.
2. Arkovitz MS, Szabó C, Wispé JR, Ziegler MM, and Garcia VF. Hyperoxia upregulates alveolar macrophage nitric oxide production. Surg Forum 27: 696-698, 1996.
3. Barazzone C, Horowitz S, Donati YR, Rodriguez I, and Piguet P-F. Oxygen toxicity in mouse lung: pathways to cell death. Am J Respir Cell Mol Biol 19: 573-581, 1998.
4. Berg JT, White JE, and Tsan M-F. Response of alveolar macrophage-depleted rats to hyperoxia. Exp Lung Res 21: 175-185, 1995.
5. Camhi SL, Alam J, Otterbein L, Sylvester SL, and Choi AM. Induction of heme oxygenase-1 gene expression by lipopolysaccharide is mediated by AP-1 activation. Am J Respir Cell Mol Biol 13: 387-398, 1995.
6. Capellier G, Maupoil V, Boillot A, Kantelip JP, Rochette L, Regnard J, and Barale F. L-NAME aggravates pulmonary oxygen toxicity in rats. Eur Respir J 9: 2531-2536, 1996.
7. Chu SC, Marks-Konczalik J, Wu H-P, Banks TC, and Moss J. Analysis of the cytokine-stimulated human inducible nitric oxide synthase (iNOS) gene: characterization of differences between human and mouse iNOS promoters. Biochem Biophys Res Commun 248: 871-878, 1998.
8. Crapo JD, Barry BE, Foscue HA, and Shelburne J. Structural and biochemical changes in rat lungs occurring during exposure to lethal and adaptive doses of oxygen. Am Rev Respir Dis 122: 123-143, 1980.
9. Cucchiaro G, Tatum AH, Brown MC, Camporesi EM, Daucher JW, and Hakim TS. Inducible nitric oxide synthase in the lung and exhaled nitric oxide after hyperoxia. Am J Physiol Lung Cell Mol Physiol 277: L636-L644, 1999.
10. Dignam JD, Lebovitz RM, and Roeder RG. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res 11: 1475-1489, 1983.
11. Ding AH, Nathan CF, and Stuehr DJ. Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production. J Immunol 141: 2407-2412, 1988.
12. Dörger M, Jesch NK, Rieder G, Hirvonen M-R, Savolainen K, Krombach F, and Messmer K. Species differences in NO formation by rat and hamster alveolar macrophages in vitro. Am J Respir Cell Mol BM 16: 413-420, 1997.
13. Elstner EF. Der Sauerstoff. Mannheim, Germany: Wissenschaftsverlag, 1991.
14. Fujii Y, Goldberg P, and Hussain SNA. Contribution of macrophages to pulmonary nitric oxide production in septic shock. Am J Respir Crit Care Med 157: 1645-1651, 1998.
15. Garat C, Jayr C, Eddahibi S, Laffon M, Meignan M, and Adnot S. Effects of inhaled nitric oxide or inhibition of endogenous nitric oxide formation on hyperoxic lung injury. Am J Respir Crit Care Med 155: 1957-1964, 1997.
16. Haddad IY, Pataki G, Hu P, Galliani C, Beckman JS, and Matalon S. Quantitation of nitrotyrosine levels in lung sections of patients and animals with acute lung injury. J Clin Invest 94: 2407-2413, 1994.
17. Hirano S. Nitric oxide-mediated cytotoxic effects of alveolar macrophages on transformed lung epithelial cells are independent of the β2 integrin-mediated intercellular adhesion. Immunology 93: 102-108, 1998.
18. Horinouchi H, Wang C-C, Shepherd KE, and Jones R. TNFα gene and protein expression in alveolar macrophages in acute and chronic hyperoxia-induced lung injury. Am J Respir Cell Mol BM 14: 548-555, 1996.
19. Jamieson D. Oxygen toxicity and reactive oxygen metabolites in mammals. Free Radic Biol Med 7: 87-108, 1989.
20. Jesch NK, Dörger M, Enders G, Rieder G, Vogelmeier C, Messmer K, and Krombach F. Expression of inducible nitric oxide synthase and formation of nitric oxide by alveolar macrophages: an interspecies comparison. Environ Health Perspect 105: 1297-1300, 1997.
21. Kim Y-M, Lee B-S, Yi K-Y, and Paik S-G. Upstream NF-κB site is required for maximal expression of mouse inducible nitric oxide synthase gene in interferon-γ plus lipopolysaccharide-induced RAW 264.7 macrophages. Biochem Biophys Res Commun 236: 655-660, 1997.
22. Kobzik L, Bredt DS, Lowenstein CJ, Drazen J, Gaston B, Sugarbaker D, and Stamler JS. Nitric oxide in human and rat lung: immunochemical and histochemical localization. Am J Respir Cell Mol Biol 9: 371-377, 1993.
23. Kolyada AY, Savikovsky N, and Madias NE. Transcriptional regulation of the human iNOS gene in vascular-smooth-muscle cells and macrophages: evidence for tissue specificity. Biochem Biophys Res Commun 220: 600-605, 1996.
24. Kupatt C, Weber C, Wolf DA, Becker BF, Smith TW, and Kelly RA. Nitric oxide attenuates reoxygenation-induced ICAM-1 expression in coronary microvascular endothelium: role of NFkappaB. J Mol Cell Cardiol 29: 2599-2609, 1997.
25. Lavnikova N, Drapier J-C, and Laskin DL. A single exogenous stimulus activates resident rat macrophages for nitric oxide production and tumor toxicity. J Leukoc Biol 54: 322-328, 1993.
26. Lee PJ, Alam J, Sylvester SL, Inamdar N, Otterbein L, and Choi AMK. Regulation of heme oxygenase-1 expression in vivo and in vitro in hyperoxic lung injury. Am J Respir Cell Mol Biol 14: 556-568, 1996.
27. Legrand-Poels S, Maniglia S, Boelaert JR, and Piette J. Activation of transcription factor NF-κB in lipopolysaccharide-stimulated U937 cells. Biochem Pharmacol 53: 339-346, 1997.
28. Li J-J, Westergaard C, Ghosh P, and Colburn NH. Inhibitors of both nuclear factor-κB and activator protein-1 activation block the neoplastic transformation response. Cancer Res 57: 3569-3576, 1997.
29. Liu SL, Adcock IM, Old RW, Barnes PJ, and Evans TE. Lipopolysaccharide treatment in vivo induces widespread tissue expression of inducible nitric oxide synthase mRNA. Biochem Biophys Res Commun 196: 1208-1213, 1993.
30. Lohmann-Matthes M-L, Steimüller C, and Franke-Ullmann G. Pulmonary macrophages. Eur Respir J 7: 1678-1689, 1994.
31. Moncada S, Palmer RMJ, and Higgs EA. Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol Rev 43: 109-141, 1991.
32. Motterlini R, Foresti R, Intaglietta M, and Winslow RM. NO-mediated activation of heme oxygenase: endogenous cytoprotection against oxidative stress to endothelium. Am J Physiol Heart Circ Physiol 270: H107-H114, 1996.
33. Numata M, Suzuki S, Miyazawa N, Miyashita A, Nagashima Y, Inoue S, Kaneko T, and Okubo T. Inhibition of inducible nitric oxide synthase prevents LPS-induced acute lung injury in dogs. J Immunol 160: 3031-3037, 1998.
34. O'Brien-Ladner AR, Nelson ME, Cowley BD Jr, Bailey K, and Wesselius LJ. Hyperoxia amplifies TNF-γ production in LPS-stimulated human alveolar macrophages. Am J Respir Cell Mol Biol 12: 275-279, 1995.
35. Ortolani O, Conti A, De Gaudino AR, Masoni M, and Novelli G. Protective effects of N-acetylcysteine and rutin on the lipid peroxidation of the lung epithelium during the adult respiratory distress syndrome. Shock 13: 14-18, 2000.
36. m for oxygen of nitric oxide synthase isoforms. J Pharmacol Exp Ther 276: 30-33, 1996.
37. Schenk H, Klein M, Erdbrügger W, Droge W, and Schulze-Osthoff K. Distinct effects of thioredoxin and antioxidants on the activation of transcription factors NF-κB and AP-1. Proc Natl Acad Sci USA 91: 1672-1676, 1994.
38. Schreck R, Albermann K, and Baeuerle PA. Nuclear factor κB: an oxidative stress-responsive transcription factor of eukaryotic cells (a review). Free Radic Res Commun 17: 221-237, 1992.
39. Schreck R, Grassmann R, Fleckenstein B, and Baeuerle PA. Antioxidants selectively suppress activation of NF-kappa B by human T-cell leukemia virus I tax protein. J Virol 66: 6288-6293, 1992.
40. Sen CK and Packer L. Antioxidant and redox regulation of gene transcription. FASEB J 10: 709-720, 1996.
41. Sies H. Oxidative stress: oxidants and antioxidants. Exp Physiol 82: 291-295, 1997.
42. Smith PK, Krohn RI, Hermanson GT, Mallia AK, Gartner FH, Provenzano MD, Fujimoto EK, Goeke NM, Olson BJ, and Klenk DC. Measurement of protein using bicinchoninic acid. Anal Biochem 150: 76-85, 1985.
43. Suzuki YJ, Forman HJ, and Sevanian A. Oxidants as stimulators of signal transduction. Free Radic Biol Med 22: 269-285, 1996.
44. Taylor BS, Kim YM, Wang Q, Shapiro RA, Billiar TR, and Geller DA. Nitric oxide down-regulates hepatocyte-inducible nitric oxide synthase gene expression. Arch Surg 132: 1177-1183, 1997.
45. Tracey WR, Xue C, Klinghofer V, Barlow J, Pollock JS, Forstermann U, and Johns RA. Immunochemical detection of inducible NO synthase in human lung. Am J Physiol Lung Cell Mol Physiol 266: L722-L727, 1994.
46. Turnage RH, Wright JK, Iglesias J, LaNoue JL, Nguyen H, Kim L, and Myers S. Intestinal reperfusion-induced pulmonary edema is related to increased pulmonary inducible nitric oxide synthase activity. Surgery 124: 457-462, 1998.
47. Vanden Hoek TL, Li C, Shao Z, Schumacker PT, and Becker LB. Significant levels of oxidants are generated by isolated cardiomyocytes during ischemia prior to reperfusion. J Mol Cell Cardiol 29: 2571-2583, 1997.
48. VanOtteren GM, Standiford TJ, Kunkel SL, Danforth JM, and Strieter RM. Alterations of ambient oxygen tension modulate the expression of tumor necrosis factor and macrophage inflammatory protein-1 alpha from murine alveolar macrophages. Am J Respir Cell Mol Biol 13: 399-409, 1995.
49. Vermes I, Haanen C, Steffens-Nakken H, and Reutelingsperger C. A novel assay for apoptosis. Flow cytometer detection of phosphatidylserine expression on early apoptotic cells using fluorescein labeled annexin V. J Immunol Methods 184: 39-51, 1995.
50. Xie Q-W, Whisnant R, and Nathan C. Promoter of the mouse gene encoding calcium-independent nitric oxide synthase confers inducibility by interferon γ and bacterial lipopolysaccharide. J Exp Med 177: 1779-1784, 1993.