Silencing of the gene for the α-subunit of human chorionic gonadotropin by the embryonic transcription factor Oct-3/4

Molecular Endocrinology

Volumn 11, Issue 11, 1997, Pages 1651-1658

  Liu, Limin ^a,b   Leaman, Douglas ^a,c   Villalta, Michel ^a,d   Roberts, R Michael ^a  

^a UNIVERSITY OF MISSOURI   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

^c LERNER RESEARCH INSTITUTE   (United States)

^d Servicio de Investigaci   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CHORIONIC GONADOTROPIN ALPHA SUBUNIT; CYCLIC AMP; MESSENGER RNA; TRANSCRIPTION FACTOR;

ARTICLE; BINDING SITE; CHORIOCARCINOMA; CONTROLLED STUDY; DNA FOOTPRINTING; ELECTROPHORETIC MOBILITY; EMBRYO; HUMAN; HUMAN CELL; METHYLATION; PRIORITY JOURNAL; PROMOTER REGION; REPORTER GENE; SILENT GENE; SITE DIRECTED MUTAGENESIS; TRANSCRIPTION REGULATION; TROPHOBLAST;

BASE SEQUENCE; BINDING SITES; CHORIOCARCINOMA; CHORIONIC GONADOTROPIN, BETA SUBUNIT, HUMAN; CONSENSUS SEQUENCE; DNA FOOTPRINTING; DNA-BINDING PROTEINS; FEMALE; FETAL PROTEINS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE EXPRESSION REGULATION, NEOPLASTIC; GLYCOPROTEIN HORMONES, ALPHA SUBUNIT; HOMEODOMAIN PROTEINS; HOST CELL FACTOR C1; HUMANS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; NEOPLASM PROTEINS; OCTAMER TRANSCRIPTION FACTOR-1; OCTAMER TRANSCRIPTION FACTOR-2; OCTAMER TRANSCRIPTION FACTOR-3; PROMOTER REGIONS (GENETICS); REGULATORY SEQUENCES, NUCLEIC ACID; REPRESSOR PROTEINS; TRANSCRIPTION FACTORS; TRANSFECTION; TUMOR CELLS, CULTURED; UTERINE NEOPLASMS;

EID: 0030752573     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.11.11.1651     Document Type: Article

References (40)

1. Jameson JL, Hollenberg AN 1993 Regulation of chorionic gonadotropin gene expression. Endocr Rev 14:203-219
2. Ogren L, Talamantes F 1994 The placenta as an endocrine organ: polypeptides. In: Knobil E, Neill JD (eds)The Physiology of Reproduction, ed 2. Raven Press Ltd, New York, vol 2:875-945
3. Cole LA, Kroll TG, Ruddon RW, Robert OH 1984 Differential occurrence of free beta and free alpha subunits of human chorionic gonadotropin (hCG) in pregnancy sera. J Clin Endocrinol Metab 58:1200-1202
4. Ozturk M, Bellet D, Manil L, Hennen GM, Frydman G, Wands JR 1987 Physiological studies of human chorionic gonadotropin (hCG) αhCG and βhCG as measured by specific monoclonal immunoradiometric assays. Endocrinology 120:549-558
5. Boothby M, Ruddon RW, Anderson C, McWilliams D, Boime I 1981 A single gonadotropin a-subunit gene in normal tissue and tumor-derived cell lines. J Biol Chem 256:5121-5127
6. Fiddes JC, Goodman HM 1981 The gene encoding the common a subunit of the four human glycoprotein hormones. J Mol Appl Genet 1:3-18
7. Bo M, Boime I 1992 Identification of the transcriptionally active genes of the chorionic gonadotropin β gene cluster in vivo. J Biol Chem 267:3179-3184
8. Silver BJ, Bokar JA, Virgin JB, Vallen EA, Milsted A, Nilson JH 1987 Cyclic AMP regulation of the human glycoprotein hormone alpha-subunit gene is mediated by an 18-base-pair element. Proc Natl Acad Sci USA 84:2198-2202
9. Deutsch PJ, Jameson JL, Habener JF 1987 Cyclic AMP responsiveness of human gonadotropin-α gene transcription is directed by a repeated 18-base pair enhancer. J Biol Chem 262:12169-12174
10. Delegeane AM, Fedand LH, Mellon PL 1987 Tissue-specific enhancer of the human glycoprotein hormone α-subunit gene: dependence on cyclic AMP-inducible elements. Mol Cell Biol 7:3994-4002
11. Jameson JL, Albanese C, Habener JF 1989 Distinct adjacent protein-binding domains in the glycoprotein hormone alpha gene interact independently with a c AMP-responsive enhancer. J Biol Chem 264:16190-16196
12. Jameson JL, Powers AC, Gallagher GD, Habener JF 1989 Enhancer, promoter element interactions dictate cyclic adenosine monophosphate mediated, cell-specific expression of the glycoprotein hormone a-gene. Mol Endocrinol 3:763-772
13. Andersen B, Kennedy GC, Nilson JH 1990 A cis-acting element located between the cAMP response elements and CCAAT box augments cell-specific expression of the glycoprotein hormone alpha subunit gene. J Biol Chem 265:21874-21880
14. Kennedy GC, Andersen B, Nilson JH 1990 The human a subunit glycoprotein hormone gene utilizes a unique CCAAT binding factor. J Biol Chem 265:6279-6285
15. Steger DJ, Altschmied J, Boscher M, Mellon PL 1991 Evolution of placenta-specific gene expression: comparison of the equine and human gonadotropin α-subunit genes. Mol Endocrinol 5:243-255
16. Jameson JL, Lindell CM 1988 Isolation and characterization of the human chorionic gonadotropin βsubunit (CGβ) gene cluster: regulation of a transcriptionally active CGβ gene by cyclic AMP. Mol Cell Biol 8:5100-5107
17. Otani T, Otani F, Krych M, Chaplin DD, Boime I 1988 Identification of a promoter region in the CGβ gene cluster. J Biol Chem 263:7322-7329
18. Steger DJ, Böscher M, Hecht JH, Mellon PL 1993 Coordinate control of the α- and β-subunit genes of human chorionic gonadotropin by trophoblast-specific element-binding protein. Mol Endocrinol 7:1579-1588
19. Pestell RG, Hollenberg AN, Albanese C, Jameson JL (1994) C-Jun represses transcription of the human chorionic gonadotropin a and β genes through distinct types of CR Es. J Biol Chem 269:31090-31096
20. Okamoto K, Okazawa H, Okuda A, Sakai M, Muramatsu M, Hamada H 1990 A novel octamer binding transcription factor is differentially expressed in mouse embryonic cells. Cell 60:461-472
21. Rosner MH, Vigano MA, Ozato K, Timmons PM, Poirier F, Rigby PW, Staudt LM 1990 A POU-domain transcription factor in early stem cells and germ cells of the mammalian embryo. Nature 345:686-692
22. Schöler HR, Dressier GR, Balling R, Rohdewohld H, Gruss P 1990a Oct-4: a germline-specific transcription factor mapping to the mouse t-complex. EMBO J 9:2185-2195
23. Schöler HR, Ruppert S, Suzuki N, Chowhurdy K, Gruss P 1990b A new type of POU domain in germ line-specific protein Oct-4. Nature 344:435-439
24. Palmier SL, Peter W, Hess H, Schöler HR 1994 Oct-4 transcription factor is differentially expressed in the mouse embryo during establishment of the first two extraembryonic cell lineages involved in implantation. Dev Biol 166:259-267
25. Liu L, Roberts RM 1996 Silencing of the gene for the β-subunit of human chorionic gonadotropin by the embryonic transcription factor Oct-3/4. J Biol Chem 271: 16683-16689
26. Pittman RH, Clay CM, Farmerie TA, Nilson JH 1994 Functional analysis of the placenta-specific enhancer of the human glycoprotein hormone a subunit gene. J Biol Chem 269:19360-19368
27. Darnell RB, Boime I 1985 Differential expression of the human gonadotropin alpha gene in ectopic and eutopic cells. Mol Cell Biol 5:3157-3167
28. Jameson JL, Jaffe RC, Deutsch PJ, Albanese C, Habener JF 1988 The gonadotropin α-gene contains multiple protein binding domains that interact to modulate basal and cAMP-responsive transcription. J Biol Chem 263:9879-9886
29. Bokar JA, Keri RA, Farmerie TA, Fenstermaker RA, Andersen B, Hamerink DL, Yun J, Wagner T, Nilson JH 1989 Expression of the glycoprotein hormone alpha-subunit gene in the placenta requires a functional cyclic AMP response element, whereas a different cis-acting element mediates pituitary-specific expression. Mol Cell Biol 9:5113-5122
30. McKnight SL, Gavis ER, Kingsbury R, Axel R 1981 Analysis of transcriptional regulatory signals of the HSV thymidine kinase gene: identification of an upstream control region. Cell 25:385-398
31. Inostroza JA, Mermelstein FH, Ha I, Lane WS, Reinberg D 1992 DrI, a TATA-binding protein-associated phosphoprotein and inhibitor of class II gene transcription. Cell 70:477-489
32. Kim TK, Zhao Y, Ge H, Bernstein R, Roeder RG 1995 TATA-binding protein residues implicated in a functional interplay between negative cofactor NC2 (Dr1) and general factors TFIIA and TFIIB. J Biol Chem 270:10976-10981
33. Meyer TE, Habener JF 1993 Cyclic adenosine 3′,5′-monophate response element binding protein (CREB) and related transcription-activating deoxyribonucleic acid-binding proteins. Endocr Rev 14:269-290
34. Gstaiger M, Knoepfel L, Georgiev O, Schaffner W, Hovens CM 1995 A B-cell coactivator of octamer-binding transcription factors. Nature 373:360-362
35. Strubin M, Newell JW, Matthias P 1995 OBF-1, a novel B cell-specific coactivator that stimulates immunoglobulin promoter activity through association with octamer-binding proteins. Cell 80:497-506
36. Luo Y, Roeder RG 1995 Cloning, functional characterization, and mechanism of action of the B-cell-specific transcriptional coactivator OCA-B. Mol Cell Biol 15:4115-4124
37. Verrijzer CP, Alkema MJ, Van Weperen WW, Van Leeuwen HC, Strating MJJ, van der Vliet PC 1992 The DNA binding specificity of the bipartite POU domain and its subdo-mains. EMBO J 11:4993-5003
38. Tanaka M, Herr W 1990 Differential transcriptional activation by Oct-1 and Oct-2: independent activation domains induce Oct-2 phosphorylation. Cell 60:375-386
39. SAS Institute Inc 1989 SAS/STAT User's Guide, Version 6, ed 4. SAS Institute, Inc., Cary, NC
40. Braunstein GD, Forsythe AB, Rador JL, Van Scoy-Mosher MB, Thompson RW, Wade ME 1979 Serum glycoprotein hormone alpha subunit levels in patients with cancer. Cancer 44:1644-1651