Inhibition of calcineurin activity and protection against cyclosporine A induced cytotoxicity by prednisolone sodium succinate in human peripheral mononuclear cells

Immunopharmacology

Volumn 48, Issue 1, 2000, Pages 87-92

  Sipka, Sándor ^a   Szücs, Kornélia ^a   Szántó, Sándor ^a   Kovács, Ildikó ^a   Lakos, Gabriella ^a   Antal Szalmás, Péter ^a   Szegedi, Gyula ^a   Gergely, Pál ^a  

^a UNIVERSITY OF DEBRECEN   (Hungary)

Author keywords

Arachidonic acid; Calcineurin; Cyclosporin A; Glucocorticosteroid

Indexed keywords

ARACHIDONIC ACID; CALCINEURIN; CYCLOSPORIN A; LACTATE DEHYDROGENASE; PHOSPHOPROTEIN PHOSPHATASE 2A; PREDNISOLONE SODIUM SUCCINATE;

ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; GRAFT REJECTION; HUMAN; HUMAN CELL; INFLAMMATION; NEPHROTOXICITY; PERIPHERAL BLOOD STEM CELL; PRIORITY JOURNAL;

ADULT; ARACHIDONIC ACID; CALCINEURIN; CELL MEMBRANE; CYCLOSPORINE; DRUG INTERACTIONS; FEMALE; HUMANS; L-LACTATE DEHYDROGENASE; MALE; MIDDLE AGED; MONOCYTES; PHOSPHOLIPASES A; PREDNISOLONE;

EID: 0342313540     PISSN: 01623109     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0162-3109(00)00180-6     Document Type: Article

References (28)

1. +-adenosine triphosphatase activity in cultured hamster renal tubular cells. Toxicol. Appl. Pharmacol. 125:1994;176-183.
2. Antoni F.A. Mortyn Jones Memorial Lecture - 1995. Calcium checks cyclic AMP corticosteroid feedback in adenohypophysial corticotrophs. J. Neuroendocrinol. 8:1996;659-672.
3. Barnes P.J. Molecular mechanism of steroid action in asthma. J. Allergy Clin. Immunol. 97:1996;159-168.
4. Batiuk T.D., Kung L., Halloran P.F. Evidence that calcineurin is rate-limiting for primary human lymphocyte activation. J. Clin. Invest. 100:1997;1894-1901.
5. Boyum A. Isolation of mononuclear cells and granulocytes from human blood. J. Clin. Lab. Invest. Suppl. 97:1968;77-108.
6. Buttgereit F., Wehling M., Burgmeister G-R. A new hypothesis of modular glucocorticoid actions. Arthritis Rheum. 41:1998;761-767.
7. Cohen P., Foulkes G., Holmes C.F.B., Nimmo G.A., Tonks N.K. Protein phosphatase inhibitor-1 and inhibitor-2 from rabbit skeletal muscle. Methods Enzymol. 159:1988;427-433.
8. Damjanovich S., Aszalos A., Mulhem S., Szöllösi J., Balázs M., Tron L., Fulwyler M.J. Cyclosporin depolarizes human lymphocytes. Earliest observed effect on cell metabolism. Eur. J. Immunol. 17:1987;763-768.
9. 2 superfamily of signal transduction enzymes. TIBS. 22:1997;1-2.
10. Firestein G.S., Manning A.M. Signal transduction and transcription factors in rheumatic disease. Arthritis Rheum. 42:1999;609-621.
11. Ho S., Clipstone N., Timmermann L., Northtrop J., Graef I., Fiorentino D., Nourse J., Crabtree G.R. The mechanism of action of cyclosporin A and FK506. Clin. Immunol. Immunopathol. 80:1996;S40-S45.
12. Kobayashi T., Okamoto K., Kobata T., Hasunuma T., Sumida T., Nishioka T. Tumor necrosis factor alpha regulation of the FAS-mediated apoptosis-signaling pathway in synovial cells. Arthritis Rheum. 42:1999;519-526.
13. Kurosawa M., Amano H., Kanbe N., Igarashi J., Nagata H., Yamashita T., Kurimoto F., Miyachi Y. Response to cyclosporin and low dose methylprednisolone in aggressive systemic mastocytosis. J. Allergy Clin. Immunol. 103:1999;S412-S420.
14. 2. J. Biol. Chem. 272:1997;16709-16712.
15. 2 is coupled to hormonally regulated release of arachidonic acid. Proc. Natl. Acad. Sci. U. S. A. 89:1992;6147-6151.
16. Misra U.K., Gawdi G., Pizzo S.V. Cyclosporin A inhibits inositol 1,4,5-triphosphate binding to its receptors and release of calcium from intracellular stores in peritoneal macrophages. J. Immunol. 161:1998;6122-6127.
17. 2+ fluxes in isolated hepatocytes. J. Biol. Chem. 260:1985;13613-13618.
18. Paliogianni F., Boumpas D.T. Glucocorticoids regulate calcineurin dependent transactivating pathways for interleukin-2 gene transcription in human T lymphocytes. Transplantation. 59:1995;1333-1339.
19. Parra T., de Arriba G., Conejo J.R., Cantero M., Arribas I., Rodriguez-Puyol D., Rodriguez-Puyol M., Carballo F. Cyclosporine increases local glomerular synthesis of reactive oxygen species in rats. Transplantation. 66:1998;1325-1329.
20. Quien R.M., Kaiser B.A, Dunn S.P., Kulinsky A., Polinsky M., Baluarte H.J., Batiuk T.D., Halloran P.F. Calcineurin activity in children with renal transplants receiving cyclosporin. Transplantation. 64:1997;1486-1489.
21. Redington A.E., Hardinge F.M., Madden J., Holgate S.T., Howarth P.H. Cyclosporin A treatment and airways inflammation in corticosteroid-dependent asthma. Allergy. 53:1998;94-98.
22. Rühlmann A., Nordheim A. Effects of immunosuppressive drugs CsA and FK506 on intracellular signaling and gene regulation. Immunobiology. 198:1997;192-206.
23. Sun L., Youn H.D., Loh C., Stolow M., He W., Liu J.O. Cabin 1, a negativ regulator for calcineurin signaling in T lymphocytes. Immunity. 8:1998;703-711.
24. Szegedi G., Kiss E., Bodolay E., Zeher M., Dankó K., Czirják L., Szücs G., Szekanecz Z., Sipka S. Polysystemic autoimmune diseases - clinical and basic research made in Hungary. Allergy Clin. Immunol. 8:1996;90-93.
25. Thiru S., Maher E.R., Hamilton D.V., Evans D.B., Calne R.Y. Tubular changes in renal transplant recipients on cyclosporin. Transplant. Proc. 15:1983;2846-28451.
26. 2+ level of human lymphoid cell lines and mouse thymocytes. Biochim. Biophys. Acta. 1019:1990;159-165.
27. Yang S.D., Tallant A.N., Cheung W.Y. Calcineurin is a calmodulin-dependent protein phosphatase. Biochem. Biophys. Res. Commun. 4:1982;1419-1423.
28. Zor U., Ferber E., Gergely P., Szücs K., Dombrádi V., Goldman R. Reactive oxygen species mediate phorbol ester-regulated tyrosine phosphorylation and phospholipase A2 activation: potentiation by vanadate. Biochem. J. 295:1993;879-888.