메뉴 건너뛰기




Volumn 47, Issue 4, 2003, Pages 383-390

Ganglioside GM1 binding toxins and human neuropathy-associated IgM antibodies differentially promote neuritogenesis in a PC12 assay

Author keywords

Anti GM1 antibodies; Cholera toxin; Escherichia coli heat labile enterotoxin; GM1 ganglioside; Neuritogenesis; Neuropathy; Neurotrophin receptor; PC12 cells

Indexed keywords

ADENYLATE CYCLASE; CHOLERA TOXIN B SUBUNIT; ESCHERICHIA COLI ENTEROTOXIN; GANGLIOSIDE GM1; IMMUNOGLOBULIN M ANTIBODY; MONOCLONAL ANTIBODY; NERVE GROWTH FACTOR RECEPTOR;

EID: 0242720745     PISSN: 01680102     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-0102(03)00239-6     Document Type: Article
Times cited : (13)

References (47)
  • 2
    • 0028358645 scopus 로고
    • TrkA cross-linking mimics neuronal responses to nerve growth factor
    • Clary D.O., Weskamp G., Austin L.R., Reichardt L.F. TrkA cross-linking mimics neuronal responses to nerve growth factor. Mol. Biol. Cell. 5:1994;549-563.
    • (1994) Mol. Biol. Cell , vol.5 , pp. 549-563
    • Clary, D.O.1    Weskamp, G.2    Austin, L.R.3    Reichardt, L.F.4
  • 3
    • 0035845497 scopus 로고    scopus 로고
    • Partitioning of Thy-1, GM1, and cross-linked phospholipid analogs into lipid rafts reconstituted in supported model membrane monolayers (comment)
    • Dietrich C., Volovyk Z.N., Levi M., Thompson N.L., Jacobson K. Partitioning of Thy-1, GM1, and cross-linked phospholipid analogs into lipid rafts reconstituted in supported model membrane monolayers (comment). Proc. Natl. Acad. Sci. U.S.A. 98:2001;10642-10647.
    • (2001) Proc. Natl. Acad. Sci. U.S.A. , vol.98 , pp. 10642-10647
    • Dietrich, C.1    Volovyk, Z.N.2    Levi, M.3    Thompson, N.L.4    Jacobson, K.5
  • 5
    • 0036316259 scopus 로고    scopus 로고
    • GM1 ganglioside induces phosphorylation and activation of Trk and Erk in brain
    • Duchemin A.M., Ren Q., Mo L., Neff N.H., Hadjiconstantinou M. GM1 ganglioside induces phosphorylation and activation of Trk and Erk in brain. J. Neurochem. 81:2002;696-707.
    • (2002) J. Neurochem. , vol.81 , pp. 696-707
    • Duchemin, A.M.1    Ren, Q.2    Mo, L.3    Neff, N.H.4    Hadjiconstantinou, M.5
  • 6
    • 0030929378 scopus 로고    scopus 로고
    • Ganglioside GM1 enhances induction by nerve growth factor of a putative dimer of TrkA
    • Farooqui T., Franklin T., Pearl D.K., Yates A.J. Ganglioside GM1 enhances induction by nerve growth factor of a putative dimer of TrkA. J. Neurochem. 68:1997;2348-2355.
    • (1997) J. Neurochem. , vol.68 , pp. 2348-2355
    • Farooqui, T.1    Franklin, T.2    Pearl, D.K.3    Yates, A.J.4
  • 7
    • 0028873047 scopus 로고
    • Prevention of apoptotic neuronal death by GM1 ganglioside. Involvement of Trk neurotrophin receptors
    • Ferrari G., Anderson B.L., Stephens R.M., Kaplan D.R., Greene L.A. Prevention of apoptotic neuronal death by GM1 ganglioside. Involvement of Trk neurotrophin receptors. J. Biol. Chem. 270:1995;3074-3080.
    • (1995) J. Biol. Chem. , vol.270 , pp. 3074-3080
    • Ferrari, G.1    Anderson, B.L.2    Stephens, R.M.3    Kaplan, D.R.4    Greene, L.A.5
  • 8
    • 0027489512 scopus 로고
    • Gangliosides as receptors for bacterial endotoxins
    • Fishman P.H., Pacuszka T., Orlandi P.A. Gangliosides as receptors for bacterial endotoxins. Adv. Lipid Res. 25:1993;165-187.
    • (1993) Adv. Lipid Res. , vol.25 , pp. 165-187
    • Fishman, P.H.1    Pacuszka, T.2    Orlandi, P.A.3
  • 9
    • 0027931585 scopus 로고
    • Importance of ADP-ribosylation in the morphological changes of PC12 cells induced by cholera toxin
    • Glineur C., Locht C. Importance of ADP-ribosylation in the morphological changes of PC12 cells induced by cholera toxin. Infect. Immun. 62:1994;4176-4185.
    • (1994) Infect. Immun. , vol.62 , pp. 4176-4185
    • Glineur, C.1    Locht, C.2
  • 10
    • 0019867414 scopus 로고
    • The action of nerve growth factor and dibutyryl adenosine cyclic 3′:5′-monophosphate on rat pheochromocytoma reveals distinct stages in the mechanisms underlying neurite outgrowth
    • Gunning P.W., Letourneau P.C., Landreth G.E., Shooter E.M. The action of nerve growth factor and dibutyryl adenosine cyclic 3′:5′- monophosphate on rat pheochromocytoma reveals distinct stages in the mechanisms underlying neurite outgrowth. J. Neurosci. 1:1981;1085-1095.
    • (1981) J. Neurosci. , vol.1 , pp. 1085-1095
    • Gunning, P.W.1    Letourneau, P.C.2    Landreth, G.E.3    Shooter, E.M.4
  • 12
    • 0003122268 scopus 로고
    • Biogenesis of cholera toxin and related oligomeric enterotoxins
    • Moss, J., Vaughan, M., Igleweski, B., Tu, A. (Eds.), Marcel Dekker, New York
    • Hirst, T.R., 1995. Biogenesis of cholera toxin and related oligomeric enterotoxins. In: Moss, J., Vaughan, M., Igleweski, B., Tu, A. (Eds.), Bacterial Toxins and Virulence Factors in Disease, Marcel Dekker, New York, pp. 123-184.
    • (1995) Bacterial Toxins and Virulence Factors in Disease , pp. 123-184
    • Hirst, T.R.1
  • 13
    • 0036198278 scopus 로고    scopus 로고
    • New insights into the structure-function relationships and therapeutic applications of cholera-like enterotoxins
    • Hirst T.R., Fraser S., Soriani M., Aman A.T., de H.L., Hearn A., Merritt E. New insights into the structure-function relationships and therapeutic applications of cholera-like enterotoxins. Int. J. Med. Microbiol. 291:2002;531-535.
    • (2002) Int. J. Med. Microbiol. , vol.291 , pp. 531-535
    • Hirst, T.R.1    Fraser, S.2    Soriani, M.3    Aman, A.T.4    De, H.L.5    Hearn, A.6    Merritt, E.7
  • 14
    • 0033525118 scopus 로고    scopus 로고
    • Rabbit experimental sensory ataxic neuropathy: Anti-GD1b antibody-mediated trkC downregulation of dorsal root ganglia neurons
    • Hitoshi S., Kusunoki S., Murayama S., Tsuji S., Kanazawa I. Rabbit experimental sensory ataxic neuropathy: anti-GD1b antibody-mediated trkC downregulation of dorsal root ganglia neurons. Neurosci. Lett. 260:1999;157-160.
    • (1999) Neurosci. Lett. , vol.260 , pp. 157-160
    • Hitoshi, S.1    Kusunoki, S.2    Murayama, S.3    Tsuji, S.4    Kanazawa, I.5
  • 15
    • 0019935016 scopus 로고
    • Rabbit intestinal glycoprotein receptor for Escherichia coli heat-labile enterotoxin lacking affinity for cholera toxin
    • Holmgren J., Fredman P., Lindblad M. Rabbit intestinal glycoprotein receptor for Escherichia coli heat-labile enterotoxin lacking affinity for cholera toxin. Infect. Immun. 38:1982;424-433.
    • (1982) Infect. Immun. , vol.38 , pp. 424-433
    • Holmgren, J.1    Fredman, P.2    Lindblad, M.3
  • 16
    • 0021830077 scopus 로고
    • Comparison of receptors for cholera and Escherichia coli enterotoxins in human intestine
    • Holmgren, J., Lindblad, M., Fredman, P., 1985. Comparison of receptors for cholera and Escherichia coli enterotoxins in human intestine. Gastroenterology 89, 27-35.
    • (1985) Gastroenterology , vol.89 , pp. 27-35
    • Holmgren, J.1    Lindblad, M.2    Fredman, P.3
  • 17
    • 0027050178 scopus 로고
    • Nerve growth factor mediates signal transduction through trk homodimer receptors
    • Jing S., Tapley P., Barbacid M. Nerve growth factor mediates signal transduction through trk homodimer receptors. Neuron. 9:1992;1067-1079.
    • (1992) Neuron , vol.9 , pp. 1067-1079
    • Jing, S.1    Tapley, P.2    Barbacid, M.3
  • 18
    • 0032835428 scopus 로고    scopus 로고
    • Degeneration of rabbit sensory neurons induced by passive transfer of anti-GD1b antiserum
    • Kusunoki S., Hitoshi S., Kaida K., Murayama S., Kanazawa I. Degeneration of rabbit sensory neurons induced by passive transfer of anti-GD1b antiserum. Neurosci. Lett. 273:1999;33-36.
    • (1999) Neurosci. Lett. , vol.273 , pp. 33-36
    • Kusunoki, S.1    Hitoshi, S.2    Kaida, K.3    Murayama, S.4    Kanazawa, I.5
  • 19
    • 0030444083 scopus 로고    scopus 로고
    • Cholera toxin B subunit binding to an antigen-presenting cell directly co-stimulates cytokine production from a T cell clone
    • Li T.-K., Fox B.S. Cholera toxin B subunit binding to an antigen-presenting cell directly co-stimulates cytokine production from a T cell clone. Int. Immunol. 8:1996;1849-1856.
    • (1996) Int. Immunol. , vol.8 , pp. 1849-1856
    • Li, T.-K.1    Fox, B.S.2
  • 21
    • 0031041314 scopus 로고    scopus 로고
    • Quantitative analysis of bacterial toxin affinity and specificity for glycolipid receptors by surface plasmon resonance
    • MacKenzie C.R., Hirama T., Lee K.K., Altman E., Young N.M. Quantitative analysis of bacterial toxin affinity and specificity for glycolipid receptors by surface plasmon resonance. J. Biol. Chem. 272:1997;5533-5538.
    • (1997) J. Biol. Chem. , vol.272 , pp. 5533-5538
    • Mackenzie, C.R.1    Hirama, T.2    Lee, K.K.3    Altman, E.4    Young, N.M.5
  • 22
    • 0013797229 scopus 로고
    • Immunochemical quantitation of antigens by single radial immunodiffusion
    • Mancini G., Carbonara A.O., Heremans J.F. Immunochemical quantitation of antigens by single radial immunodiffusion. Immunochemistry. 2:1965;235.
    • (1965) Immunochemistry , vol.2 , pp. 235
    • Mancini, G.1    Carbonara, A.O.2    Heremans, J.F.3
  • 23
    • 0025988670 scopus 로고
    • Interaction of ganglioside GM1 with the B subunit of cholera toxin modulates growth and differentiation of neuroblastoma N18 cells
    • Masco D., Van de Walle M., Spiegel S. Interaction of ganglioside GM1 with the B subunit of cholera toxin modulates growth and differentiation of neuroblastoma N18 cells. J. Neurosci. 11:1991;2443-2452.
    • (1991) J. Neurosci. , vol.11 , pp. 2443-2452
    • Masco, D.1    Van De Walle, M.2    Spiegel, S.3
  • 24
    • 0026451970 scopus 로고
    • Interaction of ganglioside GM1 with the B subunit of cholera toxin modulates intracellular free calcium in sensory neurons
    • Milani D., Minozzi M.-C., Petrelli L., Guidolin D., Spoerri P.E. Interaction of ganglioside GM1 with the B subunit of cholera toxin modulates intracellular free calcium in sensory neurons. J. Neurosci. Res. 33:1992;466-475.
    • (1992) J. Neurosci. Res. , vol.33 , pp. 466-475
    • Milani, D.1    Minozzi, M.-C.2    Petrelli, L.3    Guidolin, D.4    Spoerri, P.E.5
  • 25
    • 0027468733 scopus 로고
    • The effect of the B subunit of cholera toxin on the action of nerve growth factor on PC12 cells
    • Mutoh T., Tokuda A., Guroff G., Fujiki N. The effect of the B subunit of cholera toxin on the action of nerve growth factor on PC12 cells. J. Neurochem. 60:1993;1540-1547.
    • (1993) J. Neurochem. , vol.60 , pp. 1540-1547
    • Mutoh, T.1    Tokuda, A.2    Guroff, G.3    Fujiki, N.4
  • 27
    • 0032475936 scopus 로고    scopus 로고
    • Glucosylceramide synthase inhibitor inhibits the action of nerve growth factor in PC12 cells
    • Mutoh T., Tokuda A., Inokuchi J., Kuriyama M. Glucosylceramide synthase inhibitor inhibits the action of nerve growth factor in PC12 cells. J. Biol. Chem. 273:1998;26001-26007.
    • (1998) J. Biol. Chem. , vol.273 , pp. 26001-26007
    • Mutoh, T.1    Tokuda, A.2    Inokuchi, J.3    Kuriyama, M.4
  • 28
    • 0036694862 scopus 로고    scopus 로고
    • Stable transfection of GM1 synthase gene into GM1-deficient NG108-15 cells, CR-72 cells, rescues the responsiveness of Trk-neurotrophin receptor to its ligand, NGF
    • Mutoh T., Hamano T., Yano S., Koga H., Yamamoto H., Furukawa K., Ledeen R.W. Stable transfection of GM1 synthase gene into GM1-deficient NG108-15 cells, CR-72 cells, rescues the responsiveness of Trk-neurotrophin receptor to its ligand, NGF. Neurochem. Res. 27:2002;801-806.
    • (2002) Neurochem. Res. , vol.27 , pp. 801-806
    • Mutoh, T.1    Hamano, T.2    Yano, S.3    Koga, H.4    Yamamoto, H.5    Furukawa, K.6    Ledeen, R.W.7
  • 29
    • 0030067912 scopus 로고    scopus 로고
    • Anti-GM1 ganglioside antibodies cloned from autoimmune neuropathy patients show diverse binding patterns in the rodent nervous system
    • O'Hanlon G.M., Paterson G.J., Wilson G., Doyle D., McHardie P., Willison H.J. Anti-GM1 ganglioside antibodies cloned from autoimmune neuropathy patients show diverse binding patterns in the rodent nervous system. J. Neuropathol. Exp. Neurol. 55:1996;184-195.
    • (1996) J. Neuropathol. Exp. Neurol. , vol.55 , pp. 184-195
    • O'Hanlon, G.M.1    Paterson, G.J.2    Wilson, G.3    Doyle, D.4    Mchardie, P.5    Willison, H.J.6
  • 30
    • 0031776979 scopus 로고    scopus 로고
    • Mapping immunoreactive epitopes in the human peripheral nervous system using human monoclonal anti-GM1 ganglioside antibodies
    • O'Hanlon G.M., Paterson G.J., Veitch J., Wilson G., Willison H.J. Mapping immunoreactive epitopes in the human peripheral nervous system using human monoclonal anti-GM1 ganglioside antibodies. Acta Neuropathol. 95:1998;605-616.
    • (1998) Acta Neuropathol. , vol.95 , pp. 605-616
    • O'Hanlon, G.M.1    Paterson, G.J.2    Veitch, J.3    Wilson, G.4    Willison, H.J.5
  • 31
    • 0029029954 scopus 로고
    • Analysis of anti-GM1 ganglioside IgM antibodies cloned from motor neuropathy patients demonstrates diverse v-region gene usage with extensive somatic mutation
    • Paterson G., Wilson G., Kennedy P.G.E., Willison H.J. Analysis of anti-GM1 ganglioside IgM antibodies cloned from motor neuropathy patients demonstrates diverse v-region gene usage with extensive somatic mutation. J. Immunol. 155:1995;3049-3059.
    • (1995) J. Immunol. , vol.155 , pp. 3049-3059
    • Paterson, G.1    Wilson, G.2    Kennedy, P.G.E.3    Willison, H.J.4
  • 32
    • 0029047948 scopus 로고
    • GM1 ganglioside activates the high-affinity nerve growth factor receptor trkA
    • Rabin S.J., Mocchetti I. GM1 ganglioside activates the high-affinity nerve growth factor receptor trkA. J. Neurochem. 65:1995;347-354.
    • (1995) J. Neurochem. , vol.65 , pp. 347-354
    • Rabin, S.J.1    Mocchetti, I.2
  • 33
    • 0035132833 scopus 로고    scopus 로고
    • Protective mucosal immunity to ocular herpes simplex virus type 1 infection in mice by using Escherichia coli heat-labile enterotoxin B subunit as an adjuvant
    • Richards C.M., Aman A.T., Hirst T.R., Hill T.J., Williams N.A. Protective mucosal immunity to ocular herpes simplex virus type 1 infection in mice by using Escherichia coli heat-labile enterotoxin B subunit as an adjuvant. J. Virol. 75:2001;1664-1671.
    • (2001) J. Virol. , vol.75 , pp. 1664-1671
    • Richards, C.M.1    Aman, A.T.2    Hirst, T.R.3    Hill, T.J.4    Williams, N.A.5
  • 34
    • 0033548246 scopus 로고    scopus 로고
    • Structural basis for the differential toxicity of cholera toxin and Escherichia coli heat-labile enterotoxin: Construction of hybrid toxins identifies the A2-domain as the determinant of differential toxicity
    • Rodighiero C., Aman A.T., Kenny M.J., Moss J., Lencer W.I., Hirst T.R. Structural basis for the differential toxicity of cholera toxin and Escherichia coli heat-labile enterotoxin: construction of hybrid toxins identifies the A2-domain as the determinant of differential toxicity. J. Biol. Chem. 274:1999;3962-3969.
    • (1999) J. Biol. Chem. , vol.274 , pp. 3962-3969
    • Rodighiero, C.1    Aman, A.T.2    Kenny, M.J.3    Moss, J.4    Lencer, W.I.5    Hirst, T.R.6
  • 35
    • 0030949124 scopus 로고    scopus 로고
    • Functional rafts in cell membranes
    • Simons K., Ikonen E. Functional rafts in cell membranes. Nature. 387:1997;569-572.
    • (1997) Nature , vol.387 , pp. 569-572
    • Simons, K.1    Ikonen, E.2
  • 36
    • 0024285585 scopus 로고
    • Insertion of ganglioside GM1 into rat glioma C6 cells renders them susceptible to growth inhibition by the B subunit of cholera toxin
    • Spiegel S. Insertion of ganglioside GM1 into rat glioma C6 cells renders them susceptible to growth inhibition by the B subunit of cholera toxin. Biochim. Biophys. Acta Ser. Mol. Cell. Res. 969:1988;249-256.
    • (1988) Biochim. Biophys. Acta Ser. Mol. Cell. Res. , vol.969 , pp. 249-256
    • Spiegel, S.1
  • 37
    • 0025238467 scopus 로고
    • Cautionary note on the use of the B subunit of cholera toxin as a ganglioside GM1 probe: Detection of cholera toxin A subunit in B subunit preparations by a sensitive adenylate cyclase assay
    • Spiegel S. Cautionary note on the use of the B subunit of cholera toxin as a ganglioside GM1 probe: detection of cholera toxin A subunit in B subunit preparations by a sensitive adenylate cyclase assay. J. Cell. Biochem. 42:1990;143-152.
    • (1990) J. Cell. Biochem. , vol.42 , pp. 143-152
    • Spiegel, S.1
  • 38
    • 0022377772 scopus 로고
    • Direct evidence that endogenous GM1 ganglioside can mediate thymocyte proliferation
    • Spiegel, S., Fishman, P.H., Weber, R.J., 1985. Direct evidence that endogenous GM1 ganglioside can mediate thymocyte proliferation. Science 230, 1285-1287.
    • (1985) Science , vol.230 , pp. 1285-1287
    • Spiegel, S.1    Fishman, P.H.2    Weber, R.J.3
  • 39
    • 0028558414 scopus 로고
    • Comparison of the glycolipid-binding specificities of cholera toxin and porcine Escherichia coli heat-labile enterotoxin: Identification of a receptor-active non-ganglioside glycolipid for the heat-labile toxin in infant rabbit small intestine
    • Teneberg S., Hirst T.R., Angstrom J., Karlsson K.-A. Comparison of the glycolipid-binding specificities of cholera toxin and porcine Escherichia coli heat-labile enterotoxin: identification of a receptor-active non-ganglioside glycolipid for the heat-labile toxin in infant rabbit small intestine. Glycoconj. J. 11:1994;533-540.
    • (1994) Glycoconj. J. , vol.11 , pp. 533-540
    • Teneberg, S.1    Hirst, T.R.2    Angstrom, J.3    Karlsson, K.-A.4
  • 40
    • 0035082123 scopus 로고    scopus 로고
    • Segregation of gangliosides GM1 and GD3 on cell membranes, isolated membrane rafts, and defined supported lipid monolayers
    • Vyas K.A., Patel H.V., Vyas A.A., Schnaar R.L. Segregation of gangliosides GM1 and GD3 on cell membranes, isolated membrane rafts, and defined supported lipid monolayers. Biol. Chem. 382:2001;241-250.
    • (2001) Biol. Chem. , vol.382 , pp. 241-250
    • Vyas, K.A.1    Patel, H.V.2    Vyas, A.A.3    Schnaar, R.L.4
  • 41
    • 0033083188 scopus 로고    scopus 로고
    • Immune modulation by the cholera-like enterotoxins: From adjuvant to therapeutic
    • Williams N.A., Hirst T.R., Nashar T.O. Immune modulation by the cholera-like enterotoxins: from adjuvant to therapeutic. Immunol. Today. 20:1999;95-101.
    • (1999) Immunol. Today , vol.20 , pp. 95-101
    • Williams, N.A.1    Hirst, T.R.2    Nashar, T.O.3
  • 42
    • 0036895610 scopus 로고    scopus 로고
    • Peripheral neuropathies and anti-glycolipid antibodies
    • Willison H.J., Yuki N. Peripheral neuropathies and anti-glycolipid antibodies. Brain. 125:2002;1-35.
    • (2002) Brain , vol.125 , pp. 1-35
    • Willison, H.J.1    Yuki, N.2
  • 44
    • 0028316540 scopus 로고
    • Cloning of human anti-GM1 antibodies from motor neuropathy patients
    • Willison H.J., Paterson G., Kennedy P.G.E., Veitch J. Cloning of human anti-GM1 antibodies from motor neuropathy patients. Ann. Neurol. 35:1994;471-478.
    • (1994) Ann. Neurol. , vol.35 , pp. 471-478
    • Willison, H.J.1    Paterson, G.2    Kennedy, P.G.E.3    Veitch, J.4
  • 45
    • 0029983215 scopus 로고    scopus 로고
    • A somatically mutated human antiganglioside IgM antibody that induces experimental neuropathy in mice is encoded by the variable region heavy chain gene, V1-18
    • Willison H.J., O'Hanlon G.M., Paterson G., Veitch J., Wilson G., Roberts M., Tang T., Vincent A. A somatically mutated human antiganglioside IgM antibody that induces experimental neuropathy in mice is encoded by the variable region heavy chain gene, V1-18. J. Clin. Invest. 97:1996;1155-1164.
    • (1996) J. Clin. Invest. , vol.97 , pp. 1155-1164
    • Willison, H.J.1    O'Hanlon, G.M.2    Paterson, G.3    Veitch, J.4    Wilson, G.5    Roberts, M.6    Tang, T.7    Vincent, A.8
  • 46
    • 0028286055 scopus 로고
    • Inhibition of neurite outgrowth of neuroblastoma Neuro-2a cells by cholera toxin B-subunit and anti-GM1 antibody
    • Wu G., Nakamura K., Ledeen R.W. Inhibition of neurite outgrowth of neuroblastoma Neuro-2a cells by cholera toxin B-subunit and anti-GM1 antibody. Mol. Chem. Neuropathol. 21:1994;259-271.
    • (1994) Mol. Chem. Neuropathol. , vol.21 , pp. 259-271
    • Wu, G.1    Nakamura, K.2    Ledeen, R.W.3
  • 47
    • 0029913460 scopus 로고    scopus 로고
    • Trophic effect of cholera toxin B subunit in cultured cerebellar granule neurons: Modulation of intracellular calcium by GM1 ganglioside
    • Wu G., Lu Z.-H., Nakamura K., Spray D.C., Ledeen R.W. Trophic effect of cholera toxin B subunit in cultured cerebellar granule neurons: modulation of intracellular calcium by GM1 ganglioside. J. Neurosci. Res. 44:1996;243-254.
    • (1996) J. Neurosci. Res. , vol.44 , pp. 243-254
    • Wu, G.1    Lu, Z.-H.2    Nakamura, K.3    Spray, D.C.4    Ledeen, R.W.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.