Helicobacter pylori and Coronary Heart Disease: Which Directions for Future Studies?

Critical Reviews in Microbiology

Volumn 29, Issue 4, 2003, Pages 351-359

  Pellicano, Rinaldo ^a,d   Fagoonee, Sharmila ^b   Rizzetto, Mario ^a   Ponzetto, Antonio ^c  

^a MOLINETTE HOSPITAL   (Italy)

^b UNIVERSITY OF TURIN   (Italy)

^c UNIVERSITY OF TURIN   (Italy)

^d UOADU Gastro Hepatology   (Italy)

Author keywords

Coronary heart disease; Helicobacter pylori; Myocardial infarction

Indexed keywords

BACTERIAL INFECTION; CORONARY RISK; DISEASE ASSOCIATION; ENVIRONMENTAL FACTOR; FUTUROLOGY; HEART INFARCTION; HELICOBACTER PYLORI; HUMAN; ISCHEMIC HEART DISEASE; MUCOSA ASSOCIATED LYMPHOID TISSUE LYMPHOMA; PATHOGENESIS; PRIORITY JOURNAL; PROSPECTIVE STUDY; REVIEW; SEROPREVALENCE;

ANIMALIA; BACTERIA (MICROORGANISMS); HELICOBACTER; HELICOBACTER PYLORI;

EID: 0242608390     PISSN: 1040841X     EISSN: None     Source Type: Journal    
DOI: 10.1080/713608015     Document Type: Review

References (72)

1. Murray, C.J.L. and Lopez, A.D., Mortality by cause for eight regions of the world: Global Burden of Disease Study, Lancet 349, 1269-1276, 1997.
2. Jousilahti, P., Vartiainen, E., Tuomilehto, J., Pekkanen, J., and Puska, P., Role of known risk factors in explaining the difference in the risk of coronary heart disease between eastern and southwestern Finland, Ann. Med. 30, 481-487, 1998.
3. Bainton, D., Jones, G.R., and Hole, D., Influenza and ischaemic heart disease - a possible trigger for acute myocardial infarction? Int. J. Epidemiol. 7, 231-239, 1978.
4. Mattila, K.J., Nieminen, M.S., Valtonen, V.V., Rasi, V.P., Kesäniemi, Y.A., Syrjälä, S.L., Jungell, P.S., Isoluoma, M., Hietaniemi, K., Jokinen, M.J., and Huttunen, J.K., Association between dental health and acute myocardial infarction, BMJ 298, 779-781, 1989.
5. Danesh, J., Collins, R., and Peto, R., Chronic infections and coronary heart disease: Is there a link? Lancet 350, 430-436, 1997.
6. Hopkins, R.J., Girardi, L.S., and Turney, E.A., Relationship between Helicobacter pylori eradication and reduced duodenal and gastric ulcer recurrence: A review, Gastroenterology 110, 1244-1252, 1996.
7. Uemura, N., Okamoto, S., Yamamoto, S., Matsumura, N., Yamaguchi, S., Yamakido, M., Taniyama, K., Sasako, N., and Schlemper, R.J., Helicobacter pylori infection and the development of gastric cancer, N. Engl. J. Med. 345, 784-789, 2001.
8. Parsonnet, J., Hansen, S., Rodriguez, L., Gelb, A.B., Warnke, R.A., Jellum, E., Orentreich, N., Vogelman, J.H., and Friedman, G.D., Helicobacter pylori infection and gastric lymphoma, N. Engl. J. Med. 330, 1267-1271, 1994.
9. Cremonini, F., Canducci, F., Gabrielli, M., Di Caro, S., Santarelli, L., Nista, E.C., Lupascu, A., Gasbarrini, G., and Gasbarrini, A., Helicobacter pylori : A culprit in extraintestinal diseases? Min Gastroenterol Dietol 47, 129-135, 2001.
10. Mendall, M.A., Goggin, P.M., Molineaux, N., Levy, J., Toosy, T., Strachan, D., Camm, A.J., and Northfield, T.C., Relation of Helicobacter pylori infection and coronary heart disease, Br. Heart J. 11, 437-439, 1994.
11. Pellicano, R., Rizzetto, M., and Ponzetto, A., Helicobacter pylori infection and coronary heart disease. A continuously debated question, Panminerva Med. 43, 139-140, 2001.
12. Pellicano, R., Mladenova, I., Broutet, N., Salmi, L.R., and Mégraud, F., Is there an association between Helicobacter pylori infection and coronary heart disease, Eur. J. Epidemiol. 15, 611-619, 1999.
13. Lilinfield, A.M. and Lilinfield, D.E., Foudations of Epidemiology. Oxford University Press, New York 1980.
14. Hill, B.A., The environment and disease: Association or causation, Proc. R. Soc. Med. 58, 295-300, 1965.
15. Banatvala, N., Mayo, K., Megraud, F., Jennings, R., Deeks, J.J., and Feldman, R.A., The cohort effect and Helicobacter pylori, J. Infect. Dis. 168, 219-221, 1993.
16. Danesh, J., Coronary heart disease, Helicobacter pylori, dental disease, Chlamydia pneumoniae, and cytomegalovirus: Meta-analyses of prospective studies, Am. Heart J. 138, S434-S437, 1999.
17. Strachan, D.P., Mendall, M.A., Carrington, D., Butland, B.K., Yarnell, J.W.G., Sweetnam, P.M., and Elwood, P.C., Relation of Helicobacter pylori infection to 13-year mortality and incident ischemic heart disease in the Caerphilly Prospective Heart Disease Study, Circulation 98, 1286-1290, 1998.
18. Folsom, A.R., Nieto, F.J., Sorlie, P., Chambless, L.E., and Graham, D.Y., for the Atherosclerosis Risk in Communities (ARIC) Study Investigators, Helicobacter pylori seropositivity and coronary heart disease incidence, Circulation 98, 845-850, 1998.
19. Zhu, J., Quyyumi, A.A., Muhlestein, J.B., Nieto, F.J., Home, B.D., Zalles-Ganley, A., Anderson, J.L., and Epstein, S.E., Lack of association of Helicobacter pylori infection with coronary artery disease and frequency of acute myocardial infection or death, Am. J. Cardiol. 89, 155-158, 2002.
20. Rupprecht, H.J., Blankenberg, S., Bickel, C., Rippin, G., Hafner, G., Prellwitz, W., Schlumberger, W., and Meyer, J., Impact of viral and bacterial infectious burden on long-term prognosis in patients with coronary artery disease, Circulation 104, 25-31, 2001.
21. Carlsson, J., Miketic, S., Brom, J., Ross, R., Bachmann, H., and Tebbe, U., Prior cytomegalovirus, Chlamydia pneumoniae or Helicobacter pylori infection and the risk of restenosis after percutaneous transluminal coronary angioplasty, Int. J. Cardiol. 73, 165-171, 2000.
22. Haider, A.W., Wilson, P.W., Larson, M.G., Evans, J.C., Michelson, E.L., Wolf, P.A., O'Donnell, C.J., and Levy, D., The association of seropositivity to Helicobacter pylori, Chlamydia pneumoniae, and cytomegalovirus with risk of cardiovascular disease. A prospective study, J. Am. Coll. Cardiol. 40, 1408-1413, 2002
23. Koenig, W., Rothenbacher, D., Hoffmeister, A., Miller, M., Bode, G., Adler, G., Hombach, V., März, W., Pepys, M.B., and Brenner, H., Infection with Helicobacter pylori is not a major independent risk factor for stable coronary heart disease, Circulation 100, 2326-2331, 1999.
24. Pellicano, R., Oliaro, E., Gandolfo, N., Aruta, E., Mangiardi, L., Orzan, F., Bergerone, S., Rizzetto, M., and Ponzetto, A., Ischemic cardiovascular disease and Helicobacter pylori. Where is the link? J. Cardiovasc. Surg. 41, 829-833, 2000.
25. Kahan, T., Lundman, P., Olsson, G., and Wendt, M., Greater than normal prevalence of seropositivity for Helicobacter pylori among patients who have suffered myocardial infarction, Coron Artery Dis. 11, 523-526, 2000.
26. Pellicano, R., Mazzarello, M.G., Morelloni, S., Allegri, M., Arena, V., Ferrari, M., Rizzetto, M., and Ponzetto, A., Acute myocardial infarction and Helicobacter pylori seropositivity, Int. J. Clin. Lab. Res. 29, 141-144, 1999.
27. Hara, K., Morita, Y., Kamihata, H., Iwasaka, T., and Takahashi, H., Evidence for infection with Helicobacter pylori in patients with acute myocardial infarction, Clin Chim Acta 313, 87-94, 2001.
28. Danesh, J., Youngman, L., Clark, S., Parish, S., Peto, R., and Collins, R., Helicobacter pylori infection and early onset myocardial infarction: Case-control and sibling pairs study. BMJ 319, 1157-1162, 1999.
29. Regnström, J., Jovinge, S., Båvenholm, P., Ericsson, C.G., De Faire, U., Hamsten, A., Hellenius, M-L., Nilsson, J., and Tornvall, P., Helicobacter pylori seropositivity is not associated with inflammatory parameters, lipid concentrations and degree of coronary artery disease, J. Intern. Med. 243, 109-113, 1998.
30. Working Party of the European Helicobacter pylori Study Group. Guidelines for clinical trials in Helicobacter pylori infection, Gut 41(2), S1-S23, 1997.
31. Pasceri, V., Cammarota, G., Patti, G., Cuoco, L., Gasbarrini, A., Grillo, R.L., Fedeli, G., Gasbarrini, G., and Maseri, A., Association of virulent Helicobacter pylori strains with ischemic heart disease, Circulation 97, 1675-1679, 1998.
32. Gunn, M., Stephens, J.C., Thompson, J.R., Rathbone, B.J., and Samani, N.J., Significant association of cagA positive Helicobacter pylori strains with risk of premature myocardial infarction, Heart 84, 267-271, 2000.
33. Singh, R.K., McMahon, A.D., Patel, H., Packard, C.J., Rathbone, B.J., and Samani, N.J., for the West of Scotland Coronary Prevention Group. Prospective analysis of the association of infection with CagA bearing strains of Helicobacter pylori and coronary heart disease, Heart 88, 43-46, 2002.
34. Figura, N., Palazzuoli, A., Faglia, S., Lenzi, C., Borrello, F., Palazzuoli, V., Nami, R., Dal Canto, N., De Regis, F., Vaira, D., Gennari, L., Giordano, N., and Gennari, C., Infection by CagA-positive Helicobacter pylori strains in patients with ischemic heart disease. Prevalence and association with exercise-induced electrocardiographic abnormalities, Dig. Dis. Sci. 47, 831-836, 2002.
35. Whincup, P., Danesh, J., Walker, M., Lennon, L., Thomson, A., Appleby, P., Hawkey, C., and Atherton, J., Prospective study of potentially virulent strains of Helicobacter pylori and coronary heart disease in middle-aged men, Circulation 101, 1647-1652, 2000.
36. Murray, L.J., Bamford, K.B., Kee, F., McMaster, D., Cambien, F., Dallongeville, J., and Evans, A., Infection with Helicobacter pylori virulent strains is not associated with ischaemic heart disease: Evidence from a population-based case-control study of myocardial infarction, Atherosclerosis 149, 379-385, 2000.
37. Stone, A.F., Risley, P., Markus, H.S., Butland, B.K., Strachan, D.P., Elwood, P.C., and Mendall, M.A., Ischaemic heart disease and CagA strains of Helicobacter pylori in the Caerphilly Heart Disease study, Heart 86, 506-509, 2001.
38. Ridker, P.M., Danesh, J., Youngman, L., Collins, R., Stampfer, M.J., and Peto, R., A prospective study of Helicobacter pylori seropositivity and myocardial infarction among socioeconomically similar U.S. men, Ann. Intern. Med. 135, 184-188, 2001.
39. Braunwald, E., Antman, E.M., Beasley, J.W., Califf, R.M., Cheitlin, M.D., Hochman, J.S., Jones, R.H., Kereiakes, D., Kupersmith, J., Levin, T.N., Pepine, C.J., Dchaeffer, J.W., Smith III, EE., Steward, D.E., and Théroux, P., ACC/AHA 2002 Guideline update for the management of patients with unstable angina and Non-ST-segment elevation myocardial infarction. A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on the Management of patients with unstable angina). ACC 2002; http://www.acc.org/clinical guidelines/ unstable/unstable.pdf
40. American College of Cardiology. Key data elements and definitions for measuring the clinical mangement and outcomes of patients with acute coronary syndromes. A Report of the American College of Cardiology Task Force on Clinical Data Standards (Acute Coronary Syndromes Writing Committee), JACC 38, 2114-2130, 2001.
41. Garfunkel, E., Bozovich, G., Daroca, A., Beck, E., and Mautner, B., Randomised trial of roxithromycin in non-Q-wave coronary syndromes: ROXIS pilot study, Lancet 350, 404-407, 1997.
42. Gupta, S., Leatham, E.W., Carrington, D., Mendall, M.A., Kaski, J.C., and Camm, J., Elevated Chlamydia pneumoniae antibodies, cardiovascular events, and azithromycin in male survivors of myocardial infarction, Circulation 96, 404-407, 1997.
43. Stone, A.F.M., Mendall, M.A., Kaski, J., Edger, T.M., Risley, P., Poloniecki, J., Camm, J., and Northfield, T.C., Effect of treatment for Chlamydia pneumoniae and Helicobacter pylori on markers of inflammation and cardiac events in patients with acute coronary syndromes. South Thames trial of antibiotics in myocardial infarction and unstable angina (STAMINA), Circulation 106, 1219-1223, 2002.
44. Farsak, B., Yildirir, A., Akyon, Y., Pinar, A., Oc, M., Boke, E., Kes, S., and Tokgozoglu, L., Detection of Chlamydia pneumoniae and Helicobacter pylori DNA in human atherosclerotic plaques by PCR, J. Clin. Microbiol. 38, 4408-4411, 2000.
45. Espinola-Klein, C., Rupprecht, H.J., Blankenberg, S., Bickel, C., Kopp, H., Rippin, G., Victor, A., Hafner, G., Schlumberger, W., and Meyer, J., Impact of infectious burden on extent and long-term prognosis of atherosclerosis, Circulation 105, 15-21, 2002.
46. Ossei-Gerning, N., Moayyedi, P., Smith, S., Braunholtz, D., Wilson, J.I., Axon, A.T.R., and Grant, P.J., Helicobacter pylori infection is related to atheroma in patients undergoing coronary angiography, Cardiovasc Research 35, 120-124, 1997.
47. Markus, H.S. and Mendall, M.A., Helicobacter pylori infection: A risk factor for ischaemic cerebrovascular disease and carotid atheroma, J Neurol Neurosurg Psychiatry 64, 104-107, 1998.
48. Niemelä, S., Karttunen, T., Korhonen, T., Läärä, E., Karttunen, R., Ikäheimo, M., and Kesäniemi, Y.A., Could Helicobacter pylori infection increase the risk of coronary heart disease by modifying serum lipid concentrations? Heart 75, 573-575, 1996.
49. Hoffmeister, A., Rothenbacher, D., Bode, G., Persson, K., Marz, W., Nauck, M.A., Brenner, H., Hombach, V., and Koenig, W., Current infection with Helicobacter pylori, but not seropositivity to Chlamydia pneumoniae or Cytomegalovirus, is associated with an atherogenic, modified profile, Arterioscler Thromb. Vasc. Biol. 21, 427-432, 2001.
50. Laurila, A., Bloigu, A., Näyhä, S., Hassi, J., Leinonen, M., and Saikku, P., Association of Helicobacter pylori infection with elevated serum lipids, Atherosclerosis 142, 207-210, 1999.
51. Parente, F., Maconi, G., Imbesi, V., Sangaletti, O., Poggio, M., Rossi, E., Duca, P., and Bianchi Porro, G., Helicobacter pylori infection and coagulation in healthy people, BMJ 314, 1318-1319, 1997.
52. Prasad, A., Zhu, J., Halcox, J.P.J., Waclawiw, M.A., Epstein, S.E., and Quyyumi, A.A., Predisposition to atherosclerosis by infections. Role of endothelial dysfunction, Circulation 106, 184-190, 2002.
53. Mach, F., Sukhova, G.K., Michetti, M., Libby, P., and Michetti, P., Influence of Helicobacter pylori infection during atherogenesis in vivo in mice, Circ. Res. 90, E1-E4, 2002.
54. Crabtree, J.E., Shallcross, T.M., Heatley, R.V., and Wyatt, J.I., Mucosal tumor necrosis factor α and interleukin in patients with Helicobacter pylori associated gastritis, Gut 32, 1473-1477, 1991.
55. Patel, P., Mendall, M.A., Carrington, D., Strachan, D.P., Leatham, E., Molineaux, N., Levy, J., Blakeston, C., Seymour, C.A., Camm, A.J., and Northfield, T.C., Association of Helicobacter pylori and Chlamydia pneumoniae infections with coronary heart disease and cardiovascular risk factors, BMJ 311, 711-714, 1995.
56. Zito, F., Di Castelnuovo, A., D'Orazio, A., Negrini, R., De Lucia, D., Donati, M.B., and Iacoviello, L., Helicobacter pylori infection and the risk of myocardial infarction: Role of fibrinogen and its genetic control, Thromb Haemost 82, 14-18, 1999.
57. Parente, F., Imbesi, V., Cucino, C., MacOni, G., Russo, U., Duca, P.G., and Bianchi Porro, G., Helicobacter pylori CagA seropositivity does not influence inflammatory parameters, lipid concentrations and haemostatic factors in healthy individuals. J. Intern. Med. 247, 213-217, 2000.
58. Torgano, G., Cosentini, R., Mandelli, C., Perondi, R., Blasi, F., Bertinieri, G., Van Tien, T., Ceriani, G., Tarsia, P., Arosio, C., and Ranzi, M.L., Treatment of Helicobacter pylori and Chlamydia pneumoniae infections decreases fibrinogen plasma level in patients with ischemic heart disease, Circulation 99, 1555-1559, 1999.
59. Danesh, J. and Peto, R., Risk factors for coronary heart disease and infection with Helicobacter pylori: Meta-analysis of 18 studies, BMJ 316, 1130-1132, 1998.
60. Danesh, J., Whincup, P., Walker, M., Lennon, L., Thomson, A., Appleby, P., Gallimore, J.R., and Pepys, M.B., Low grade inflammation and coronary heart disease: Prospective study and updated meta-analyses. BMJ 321, 199-204, 2000.
61. Brenner, H., Berg, G., Fröhlich, M., Boeing, H., and Koenig, W., Chronic infection with Helicobacter pylori does not provoke major systemic inflammation in healthy adults: Results from a large population-based study, Atherosclerosis 147, 399-403, 1999.
62. Elizalde, J.I., Gomez, J., Panes, J., Lozano, M., Casadevall, M., Ramirez, J., Pizcueta, P., Marco, F., Diaz de Rojas, F., Granger, D.N., and Piqué, J.M., Platelet activation in mice and human Helicobacter pylori infection, J. Clin. Invest. 100, 996-1005, 1997.
63. Aguejouf, O., Mayo, K., Malfatti, E., Doutremepuich, C., and Mégraud, F., Arterial thrombosis and chronic Helicobacter pylori infection in mice, Gut 43(Suppl 2), A104. (abstr), 1998.
64. Kalia, N., Bardhan, K.D., Reed, M.W., Jacob, S., and Brown, N.J., Effects of chronic administration of Helicobacter pylori extracts on rat gastric mucosal microcirculation in vivo, Dig. Dis. Sci. 45, 1343-1351, 2000.
65. Harvey, R., Lane, A., Murray, L., Harvey, I., Nair, P., and Donovan, J., Effect of Helicobacter pylori infection on blood pressure: A community based cross sectional study, BMJ 323, 264-265, 2001.
66. Appelmelk, B.J., Simons-Smit, I., Negrini, R., Moran, A.P., Aspinall, G.O., Forte, J.G., De Vries, T., Quan, H., Verboom, T., Maaskant, J.J., Ghiara, P., Kuipers, E.J., Bloemena, E., Tadema, T.M., Townsend, R.R., Tyagarajan, K., Gothers, J.M. jr., Monteiro, M.A., Savio, A., and De Graaf, J., Potential role of molecular mimicry between Helicobacter pylori lipopolysaccharides and host Lewis blood group antigens in autoimmunity, Infect. Immun. 64, 2031-2040, 1996.
67. Birnie, D.H., Holme, E.R., McKay, I.C., Hood, S., McColl, K.E., and Hillis, W.S., Association between antibodies to heat shock protein 65 and coronary atherosclerosis. Possible mechanism of action of Helicobacter pylori and other bacterial infections in increasing cardiovascular risk, Eur. Heart J. 19, 387-394, 1998.
68. Rothenbacker, D., Hoffmeister, A., Bode, G., Miller, M., Koenig, W., and Brenner, H., Helicobacter pylori heat shock protein 60 and risk of coronary heart disease: A case-control study with focus on markers of systemic inflammation and lipids, Atherosclerosis 156, 193-199, 2001.
69. Prohászka, Z., Duba, J., Horváth, L., Császar, A., Karádi, I., Szebeni, A., Singh, M., Fekete, B., Romics, L., and Füst, G., Comparative study on antibodies to human and bacterial 60 kDa heat shock proteins in a large cohort of patients with coronary heart disease and healthy subjects, Eur. J. Clin. Invest. 31, 285-292, 2001.
70. Franceschi, F., Sepulveda, A.R., Gasbarrini, A., Pola, P., Gentiloni Silveri, N., Gasbarrini, G., Graham, D.Y., and Genta, R.M., Cross-reactivity of anti-CagA antibodies with vascular wall antigens. Possible pathogenic link between Helicobacter pylori infection and atherosclerosis, Circulation 106, 430-434, 2002.
71. Sung, J.J.K. and Sanderson, J.E., Hyperhomocysteinaemia, Helicobacter pylori and coronary heart disease, Heart 76, 305-307, 1996.
72. Tamura, A., Fujioka, T., and Nasu, M., Relation of Helicobacter pylori infection to plasma vitamin B12, folic acid and homocysteine levels in patients who underwent diagnostic coronary arteriography, Am. J. Gastroenterol. 97, 861-866, 2002.