Staphylococcal epidermolysins

Current Opinion in Infectious Diseases

Volumn 16, Issue 2, 2003, Pages 71-76

  Prévost, Gilles ^a   Couppié, Pierre ^b   Monteil, Henri ^a  

^a UNIVERSITÉ DE STRASBOURG   (France)

^b CENTRE HOSPITALIER DE CAYENNE   (French Guiana)

Author keywords

Blisters; Desmoglein 1; Epidermolysins; Specific proteases

Indexed keywords

BACTERIAL TOXIN; DESMOGLEIN 1; EPIDERMOLYSIN; INTERMEDIN; PROTEINASE; SUPERANTIGEN; UNCLASSIFIED DRUG;

BULLOUS SKIN DISEASE; DESMOSOME; EPIDEMIC; EXFOLIATIVE DERMATITIS; FEMALE; HIGH RISK POPULATION; HUMAN; IMPETIGO BULLOSA; INFECTION RISK; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PEMPHIGUS FOLIACEUS; PROTEIN DEGRADATION; REVIEW; STAPHYLOCOCCUS HYICUS; TOXIC EPIDERMAL NECROLYSIS;

EID: 0242584493     PISSN: 09517375     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001432-200304000-00002     Document Type: Review

References (70)

1. Todd JK. Toxic shock syndrome. Clin Microbiol Rev 1988; 1:432-436.
2. Couppié P, Cribier B, Prévost G, et al. Leucocidin from Staphylococcus aureus and cutaneous infections: an epidemiological study. Arch Dermatol 1994; 130:1208-1209.
3. Gillet Y, Issartel B, Vanhems P, et al. Association between Staphylococcus aureus strains carrying gene for Panton-Valentine leukocidin and highly lethal necrotising pneumonia in young immunocompetent patients. Lancet 2002; 359:753-759. Staphylococcal Panton-Valentine leucocidin is not only associated with furuncles and carbuncles, but also with community-acquired pneumonia.
4. Melish ME, Glasgow LA. The staphylococcal scalded skin syndrome: the expanded clinical syndrome. J Pediatr 1971; 78:958-967.
5. Kondo I, Sakurai S, Sarai Y. New type of exfoliatin obtained from staphylococcal strains belonging to phage groups other than group 2, isolated from patients with impetigo and Ritter's disease. Infect Immun 1974; 10:851-861.
6. Graver A, Couppié P, Meunier O, et al. Staphylococcus aureus isolated from impetigo produces both epidermolysins A or B and LukE+LukD in 78% of 131 retrospective and prospective cases. J Clin Microbiol 2001; 39:4349-4356. Production by Staphylococcus aureus strains of epidermolysins and the leucotoxin LukE-LukD is significantly associated with bullous impetigo.
7. Graver A, Rondeau M, Harf-Monteil C, et al. Predominant Staphylococcus aureus isolated from antibiotic-associated diarrhea is clinically relevant and produces enterotoxin A and the bi-component toxin LukE/LukD. J Clin Microbiol 1999; 37:4012-4019.
8. Melish ME, Glasgow LA. The staphylococcal scalded skin syndrome: development of an experimental model. N Engl J Med 1970; 282:1114-1119.
9. Auquier-Dunant A, Mockenhaupt M, Naldi L, et al. Correlations between clinical patterns and causes of erythema multiforme majus, Stevens-Johnson syndrome, and toxic epidermal necrolysis: results of an international prospective study. Arch Dermatol 2002; 138:1019-1028. This was a clinical study of Lyell syndrome or epidermal necrolysis and related syndromes.
10. Dancer SJ, Simmons NA, Poston SM, Noble WC. Outbreak of staphylococcal scalded skin syndrome among neonates. J Infect 1988; 16:87-103.
11. Howells CHL, Jones EH. Two outbreaks of neonatal skin sepsis caused by Staphylococcus aureus. Arch Dis Child 1961; 36:214-216.
12. Kapral FA, Miller MM. Product of Staphylococcus aureus responsible for staphylococcal scalded skin syndrome. Infect Immun 1971; 4:541-545.
13. Kondo I, Sakurai S, Sarai Y, Futaki S. Two serotypes of exfoliatin and their distribution in staphylococcal strains isolated from patients with staphylococcal scalded skin syndrome. J Clin Microbiol 1975; 1:397-400.
14. Couppié P, Sainte-Marie D, Prévost G, et al. L'Impétigo en Guyane Française: études clinique, bactériologique, toxinologique et de sensibilité aux antibiotiques [in French]. Ann Dermatol Vénéréol 1997; 125:688-693.
15. Piémont Y, Monteil H. New approach in the separation of two exfoliative toxins from Staphylococcus aureus. FEMS Microbiol Lett 1983; 17:191-195.
16. Ladhani S, Cameron J, Chapple DS, et al. A novel method for rapid production and purification of exfoliative toxin A of Staphylococcus aureus. FEMS Microbiol Lett 2002; 212:35-59. This provides some actual and quite easy-to-do methods for production and purification of epidermolysins.
17. Cavarelli J, Prévost G, Bourguet W, et al. The structure of Staphylococcus aureus epidermolytic toxin A, an atypic serine protease, at 1.7Å resolution. Structure 1997; 5:813-824.
18. Yamazaki T, Sakurai S, Matsuo N, et al. A simple method for purifying staphylococcal exfoliative toxin A. Microbiol Immunol 2000; 44:1067-1070.
19. O'Toole PW, Foster TJ. Nucleotide sequence of the epidermolytic toxin A gene of Staphylococcus aureus. J Bacteriol 1987; 169:3910-3915.
20. Lee CY, Schmitt JJ, Johnson WAD, et al. Sequence determination and comparison of the exfoliative toxin A and toxin B genes from Staphylococcus aureus. J Bacteriol 1987; 169:3904-3909.
21. Yoshizawa Y, Sakurada J, Sakurai S, et al. An exfoliative toxin A-converting phage isolated from Staphylococcus aureus strain ZM. Microbiol Immunol 2000; 44:189-191.
22. Yamaguchi T, Hayashi T, Takami H, et al. Phage conversion of exfoliative toxin A production in Staphylococcus aureus. Mol Microbiol 2000; 38:694-705.
23. Black LW. DNA packaging in ds DNA bacteriophages. Ann Rev Microbiol 1989; 43:267-292.
24. Yamaguchi T, Hayashi T, Takami H, et al. Complete nucleotide sequence of a Staphylococcus aureus exfoliative toxin B plasmid and identification of a novel ADP-ribosyltransferase, EDIN-C. Infect Immun 2001; 69:7760-7771. This describes genomic studies in which characterization of the biology of a staphylococcal plasmid and genetic association between two virulence factors were demonstrated.
25. Yamaguchi T, Nishifuji K, Sasaki M, et al. Identification of the Staphylococcus aureus etd pathogenicity island which encodes a novel exfoliative toxin, ETD, and EDIN-B. Infect Immun 2002; 70:5835-5845. A novel epidermolysin serotype, ETD, is characterised into a 9 kb inserted element. It cleaves desmoglein-1.
26. Sato H, Matsumori Y, Tanabe T, et al. A new type of staphylococcal exfoliative toxin from a Staphylococcus aureus strain isolated from a horse with phlegmon. Infect Immun 1994; 62:3780-3785.
27. Andresen LO. Differentiation and distribution of three types of exfoliative toxin produced by Staphylococcus hyicus from pigs with exudative epidermitis. FEMS Immunol Med Microbiol 1998; 20:301-310.
28. Sato H, Watanabe T, Higuchi K, et al. Chromosomal and extrachromosomal synthesis of exfoliative toxin from Staphylococcus hyicus. J Bacteriol 2000; 182:4096-4100.
29. Watanabe T, Sato H, Hatakeyama Y, et al. Cloning of the gene coding for Staphylococcus hyicus exfoliative toxin B and its expression in Escherichia coli. J Bacteriol 2000; 182:4101-4103.
30. Jarraud S, Mougel C, Thioulouse J, et al. Relationships between Staphylococcus aureus genetic background, virulence factors, agr groups (alleles), and human diseases. Infect Immun 2002; 70:631-841. Some virulence factors producing S. aureus may be associated with specific regulation alleles of agr, especially auto-inducing peptides.
31. Dancer SJ, Garratt R, Saldanha J, et al. The epidermolytic toxins are proteases. FEBS Lett 1990; 268:129-132.
32. Bailey CJ, Redpath MB. The esterolytic activity of epidermolytic toxins. Biochem J 1992; 284:177-180.
33. Prévost G, Rifai S, Chaix ML, Piémont Y. Functional evidence that the Ser-195 residue of staphylococcal exfoliative toxin A is essential for biological activity. Infect Immun 1991; 59:3337-3339.
34. Redpath MB, Foster TJ, Bailey CJ. The role of the serine protease active site in the mode of action of epidermolytic toxin of S. aureus. FEMS Microbiol Lett 1991; 81:151-156.
35. Sakurai S, Suzuki H, Saito S, et al. New evidence that the Tyr-157 and Tyr-159 residues of staphylococcal exfoliative toxin B are essential for its toxicity. Microbiol Immunol 1998; 42:829-836.
36. Marrack P, Kappler JW. The staphylococcal enterotoxins and their relatives. Science 1990; 248:705-711.
37. Fleischer B, Bailey CJ. Recombinant epidermolytic (exfoliative) toxin A of Staphylococcus aureus is not a superantigen. Med Microbiol Immunol 1992; 180:273-278.
38. Gentilhomme E, Faure M, Piémont Y, et al. Action of staphylococcal exfoliative toxins on epidermal cell cultures and organotropic skin. J Dermatol 1990; 17:526-532.
39. th International Symposium on Staphylococci and Staphylococcal Infections. 29 June-3 July 1992; Stockholm.
40. Ladhani S, Poston SM, Joannou CL, Ewans RW. Staphylococcal scalded skin syndrome: exfoliative toxin A (ETA) induces serine protease activity when combined with A431 cells. Acta Pediatr 1999; 40:776-779.
41. Vath GM, Earhart CA, Rago JV, et al. The structure of the superantigen exfoliative toxin A suggests a novel regulation as a serine protease. Biochemistry 1997; 36:1559-1566.
42. Vath GM, Earhart CA, Monie DD, et al. The crystal structure of exfoliative toxin B: a superantigen with enzymatic activity. Biochemistry 1999; 38:10239-10246.
43. Fields BA, Malchiodi EL, Li H, et al. Crystal structure of a T-cell receptor beta-chain complexed with a superantigen. Nature 1996; 384:188-192.
44. Papageorgiou AC, Piano LRW, Collins CM, Acharya KR. Structural similarities and differences in Staphylococcus aureus exfoliative toxins A and B as revealed by their crystal structures. Protein Sci 2000; 9:610-618.
45. Rago JV, Vath GM, Bohach GA, et al. Mutational analysis of the superantigen staphylococcal exfoliative toxin A (ETA). J Immunol 2000; 164:2207-2213.
46. Rago JV, Vath GM, Tripp TJ, et al. Staphylococcal exfoliative toxins cleave α. and β-melanocyte-stimulating hormones. Infect Immun 2000; 68:2366-2368.
47. Plano LRW, Gutman DM, Woischnik M, Collins CM. Recombinant Staphylococcus aureus exfoliative toxins are not superantigens. Infect Immun 2000; 68:3048-3052.
48. Amagai M, Matsuyoshi N, Wang ZH, et al. Toxin in bullous impetigo and staphylococcal scalded-skin syndrome targets desmoglein 1. Nature Med 2000; 6:1275-1277.
49. Amagai M, Yamaguchi T, Hanakawa Y, et al. Staphylococcal exfoliative toxin B specifically cleaves desmoglein 1. J Invest Dermatol 2002; 118:845-850. ETA and ETB target and cleave an identical target.
50. Hankawa Y, Schechter NM, Lin C, et al. Molecular mechanisms of blister formation in bullous impetigo and staphylococcal scalded skin syndrome. J Clin Invest 2002; 110:53-60. This is an enzymatic study of the proteolytic functions of ETA and ETB.
51. Plano LRW, Adkins B, Woischnik M, et al. Toxin levels in serum correlate with the development of staphylococcal scalded skin syndrome in a murine model. Infect Immun 2001; 69:5193-5197. The ability of epidermolysins to promote SSSS in immunocompromised mice towards bloodstream has been experimented and is discussed in regards to the occurrence of the disease in infants and adults.
52. Cribier B, Piémont Y, Grosshans E. Staphylococcal scalded skin syndrome in adults: a clinical review illustrated with a new case. J Am Acad Dermatol 1994; 30:319-324.
53. Leauté-Labrèze C, Sarlangue J, Pedespan L, et al. Epidermolyse staphylococcique néonatale à transmission materno-fœtale [in French]. Ann Dermatol Venereol 1999; 126:713-715.
54. Oyake S, Oh-i T, Koga M. Staphylococcal scalded skin syndrome in a healthy adult. J Dermatol 2001; 28:145-148. This presents a case report of SSSS in a healthy adult.
55. Oyake S, Oh-i T, Koga M. Staphylococcal scalded skin syndrome developing during burn treatment. J Dermatol 2001; 28:557-559. The authors provide a case report of SSSS in an infant after burn.
56. Ansai S, Shimanuki T, Uchine H, et al. Staphylococcal scalded skin syndrome with prosthetic valve endocarditis. Eur J Dermatol 2000; 10:630-632.
57. Ito Y, Funebashi Yoh M, Toda K, et al. Staphylococcal scalded skin syndrome in an adult due to methicillin-resistant Staphylococcus aureus. J Infect Chemother 2002; 8:256-261. This is a case report of an methicillin-resistant Staphylococcus aureus producing epidermolysin.
58. Bunikowski R, Mielke MEA, Skarabis H, et al. Evidence for a disease-promoting effect of Staphylococcus aureus-derived exotoxins in atopic dermatitis. J Allergy Clin Immunol 2000; 105:814-819.
59. Capoluongo E, Giglio A, Lavieri MM, et al. Genotypic and phenotypic characterisation of Staphylococcus aureus strains isolated in subjects with atopic dermatitis. Higher prevalence of exfoliative B toxin production in lesional strains and correlation between markers of disease intensity and colonisation density. J Dermatol Sci 2001; 26:145-155. The authors describe the possible prevalence of epidermelysin B and incidence of lesion intensity in atopic dermatitis.
60. Zhu H, Wilcow MDP. Detection of staphylococcal superantigens from contact-lens-induced inflammatory diseases. Aust N Z J Ophthalmol 1999; 27:237-240.
61. Yamaguchi T, Yokota Y, Terajima J, et al. Clonal association of Staphylococcus aureus causing bullous impetigo and the emergence of new methicillin-resistant clonal groups in Kansai district in Japan. J Infect Dis 2002; 185:1511-1516. This presents a demonstration of an epidemic of methicillin-resistant Staphylococcus aureus-producing epidermolysins.
62. Becker K, Haverkämper G, von Eiff C, et al. Survey of staphylococcal enterotoxin genes, exfoliative toxin genes, and toxic shock syndrome toxin 1 in non Staphylococcus aureus species. Eur J Clin Microbiol Infect Dis 2001; 20:407-409.
63. Akineden O, Annemüller C, Hassan AA, et al. Toxin genes and other characteristics of Staphylococcus aureus isolates from milk of cows with mastitis. Clin Diag Lab Immunol 2001; 8:959-964. This study found no prevalence of ETA or ETB-producing strains in cases of cows with mastitis.
64. Larsen HD, Huda A, Eriksen NHR, Jensen NE. Differences between Danish bovine and human Staphylococcus aureus isolates in possession of superantigens. Vet Microbiol 2000; 76:153-162.
65. Larsen HD, Aarestrup FM, Jensen NE. Geographical variation in the presence of genes encoding superantigenic exotoxins and beta-hemolysin among Staphylococcus aureus isolated from bovine mastitis in Europe and USA. Vet Microbiol 2002; 85:61-67. This study also found no prevalence of ETA or ETB-proucing strains in cases of cows with mastitis.
66. Hayakawa Y, Hashimoto N, Imaizumi K, et al. Genetic analysis of exfoliative toxin A-producing Staphylococcus aureus isolated from mastitic cow's milk. Vet Microbiol 2001; 78:39-48.
67. Mehrotra M, Wang G, Johnson WM. Multiplex PCR for detection of genes for Staphylococcus aureus enterotoxins, exfoliative toxins toxic shock syndrome 1, and methicillin-resistance. J Clin Microbiol 2000; 38:1032-1035.
68. Ladhani S, Robbie S, Garratt RC, et al. Development and evaluation of detection systems for staphylococcal exfoliative toxins toxin A and B responsible for staphylococcal scalded skin syndrome. J Clin Microbiol 2001; 39:2050-2054. This describes a comparison of different methods with a rapid ELISA for the detection of epidermolysin production.
69. Amagai M. Pemphigus as a paradigm of autoimmunity and cell adhesion. Keio J Med 2002; 5:133-139. This is a short review of clinical aspects and questions regarding pemphigus foliaceus.
70. Ajdic D, McShan WM, McLaughin RE, et al. Genome sequence of Streptococcus mutans UA159, a cariogenic dental pathogen. Proc Natl Acad Sci U S A 2002; 99:14434-14439. The sequence analysis of this genome revealed the existence of genes homologous to those encoding epidermolysins. There was no biochemical characterization.