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Pemphigus
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Paraneoplastic pemphigus. An autoimmune mucocutaneous disease associated with neoplasia
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Anhalt GJ, Kim S, Stanley JR, Korman NJ, Jabs DA, Kory M, Izumi H, Ratrie H, Mutasim D, Ariss AL et al: Paraneoplastic pemphigus. An autoimmune mucocutaneous disease associated with neoplasia. N Engl J Med 1990; 323: 1729-1735
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Demonstration of skin antibodies in sera of pemphigus vulgaris patients by indirect immunofluorescent staining
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Beutner EH, Jordon RE: Demonstration of skin antibodies in sera of pemphigus vulgaris patients by indirect immunofluorescent staining. Proc Soc Exp Biol Med 1964; 117: 505-510
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Pemphigus antibodies identify a cell surface glycoprotein synthesized by human and mouse keratinocytes
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Stanley JR, Yaar M, Hawley NP, Katz SI: Pemphigus antibodies identify a cell surface glycoprotein synthesized by human and mouse keratinocytes. J Clin Invest 1982; 70: 281-288
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Distinction between epidermal antigens binding pemphigus vulgaris and pemphigus foliaceus autoantibodies
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Stanley JR, Koulu L, Thivolet C: Distinction between epidermal antigens binding pemphigus vulgaris and pemphigus foliaceus autoantibodies. J Clin Invest 1984; 74: 313-320
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Human autoantibodies against a desmosomal protein complex with a calcium-sensitive epitope are characteristic of pemphigus foliaceus patients
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Eyre RW, Stanley JR: Human autoantibodies against a desmosomal protein complex with a calcium-sensitive epitope are characteristic of pemphigus foliaceus patients. J Exp Med 1987; 165: 1719-1724
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Identification of pemphigus vulgaris antigen extracted from normal human epidermis and comparison with pemphigus foliaceus antigen
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Eyre RW, Stanley JR: Identification of pemphigus vulgaris antigen extracted from normal human epidermis and comparison with pemphigus foliaceus antigen. J Clin Invest 1988; 81: 807-812
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Detection of pemphigus vulgaris and pemphigus foliaceus antigens by immunoblot analysis using different antigen sources
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Hashimoto T, Ogawa MM, Konohana A, Nishikawa T: Detection of pemphigus vulgaris and pemphigus foliaceus antigens by immunoblot analysis using different antigen sources. J Invest Dermatol 1990; 94: 327-331
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Identification of desmoglein, a constitutive desmosomal glycoprotein, as a member of the cadherin family of cell adhesion molecules
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Koch PJ, Walsh MJ, Schmelz M, Goldschmidt MD, Zimbelmann R, Franke WW: Identification of desmoglein, a constitutive desmosomal glycoprotein, as a member of the cadherin family of cell adhesion molecules. Eur J Cell Biol 1990; 53: 1-12
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Autoantibodies against a novel epithelial cadherin in pemphigus vulgaris, a disease of cell adhesion
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Amagai M, Klaus-Kovtun V, Stanley JR: Autoantibodies against a novel epithelial cadherin in pemphigus vulgaris, a disease of cell adhesion. Cell 1991; 67: 869-877
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Autoantibodies against the amino-terminal cadherin-like binding domain of pemphigus vulgaris antigen are pathogenic
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Amagai M, Karpati S, Prussick R, Klaus-Kovtun V, Stanley JR: Autoantibodies against the amino-terminal cadherin-like binding domain of pemphigus vulgaris antigen are pathogenic. J Clin Invest 1992; 90: 919-926
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Absorption of pathogenic autoantibodies by the extracellular domain of pemphigus vulgaris antigen (Dsg3) produced by baculovirus
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Amagai M, Hashimoto T, Shimizu N, Nishikawa T: Absorption of pathogenic autoantibodies by the extracellular domain of pemphigus vulgaris antigen (Dsg3) produced by baculovirus. J Clin Invest 1994; 94: 59-67
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Amagai M, Hashimoto T, Green KJ, Shimizu N, Nishikawa T: Antigen-specific immunoadsorption of pathogenic autoantibodies in pemphigus foliaceus. J Invest Dermatol 1995; 104: 895-901
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Lack of mucosal involvement in pemphigus foliaceus may be due to low expression of desmoglein1
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Shirakata Y, Amagai M, Hanakawa Y, Nishikawa T, Hashimoto K: Lack of mucosal involvement in pemphigus foliaceus may be due to low expression of desmoglein1. J Invest Dermatol 1998; 110: 76-78
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Explanation for the clinical and microscopic localization of lesions in pemphigus foliaceus and vulgaris
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Mahoney MG, Wang Z, Rothenberger KL, Koch PJ, Amagai M, Stanley JR: Explanation for the clinical and microscopic localization of lesions in pemphigus foliaceus and vulgaris. J Clin Invest 1999; 103: 461-468
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Autoimmunity against desmosomal cadherins in pemphigus
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Amagai M: Autoimmunity against desmosomal cadherins in pemphigus. J Dermatol Sci 1999; 20: 92-102
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The clinical phenotype of pemphigus is defined by the antidesmoglein autoantibody profile
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Amagai M, Tsunoda K, Zillikens D, Nagai T, Nishikawa T: The clinical phenotype of pemphigus is defined by the antidesmoglein autoantibody profile. J Am Acad Dermatol 1999; 40: 167-170
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Pemphigus vulgaris antigen (desmoglein3) is localized in the lower epidermis, the site of blister formation in patients
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Amagai M, Koch PJ, Nishikawa T, Stanley JR: Pemphigus vulgaris antigen (Desmoglein3) is localized in the lower epidermis, the site of blister formation in patients. J Invest Dermatol 1996; 106: 351-355
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Protection against pemphigus foliaceus by desmoglein3 in neonates
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Wu H, Wang ZH, Yan A, Lyle S, Fakharzadeh S, Wahl JK, Wheelock MJ, Ishikawa H, Uitto J, Amagai M et al: Protection against pemphigus foliaceus by desmoglein3 in neonates. N Engl J Med 2000; 343: 31-35
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The staphylococcal scalded skin syndrome: Development of an experimental model
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Toxin in bullous impetigo and staphylococcal scalded skin syndrome targets desmoglein1
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Amagai M, Matsuyoshi N, Wang ZH, Andl C, Stanley JR: Toxin in bullous impetigo and staphylococcal scalded skin syndrome targets desmoglein1. Nature Medicine 2000; 6: 1275-1277
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Staphylococcal exfoliative toxin B specifically cleaves Desmoglein1
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Amagai M, Yamaguchi T, Hanakawa Y, Nishifuji K, Sugai M, Stanley JR: Staphylococcal Exfoliative Toxin B Specifically Cleaves Desmoglein1. J Invest Dermatol 2002; 118: 845-850
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Targeted disruption of the pemphigus vulgaris antigen (desmoglein3) gene in mice causes loss of keratinocyte cell adhesion with a phenotype similar to pemphigus vulgaris
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Koch PJ, Mahoney MG, Ishikawa H, Pulkkinen L, Uitto J, Shultz L, Murphy GF, Whitaker-Menezes D, Stanley JR: Targeted disruption of the pemphigus vulgaris antigen (desmoglein3) gene in mice causes loss of keratinocyte cell adhesion with a phenotype similar to pemphigus vulgaris. J Cell Biol 1997; 137: 1091-1102
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Ohyama M, Amagai M, Tsunoda K, Ota T, Koyasu S, Umezawa A, Hata J, Nishikawa T: Immunologic and histopathologic characterization of active disease mouse model for pemphigus vulgaris. J Invest Dermatol 2002; 118: 199-204
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Tsunoda K, Ota T, Suzuki H, Ohyama M, Nagai T, Nishikawa T, Amagai M, Koyasu S: Pathogenic autoantibody production requires loss of tolerance against desmoglein 3 in both T and B cells in experimental pemphigus vulgaris. Eur J Immunol 2002; 32: 627-633
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