The role of cytokines in depression;Rola cytokin w depresji

Psychiatria Polska

Volumn 37, Issue 5, 2003, Pages 787-798

  Dubas Ślemp, Halina ^a   Marmurowska Michałowska, Halina ^a   Szuster Ciesielska, Agnieszka ^b   Kamińska, Teresa ^b   Kandefer Szerszeń, Martyna ^b  

^a MEDICAL UNIVERSITY OF LUBLIN   (Poland)

^b MARIA CURIE SK ODOWSKA UNIVERSITY   (Poland)

Author keywords

Antidepressants; Cytokines; Depression; Hypothalamic pituitary adrenal axis; Immune system

Indexed keywords

ANTIDEPRESSANT AGENT; CD4 ANTIGEN; CORTICOTROPIN RELEASING FACTOR; CYTOKINE; HLA DR ANTIGEN; INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 6; MESSENGER RNA; PROSTAGLANDIN E2; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; BEHAVIOR; BRAIN; DEPRESSION; HUMAN; HYPOPHYSIS ADRENAL SYSTEM; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; HYPOTHALAMUS HYPOPHYSIS SYSTEM; IMMUNE SYSTEM; IMMUNOLOGY; MENTAL DISEASE; METABOLISM; NEUROCHEMISTRY; NONHUMAN; PHYSIOLOGY; PSYCHOPHARMACOTHERAPY;

BRAIN; CORTICOTROPIN-RELEASING HORMONE; CYTOKINES; DEPRESSION; HUMANS; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; PITUITARY-ADRENAL SYSTEM;

EID: 0242570669     PISSN: 00332674     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (61)

1. Solomon GF, Moos RH. Emotions, immunity, and disease: A speculative theoretical integration. Arch. Gen. Psychiatry 1964; 11: 657-674.
2. Corrigan FM. Depression: immunological resignation of the will to live? Med. Hypotheses 1998; 50: 9-18.
3. Maes M, Smith RS, Fatty acids, cytokines, and major depression. Biol. Psychiatry 1998; 34: 313-314.
4. Maes M, Smith R, Scharpe S. The monocyte-T-lymphocyte hypotheses of major depression. Psychoneuroendocrinol. 1995; 20: 111-116.
5. Smith RS. The macrophage theory of depression. Med. Hypotheses 1991; 35: 298-306.
6. Jȩdrzejczak WW, Podolak-Dawidziak M. Cytokiny i ich zastosowanie kliniczne. Wrocław: Volumed; 1997.
7. Robak T. Biologia i farmakologia cytokin. Warszawa, Łó dź: PWN; 1995.
8. Connor TJ, Leonard BE. Depression, stress and immunological activation: the role of cytokines in depressive disorders. Life Sc. 1998; 62: 583-606.
9. Hopkins SJ, Rothwell NJ. Cytokines and the nervous system. I. Expression recognition. Trends Neurosc. 1995; 18: 83-88.
10. Banks WA, Kastin AJ, Gutierrez P. Interleukin-1 alpha in blood has direct access to cortical brain cells. Neurosc. Lett. 1993; 163: 41-44.
11. Lavicky J, Dunn AJ. Corticotropin-releasing factor stimulates catecholamine release in hypothalamus and prefrontal cortex in freely moving rats as assessed by microdialysis. J. Neurochem. 1993; 60: 602-612.
12. Lavicky J, Dunn AJ. Endotoxin administration stimulates cerebral catecholamine release in freely moving rats as assessed by microdialysis. J. Neurosc. Res. 1995; 15: 407-413.
13. Fleshner M, Goehler LE, Hermann J, Relton JK, Maier SF, Watkins LR. Interleukin-1 beta induced corticosterone elevation and hypothalamic NE depletion is vagally mediated. Brain Res. Bull. 1995; 37: 605-610.
14. Dyr W. Psychoneuroimmunologiczne oddziaływanie cytokin w ośrodkowyn układzie nerwowym. Wiad. Psychiatr. 2002; 5: 33-37.
15. Yirmiya R. Endotoxin produces a depressive-like episode in rats. Brain Res. 1996; 711: 163-174.
16. Yirmiya R. Behavioral and psychological effects of immune activation: Implications for depression due to a general medical condition. Curr. Op. Psychiatry 1997; 10: 470-476.
17. Young MR, Matthews JP. Serotonin regulation of T cell subpopulations and of macrophage accessory function. Immunol. 1995; 84: 148-152.
18. Pauli S, Linthorst AC. Reul JM. Tumor necrosis factor-alpha and interleukin-2 differentially affect hipocampal serotonergic neurotransmission, behavioural activity, body temperature and hypothalamic-pituitary-adrenocortical axis activity in the rats. Eur. J. Neurosc. 1998; 10: 868-878.
19. Konan KW, Taylor MW. Importance of the two interferon-stimulated response element (ISRE) sequences in the regulation of human indoleamine 2,3-dioxygenase gene. J. Biol. Chem. 1996; 271: 19140-19145.
20. Castanon N, Leonard BE, Neveu PJ, Yirmiya R. Effects of antidepressants on cytokine production and action. Brain. Behav. Immun. 2002; 16: 569-574.
21. Maes M, Song C, Lin A, De Jongh R, Van Gastel A, Kenis G, Bosmans E, De Meester I, Benoy I, Neels H, Demendts P, Janca A, Scharpe S, Smith RS. The effect of psychological stress on humans: increased production of pro-inflammatory cytokines and a Th1-like response in stress-induced anxiety. Cytokine 1998; 10: 313-318.
22. Irwin M. Neuroimmunology of disordered sleep in depression and alcoholism. Neuropsychopharmacol. 2001; 25, supl.: 45-49.
23. Maes M, Bosmans E, Meltzer HY, Charpe S, Suy E. Interleukin-1β: A putative mediator of HPA-axis hyperactivity in major depression? Am. J. Psychiatry 1993; 150: 1189-1193.
24. Shen Y, Connor TJ, Nolan Y, Kelly JP, Leonard BE. Differential effect of chronic antidepressant treatment of lipopolysaccharide-induced depressive-like behavioural sytnptoms in the rat. Life. Sc. 1999; 65: 1773-1786.
25. Służewska A, Rybakowski J, Sobieska M, Bosmans E, Pollet H, Wiktorowicz K. Increased levels of alpha-1-acid glycoprotein, and IL-6 in refractory depression. Depr. 1995; 3: 170-175.
26. Służewska A, Rybakowski J, Sobieska M, Wiktorowicz K. Concentrations and microheterogeneity glycophorms of alpha-1-acid glycoprotein in major depression. J. Affec. Disord. 1996; 39: 149-155.
27. Song C, Dinan T, Leonard BE. Changes in immunoglobulin, complement and acute phase protein levels in the depressed patients and normal controls. J. Affec. Disord. 1994: 30: 283-288.
28. Brambilla F, Maggioni M. Blood levels of cytokines in elderly patients with major depressive disorder. Acta Psychiatr. Scand. 1998; 97: 309-313.
29. Frommberger UH, Bauer J, Haselbauer P, Fraulin A, Riemann D, Berger M. Interleukin-6 (IL-6) plasma levels in depression and schizophrenia: Comparison between acute state and after remission. Eur. Arch. Psychiatry Clin. Neurosc. 1997; 247: 228-233.
30. Inglot A, Leszek J, Piasecki E, Sypuła. A Interferon responses in schizophrenia and major depressive disorders. Biol. Psychiatry 1994; 35: 464-473.
31. Kubera M, Kenis G, Bosmans E, Ziȩba A, Dudek D, Nowak G, Maes M. Plasma levels of interleukin-6, interleukin-10, and interleukin-1 receptor antagonist in depression: comparison between the acute state and after remission. Pol. J. Pharmacol. 2000; 52: 237-241.
32. Kubera M, Lin AH, Kenis G, Bosmans E, Van Bockstaele D, Maes M. Anti-inflammatory effects of antidepression through suppression of the interferon-gamma-interleukin-10 production ration. J. Clin. Psychopharmacol. 2001; 21: 199-206.
33. Maes M, Bosmans E, De Jongh R, Kenis G, Vandoolaeghe E, Neels H. Increased serum IL-6 and IL-1 receptor antagonist concentrations in major depression and treatment resistant depression. Cytokine 1997; 9: 853-858.
34. Maes M, Meltzer HY, Bosmans E, Bergmans R, Vandoolaeghe E, Ranjan R, Desnyder R. Increased plasma concentrations of interleukin-6, soluble interleukin-6, soluble interleukin-2 and transferring receptor in major depression. J. Affec. Disord. 1995; 34: 301-309.
35. Maes M, Scharpe S, Meltzer HY, Okayli G, Bosmans E, D'Hondt P, Vanden Bossche B, Cosyns P. Increased neopterin and interferon-γ secretion and lower availability of L-tryptophan in major depression: Further evidence for activation of cell-mediated immunity. Psychiatr. Res. 1994; 54: 143-160.
36. Owen BM, Eccleston D, Ferrier IN, Young AH. Raised levels of plasma IL-1 beta in major and postviral depression. Acta Psychiatr. Scand. 2001; 103: 161-162.
37. Maes M, Song C, Lin AH, Bonaccorso S, Kenis G, De Jong R, Bosmans E, Scharpe S. Negative immunoregulatory effects of antidepressants: Inhibition of interferon-γ and stimulation of interleukin-10 secretion. Neuropsychopharmacol. 1999; 20: 370-379.
38. Maes M, Vandoolaeghe E, Van Hunsel F, Bril T, Demedts P, Wauters A, Neels H. Immune disturbances in treatment-resistant depression: modulation by antidepressive treatments. Human Psychopharmacol. 1997; 12: 153-162.
39. Seidel A, Arolt V, Hunstiger M, Rink L, Behnisch A, Kirchner H. Cytokine production and serum proteins in depression. Scand. J. Immunol. 1995; 41; 534-538.
40. Seidel A, Arolt V, Hunstiger M, Rink L, Behnisch A, Kirchner H. Increased CD56+ natural killer cells and related cytokines in major depression. Clin. Immunol. Immunopathol. 1996; 78: 83-85.
41. Weizman R, Laor N, Podliszewski E, Notti I, Djaldetti M, Bessler H. Cytokine production in major depressed patients before and after clomipramine treatment. Biol. Psychiatry 1995; 35: 42-47.
42. Haack M, Hinze-Selch D, Fenzel T, Kraus T, Kuhn M, Schuld A, Pollmacher T. Plasma levels of cytokines and soluble cytokine receptors in psychiatric patients upon hospital admission: effects of confounding factors and diagnosis. J. Psychiatr. Res. 1999; 33: 407-418.
43. Hickie I, Hickie C, Bennett B, Wakefield D, Silove D, Mitchell P, Lloyd A. Biochemical correlates of in vivo cell-mediated immune dysfunction in patients with depression: a preliminary report. Int. J. Immunopharmacol. 1995; 17: 685-690.
44. Służewska A, Rybakowski J, Bosmans E, Sobieska M, Berghmans R, Maes M, Wiktorowicz K. Indicators of immune activation in major depression. Psychiatr. Res. 1996; 64: 161-167.
45. Anisman H, Ravidran AV, Griffith J, Merali Z. Endocrine and cytokine correlates of major depression and dysthymia with typical or atypical features. Mol. Psychiatry 1999; 4: 182-188.
46. Johnson RW, Propes MJ, Shavit Y. Corticosterone modulates behavioural and metabolic effects of lipopolysaccharide. Am. J. Physiol. 1996; 270: 192-198.
47. Miller GE, Cohen S, Herbert TB. Pathways linking major depression and immunity in ambulatory female patients. Psychosom. Med. 1999; 61: 850-860.
48. Miller GE, Cohen S, Ritchey AK. Chronic physiological stress and the regulation of proinflammatory cytokines: a glucocorticoid-resistance model. Health Psychol. 2002; 21: 531-541.
49. Owens MJ, Nemeroff CB. Physiology and pharmacology of cortocotropin-releasing factor. Pharmacol. Rev. 1991; 43: 425-473.
50. Riad M, Mogos M, Thangathurai D, Lumb PD. Steroids. Curr. Opin. Crit. Care 2002; 8: 281-284.
51. Joels M. Steroid hormones and excitability in mammalian brain. Front. Neuroendocrinol. 1997; 18: 2-48
52. Seckl JR. IIbeta-hydroxysteroid dehydrogenase in the brain: a novel regulator of glucocorticoid action? Front. Neuroendocrinol. 1997; 18: 49-99.
53. Bonaccorso S, Marino V, Puzella A, Pasquini M, Biondi M, Artini M, Almerighi C, Verkerk R, Meltzer H, Maes M. Increased depressive ratings in patients with hepatitis C receiving interferon-alpha-based immunotherapy are related to interferon-alpha-induced changes in the serotonegic system. J. Clin. Psychopharmacol. 2002; 22: 86-90.
54. Kiecolt-Glaser JK, Robles TF, Glaser R. Psychoneuroimmunology: Psychological influences on immune function and health J. Consult. Clin. Psychol. 2002; 70: 537-547.
55. Capuron L, Ravaud A. Prediction of the depressive effect of interferon alpha by the patient's initial affective state. New Eng. J. Med. 1999; 340: 1370.
56. Iv EC. Interferons: potential roles in affect. Med. Hypoth. 2001; 56: 558-566.
57. Katilla H, Cantell K, Appelberg B, Rimon R. Is there a seasonal variation in the interferon-producing capacity of the healthy subjects? J. Interferon Res. 1993; 13: 267-269.
58. Lambert GW, Reid C, Kaye DM, Jennings GL, Esler MD. Effect of sunlight and season on serotonin turnover in the brain. Lancet 2002; 360: 1840-1842.
59. Bluthe RM, Castanon N, Pousset F, Bristow A, Ball C, Lestage J, Michaud B, Kelley KW, Danzer R. Central injection of IL-10 antagonizes the behavioural effects of lipopolysaccharide in rats. Psychoneuroendocrinol. 1999; 24: 301-311.
60. Służewska A, Rybakowski J, Laciak M, Mackiewicz A, Sobieska M, Wiktorowicz K. Interleukin 6 serum levels in depressed patients before and after treatment with fluoxetine. Ann. N.Y. Acad. Sc. 1995; 762: 474-476.
61. Xia Z, DePierre JW, Nassberger L. Tricyclic antidepressants inhibit IL-6, IL-1β and TNF-α release in human blood monocytes and IL-2 and interferon-γ in T cells. Immunopharmacol. 1996; 34: 27-37.