A Split-Field Drift Tube for Separation and Efficient Fragmentation of Biomolecular Ions

Analytical Chemistry

Volumn 75, Issue 22, 2003, Pages 6202-6208

  Valentine, Stephen J ^a   Koeniger, Stormy L ^b   Clemmer, David E ^b  

^a Beyond Genomics   (United States)

^b INDIANA UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DISSOCIATION; MIXTURES; SEPARATION; TUBES (COMPONENTS);

COLLISION-INDUCED FRAGMENTATION;

PROTEINS;

BRADYKININ; ION; MYOGLOBIN; PROTEIN;

ARTICLE; DISSOCIATION; ELECTRIC FIELD; INSTRUMENT; MASS SPECTROMETRY; OSCILLATION; PRECURSOR; SEPARATION TECHNIQUE; TUBE;

BRADYKININ; IONS; MYOGLOBIN; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TIME FACTORS;

EID: 0242543428     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac030111r     Document Type: Article

References (50)

1. Biemann, K. Methods Enzymol. 1990, 193, 351.
2. Yost, R. A.; Boyd, R. K. Methods Enzymol. 1990, 193, 154.
3. Gross, M. L. Methods Enzymol. 1990, 193, 131.
4. Tober, K. B. Mass Spectrom. Rev. 1989, 8, 445.
5. Biemann, K. Biomed. Environ. Mass Spectrom. 1988, 16, 99.
6. Hunt, D. F.; Henderson, R. A.; Shabanowitz, J.; Sakaguchi, K.; Michel, H.; Sevilir, N.; Cox, A. L.; Appella, E.; Engelhard, V. H. Science 1992, 255, 1261.
7. Hunt, D. F.; Michel, H.; Dickinson, T. A.; Shabanowitz, J.; Cox, A. L.; Sakaguchi, K.; Appella, E.; Grey, H. M.; Sette, A. Science 1992, 256, 1817.
8. Ballard, K. D.; Gaskell, S. J. Int. J. Mass Spectrom. Ion Processes 1991, 111, 173.
9. Johnson, R. S.; Martin, S. A.; Biemann, K.; Stults, J. T.; Watson, J. T. Anal. Chem. 1987, 59, 2621.
10. Johnson, R. S.; Martin, S. A.; Biemann, K. Int. J. Mass Spectrom. Ion Processes 1988, 86, 137.
11. McCormack, A. L.; Somogyi, Á.; Dongré, A. R.; Wysocki, V. H. Anal. Chem. 1993, 65, 2859.
12. Jones, J. L.; Dongré, A. R.; Somogyi, Á.; Wysocki, V. H. J. Am. Chem. Soc. 1994, 116, 8368.
13. Mortz, E.; O'Connor, P. B.; Roepstorff, P.; Kelleher, N. L.; Wood, T. D. ; McLafferty, F. W.; Mann, M. Proc. Natl. Acad. Sci. U.S.A. 1996. 93, 8264.
14. Cargile, B. J.; McLuckey, S. A.; Stephenson, J. L., Jr. Anal. Chem. 2001, 73, 1277.
15. Speir, J. P.; Senko, M. W.; Little, D. P.; Loo, J. A.; McLafferty, F. W. J. Mass Spectrom. 1995, 30, 39.
16. Little, D. P.; Speir, J. P.; Senko, M. W.; O'Connor, P. B.; McLafferty, F. W. Anal. Chem. 1994, 66, 2809.
17. Chorush, R. A.; Little, D. P.; Beu, S. C.; Wood, T. D.; McLafferty, F. W. Anal. Chem. 1995, 67, 1042.
18. Cooks, R. G.; Ast, T.; Mabud, MD. A. Int. J. Mass Spectrom. Ion Processes 1990, 103, 1.
19. Mabud, MD. A.; Dekrey, M. J.; Cooks, R. G. Int. J. Mass Spectrom. Ion Processes 1985, 67, 285.
20. Senko, M. W.; Beu, S. C.; McLafferty, F. W. Anal. Chem. 1994, 66, 415.
21. Hunt, D. F.; Yates, J. F., III; Shabanovitz, J.; Winston, S.; Hauer, C. R. Proc. Natl. Acad. Sci. U. S. A. 1986, 83, 6233.
22. Biemann, K.; Scoble, H. A. Science 1987, 237, 992.
23. Schnier, P. D.; Price, W. D.; Jockusch, R. A.; Williams, E. R. J. Am. Chem. Soc. 1996, 118, 7178.
24. Ge, Y.; Horn, D. M.; McLaffertyk, F. W. Int. J. Mass Spectrom. 2001, 210, 203.
25. Little, D. P.; Speir, J. P.; Senko, M. W.; O'Connor, P. B.; McLafferty, F. W. Anal. Chem. 1994, 66, 2809.
26. Price, W. D.; Schnier, P. D.; Williams, E. R. Anal. Chem. 1996, 68, 859.
27. Freitas, M. A.; Hendrickson, C. L.; Marshall, A. G. J. Am. Chem. Soc. 1996, 118, 7390.
28. Alexander, A. J.; Thibault, P.; Boyd, R. K. Rapid Commun. Mass Spectrom. 1989, 3, 30.
29. Medzihradszky, K. F.; Maltby, D. A.; Qiu, Y.; Yu, Z.; Hall, S. C.; Chen, Y. Burlingame, A. L. Int. J. Mass Spectrom. Ion Processes 1997, 160, 357.
30. Dongré, A. R.; Jones, J. L.; Somogyi, A.; Wysocki, V. H. J. Am. Chem. Soc. 1996, 118, 8365.
31. Lee, Y. J.; Hoaglund-Hyzer, C. S.; Taraszka, J. A.; Zientara, G. A.; Counterman, A. E.; Clemmer, D. E. Anal. Chem. 2001, 73, 3549-3555.
32. Direct comparisons of the high-field ion fragmentation method with the orifice skimmer cone CID method have been carried out for several peptide ions (bradykinin, angiotensin I, angiotensin II, methionine enkephalin, substance P) as well as those produced from tryptic digestion of cytochrome c. Ion intensities in fragment spectra are more than 1 order of magnitude higher when recorded using the high-field fragmentation method. We also note that fragmentation efficiency in the high-field method appears to be greater for most ions.
33. St. Louis, R. H.; Hill, H. H. Crit. Rev. Anal. Chem. 1990, 21, 321.
34. Wyttenbach, T.; Bushnell, J. E.; Bowers, M. T. J. Am. Chem. Soc. 1998, 120, 5098.
35. Clemmer, D. E.; Jarrold, M. F. J. Mass Spectrom. 1997, 32, 577.
36. Hoaglund Hyzer, C. S.; Counterman, A. E.; Clemmer, D. E. Chem. Rev. 1999, 99, 3037.
37. Jarrold, M. F. Annu. Rev. Phys. Chem. 2000, 51, 179.
38. Hoaglund, C. S.; Valentine, S. J.; Sporleder, C. R.; Reilly, J. P.; Clemmer, D. E. Anal. Chem. 1998, 70, 2236-2242.
39. Hoaglund-Hyzer, C. S.; Clemmer, D. E. Anal. Chem. 2001, 73, 177-184.
40. Fenn, J. B.; Mann, M.; Meng, C. K.; Wong, S. F.; Whitehouse, C. M. Science 1989, 246, 64.
41. Dahl, D. A. SIMION (Version 7.0): Idaho National Engineering Laboratory: Idaho Falls, ID.
42. Counterman, A. E.; Valentine, S. J.; Srebalus, C. A.; Henderson, S. C.; Hoaglund, C. S.; Clemmer, D. E. J. Am. Soc. Mass Spectrom. 1998, 9, 743-759.
43. Wyttenbach, T.; Kemper, P. R.; Bowers, M. T. Int. J. Mass Spectrom. 2001, 1-3, 212.
44. Hoaglund-Hyzer, C. S.; Li, J.; Clemmer, D. E. Anal. Chem. 2000, 72, 2737.
45. Hoaglund-Hyzer, C. S.; Lee, Y. J.; Counterman, A. E.; Clemmer, D. E. Anal. Chem. 2002, 74, 992-1006.
46. Clemmer, D. E.; Hudgins, R. R.; Jarrold, M. F. J. Am. Chem. Soc. 1995, 117, 10141.
47. Shelimov, K. B.; Jarrold, M. F. J. Am. Chem. Soc. 1996, 118, 10313.
48. Shelimov, K. B.; Clemmer, D. E.; Hudgins, R. R.; Jarrold, M. F. J. Am. Chem. Soc. 1997, 119, 2240.
49. Woenkhaus, J.; Mao, Y.; Jarrold, M. F. J. Phys. Chem. B 1997, 101, 847.
50. Newton, K. A.; Chrisman, P. A.; Reid, G. E.; Wells, J. M.; McLuckey, S. A. Int. J. Mass Spectrom. 2001, 212, 359.