The regulatory E2 proteins of human genital papillomaviruses are pro-apoptotic

Biochimie

Volumn 85, Issue 8, 2003, Pages 813-819

  Blachon, S ^a   Demeret, C ^a  

^a INSTITUT PASTEUR   (France)

Author keywords

Apoptosis; Caspases; Cell cycle arrest; Extrinsic pathway; HPV E2

Indexed keywords

BENZYLOXYCARBONYLISOLEUCYLGLUTAMYLTHREONYLASPARTYL FLUOROMETHYL KETONE; BENZYLOXYCARBONYLLEUCYLGLUTAMYLHISTIDYLASPARTYL FLUOROMETHYL KETONE; BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CASPASE; CASPASE 8; CASPASE INHIBITOR; HELICASE; PROTEIN P53; UNCLASSIFIED DRUG; VIRUS DNA; VIRUS PROTEIN; WART VIRUS E2 PROTEIN;

AMINO TERMINAL SEQUENCE; APOPTOSIS; CARCINOGENESIS; CARCINOMA CELL; CELL CYCLE G1 PHASE; CELL DEATH; CELL PROLIFERATION; CELL SURVIVAL; DNA REPLICATION; HUMAN; INHIBITION KINETICS; NONHUMAN; NUCLEIC ACID AMPLIFICATION; PAPILLOMA VIRUS; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS REGULATION; REGULATORY MECHANISM; REVIEW; TRANSACTIVATION; TRANSCRIPTION REGULATION; UTERINE CERVIX CARCINOMA; VIRUS ONCOGENE;

PAPILLOMAVIRUS;

EID: 0242521624     PISSN: 03009084     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biochi.2003.09.008     Document Type: Article

References (38)

1. J.M. Walboomers, M.V. Jacobs, M.M. Manos, F.X. Bosch, J.A. Kummer, K.V. Shah, P.J. Snijders, J. Peto, C.J. Meijer, N. Munoz, Human papillovirus is a necessary cause of invasive cervical cancer worldwide, J. Pathol. 189 (1999) 12-19.
2. J. Doorbar, S. Ely, J. Sterling, C. McLean, L. Crawford, Specific interaction between HPV-16 E1-E4 and cytokeratins results in collapse of the epithelial cell intermediate filament network, Nature 352 (1991) 824-837.
3. F.J. Hughes, M.A. Romanos, E1 protein of human papillomavirus is a DNA helicase/ATPase, Nucleic Acids Res. 21 (1993) 5817-5823.
4. Y.-S. Seo, F. Müller, M. Lusky, J. Hurwitz, Bovine papillomavirus (BPV)-encoded E1 protein contains multiple activities required for BPV DNA replication, Proc. Natl. Acad. Sci. USA 90 (1993) 702-706.
5. F. Fehrmann, D.J. Klumpp, L.A. Laimins, Human papillomavirus type 31 E5 protein supports cell cycle progression and activates late viral functions upon epithelial differentiation, J. Virol. 77 (2003) 2819-2831.
6. J.M. Huibregtse, M. Scheffner, P.M. Howley, Cloning and expression of the cDNA for E6-AP, a protein that mediates the interaction of the human papillomavirus E6 oncoprotein with p53, Mol. Cell. Biol. 13 (1993) 775-784.
7. M. Scheffner, B.A. Werness, J.M. Huibregtse, A.J. Levine, P.M. Howley, The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53, Cell 63 (1990) 1129-1136.
8. N. Dyson, P.M. Howley, K. Münger, E. Harlow, The human papillomavirus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product, Science 243 (1989) 934-937.
9. K. Münger, P.M. Howley, Human papillomavirus immortalization and transformation functions, Virus Res. 89 (2002) 213-228.
10. E.R. Flores, P.F. Lambert, Evidence for a switch in the mode of human papillomavirus type 16 DNA replication during the viral life cycle, J. Virol. 71 (1997) 7167-7179.
11. M.A. Stanley, Human papillomavirus and cervical carcinogenesis, Best Pract. Res. Clin. Obstet. Gynaecol. 15 (2001) 663-676.
12. I. Giri, M. Yaniv, Structural and mutational analysis of E2 trans-activating proteins of papillomaviruses reveals three distinct functional domains, EMBO J. 7 (1988) 2823-2929.
13. R.S. Hegde, S.R. Grossman, L.A. Laimins, P.B. Sigler, Crystal structure at 1.7 A of the bovine papillomavirus-1 E2 DNA-binding domain bound to its DNA target, Nature 359 (1992) 505-512.
14. R.S. Hegde, E.J. Androphy, Crystal structure of the E2 DNA-binding domain from human papillomavirus type 16: Implications for its DNA binding-site selection mechanism, J. Mol. Biol. 284 (1998) 1479-1489.
15. S.S. Kim, J.K. Tam, A.F. Wang, R.S. Hegde, The structural basis of DNA target discrimination by papillomavirus E2 proteins, J. Biol. Chem. 275 (2000) 31245-31254.
16. S.F. Harris, M.R. Botchan, Crystal structure of the human papillomavirus type 18 E2 activation domain, Science 284 (1999) 1673-1677.
17. A.A. Antson, J.E. Burns, O.V. Moroz, D.J. Scott, C.M. Sanders, I.B. Bronstein, G.G. Dodson, K.S. Wilson, N.J. Maitland, Structure of the intact transactivation domain of the human papillomavirus E2 protein, Nature 403 (2000) 805-809.
18. M. Remm, R. Brain, J.R. Jenkins, The E2 binding sites determine the efficiency of replication for the origin of human papillomavirus type 18. Nucleic Acids Res. 20 (1992) 6015-6021.
19. C. Demeret, M. Le Moal, M. Yaniv, F. Thierry, Control of HPV18 DNA replication by cellular and viral transcription factors, Nucleic Acids Res. 23 (1995) 4777-4784.
20. C. Demeret, C. Desaintes, M. Yaniv, F. Thierry, Different mechanisms contribute to the E2-mediated transcriptional repression of HPV18 viral oncogenes, J. Virol. 71 (1997) 9343-9349.
21. N. Dostatni, P.F. Lambert, R. Sousa, J. Ham, P.M. Howley, M. Yaniv, The functional BPV1 E2 trans-activating protein can act as a repressor by preventing formation of the initiation complex, Genes Dev. 5 (1991) 1657-1671.
22. V. Bouvard, A. Storey, D. Pinn, L. Banks, Characterization of the human papillomavirus E2 protein: Evidence of trans-activation and trans-repression in cervical keratinocytes, EMBO J. 13 (1994) 5451-5459.
23. G. Steger, S. Corbach, Dose-dependent regulation of the early promoter of human papillomavirus type 18 by the viral E2 protein, J. Virol. 71 (1997) 50-58.
24. S.A. Corden, L.J. Sant-Cassia, A.J. Easton, A.G. Morris, The integration of HPV-18 DNA in cervical carcinoma, Pathol. Mol. Pathol. 52 (1999) 275-282.
25. F. Thierry, M. Yaniv, The BPV1-E2 trans-acting protein can be either an activator or a repressor of the HPV18 regulatory region, EMBO J. 6 (1987) 3391-3397.
26. C. Desaintes, C. Demeret, S. Goyat, M. Yaniv, F. Thierry, Expression of the papillomavirus E2 protein in HeLa cells leads to apoptosis, EMBO J. 16 (1997) 504-514.
27. J.J. Dowhanick, A.A. McBride, P.M. Howley, Suppression of cellular proliferation by the papillomavirus E2 protein. J. Virol. 69 (1995) 7791-7799.
28. E.S. Hwang, D.J. Riese, J. Settleman, L.A. Nilson, J. Honig, S. Flynn, D. Di Maio, Inhibition of cervical carcinoma cell line proliferation by the introduction of a bovine regulatory gene. J. Virol. 67 (1993) 3720-3729.
29. C. Demeret, A. Garcia-Carranca, F. Thierry, Transcription-independent triggering of the extrinsic pathway of apoptosis by human papillomavirus 18 E2 protein, Oncogene 22 (2003) 168-175.
30. C. Desaintes, S. Goyat, S. Garbay, M. Yaniv, F. Thierry, Papillomavirus E2 induces p53-independent apoptosis in HeLa cells, Oncogene 18 (1999) 4538-4545.
31. K. Webster, J. Parish, M. Pandya, P.L. Stern, A.R. Clarke, K. Gaston, The human papillomavirus (HPV) 16 E2 protein induces apoptosis in the absence of other HPV proteins and via a p53-dependent pathway, J. Biol. Chem. 275 (2000) 87-94.
32. E.C. Goodwin, E. Yang, C.J. Lee, H.W. Lee, D. Di Maio, E.S. Hwang, Rapid induction of senescence in human cervical carcinoma cells, Proc. Natl. Acad. Sci. USA 97 (2000) 10978-10983.
33. S.I. Wells, D.A. Francis, A.Y. Karpova, J.J. Dowhanick, J.D. Benson, P.M. Howley, Papillomavirus E2 induces senescence in HPV-positive cells via pRB- and p21(CIP)-dependent pathways, EMBO J. 19 (2000) 5762-5771.
34. S. Bellanger, C. Demeret, S. Goyat, F. Thierry, Stability of the human papillomavirus type 18 E2 protein is regulated by a proteasome degradation pathway through its amino-terminal transactivation domain, J. Virol. 75 (2001) 7244-7251.
35. A. Ashkenazi, V.M. Dixit, Death receptors: Signaling and modulation, Science 281 (1998) 1305-1308.
36. N.A. Thornberry, T.A. Rano, E.P. Peterson, D.M. Rasper, T. Timkey, M. Garcia-Calvo, V.M. Houtzager, P.A. Nordstrom, S.Roy, J.P. Vaillancourt, K.T. Chapman, D.W. Nicholson, A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis, J. Biol. Chem. 272 (1997) 17907-17911.
37. S. Mazumder, B. Gong, Q. Chen, J.A. Drazba, J.C. Buchsbaum, A. Almasan, Proteolytic cleavage of cyclin E leads to inactivation of associated kinase activity and amplification of apoptosis in hematopoietic cells, Mol. Cell. Biol. 22 (2002) 2398-2409.
38. M.O. Hengartner, The biochemistry of apoptosis, Nature 407 (2000) 770-776.