Stability of the human papillomavirus type 18 E2 protein is regulated by a proteasome degradation pathway through its amino-terminal transactivation domain

Journal of Virology

Volumn 75, Issue 16, 2001, Pages 7244-7251

  Bellanger, S ^a   Demeret, C ^a   Goyat, S ^a   Thierry, F ^a  

^a Institut Pasteur   (France)

Author keywords

[No Author keywords available]

Indexed keywords

GREEN FLUORESCENT PROTEIN; PROTEASOME; UBIQUITIN; VIRUS PROTEIN;

AMINO TERMINAL SEQUENCE; ARTICLE; CELL CYCLE; CELL CYCLE G1 PHASE; CELL GROWTH; DNA REPLICATION; GENETIC TRANSFECTION; HALF LIFE TIME; HELA CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN STABILITY; TRANSACTIVATION; TRANSCRIPTION REGULATION; VIRUS TRANSCRIPTION; WART VIRUS;

CYSTEINE ENDOPEPTIDASES; GENE EXPRESSION REGULATION, VIRAL; HELA CELLS; HUMANS; MULTIENZYME COMPLEXES; ONCOGENE PROTEINS, VIRAL; PAPILLOMAVIRIDAE; PROTEASOME ENDOPEPTIDASE COMPLEX; STRUCTURE-ACTIVITY RELATIONSHIP; TRANS-ACTIVATION (GENETICS); VIRUS REPLICATION;

EID: 0034910932     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.75.16.7244-7251.2001     Document Type: Article

References (40)

1. Structure of the intact transactivation domain of the human papillomavirus E2 protein
2. Genome amplification of human papillomavirus types 16 and 18 in cervical carcinomas is related to the retention of E1/E2 genes
3. The integration of HPV-18 DNA in cervical carcinoma
4. Recombinational construction in Escherichia coli of infectious adenovirus genomes
5. Analysis of the physical state of different human papillomavirus DNAs in intraepithelial and invasive cervical neoplasm
6. Different mechanisms contribute to the E2-mediated transcriptional repression of human papillomavirus type 18 viral oncogenes
7. The E2 transcriptional repressor can compensate for Sp1 activation of the human papillomavirus type 18 early promoter
8. Control of papillomavirus DNA replication and transcription
9. Expression of the papillomavirus E2 protein in HeLa cells leads to apoptosis
10. Papillomavirus E2 induces p53-independent apoptosis in HeLa cells
11. Human papillomavirus type 11 E2 proteins repress the homologous E6 promoter by interfering with the binding of host transcription factors to adjacent elements
12. The functional BPV1 E2 trans-activating protein can act as a repressor by preventing formation of the initiation complex
13. A dimer of BPV-1 E2 containing a protease resistant core interacts with its DNA target
14. Suppression of cellular proliferation by the papillomavirus E2 protein
15. Association of activating transcription factor 2 (ATF2) with the ubiquitin-conjugating enzyme hUBC9. Implication of the ubiquitin/proteasome pathway in regulation of ATF2 in T cells
16. Induction of human papillomavirus type 18 late gene expression and genomic amplification in organotypic cultures from transfected DNA templates
17. Structural and mutational analysis of E2 trans-activating proteins of papillomaviruses reveals three distinct functional domains
18. Transactivation-competent bovine papillomavirus E2 protein is specifically required for efficient repression of human papillomavirus oncogene expression and for acute growth inhibition of cervical carcinoma cell lines
19. Crystal structure of the human papillomavirus type 18 E2 activation domain
20. Degradation of E2F by the ubiquitin-proteasome pathway: Regulation by retinoblastoma family proteins and adenovirus transforming proteins
21. Mdm2 promotes the rapid degradation of p53
22. Crystal structure at 1.7 A of the bovine papillomavirus-1 E2 DNA-binding domain bound to its DNA target
23. Inhibition of cervical carcinoma cell line proliferation by the introduction of a bovine papillomavirus regulatory gene
24. Regulation of Mdm2-directed degradation by the C terminus of p53
25. A papillomavirus E2 phosphorylation mutant exhibits normal transient replication and transcription but is defective in transformation and plasmid retention
26. Phosphorylation sites of the E2 transcriptional regulatory proteins of bovine papillomavirus type 1
27. E2 polypeptides encoded by bovine papillomavirus type 1 form dimers through the common carboxyl-terminal domain: Transactivation is mediated by the conserved amino-terminal domain
28. Synthesis of infectious human papillomavirus type 18 in differentiating epithelium transfected with viral DNA
29. Human Scribble (vartul) is targeted for ubiquitin-mediated degradation by the high-risk papillomavirus E6 proteins and the E6AP ubiquitin-protein ligase
30. Proteasome-mediated degradation of the papillomavirus E2-TA protein is regulated by phosphorylation and can modulate viral genome copy number
31. Destruction of Myc by ubiquitin-mediated proteolysis: Cancer-associated and transforming mutations stabilize Myc
32. Functional overlap of sequences that activate transcription and signal ubiquitin-mediated proteolysis
33. Structure and transcription of human papillomavirus sequences in cervical carcinoma cells
34. The bovine papillomavirus type 1 E2 transactivator and repressor proteins use different nuclear localization signals
35. Inverse relationship between the expression of the human papillomavirus type 16 transcription factor E2 and virus DNA copy number during the progression of cervical intraneoplasia
36. The human papillomavirus type 16 E2 transcription factor binds with low cooperativity to two flanking sites and represses the E6 promoter through displacement of Sp1 and TFIID
37. Cooperative activation of transcription by bovine papillomavirus type 1 E2 can occur over a large distance
38. Characterization of a transcriptional promoter of human papillomavirus 18 and modulation of its expression by simian virus 40 and adenovirus early antigens
39. Ubiquitin-dependent c-Jun degradation in vivo is mediated by the delta domain
40. The hinge of the human papillomavirus type 11 E2 protein contains major determinants for nuclear localization and nuclear matrix association