-
3
-
-
0027513268
-
Apoptosis
-
Cohen JJ. Apoptosis. Immunol Today 1993 ; 14:126-30.
-
(1993)
Immunol Today
, vol.14
, pp. 126-130
-
-
Cohen, J.J.1
-
4
-
-
12044249765
-
Linkage of a gene causing FALS to chromosome 21
-
Siddique T, Figlewicz MA, Paricak MA et al. Linkage of a gene causing FALS to chromosome 21. N Engl J Med 1991 ; 324:1380-4.
-
(1991)
N Engl J Med
, vol.324
, pp. 1380-1384
-
-
Siddique, T.1
Figlewicz, M.A.2
Paricak, M.A.3
-
5
-
-
0027401203
-
Mutations in Cu-Zn SOD gene are associated with FALS
-
Rosen DR, Siddique T, Patterson D et al. Mutations in Cu-Zn SOD gene are associated with FALS Nature 1993 ; 362:59-62.
-
(1993)
Nature
, vol.362
, pp. 59-62
-
-
Rosen, D.R.1
Siddique, T.2
Patterson, D.3
-
6
-
-
0029048169
-
Identification of 3 novel mutations in the gene for Cu-Zn SOD in patients with FALS
-
Sapp P, Rosen D, Hosler B et al. Identification of 3 novel mutations in the gene for Cu-Zn SOD in patients with FALS. Neuromusc Disord 1995 ; 5:353-7.
-
(1995)
Neuromusc Disord
, vol.5
, pp. 353-357
-
-
Sapp, P.1
Rosen, D.2
Hosler, B.3
-
7
-
-
0344360068
-
Motor neuron degeneration in mice expressing a human Cu-Zn SOD mutation
-
Gumey ME, Pu H, Chiu AY et al. Motor neuron degeneration in mice expressing a human Cu-Zn SOD mutation. Science 1994 ; 264:1172-5.
-
(1994)
Science
, vol.264
, pp. 1172-1175
-
-
Gumey, M.E.1
Pu, H.2
Chiu, A.Y.3
-
9
-
-
0027952571
-
Cu-Zn SOD Activity in FALS and in sporadic ALS
-
Robberecht W, Sapp P, Viaene MK. Cu-Zn SOD Activity in FALS and in sporadic ALS. J Neurochem 1994 ; 62:384-7.
-
(1994)
J Neurochem
, vol.62
, pp. 384-387
-
-
Robberecht, W.1
Sapp, P.2
Viaene, M.K.3
-
12
-
-
0027293275
-
ALS, SOD and peroxynitrite
-
Beckman JS, Carson M, Smith CD, Koppenol W. H. ALS, SOD and peroxynitrite. Nature 1993 ; 364:584.
-
(1993)
Nature
, vol.364
, pp. 584
-
-
Beckman, J.S.1
Carson, M.2
Smith, C.D.3
Koppenol, W.H.4
-
13
-
-
0028915976
-
Mutations associated with ALS convert SOD from an antiapoptic gene to a proapoptic gene
-
Ravizadeh S, Gralla EB, Borchelt DR et al. Mutations associated with ALS convert SOD from an antiapoptic gene to a proapoptic gene. Proc Natl Acod Sci USA 1995 ; 92:3024-8.
-
(1995)
Proc Natl Acod Sci USA
, vol.92
, pp. 3024-3028
-
-
Ravizadeh, S.1
Gralla, E.B.2
Borchelt, D.R.3
-
15
-
-
0030050727
-
Benefit of vitamine E, riluzole, and gabapentin in a transgenic model of FALS
-
Gurney ME, Cuttings FB, Zai P et al. Benefit of vitamine E, riluzole, and gabapentin in a transgenic model of FALS. Ann Neurol 1996 ; 39:147-57.
-
(1996)
Ann Neurol
, vol.39
, pp. 147-157
-
-
Gurney, M.E.1
Cuttings, F.B.2
Zai, P.3
-
16
-
-
0029053881
-
An adverse property of a FALS linked SOD mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria
-
Wong PC, Pardo CA, Borchelt DR et al. An adverse property of a FALS linked SOD mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria. Neuron 1995 ; 14:1105-16.
-
(1995)
Neuron
, vol.14
, pp. 1105-1116
-
-
Wong, P.C.1
Pardo, C.A.2
Borchelt, D.R.3
-
17
-
-
0027966078
-
Cu-Zn SOD like immuno reactivity in Lewy body-like indusions of sporadic ALS
-
Shibata N, Hirano A, Kobayashi A et al. Cu-Zn SOD like immuno reactivity in Lewy body-like indusions of sporadic ALS. Neurosci Lett 1994 ; 179:149-52.
-
(1994)
Neurosci Lett
, vol.179
, pp. 149-152
-
-
Shibata, N.1
Hirano, A.2
Kobayashi, A.3
-
18
-
-
0028176651
-
Oxidative stress as a mediator of apoptosis
-
Buttke TM, Sandstrom PA. Oxidative stress as a mediator of apoptosis. Immunol Today 1994 ; 15:7-10.
-
(1994)
Immunol Today
, vol.15
, pp. 7-10
-
-
Buttke, T.M.1
Sandstrom, P.A.2
-
19
-
-
0028205372
-
Chronic inhibition of SOD produces apoptic death of spinal neurons
-
Rothstein JD, Bristol LA, Hoosler B et al. Chronic inhibition of SOD produces apoptic death of spinal neurons. Proc Natl Acad Sci USA 1994 ; 91:4155-9.
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 4155-4159
-
-
Rothstein, J.D.1
Bristol, L.A.2
Hoosler, B.3
-
20
-
-
0345222781
-
Bcl-2 down-regulates the activity of NF-kB induced upon apoptisis
-
Grimm, Bauer MKA, Bauerle PA et al. Bcl-2 down-regulates the activity of NF-kB induced upon apoptisis. J Cell Biol 1988 ; 134:13-23.
-
(1988)
J Cell Biol
, vol.134
, pp. 13-23
-
-
Bauer, M.K.A.1
Bauerle, P.A.2
-
22
-
-
0028762647
-
Excitatory amino acids as a final common pathway for neurologic disorders
-
Lipton SA, Rosenberg PA. Excitatory amino acids as a final common pathway for neurologic disorders. N Engl J Med 1994 ; 330:613-22.
-
(1994)
N Engl J Med
, vol.330
, pp. 613-622
-
-
Lipton, S.A.1
Rosenberg, P.A.2
-
23
-
-
0344629013
-
Oxidative modification of glutamine-synthase
-
Levine RL. Oxidative modification of glutamine-synthase. J Biol Chem 1983 ; 258:11826-7.
-
(1983)
J Biol Chem
, vol.258
, pp. 11826-11827
-
-
Levine, R.L.1
-
24
-
-
0025832844
-
Reversal of age related increase in brain protein oxidation, decrease in enzyme activity, and loss in temporal and spartial memory by chronic administration of spin trapping compound N-tertbutyl-a-phenylnitrone
-
Carney JM, Starke Reed PE, Olivier CW et al. Reversal of age related increase in brain protein oxidation, decrease in enzyme activity, and loss in temporal and spartial memory by chronic administration of spin trapping compound N-tertbutyl-a-phenylnitrone. Proc Natl Acad Sci USA 1991 ; 88:3633-6.
-
(1991)
Proc Natl Acad Sci USA
, vol.88
, pp. 3633-3636
-
-
Carney, J.M.1
Starke Reed, P.E.2
Olivier, C.W.3
-
25
-
-
0026533608
-
ALS and glutamate - Too much of a good thing
-
Choi DW. ALS and glutamate - Too much of a good thing. N Engl J Med 1992 ; 326:1493-5.
-
(1992)
N Engl J Med
, vol.326
, pp. 1493-1495
-
-
Choi, D.W.1
-
27
-
-
0027527023
-
Oxidative damage to mithochondrial DNA shows marked age dependent increases in human brain
-
Mecocci P, Macgarvey U, Kaufman AE et al. Oxidative damage to mithochondrial DNA shows marked age dependent increases in human brain. Ann Neurol 1993 ; 34:609-16.
-
(1993)
Ann Neurol
, vol.34
, pp. 609-616
-
-
Mecocci, P.1
Macgarvey, U.2
Kaufman, A.E.3
-
28
-
-
0026584524
-
Does impairment of energy metabolism results in excitotoxic neuronal death in neurodegenerative illnesses
-
Beal MF. Does impairment of energy metabolism results in excitotoxic neuronal death in neurodegenerative illnesses. Ann Neurol 1992 ; 31:119-30.
-
(1992)
Ann Neurol
, vol.31
, pp. 119-130
-
-
Beal, M.F.1
-
29
-
-
0030451407
-
Immunologic NOS: Elevation in severe AIDS dementia and induction by HIV-1 gp41
-
Adamson DC, Wilddemann B, Sasaki M et al. Immunologic NOS: Elevation in severe AIDS dementia and induction by HIV-1 gp41. Science 1996 ; 274:1917-21.
-
(1996)
Science
, vol.274
, pp. 1917-1921
-
-
Adamson, D.C.1
Wilddemann, B.2
Sasaki, M.3
-
30
-
-
0026704066
-
An introduction to the free radical hypothesis in Parkinson's Disease
-
Olanow CW. An introduction to the free radical hypothesis in Parkinson's Disease. Ann Neurol 1992 ; 32:S2-9.
-
(1992)
Ann Neurol
, vol.32
-
-
Olanow, C.W.1
-
31
-
-
0029330597
-
Oxidative stress and Alzheimer's disease
-
Choi BH. Oxidative stress and Alzheimer's disease. Neurobiol Aging 1995 ; 16:675-8.
-
(1995)
Neurobiol Aging
, vol.16
, pp. 675-678
-
-
Choi, B.H.1
-
32
-
-
0029125857
-
Aging, energy, and oxidative stress in neurodegenerative diseases
-
Beal MF. Aging, energy, and oxidative stress in neurodegenerative diseases. Ann Neurol 1995 ; 38:557-68.
-
(1995)
Ann Neurol
, vol.38
, pp. 557-568
-
-
Beal, M.F.1
-
34
-
-
0028966205
-
Regulation of nitric oxide synthase activity in HIV-1 infected monocytes: Implications for HIV-associated neurological disease
-
Bukrinsky MI, Nottet HS, Schmidtmayeriva H et al. Regulation of nitric oxide synthase activity in HIV-1 infected monocytes: implications for HIV-associated neurological disease. J Exp Med 1995 ; 181:735-45.
-
(1995)
J Exp Med
, vol.181
, pp. 735-745
-
-
Bukrinsky, M.I.1
Nottet, H.S.2
Schmidtmayeriva, H.3
-
36
-
-
0027496238
-
A radical hypothesis for neurodegeneration
-
Olanow CW. A radical hypothesis for neurodegeneration. TINS 1993 ; 16:439-44.
-
(1993)
TINS
, vol.16
, pp. 439-444
-
-
Olanow, C.W.1
-
37
-
-
0344791966
-
Basal lipid peroxidation is increased in Parkinson's disease
-
Dexter D, Carter C, Javoy H et al. Basal lipid peroxidation is increased in Parkinson's disease. J Neuroche 1989 ; 52:53692-7.
-
(1989)
J Neuroche
, vol.52
, pp. 53692-53697
-
-
Dexter, D.1
Carter, C.2
Javoy, H.3
-
38
-
-
0026040282
-
Iron melanin interaction and lipid peroidation: Implications for Parkinson's Disease
-
Ben-Sachar D, Riedeerer P, Youdim MBH. Iron melanin interaction and lipid peroidation: implications for Parkinson's Disease. J Neurochem 1991 ; 57:609-12.
-
(1991)
J Neurochem
, vol.57
, pp. 609-612
-
-
Ben-Sachar, D.1
Riedeerer, P.2
Youdim, M.B.H.3
-
39
-
-
0026746512
-
Neuromelanin-containing neurons of the substantia nigra accumulate iron and aluminium in Parkinson's disease
-
Good PF, Olanow CW, Perl DP. Neuromelanin-containing neurons of the substantia nigra accumulate iron and aluminium in Parkinson's disease. Brain Res 1992 ; 5933:343-6.
-
(1992)
Brain Res
, vol.5933
, pp. 343-346
-
-
Good, P.F.1
Olanow, C.W.2
Perl, D.P.3
-
40
-
-
0026635456
-
Iron and oxygen radicals in brain
-
Gutteridge JMC. Iron and oxygen radicals in brain. Ann Neurol 1992 ; 32:S16-22.
-
(1992)
Ann Neurol
, vol.32
-
-
Gutteridge, J.M.C.1
-
41
-
-
0026635461
-
Oxidative stress as a cause of nigral cell death in Parkinson's Disease and incidental Lewy body disease
-
Jenner P, Dexter DT, Sian J et al. Oxidative stress as a cause of nigral cell death in Parkinson's Disease and incidental Lewy body disease. Ann Neurol 1992 ; 32:S82-8.
-
(1992)
Ann Neurol
, vol.32
-
-
Jenner, P.1
Dexter, D.T.2
Sian, J.3
-
43
-
-
0030915855
-
Oxidative stress hypothesis in Alzheimer's disease
-
Markesbery WR. Oxidative stress hypothesis in Alzheimer's disease. Free Radic Biol Med 1997 ; 23:134-47.
-
(1997)
Free Radic Biol Med
, vol.23
, pp. 134-147
-
-
Markesbery, W.R.1
-
44
-
-
0007627726
-
Oxidative damage in Alzheimer's disease
-
Smith MA, Perry G, Richey PL et al. Oxidative damage in Alzheimer's disease. Nature 1996 ; 382:120-2.
-
(1996)
Nature
, vol.382
, pp. 120-122
-
-
Smith, M.A.1
Perry, G.2
Richey, P.L.3
-
45
-
-
0028180518
-
A model of ß-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: Relevance to Alzheimer's disease
-
Hensley K, Carney JM, Mattson MP et al. A model of ß-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: Relevance to Alzheimer's disease. Proc Natl Acad Sci USA 1994 ; 91:3270-4.
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 3270-3274
-
-
Hensley, K.1
Carney, J.M.2
Mattson, M.P.3
-
46
-
-
0028980414
-
ß-amyloid derived OFR inhibit glutamate uptake in cultured astrocytes: Implications for Alzheimer's disease
-
Harris ME, Carney JM, Cole PS et al. ß-amyloid derived OFR inhibit glutamate uptake in cultured astrocytes: implications for Alzheimer's disease. Neuroreport 1995 ; 6:1875-9.
-
(1995)
Neuroreport
, vol.6
, pp. 1875-1879
-
-
Harris, M.E.1
Carney, J.M.2
Cole, P.S.3
-
47
-
-
0031020476
-
A role of 4-hydroxynonenal, in disruption of ion homeostasis and neuronal death induced by ß-amyloid-peptide
-
Mark RJ, Lovell MA, Markesbery WR et al. A role of 4-hydroxynonenal, in disruption of ion homeostasis and neuronal death induced by ß-amyloid-peptide. J Neurochem 1997 ; 8:255-64.
-
(1997)
J Neurochem
, vol.8
, pp. 255-264
-
-
Mark, R.J.1
Lovell, Ma.2
Markesbery, W.R.3
-
48
-
-
0030155860
-
Amytoid-ß-peptide and oxidativecellular injury in Alzheimer's disease
-
Mark RJ, Blance M, Mattson MT. Amytoid-ß-peptide and oxidativecellular injury in Alzheimer's disease. Mol Neurobiol 1996 ; 38:211-24.
-
(1996)
Mol Neurobiol
, vol.38
, pp. 211-224
-
-
Mark, R.J.1
Blance, M.2
Mattson, M.T.3
-
49
-
-
0025790342
-
Excess brain protein oxidation and enzyme dysfunction in normal aging and Alzheimer's disease
-
Smith CD, Carney JM, Starke-Reed PE et al. Excess brain protein oxidation and enzyme dysfunction in normal aging and Alzheimer's disease. Proc Natl Acad Sci USA 1991 ; 88:10540-3.
-
(1991)
Proc Natl Acad Sci USA
, vol.88
, pp. 10540-10543
-
-
Smith, C.D.1
Carney, J.M.2
Starke-Reed, P.E.3
-
52
-
-
0030967165
-
A controlled trial of Selegine, alpha-tocopherol or both as treament for Alzheimer's disease
-
Sano M, Emesto C, Thmasr G et al. A controlled trial of Selegine, alpha-tocopherol or both as treament for Alzheimer's disease. N Engl J Med 1997 ; 336:1216-22.
-
(1997)
N Engl J Med
, vol.336
, pp. 1216-1222
-
-
Sano, M.1
Emesto, C.2
Thmasr, G.3
-
53
-
-
0025726462
-
Intramuscular desferrioxamine in patients with Alzheimer's disease
-
Crappermaclachlan DR, Dalton AJ, Kruck TPA et al. Intramuscular desferrioxamine in patients with Alzheimer's disease. Lancet 1991 ; 337:1304-8.
-
(1991)
Lancet
, vol.337
, pp. 1304-1308
-
-
Crappermaclachlan, D.R.1
Dalton, A.J.2
Kruck, T.P.A.3
-
54
-
-
0013524059
-
Antioxidant action of melatonin
-
Reiter RJ. Antioxidant action of melatonin. Adv Pharmacol 1997 ; 38:103-11.
-
(1997)
Adv Pharmacol
, vol.38
, pp. 103-111
-
-
Reiter, R.J.1
-
55
-
-
0029150526
-
Neurotrophic factors attenuate glutamate induced accumulation of peroxides, elevation of intracellular calcium concentration, and neurotoxicity and increase antioxidant enzyme activities in hippoccampal neurons
-
Mattson MP, Lovell MA, Furukawa K, Markesbery WR. Neurotrophic factors attenuate glutamate induced accumulation of peroxides, elevation of intracellular calcium concentration, and neurotoxicity and increase antioxidant enzyme activities in hippoccampal neurons. J Neurochem 1995 ; 65:1740-51.
-
(1995)
J Neurochem
, vol.65
, pp. 1740-1751
-
-
Mattson, M.P.1
Lovell, M.A.2
Furukawa, K.3
Markesbery, W.R.4
|