Transfer of polychlorinated biphenyls and chlorinated pesticides from mother to pup in relation to cytochrome P450 enzyme activities in harp seals (Phoca groenlandica) from the gulf of St. Lawrence, Canada

Environmental Toxicology and Chemistry

Volumn 21, Issue 1, 2002, Pages 94-101

  Wolkers, Hans ^a   Burkow, Ivan C ^b   Hammill, Mike O ^c   Lydersen, Christian ^d   Witkamp, Renger F ^e  

^a NORWEGIAN INSTITUTE FOR WATER RESEARCH   (Norway)

^b NORWEGIAN INSTITUTE FOR AIR RESEARCH   (Norway)

^c NORWEGIAN POLAR INSTITUTE   (Norway)

^d FISHERIES AND OCEANS CANADA   (Canada)

^e UTRECHT UNIVERSITY   (Netherlands)

Author keywords

Chlorinated contaminants; Cytochrome P450; Harp seal; Lactational transfer; Toxaphene

Indexed keywords

ENZYME KINETICS; FOOD PRODUCTS; IMPURITIES; LIPIDS; METABOLISM; PESTICIDE EFFECTS;

CONGENERS;

POLYCHLORINATED BIPHENYLS;

1,1 DICHLORO 2,2 BIS(4 CHLOROPHENYL)ETHYLENE; CAMPHECLOR; CHLORDANE; CYTOCHROME P450; HEXACHLOROBENZENE; HEXACHLOROCYCLOHEXANE; PESTICIDE; POLYCHLORINATED BIPHENYL;

ENZYME ACTIVITY; PCB; PESTICIDE; PINNIPED;

ANIMAL EXPERIMENT; ARTICLE; CANADA; CONTROLLED STUDY; ENZYME ACTIVITY; FOOD CONTAMINATION; LACTATION; MILK; NONHUMAN; PRIORITY JOURNAL; SEAL; XENOBIOTIC METABOLISM;

ADIPOSE TISSUE; ANIMALS; ANIMALS, SUCKLING; BODY WEIGHT; CANADA; CYTOCHROME P-450 ENZYME SYSTEM; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL POLLUTANTS; FEMALE; HYDROCARBONS, CHLORINATED; MALE; MICROSOMES, LIVER; MILK; PESTICIDES; POLYCHLORINATED BIPHENYLS; SEALS, EARLESS; TISSUE DISTRIBUTION;

CANADA;

ANIMALIA; PHOCA; PHOCA GROENLANDICA; PHOCIDAE; PINNIPEDIA; VERTEBRATA;

EID: 0036138283     PISSN: 07307268     EISSN: None     Source Type: Journal    
DOI: 10.1002/etc.5620210114     Document Type: Article

References (35)

1. Environmental neurotoxic effects: The search for new protocols in functional teratology
2. PCB problems in the future: Foresight from current knowledge
3. Organochlorine contaminants in arctic marine food chains: Accumulation of specific PCBs and chlordane related compounds
4. The toxicokinetics of PCBs in marine mammals with special reference to possible interactions of individual congeners with the cytochrome P450 dependent monooxygenase system: An overview
5. Chlorinated pesticide concentrations, with an emphasis on polychlorinated camphenes (toxaphenes), in relation to cytochrome P450 enzyme activities in harp seals (Phoca groenlandica) from the Barents Sea
6. State of the marine environment in Antarctica
7. Short term fasting does not aggravate immunosuppression in harbor seal (Phoca vitulina) with high body burdens of organochlorines
8. Level sand patterns of PCBs and OC pesticides in harbor and gray sealsfrom the St. Lawrence Estuary, Canada
9. Organochlorine residues in harp seals, Phoca groenlandica, from the Gulf of St. Lawrence and Hudson Strait: An evaluation of contaminant concentrations and burdens
10. Toxic compounds and health and reproductive effects in St. Lawrence beluga whales
11. Predation by harp seals in Atlantic Canada: Preliminary consumption estimates for arctic cod, capelin and Atlantic cod
12. Behavior and energetics of ice-breeding, north Atlantic phocid seals during the lactation period
13. Transfer of organochlorine residues from blubber through the circulatory system to milk in the lactating gray seal (Halichoerus grypus)
14. Epidemiological analyses of persistent organochlorine contaminants in cetaceans
15. Cytochrome P450-mediated enzyme activities and polychlorinated biphenyl accumulation in harp seal (Phoca groenlandica)
16. Estimating the blubber content of phocid seals
17. Enantiomer selective separation of toxaphene congeners isolated from seal blubber and obtained from synthesis
18. Determination of levels of polychlorinated dibenzo-p-dioxins, dibenzofurans, biphenyls and pesticides in harp seals from the Greenland Sea
19. Interlaboratory comparison of total cytochrome P450 and protein determination in rat liver microsomes
20. Protein measurements with the Folin phenol reagents
21. Ethoxyresorufin: Direct fluorimetric assay of a microsomal O-dealkylation which is preferentially inducible by 3-methylcholanthrene
22. The isoenzyme pattern of cytochrome P450 in rat hepatocytes in primary culture, comparing different enzyme activities in microsomal incubations and intact monolayers
23. CB pattern in the harbor porpoise: Bioaccumulation, metabolism and evidence for cytochrome 450IIB activity
24. Hexachlorobenzene accumulated by dams during pregnancy is transferred to suckling rats during early lactation
25. Transplacental and lactational transfer of p, p-DDE in Sprague-Dawley rats
26. Pharmacokinetics in the infant
27. Effect of chlorinated hydrocarbons on expression of cytochrome P450 1A1, 1A2, and 1B1 and 2- and 4-hydroxylation of 17-beta-estradiol in female Sprague-Dawley rats
28. Progesterone and oestradiol-17β concentration profiles throughout the reproductive cycle in harbour seals (Phoca vitulina)
29. Suppressive effects of estradiol on 2, 3, 7, 8-tetrachloro-p-dioxin-mediated transcriptional activation of murine CYP1A-1 in mouse hepatoma hepa 1c1c7 cells
30. Influence of estradiol and testosterone on cytochrome P450 and monooxygenase activity in immature brook trout (Salvelinus fontinalus)
31. Pro- and anti-oxidant parameters in rat liver after short-term exposure to hexachlorobenzene
32. Comparison of the urinary metabolite profiles of hexachlorobenzene and pentachlorobenzene in the rat
33. Induction and inhibition of pesticide-metabolizing enzymes: Roles in synergism of pesticides and pesticide action
34. Induction and inhibition of cytochrome P450 isoforms by imazalil, a food contaminant, in mouse small intestine and liver
35. Identification of the cytochrome P450 isoenzymes involved in the metabolism of diazinon in the rat liver