(R)-(-)- and (S)-(+)-synadenol: Synthesis, absolute configuration, and enantioselectivity of antiviral effect

Journal of Medicinal Chemistry

Volumn 41, Issue 26, 1998, Pages 5257-5264

  Qiu, Yao Ling ^a   Hempel, Andrew ^b   Camerman, Norman ^b   Camerman, Arthur ^c   Geiser, Fiona ^d   Ptak, Roger G ^e   Breitenbach, Julie M ^e   Kira, Toshiko ^f   Li, Ling ^f   Gullen, Elizabeth ^f   Cheng, Yung Chi ^f   Drach, John C ^e   Zemlicka, Jiri ^a,g  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF TORONTO   (Canada)

^c Ardono Research   (United States)

^d Chiral Technologies Inc   (United States)

^e UNIVERSITY OF MICHIGAN   (United States)

^f YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^g KARMANOS CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYPOXANTHINE DERIVATIVE; NUCLEOSIDE ANALOG; SYNADENOL; UNCLASSIFIED DRUG;

ACYLATION; ALKYLATION; ANTIVIRAL ACTIVITY; ARTICLE; CHIRALITY; ENANTIOMER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ISOMERISM; RACEMIC MIXTURE; SYNTHESIS; X RAY CRYSTALLOGRAPHY; X RAY DIFFRACTION;

ADENINE; ANIMALS; ANTIVIRAL AGENTS; CELLS, CULTURED; CERCOPITHECUS AETHIOPS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CIRCULAR DICHROISM; CRYSTALLOGRAPHY, X-RAY; CYCLOPROPANES; CYTOMEGALOVIRUS; FIBROBLASTS; HEPATITIS B VIRUS; HERPESVIRUS 3, HUMAN; HERPESVIRUS 4, HUMAN; HIV-1; HUMANS; INHIBITORY CONCENTRATION 50; MICE; MOLECULAR CONFORMATION; PLAQUE ASSAY; SIMPLEXVIRUS; STEREOISOMERISM; VERO CELLS;

EID: 0032542317     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm980323u     Document Type: Article

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