Interleukin-4- and Interleukin-13 receptors trigger distinct JAK/STAT activation patterns in mouse lymphocytes

Signal Transduction

Volumn 3, Issue 1-2, 2003, Pages 26-32

  Friedrich, Karlheinz ^a   Brändlein, Stephanie ^b   Ehrhardt, Ingrid ^b   Krause, Sebastian ^a   Luttmann, Werner ^c  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^b UNIVERSITY OF WÜRZBURG   (Germany)

^c ROSTOCK UNIVERSITY MEDICAL CENTER   (Germany)

Author keywords

B cells; Interleukin 13; Interleukin 4; JAK STAT pathway

Indexed keywords

CYTOKINE; INTERLEUKIN 13; INTERLEUKIN 13 RECEPTOR; INTERLEUKIN 13 RECEPTOR ALPHA1; INTERLEUKIN 4; INTERLEUKIN 4 RECEPTOR; INTERLEUKIN 4 RECEPTOR ALPHA; JANUS KINASE; JANUS KINASE 1; JANUS KINASE 3; STAT PROTEIN; STAT5 PROTEIN; STAT6 PROTEIN; UNCLASSIFIED DRUG;

ALLERGIC ASTHMA; ANIMAL CELL; ARTICLE; B LYMPHOCYTE; CELL PROLIFERATION; DIMERIZATION; ENZYME ACTIVATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ANIMALIA; JANUS;

EID: 0242443865     PISSN: 16154053     EISSN: None     Source Type: Journal    
DOI: 10.1002/sita.200300023     Document Type: Article

References (29)

1. Minty, A., Chalon, P., Derocq, J. M., Dumont, X., Guillemot, J. C., Kaghad, M., Labit, C., Leplatois, P., Liauzun, P., Miloux, B. (1993) Interleukin-13 is a new human lymphokine regulating inflammatory and immune responses. Nature 362: 248-250.
2. Zurawski, G., de Vries, J. E. (1994). Interleukin 13, an interleukin 4-like cytokine that acts on monocytes and B cells, but not on T cells. Immunol. Today 15: 19-26.
3. Aman, M. J., Tayebi, N., Obiri, N. I., Puri, R. K., Modi, W. S., Leonard, W. J. (1996) cDNA cloning and characterization of the human interleukin 13 receptor α chain. J. Biol. Chem. 271: 29265-29270.
4. Caput, D., Laurent, P., Kaghad, M., Lelias, J.-M., Lefort, S., Vita, N., Ferrara, P. (1996) Cloning and characterization of a specific interleukin (IL)-13 binding protein structurally related to the IL-5 receptor α chain. J. Biol. Chem. 271: 16921-16926.
5. Hilton, D. J., Zhang, J., Metcalf, G. D., Alexander, W. S., Nicola, N. A., Willson, T. A. (1996) Cloning and characterization of a binding subunit of the interleukin 13 receptor that is also a component of the interleukin 4 receptor. Proc. Natl. Acad. Sci. USA 93: 497-501.
6. Miloux, B., Laurent, P., Bonnin, O., Lupker, J., Caput, D., Vita, N., Ferrara, P. (1997) Cloning of the human IL-13Rαl chain and reconstitution with the IL-4Rα of a functional IL-4/IL-13 receptor complex. FEBS Lett. 401: 163-166.
7. Cooks, B. G., de Waal Malefyt, R., Galizzi, J.-P., de Vries, J. E. (1993) IL-13 induces proliferation and differentiation of human B-cells activated by the CD40 ligand. Int Immunol. 5: 657-663.
8. Kawakami, K., Taguchi, J., Murata, T., Puri, R. K. (2001) The interleukin-13 receptor α2 chain: an essential component for binding and internalization but not for interleukin-13-induced signal transduction through the STAT6 pathway. Blood 97: 2673-2679.
9. Rahaman, S. O., Sharma, P., Harbor, P. C., Aman, M. J., Vogelbaum, M. A., Haque, S.J. (2002) IL-13Rα2, a decoy receptor for IL-13 acts As an inhibitor of IL-4-dependent signal transduction in glioblastoma cells. Cancer Res. 62: 1103-1109.
10. Daines, M. O., Hershey, G. K. (2002) A novel mechanism by which interferon-gamma can regulate interleukin (IL)-13 responses. Evidence for intracellular stores of IL-13 receptor alpha-2 and their rapid mobilization by interferon-gamma. J. Biol. Chem. 277: 10387-10393.
11. Idzerda, R. L., March, C. J., Mosley, B., Lyman, S. D., Bos, T. V., Gimpel, S. D., Din, W. S., Grabstein, K. H., Widmer, M. B., Park, L. S., Cosman, D., Beckman, M. P. (1990) Human interleukin 4 receptor confers biological responsiveness and defines a novel receptor superfamily. J. Exp. Med. 171: 861-873.
12. Russell, S. M., Keegan, A. D., Harada. N. (1993) Interleukin-2 receptor gamma chain: a functional component of the interleukin-4 receptor. Science 262: 1880-1883.
13. Callard, R.E., Matthews, D.J., Hibbert, L. (1996) IL-4 and IL-13 receptors: are they one and the same? Immunol. Today 17: 108-110.
14. Takeda, K., Kamanaka, M. Tanaka, T., Kishimoto, T., Akira, S. (1996) Impaired IL-13 mediated functions of macrophages in Stat6-deficient mice. J. Immunol. 157: 3220-3222.
15. Kaplan, M. H., Schindler, U., Smiley, S. T., Grusby, M. J. (1996) Stat6 is required for mediating responses to IL-4 and for the development of Th2 cells. Immunity 4: 313-319.
16. Grunig, G., Warnock, M., Wakil, A. E., Venkayya, R., Brombacher, Rennick, D. M., Sheppard, D., Mohrs, M., Donaldson, D. D., Locksley, R. M., Corry, D. B. (1998) Requirement for IL-13 independently of IL-4 in experimental asthma. Science 282: 2261-2263.
17. Wills-Karp, M., Luyimbazi, J., Xu, X., Schofield, B. Neben, T. Y., Karp, C. L., Donaldson, D. D. (1998) Interleukin-13: central mediator of allergic asthma. Science 282: 2258-2261.
18. Bochner, B. S., Klunk, D. A., Sterbinsky, S. A., Coffman, R. L., Schleimer, R. P. (1995) IL-13 selectively induces vascular cell adhesion molecule-1 expression in human endothelial cells. J. Immunol. 154: 799-803.
19. Murata, T., Noguchi, P. D., Puri, R. K. (1995) Receptors for interleukin-4 do not associate with the common γc chain, and IL-4 induces the phosphorylation of JAK2 tyrosine kinase in human colon carcinoma cells. J. Biol. Chem. 270: 30829-30836.
20. Kammer, W., Lischke, A., Moriggl, R., Groner, B., Ziemiecki, A., Gurniak, C. B., Berg, L. J., Friedrich, K. (1996) Homodimerization of interleukin-4 receptor α chain can induce intracellular signaling. J. Biol. Chem. 271: 23634-23637.
21. Lischke, A., Moriggl, R., Brändlein, S., Berchthold, S., Kammer, W., Sebald, W., Groner, B., Liu, X., Henninghausen, L., Friedrich, K. (1998). The interleukin-4 receptor activates STAT5 by a mechanism that relies upon common γ-chain. J. Biol. Chem. 273: 31222-31229.
22. Sambrook, J., Fritsch, E. F., Maniatis, T. (Eds.): Molecular cloning: a laboratory manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor (USA) 1989.
23. Lischke, A., Kammer, W., Friedrich, K. (1995) Different human interleukin-4 mutants preferentially activate human or murine common receptor γ chain. Eur. J. Biochem. 234: 100-107.
24. Lischke, A., Pagany, M., Kammer, W., Friedrich, K. (1996) A chemiluminescence-based method for the detection and quantification of antigen-antibody interactions on the surface of eukaryotic cells. Anal. Biochem. 236: 322-326.
25. Andrews, R., Rosa, L., Daines, M., Khurana Hershey, G. (2001) Reconstitution of a functional human type II IL-4/IL-13 receptor in mouse B cells: demonstration of species specificity. J. Immunol. 166: 1716-1722.
26. Andrews, A.-L., Holloway, J. W., Puddicombe, S. M., Holgate, S. T., Davies, D. E. (2002) Kinetic analysis of the interleukin-13 receptor complex. J. Biol. Chem. 277: 46073-46078.
27. Obiri, N. I., Murata, T., Debinski, W., Puri, R. K. (1997) Modulation of interleukin (IL)-13 binding and signaling by the γc chain of the IL-2 receptor. J. Biol. Chem. 272: 20251-20258.
28. Kuznetsov, V. A., Puri, R. K. (1999) Kinetic analysis of high affinity forms of interleukin (IL)-13 receptors: suppression of IL-13 binding by IL-2 receptor γ chain. Biophys J. 77: 154-172.
29. Wery-Zennaro, S., Letourneur, M., David, M., Bertoglio, J., Pierre J. (1999) Binding of IL-4 to the IL-13Ralpha(1)/IL-4Ralpha receptor complex leads to STAT3 phosphorylation but not to its nuclear translocation. FEBS Lett. 464: 91-96.