T helper cell polarisation as a measure of the maturation of the immune response

Mediators of Inflammation

Volumn 12, Issue 5, 2003, Pages 285-292

  Cameron, Scott B ^a   Stolte, Ellen H ^b   Chow, Anthony W ^a   Savelkoul, Huub F J ^b  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b WAGENINGEN UNIVERSITY   (Netherlands)

Author keywords

Cytokines; Fluorescent activated cell sorter; Intracellular cytokine staining; Magnetic activated cell sorting; Polarisation; Th cell

Indexed keywords

CD4 ANTIGEN; TOXIC SHOCK SYNDROME TOXIN 1;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL MATURATION; CELL POLARITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; FLUORESCENCE ACTIVATED CELL SORTING; HELPER CELL; HUMORAL IMMUNITY; IMMUNE RESPONSE; MOUSE; NONHUMAN; POLARIZATION; PRIORITY JOURNAL; SUPERNATANT; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION; TH2 CELL; TOXIC SHOCK SYNDROME;

ANIMALS; CELL POLARITY; CELLS, CULTURED; COLORING AGENTS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; INTERFERON TYPE II; INTERLEUKIN-4; MICE; MICE, INBRED BALB C; PROPIDIUM; SPLEEN; STAINING AND LABELING; T-LYMPHOCYTES, HELPER-INDUCER;

ANIMALIA;

EID: 0242441069     PISSN: 09629351     EISSN: None     Source Type: Journal    
DOI: 10.1080/0929350310001619744     Document Type: Article

References (15)

1. Cubillas-Tejeda AC, Ruiz-Arguelles A, Bernal-Fernandez G, Quiroz-Compean L, Lopez-Davila A, Reynaga-Hernandez E, Gonzalez-Amaro R. Cytokine production and expression of leucocyte-differentiation antigens by human mononuclear cells in response to mycobacterium tuberculosis antigens. Scand J Immunol 2003; 57: 115-124.
2. Infante-Duarte C, Kamradt T. Th1/Th2 balance in infection. Springer Semin Immunopathol 1999; 21: 317-338.
3. Verhagen CE, van der Pouw Kraan TC, Buffing AA, Chand MA, Faber WR, Aarden LA, Das PK. Type 1-and type 2-like lesional skin-derived Mycobacterium leprae-responsive T cell clones are characterized by coexpression of IFN-gamma/TNF-alpha and IL-4/IL-5/IL-13, respectively. J Immunol 1998; 160: 2380-2387.
4. Abbas AK, Murphy KM, Sher A. Functional diversity of helper T lymphocytes. Nature 1996; 383: 787-793.
5. van Zijverden M, Pijl A, van der Bol M, et al. Diesel exhaust, carbon black, and silica particles display distinct Th1/Th2 modulating activity. Toxicol Appl Pharmacol 2000; 168: 131-139.
6. Misra N, Murtaza A, Walker B, et al. Cytokine profile of circulating T cells of leprosy patients reflects both indiscriminate and polarized T-helper subsets: T-helper phenotype is stable and uninfluenced by related antigens of Mycobacterium leprae. Immunology 1995; 86: 97-103.
7. House RV. Theory and practice of cytokine assessment in immunotoxicology. Methods 1999; 19: 17-27.
8. Cameron SB, Nawijn MC, Kum WW, Savelkoul HFJ, Chow AW. Regulation of helper T cell responses to staphylococcal superantigens. Eur Cytokine Network 2001; 12: 210-222.
9. Kelso A, Groves P, Ramm L, Doyle AG. Single-cell analysis by RT-PCR reveals differential expression of multiple type 1 and 2 cytokine genes among cells within polarized CD4+ T cell populations. Int Immunol 1999; 11: 617-621.
10. Abraham C, Miller J. Molecular mechanisms of IL-2 gene regulation following costimulation through LFA-1. J Immunol 2001; 167: 5193-5201.
11. Hodge DL, Martinez A, Julias JG, Taylor LS, Young HA. Regulation of nuclear gamma interferon gene expression by interleukin 12 (IL-12) and IL-12 represents a novel form of posttrancriptional control. Mol Cell Biol 2002; 22: 1742-1753.
12. Sander B, Andersson J, Andersson U. Assessment of cytokines by immunofluorescence and the paraformaldehyde-saponin procedure. Immunol Rev 1991; 119: 65-93.
13. Schauer U, Jung T, Krug N, Frew A. Measurement of intracellular cytokines. Immunol Today 1996; 17: 305-306.
14. Chtanova T, Kemp RA, Sutherland AP, Ronchese F, Mackay CR. Gene microarrays reveal extensive differential gene expression in both CD4(+) and CD8(+) type 1 and type 2 T cells. J Immunol 2001; 167: 3057-3063.
15. Van Ommen R, Vredendaal AECM, de Gooyer M, van Oudenaren A, Savelkoul HFJ. The effect of IFN-g, alum and complete Freund adjuvant on TNP-KLH induced IgG1, IgE and IgG2a responses in mice. Mediat Inflamm 1994; 3: 387-392.