SMTP-4D, -5D, -7D and -8D, a new series of the non-lysine-analog plasminogen modulators with a D-amino acid moiety

Journal of Antibiotics

Volumn 56, Issue 10, 2003, Pages 832-837

  Hu, Weimin ^a   Kitano, Yoshikazu ^a   Hasumi, Keiji ^a  

^a TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; FIBRIN; PLASMINOGEN; PLASMINOGEN ACTIVATOR; STAPLABIN DERIVATIVE; UNCLASSIFIED DRUG; UROKINASE;

ARTICLE; BINDING AFFINITY; BIOSYNTHESIS; CONTROLLED STUDY; CULTURE MEDIUM; DRUG ISOLATION; DRUG STRUCTURE; ENZYME ACTIVE SITE; ENZYME MECHANISM; HUMAN; IN VITRO STUDY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PLASMINOGEN ACTIVATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTON NUCLEAR MAGNETIC RESONANCE; STACHYBOTRYS; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

STACHYBOTRYS MICROSPORA;

EID: 0242440321     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.7164/antibiotics.56.832     Document Type: Article

References (19)

1. Opdenakker, G. & J. Van Damme: Cytokines and proteases in invasive processes: molecular similarities between inflammation and cancer. Cytokine 4: 251-258, 1992
2. Carmeliet, P. & D. Collen: Role of the plasminogen/ plasmin system in thrombosis, hemostasis, restenosis, and atherosclerosis. Evaluation in transgenic animals. Trends Cardiovasc. Med. 5: 117-122, 1995
3. Schmitt, M.; N. Harbeck, C. Thomssen, O. Wilhelm, V. Magdolen, U. Reuning, K. Ulm, H. Höfler, F. Jänicke & H Graeff: Clinical impact of the plasminogen activation system in tumor invasion and metastasis: prognostic relevance and target for therapy. Thromb. Haemost. 78: 285-296, 1997
4. Boyle, M. D. & R. Lottenberg: Plasminogen activation by invasive human pathogens. Thromb. Haemost. 77: 1-10, 1997
5. Forsgren, M.; B. Raden, M. Israelsson, K. Larsson & L.-O. Heden: Molecular cloning and characterization of a full-length CDNA clone for human plasminogen. FEBS Lett. 213: 254-260, 1987
6. Plow, E. F.; T. Herren, A. Redlitz, L. A. Miles & J. L. Hoover-Plow: The cell biology of the plasminogen system. FASEB J. 9: 939-945, 1995
7. Christensen, U.: The AH-site of plasminogen and two C-terminal fragments. A weak lysine-binding site preferring ligands not carrying a free carboxylate function. Biochem. J. 223: 413-421, 1984
8. Marshall, J. M.; A. J. Brown & C. P. Ponting: Conformational studies of human plasminogen and plasminogen fragments: evidence for a novel third conformation of plasminogen. Biochemistry 33: 3599-3606, 1994
9. An, S. S.; C. Carreno, D. N. Marti, J. Schaller, F. Alberico & M. Llinas: Lysine-50 is a likely site for anchoring the plasminogen N-terminal peptide to lysine-binding kringles. Protein Sci. 7: 1960-1969, 1998
10. Cockell, C. S.; J. M. Marshall, K. M. Dawson, S. A. Cederholm-Williams & C. P. Ponting: Evidence that the conformation of unliganded human plasminogen is maintained via an intramolecular interaction between the lysine-binding site of kringle 5 and the N-terminal peptide. Biochem. J. 333: 99-105, 1998
11. Nesheim, M. E.; J. C. Fredenburgh & G. R. Larsen: The dissociation constants and stoichiometries of the interactions of Lys-plasminogen and chloromethyl ketone derivatives of tissue plasminogen activator and the variant ΔFEIX with intact fibrin. J. Biol. Chem. 265: 21541-21548, 1990
12. Hajjar, K. A. & R. L. Nacman: Endothelial cell-mediated conversion of Glu-plasminogen to Lysplasminogen. Further evidence for assembly of the fibrinolytic system on the endothelial cell surface. J. Clin. Invest. 82: 1769-1778, 1988
13. Shinohara, C.; K. Hasumi, W. Hatsumi & A. Endo: Staplabin, a novel fungal triprenyl phenol which stimulates the binding of plasminogen to fibrin and U937 cells. J. Antibiotics 49: 961-966, 1996
14. Takayasu, R.; K. Hasumi, C. Shinohara & A. Endo: Enhancement of fibrin binding and activation of plasminogen by staplabin through induction of a conformational change in plasminogen. FEBS Lett. 418: 58-62, 1997
15. Kohyama, T.; K. Hasumi, A. Hamanaka & A. Endo: SMTP-1 and -2, novel analogs of staplabin produced by Stachybotrys microspora IFO30018. J. Antibiotics 50: 172-174, 1997
16. Hasumi, K.; S. Ohyama, T. Kohyama, Y. Ohsaki, R. Takayasu & A. Endo: Isolation of SMTP-3, -4, -5 and -6, novel analogs of staplabin, and their effects on plasminogen activation and fibrinolysis. J. Antibiotics 51: 1059-1068, 1998
17. Hu, W.; S. Ohyama & K. Hasumi: Activation of fibrinolysis by SMTP-7 and -8, novel staplabin analogs with a pseudosymmetric structure. J. Antibiotics 53: 241-247, 2000
18. Hu, W.; S. Ohyama, R. Narasaki & K. Hasumi: Selective production of staplabin and SMTPs in cultures of Stachybotrys microspora fed with precursor amines. J. Antibiotics 54: 962-966, 2001
19. Deutsch, D. G. & E. T. Mertz: Plasminogen: purification from human plasma by affinity chromatography. Science 170: 1095-1096, 1970