메뉴 건너뛰기




Volumn 316, Issue 1, 2003, Pages 64-74

A viral transcriptional activator of Kaposi's sarcoma-associated herpesvirus (KSHV) induces apoptosis, which is blocked in KSHV-infected cells

Author keywords

Apoptosis; Cell death; KSHV RTA; Tet Off

Indexed keywords

CASPASE; DNA FRAGMENT; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; REPLICATION AND TRANSCRIPTION ACTIVATOR PROTEIN; TETRACYCLINE; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; VIRUS PROTEIN;

EID: 0242384025     PISSN: 00426822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0042-6822(03)00582-8     Document Type: Article
Times cited : (13)

References (43)
  • 1
    • 0029796383 scopus 로고    scopus 로고
    • Establishment and characterization of a primary effusion (body cavity-based) lymphoma cell line (BC-3) harboring Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) in the absence of Epstein-Barr virus
    • Arvanitakis L., Mesri E.A., Nador R.G., Said J.W., Asch A.S., Knowles D.M., Cesarman E. Establishment and characterization of a primary effusion (body cavity-based) lymphoma cell line (BC-3) harboring Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) in the absence of Epstein-Barr virus. Blood. 88:1996;2648-2654.
    • (1996) Blood , vol.88 , pp. 2648-2654
    • Arvanitakis, L.1    Mesri, E.A.2    Nador, R.G.3    Said, J.W.4    Asch, A.S.5    Knowles, D.M.6    Cesarman, E.7
  • 2
    • 0032575714 scopus 로고    scopus 로고
    • Death receptors: Signaling and modulation
    • Ashkenazi A., Dixit V.M. Death receptors signaling and modulation . Science. 281:1998;1305-1308.
    • (1998) Science , vol.281 , pp. 1305-1308
    • Ashkenazi, A.1    Dixit, V.M.2
  • 3
    • 0034967543 scopus 로고    scopus 로고
    • Human herpesvirus 8 viral FLICE-inhibitory protein inhibits Fas-mediated apoptosis through binding and prevention of procaspase-8 maturation
    • Belanger C., Gravel A., Tomoiu A., Janelle M.E., Gosselin J., Tremblay M.J., Flamand L. Human herpesvirus 8 viral FLICE-inhibitory protein inhibits Fas-mediated apoptosis through binding and prevention of procaspase-8 maturation. J. Hum. Virol. 4:2001;62-73.
    • (2001) J. Hum. Virol. , vol.4 , pp. 62-73
    • Belanger, C.1    Gravel, A.2    Tomoiu, A.3    Janelle, M.E.4    Gosselin, J.5    Tremblay, M.J.6    Flamand, L.7
  • 4
    • 0029069445 scopus 로고
    • Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomas
    • Cesarman E., Chang Y., Moore P.S., Said J.W., Knowles D.M. Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomas. N. Engl. J. Med. 332:1995;1186-1191.
    • (1995) N. Engl. J. Med. , vol.332 , pp. 1186-1191
    • Cesarman, E.1    Chang, Y.2    Moore, P.S.3    Said, J.W.4    Knowles, D.M.5
  • 5
    • 0029121668 scopus 로고
    • In vitro establishment and characterization of two acquired immunodeficiency syndrome-related lymphoma cell lines (BC-1 and BC-2) containing Kaposi's sarcoma-associated herpesvirus-like (KSHV) DNA sequences
    • Cesarman E., Moore P.S., Rao P.H., Inghirami G., Knowles D.M., Chang Y. In vitro establishment and characterization of two acquired immunodeficiency syndrome-related lymphoma cell lines (BC-1 and BC-2) containing Kaposi's sarcoma-associated herpesvirus-like (KSHV) DNA sequences. Blood. 86:1995;2708-2714.
    • (1995) Blood , vol.86 , pp. 2708-2714
    • Cesarman, E.1    Moore, P.S.2    Rao, P.H.3    Inghirami, G.4    Knowles, D.M.5    Chang, Y.6
  • 7
    • 0033850632 scopus 로고    scopus 로고
    • Transcriptional regulation of the Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor gene
    • Chen J., Ueda K., Sakakibara S., Okuno T., Yamanishi K. Transcriptional regulation of the Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor gene. J. Virol. 74:2000;8623-8634.
    • (2000) J. Virol. , vol.74 , pp. 8623-8634
    • Chen, J.1    Ueda, K.2    Sakakibara, S.3    Okuno, T.4    Yamanishi, K.5
  • 8
    • 0031017578 scopus 로고    scopus 로고
    • A Bcl-2 homolog encoded by Kaposi sarcoma-associated virus, human herpesvirus 8, inhibits apoptosis but does not heterodimerize with Bax or Bak
    • Cheng E.H., Nicholas J., Bellows D.S., Hayward G.S., Guo H.G., Reitz M.S., Hardwick J.M. A Bcl-2 homolog encoded by Kaposi sarcoma-associated virus, human herpesvirus 8, inhibits apoptosis but does not heterodimerize with Bax or Bak. Proc. Natl. Acad. Sci. USA. 94:1997;690-694.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 690-694
    • Cheng, E.H.1    Nicholas, J.2    Bellows, D.S.3    Hayward, G.S.4    Guo, H.G.5    Reitz, M.S.6    Hardwick, J.M.7
  • 9
    • 0027251720 scopus 로고
    • Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B
    • Debbas M., White E. Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B. Genes Dev. 7:1993;546-554.
    • (1993) Genes Dev. , vol.7 , pp. 546-554
    • Debbas, M.1    White, E.2
  • 10
    • 0031713755 scopus 로고    scopus 로고
    • Lymphoma cell lines: In vitro models for the study of HHV-8 + primary effusion lymphomas (body cavity-based lymphomas)
    • Drexler H.G., Uphoff C.C., Gaidano G., Carbone A. Lymphoma cell lines in vitro models for the study of HHV-8 + primary effusion lymphomas (body cavity-based lymphomas) . Leukemia. 12:1998;1507-1517.
    • (1998) Leukemia , vol.12 , pp. 1507-1517
    • Drexler, H.G.1    Uphoff, C.C.2    Gaidano, G.3    Carbone, A.4
  • 11
    • 0025313893 scopus 로고
    • Murine herpesvirus 68 is genetically related to the gammaherpesviruses Epstein-Barr virus and herpesvirus saimiri
    • Efstathiou S., Ho Y.M., Hall S., Styles C.J., Scott S.D., Gompels U.A. Murine herpesvirus 68 is genetically related to the gammaherpesviruses Epstein-Barr virus and herpesvirus saimiri. J. Gen. Virol. 71:1990;1365-1372.
    • (1990) J. Gen. Virol. , vol.71 , pp. 1365-1372
    • Efstathiou, S.1    Ho, Y.M.2    Hall, S.3    Styles, C.J.4    Scott, S.D.5    Gompels, U.A.6
  • 12
    • 0036827974 scopus 로고    scopus 로고
    • Kaposi's sarcoma-associated herpesvirus mitochondrial K7 protein targets a cellular calcium-modulating cyclophilin ligand to modulate intracellular calcium concentration and inhibit apoptosis
    • Feng P., Park J., Lee B.S., Lee S.H., Bram R.J., Jung J.U. Kaposi's sarcoma-associated herpesvirus mitochondrial K7 protein targets a cellular calcium-modulating cyclophilin ligand to modulate intracellular calcium concentration and inhibit apoptosis. J. Virol. 76:2002;11491-11504.
    • (2002) J. Virol. , vol.76 , pp. 11491-11504
    • Feng, P.1    Park, J.2    Lee, B.S.3    Lee, S.H.4    Bram, R.J.5    Jung, J.U.6
  • 14
    • 0032584081 scopus 로고    scopus 로고
    • Herpes simplex virus 1 induces and blocks apoptosis at multiple steps during infection and protects cells from exogenous inducers in a cell-type-dependent manner
    • Galvan V., Roizman B. Herpes simplex virus 1 induces and blocks apoptosis at multiple steps during infection and protects cells from exogenous inducers in a cell-type-dependent manner. Proc. Natl. Acad. Sci. USA. 95:1998;3931-3936.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 3931-3936
    • Galvan, V.1    Roizman, B.2
  • 15
    • 0026648674 scopus 로고
    • Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation
    • Gavrieli Y., Sherman Y., Ben-Sasson S.A. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J. Cell Biol. 119:1992;493-501.
    • (1992) J. Cell Biol. , vol.119 , pp. 493-501
    • Gavrieli, Y.1    Sherman, Y.2    Ben-Sasson, S.A.3
  • 16
    • 0026720075 scopus 로고
    • Tight control of gene expression in mammalian cells by tetracycline-responsive promoters
    • Gossen M., Bujard H. Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc. Natl. Acad. Sci. USA. 89:1992;5547-5551.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 5547-5551
    • Gossen, M.1    Bujard, H.2
  • 17
    • 0034083471 scopus 로고    scopus 로고
    • Kaposi's sarcoma-associated herpesvirus open reading frame 50/Rta protein activates the entire viral lytic cycle in the HH-B2 primary effusion lymphoma cell line
    • Gradoville L., Gerlach J., Grogan E., Shedd D., Nikiforow S., Metroka C., Miller G. Kaposi's sarcoma-associated herpesvirus open reading frame 50/Rta protein activates the entire viral lytic cycle in the HH-B2 primary effusion lymphoma cell line. J. Virol. 74:2000;6207-6212.
    • (2000) J. Virol. , vol.74 , pp. 6207-6212
    • Gradoville, L.1    Gerlach, J.2    Grogan, E.3    Shedd, D.4    Nikiforow, S.5    Metroka, C.6    Miller, G.7
  • 18
    • 0034990504 scopus 로고    scopus 로고
    • Kaposi's sarcoma-associated herpesvirus open reading frame 50 represses p53-induced transcriptional activity and apoptosis
    • Gwack Y., Hwang S., Byun H., Lim C., Kim J.W., Choi E.J., Choe J. Kaposi's sarcoma-associated herpesvirus open reading frame 50 represses p53-induced transcriptional activity and apoptosis. J. Virol. 75:2001;6245-6248.
    • (2001) J. Virol. , vol.75 , pp. 6245-6248
    • Gwack, Y.1    Hwang, S.2    Byun, H.3    Lim, C.4    Kim, J.W.5    Choi, E.J.6    Choe, J.7
  • 20
    • 0036682519 scopus 로고    scopus 로고
    • The lytic switch protein of KSHV activates gene expression via functional interaction with RBP-Jkappa (CSL), the target of the Notch signaling pathway
    • Liang Y., Chang J., Lynch S.J., Lukac D.M., Ganem D. The lytic switch protein of KSHV activates gene expression via functional interaction with RBP-Jkappa (CSL), the target of the Notch signaling pathway. Genes Dev. 16:2002;1977-1989.
    • (2002) Genes Dev. , vol.16 , pp. 1977-1989
    • Liang, Y.1    Chang, J.2    Lynch, S.J.3    Lukac, D.M.4    Ganem, D.5
  • 21
    • 0034953721 scopus 로고    scopus 로고
    • DNA binding by Kaposi's sarcoma-associated herpesvirus lytic switch protein is necessary for transcriptional activation of two viral delayed early promoters
    • Lukac D.M., Garibyan L., Kirshner J.R., Palmeri D., Ganem D. DNA binding by Kaposi's sarcoma-associated herpesvirus lytic switch protein is necessary for transcriptional activation of two viral delayed early promoters. J. Virol. 75:2001;6786-6799.
    • (2001) J. Virol. , vol.75 , pp. 6786-6799
    • Lukac, D.M.1    Garibyan, L.2    Kirshner, J.R.3    Palmeri, D.4    Ganem, D.5
  • 22
    • 0032830320 scopus 로고    scopus 로고
    • Transcriptional activation by the product of open reading frame 50 of Kaposi's sarcoma-associated herpesvirus is required for lytic viral reactivation in B cells
    • Lukac D.M., Kirshner J.R., Ganem D. Transcriptional activation by the product of open reading frame 50 of Kaposi's sarcoma-associated herpesvirus is required for lytic viral reactivation in B cells. J. Virol. 73:1999;9348-9361.
    • (1999) J. Virol. , vol.73 , pp. 9348-9361
    • Lukac, D.M.1    Kirshner, J.R.2    Ganem, D.3
  • 23
    • 0028800947 scopus 로고
    • Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: Inhibition by overexpression of Bcl-2 and Abl
    • Martin S.J., Reutelingsperger C.P., McGahon A.J., Rader J.A., van Schie R.C., LaFace D.M., Green D.R. Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus inhibition by overexpression of Bcl-2 and Abl . J. Exp. Med. 182:1995;1545-1556.
    • (1995) J. Exp. Med. , vol.182 , pp. 1545-1556
    • Martin, S.J.1    Reutelingsperger, C.P.2    McGahon, A.J.3    Rader, J.A.4    Van Schie, R.C.5    LaFace, D.M.6    Green, D.R.7
  • 24
    • 10544237674 scopus 로고    scopus 로고
    • Selective switch between latency and lytic replication of Kaposi's sarcoma herpesvirus and Epstein-Barr virus in dually infected body cavity lymphoma cells
    • Miller G., Heston L., Grogan E., Gradoville L., Rigsby M., Sun R., Shedd D., Kushnaryov V.M., Grossberg S., Chang Y. Selective switch between latency and lytic replication of Kaposi's sarcoma herpesvirus and Epstein-Barr virus in dually infected body cavity lymphoma cells. J. Virol. 71:1997;314-324.
    • (1997) J. Virol. , vol.71 , pp. 314-324
    • Miller, G.1    Heston, L.2    Grogan, E.3    Gradoville, L.4    Rigsby, M.5    Sun, R.6    Shedd, D.7    Kushnaryov, V.M.8    Grossberg, S.9    Chang, Y.10
  • 28
    • 0033214439 scopus 로고    scopus 로고
    • Kaposi's sarcoma-associated herpesvirus-encoded v-cyclin triggers apoptosis in cells with high levels of cyclin-dependent kinase 6
    • Ojala P.M., Tiainen M., Salven P., Veikkola T., Castanos-Velez E., Sarid R., Biberfeld P., Makela T.P. Kaposi's sarcoma-associated herpesvirus-encoded v-cyclin triggers apoptosis in cells with high levels of cyclin-dependent kinase 6. Cancer Res. 59:1999;4984-4989.
    • (1999) Cancer Res. , vol.59 , pp. 4984-4989
    • Ojala, P.M.1    Tiainen, M.2    Salven, P.3    Veikkola, T.4    Castanos-Velez, E.5    Sarid, R.6    Biberfeld, P.7    Makela, T.P.8
  • 29
    • 0036891214 scopus 로고    scopus 로고
    • Activation of human herpesvirus 8 open reading frame K5 independent of ORF50 expression
    • Okuno T., Jiang Y.B., Ueda K., Nishimura K., Tamura T., Yamanishi K. Activation of human herpesvirus 8 open reading frame K5 independent of ORF50 expression. Virus Res. 90:2002;77-89.
    • (2002) Virus Res. , vol.90 , pp. 77-89
    • Okuno, T.1    Jiang, Y.B.2    Ueda, K.3    Nishimura, K.4    Tamura, T.5    Yamanishi, K.6
  • 30
    • 0029876473 scopus 로고    scopus 로고
    • Lytic growth of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in culture
    • Renne R., Zhong W., Herndier B., McGrath M., Abbey N., Kedes D., Ganem D. Lytic growth of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in culture. Nat. Med. 2:1996;342-346.
    • (1996) Nat. Med. , vol.2 , pp. 342-346
    • Renne, R.1    Zhong, W.2    Herndier, B.3    McGrath, M.4    Abbey, N.5    Kedes, D.6    Ganem, D.7
  • 32
    • 0030702084 scopus 로고    scopus 로고
    • Caspases: Intracellular signaling by proteolysis
    • Salvesen G.S., Dixit V.M. Caspases intracellular signaling by proteolysis . Cell. 91:1997;443-446.
    • (1997) Cell , vol.91 , pp. 443-446
    • Salvesen, G.S.1    Dixit, V.M.2
  • 33
    • 0031824585 scopus 로고    scopus 로고
    • Kaposi's sarcoma-associated herpesvirus (human herpesvirus-8)
    • Schulz T.F. Kaposi's sarcoma-associated herpesvirus (human herpesvirus-8). J. Gen. Virol. 79:1998;1573-1591.
    • (1998) J. Gen. Virol. , vol.79 , pp. 1573-1591
    • Schulz, T.F.1
  • 34
    • 0034968101 scopus 로고    scopus 로고
    • Viral interferon regulatory factor I of Kaposi's sarcoma-associated herpesvirus binds to p53 and represses p53-dependent transcription and apoptosis
    • Seo T., Park J., Lee D., Hwang S.G., Choe J. Viral interferon regulatory factor I of Kaposi's sarcoma-associated herpesvirus binds to p53 and represses p53-dependent transcription and apoptosis. J. Virol. 75:2001;6193-6198.
    • (2001) J. Virol. , vol.75 , pp. 6193-6198
    • Seo, T.1    Park, J.2    Lee, D.3    Hwang, S.G.4    Choe, J.5
  • 35
    • 0035108050 scopus 로고    scopus 로고
    • Transcription activation of polyadenylated nuclear RNA by Rta in human herpesvirus 8/Kaposi's sarcoma-associated herpesvirus
    • Song M.J., Brown H.J., Wu T.T., Sun R. Transcription activation of polyadenylated nuclear RNA by Rta in human herpesvirus 8/Kaposi's sarcoma-associated herpesvirus. J. Virol. 75:2001;3129-3140.
    • (2001) J. Virol. , vol.75 , pp. 3129-3140
    • Song, M.J.1    Brown, H.J.2    Wu, T.T.3    Sun, R.4
  • 37
    • 0032167919 scopus 로고    scopus 로고
    • A viral gene that activates lytic cycle expression of Kaposi's sarcoma-associated herpesvirus
    • Sun R., Lin S.F., Gradoville L., Yuan Y., Zhu F., Miller G. A viral gene that activates lytic cycle expression of Kaposi's sarcoma-associated herpesvirus. Proc. Natl. Acad. Sci. USA. 95:1998;10866-10871.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 10866-10871
    • Sun, R.1    Lin, S.F.2    Gradoville, L.3    Yuan, Y.4    Zhu, F.5    Miller, G.6
  • 38
    • 0036888922 scopus 로고    scopus 로고
    • Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) replication and transcription activator activates the K9 (vIRF) gene through two distinct cis elements by a non-DNA-binding mechanism
    • Ueda K., Ishikawa K., Nishimura K., Sakakibara S., Do E., Yamanishi K. Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) replication and transcription activator activates the K9 (vIRF) gene through two distinct cis elements by a non-DNA-binding mechanism. J. Virol. 76:2002;12044-12054.
    • (2002) J. Virol. , vol.76 , pp. 12044-12054
    • Ueda, K.1    Ishikawa, K.2    Nishimura, K.3    Sakakibara, S.4    Do, E.5    Yamanishi, K.6
  • 39
    • 0037213589 scopus 로고    scopus 로고
    • Role of CCAAT/enhancer-binding protein alpha (C/EBPalpha) in activation of the Kaposi's sarcoma-associated herpesvirus (KSHV) lytic-cycle replication-associated protein (RAP) promoter in cooperation with the KSHV replication and transcription activator (RTA) and RAP
    • Wang S.E., Wu F.Y., Fujimuro M., Zong J., Hayward S.D., Hayward G.S. Role of CCAAT/enhancer-binding protein alpha (C/EBPalpha) in activation of the Kaposi's sarcoma-associated herpesvirus (KSHV) lytic-cycle replication- associated protein (RAP) promoter in cooperation with the KSHV replication and transcription activator (RTA) and RAP. J. Virol. 77:2003;600-623.
    • (2003) J. Virol. , vol.77 , pp. 600-623
    • Wang, S.E.1    Wu, F.Y.2    Fujimuro, M.3    Zong, J.4    Hayward, S.D.5    Hayward, G.S.6
  • 41
    • 0036677565 scopus 로고    scopus 로고
    • Lytic replication-associated protein (RAP) encoded by Kaposi sarcoma-associated herpesvirus causes p21CIP-1-mediated G1 cell cycle arrest through CCAAT/enhancer-binding protein-alpha
    • Wu F.Y., Tang Q.Q., Chen H., ApRhys C., Farrell C., Chen J., Fujimuro M., Lane M.D., Hayward G.S. Lytic replication-associated protein (RAP) encoded by Kaposi sarcoma-associated herpesvirus causes p21CIP-1-mediated G1 cell cycle arrest through CCAAT/enhancer-binding protein-alpha. Proc. Natl. Acad. Sci. USA. 99:2002;10683-10688.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 10683-10688
    • Wu, F.Y.1    Tang, Q.Q.2    Chen, H.3    ApRhys, C.4    Farrell, C.5    Chen, J.6    Fujimuro, M.7    Lane, M.D.8    Hayward, G.S.9
  • 42
    • 0032892691 scopus 로고    scopus 로고
    • Induction of human herpesvirus-8 DNA replication and transcription by butyrate and TPA in BCBL-1 cells
    • Yu Y., Black J.B., Goldsmith C.S., Browning P.J., Bhalla K., Offermann M.K. Induction of human herpesvirus-8 DNA replication and transcription by butyrate and TPA in BCBL-1 cells. J. Gen. Virol. 80:1999;83-90.
    • (1999) J. Gen. Virol. , vol.80 , pp. 83-90
    • Yu, Y.1    Black, J.B.2    Goldsmith, C.S.3    Browning, P.J.4    Bhalla, K.5    Offermann, M.K.6
  • 43
    • 0017876123 scopus 로고
    • Persisting oncogenic herpesvirus induced by the tumor promotor TPA
    • zur Hausen H., O'Neill F.J., Freese U.K., Hecker E. Persisting oncogenic herpesvirus induced by the tumor promotor TPA. Nature (Lond.). 272:1978;373-375.
    • (1978) Nature (Lond.) , vol.272 , pp. 373-375
    • Zur Hausen, H.1    O'Neill, F.J.2    Freese, U.K.3    Hecker, E.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.