Turning virulence on and off in Staphylococci

Journal of Peptide Science

Volumn 9, Issue 10, 2003, Pages 612-619

  Muir, Tom W ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

Author keywords

AIPs; Antibacterial agents; Autoinducing peptides; S. aureus

Indexed keywords

ACCESSORY GENE REGULATOR PROTEIN; ANTIINFECTIVE AGENT; AUTOINDUCING PEPTIDE; BACTERIAL PROTEIN; BACTERIAL RNA; CELL SURFACE RECEPTOR; GENE PRODUCT; MEMBRANE PROTEIN; PROTEIN HISTIDINE KINASE; PROTEIN INHIBITOR; UNCLASSIFIED DRUG; VIRULENCE FACTOR;

AMINO ACID SEQUENCE; BACTERIAL STRAIN; BACTERIAL VIRULENCE; DRUG DESIGN; GENE EXPRESSION; GENE FUNCTION; GENE LOCUS; ISOMERISM; MOLECULAR GENETICS; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; PROTEIN STRUCTURE; PROTON NUCLEAR MAGNETIC RESONANCE; REVIEW; RNA TRANSCRIPTION; SEQUENCE ANALYSIS; STAPHYLOCOCCUS AUREUS; STRUCTURE ACTIVITY RELATION;

BACTERIAL PROTEINS; MOLECULAR MIMICRY; MUTATION; PROMOTER REGIONS (GENETICS); PROTEIN STRUCTURE, SECONDARY; RECEPTORS, PEPTIDE; SIGNAL TRANSDUCTION; STAPHYLOCOCCUS AUREUS; VIRULENCE;

STAPHYLOCOCCUS; STAPHYLOCOCCUS AUREUS;

EID: 0242300075     PISSN: 10752617     EISSN: None     Source Type: Journal    
DOI: 10.1002/psc.486     Document Type: Review

References (21)

1. Roychoudhury S, Zielinski NA, Ninfa AJ, Allen NE, Jungheim LN, Nicas TI, Chakrabarty AM. Inhibitors of two-component signal transduction systems: inhibition of alginate gene activation in Pseudomonas aeruginosa. Proc. Natl Acad. Sci. USA 1993; 90: 965-969.
2. Ji G, Beavis RC, Novick RP. Cell density control of staphylococcal virulence mediated by an octapeptide pheromone. Proc. Natl Acad. Sci. USA 1995; 92: 12 055-12 059.
3. Novick RP, Ross HF, Projan SJ, Kornblum J, Kreiswirth B, Moghazeh S. Synthesis of staphylococcal virulence factors is controlled by a regulatory RNA molecule. Embo J. 1993; 12: 3967-3975.
4. Novick RP, Projan S, Kornblum J, Ross HF, Ji G, Kreiswirth B, Moghazeh S. The agr P2 operon: an autocatalytic sensory transduction system in Staphylococcus aureus. Mol. Gen. Genet. 1995; 248: 446-458.
5. Novick RP. Genetic systems in staphylococci. Methods Enzymol. 1991; 204: 587-636.
6. Ji G, Beavis R, Novick RP. Bacterial interference caused by autoinducing peptide variants. Science 1997; 276: 2027-2030.
7. Lina G, Jarraud S, Ji G, Greenland T, Pedraza A, Etienne J, Novick RP, Vandenesch F. Transmembrane topology and histidine protein kinase activity of AgrC, the agr signal receptor in Staphylococcus aureus. Mol. Microbiol. 1998; 28: 655-662.
8. Morfeldt E, Taylor D, von Gabain A, Arvidson S. Activation of alpha-toxin translation in Staphylococcus aureus by the trans-encoded antisense RNA, RNAIII. Embo J. 1995; 14: 4569-4577.
9. Otto M, Sussmuth R, Jung G, Gotz F. Structure of the pheromone peptide of the Staphylococcus epidermidis agr system. FEBS Lett. 1998; 424: 89-94.
10. Jarraud S, Lyon GJ, Figueiredo AM, Gerard L, Vandenesch F, Etienne J, Muir TW, Novick RP. Exfoliatin-producing strains define a fourth agr specificity group in Staphylococcus aureus. J. Bacteriol. 2000; 182: 6517-6522.
11. Dufour P, Jarraud S, Vandenesch F, Greenland T, Novick RP, Bes M, Etienne J, Lina G. High genetic variability of the agr locus in Staphylococcus species. J. Bacteriol. 2002; 184: 1180-1186.
12. Lyon GJ, Mayville P, Muir TW, Novick RP. Rational design of a global inhibitor of the virulence response in Staphylococcus aureus, based in part on localization of the site of inhibition to the receptor-histidine kinase, AgrC. Proc. Natl Acad. Sci. USA 2000; 97: 13 330-13 335.
13. Lyon GJ, Wright JS, Christopoulos A, Novick RP, Muir TW. Reversible and specific extracellular antagonism of receptor-histidine kinase signaling. J. Biol. Chem. 2002; 277: 6247-6253.
14. Lyon GJ, Wright JS, Muir TW, Novick RP. Key determinants of receptor activation in the agr autoinducing peptides of Staphylococcus aureus. Biochemistry 2002; 41: 10 095-10 104.
15. Wright JS et al. unpublished data.
16. Lyon GJ. PhD Thesis. Targeting receptor-histidine kinase signaling in Staphylococcus aureus, The Rockefeller University, 2002.
17. Dutta R, Qin L, Inouye M. Histidine kinases: diversity of domain organization. Mol. Microbiol. 1999; 34: 633-640.
18. Mayville P, Ji G, Beavis R, Yang H, Goger M, Novick RP, Muir TW. Structure-activity analysis of synthetic autoinducing thiolactone peptides from Staphylococcus aureus responsible for virulence. Proc. Natl Acad. Sci. USA 1999; 96: 1218-1223.
19. Camarero JA, Cotton GJ, Adeva A, Muir TW. Chemical ligation of unprotected peptides directly from a solid support. J. Pept. Res. 1998; 51: 303-316.
20. McDowell P, Affas Z, Reynolds C, Holden MTG, Wood SJ, Saint S, Cockayne A, Hill PJ, Dodd CER, Bycroft BW, Chan WC, Williams P. Structure, activity, and evolution of the group I thiolactone peptide quorum-sensing system of Staphylococcus aureus. Mol. Microbiol. 2001; 41: 503-512.
21. Zhang L, Gray L, Novick RP, Ji G. Transmembrane topology of AgrB, the protein involved in the post-translational modification of AgrD in Staphylococcus aureus. J. Biol. Chem. 2002; 277: 34 736-34 742.