Transcriptional regulation of CYP11A1

Journal of Biomedical Science

Volumn 10, Issue 6, 2003, Pages 593-598

  Guo, Ing Cherng ^a   Hu, Meng Chun ^a   Chung, Bon Chu ^b  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b INSTITUTE OF MOLECULAR BIOLOGY   (Taiwan)

Author keywords

Adrenal cortex; CYP11A1 transcription; Gonad; P450scc; SF 1; Steroid; Steroidogenesis

Indexed keywords

CYCLIC AMP; CYTOCHROME P450; CYTOCHROME P450 11A1; HYPOPHYSIS HORMONE; PROTEIN; PROTEIN C JUN; STEROID HORMONE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR SF1; UNCLASSIFIED DRUG; CORTICOTROPIN; CORTICOTROPIN RELEASING FACTOR; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYTOCHROME P450 CYP11A1; FOLLITROPIN; LUTEINIZING HORMONE; STEROIDOGENIC FACTOR 1; TATA BINDING PROTEIN; CHOLESTEROL MONOOXYGENASE (SIDE CHAIN CLEAVING); STEROID;

ADRENAL CORTEX; DOCUMENTATION; GENE SEQUENCE; GENETIC ANALYSIS; GONAD; HORMONAL REGULATION; HORMONE RELEASE; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN EXPRESSION; REVIEW; SIGNAL PROCESSING; STEROIDOGENESIS; TISSUE SPECIFICITY; TRANSCRIPTION REGULATION; ADENOHYPOPHYSIS; ADRENAL GLAND; BINDING SITE; DNA FLANKING REGION; DNA PROTEIN COMPLEX; GENE ACTIVATION; GENE ACTIVITY; GENE CONTROL; GENE EXPRESSION; HUMAN; HYPOTHALAMUS; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; OVARY; PLACENTA; PROMOTER REGION; PROTEIN ASSEMBLY; PROTEIN DNA INTERACTION; SIGNAL TRANSDUCTION; TATA BOX; TESTIS; BIOSYNTHESIS; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; METABOLISM; PHYSIOLOGY; SECOND MESSENGER;

CHOLESTEROL SIDE-CHAIN CLEAVAGE ENZYME; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; GENE EXPRESSION REGULATION; PROMOTER REGIONS (GENETICS); SECOND MESSENGER SYSTEMS; STEROIDS; TRANSCRIPTION, GENETIC;

EID: 0242299680     PISSN: 10217770     EISSN: 14230127     Source Type: Journal    
DOI: 10.1159/000073524     Document Type: Review

References (43)

1. Ahlgren R, Suske G, Waterman MR, Lund J. Role of Sp1 in cAMP-dependent transcriptional regulation of the bovine CYP11A gene. J Biol Chem 274:19422-19428;1999.
2. Chau YM, Crawford PA, Woodson KG, Polish JA, Olson LM, Sadovsky Y. Role of steroidogenic-factor 1 in basal and 3′,5′-cyclic adenosine monophosphate-mediated regulation of cytochrome P450 side-chain cleavage enzyme in the mouse. Biol Reprod 57:765-771;1997.
3. Chen C, Guo IC. Effect of cAMP on protein binding activities of three elements in upstream promoter of human CYP11A1 gene. Life Sci 67:2045-2049;2000.
4. Chou SJ, Lai KN, Chung B. Characterization of the upstream sequence of the human CYP11A1 gene for cell type-specific expression. J Biol Chem 271:22125-22129;1996.
5. Chung BC, Guo IC, Chou SJ. Transcriptional regulation of the CYP11A1 and ferredoxin genes. Steroids 62:37-42;1997.
6. Clemens JW, Lala DS, Parker KL, Richards JS. Steroidogenic factor-1 binding and transcriptional activity of the cholesterol side-chain cleavage promoter in rat granulosa cells. Endocrinology 134:1499-1508;1994.
7. Guo IC, Chung BC. Cell-type specificity of human CYP11A1 TATA box. J Steroid Biochem Mol Biol 69:329-334;1999.
8. Guo IC, Chung BC. Protein binding activity and cyclic AMP responsiveness of a weak Sp1 site in proximal promoter of human CYP11A1 gene. J Genet Mol Biol 10:9-18;1999.
9. Guo IC, Huang C, Chung BC. Differential regulation of the CYP11A1 (P450scc) and ferredoxin genes in adrenal and placental cells. DNA Cell Biol 12:849-860;1993.
10. Guo IC, Tsai HM, Chung BC. Actions of two different cAMP-responsive sequences and an enhancer of the human CYP11A1 (P450scc) gene in adrenal Y1 and placental JEG-3 cells. J Biol Chem 269:6362-6369;1994.
11. Hanukoglu I, Jefcoate CR. Mitochondrial cytochrome P-450sec. Mechanism of electron transport by adrenodoxin. J Biol Chem 255:3057-3061;1980.
12. Hanukoglu I, Privalle CT, Jefcoate CR. Mechanisms of ionic activation of adrenal mitochondrial cytochromes P-450scc and P-45011 beta. J Biol Chem 256:4329-4335;1981.
13. Hanukoglu I, Spitsberg V, Bumpus JA, Dus KM, Jefcoate CR. Adrenal mitochondrial cytochrome P-450scc. Cholesterol and adrenodoxin interactions at equilibrium and during turnover. J Biol Chem 256:4321-4328;1981.
14. Hu MC, Guo IC, Lin JH, Chung BC. Regulated expression of cytochrome P-450scc (cholesterol-side-chain cleavage enzyme) in cultured cell lines detected by antibody against bacterially expressed human protein. Biochem J 274 (pt 3):813-817;1991.
15. Hu MC, Hsu NC, Pai CI, Wang CK, Chung B. Functions of the upstream and proximal steroidogenic factor 1 (SF-1)-binding sites in the CYP11A1 promoter in basal transcription and hormonal response. Mol Endocrinol 15:812-818;2001.
16. Huang N, Miller WL. Cloning of factors related to HIV-inducible LBP proteins that regulate steroidogenic factor-1-independent human placental transcription of the cholesterol side-chain cleavage enzyme, P450scc. J Biol Chem 275:2852-2858;2000.
17. Hum DW, Aza-Blanc P, Miller WL. Characterization of placental transcriptional activation of the human gene for P450scc. DNA Cell Biol 14:451-463;1995.
18. Hum DW, Staels B, Black SM, Miller WL. Basal transcriptional activity and cyclic adenosine 3′,5′-monophosphate responsiveness of the human cytochrome P450scc promoter transfected into MA-10 Leydig cells. Endocrinology 132:546-552;1993.
19. Ishimura K, Fujita H. Light and electron microscopic immunohistochemistry of the localization of adrenal steroidogenic enzymes. Microsc Res Tech 36:445-453;1997.
20. John ME, John MC, Boggaram V, Simpson ER, Waterman MR. Transcriptional regulation of steroid hydroxylase genes by corticotropin. Proc Natl Acad Sci USA 83:4715-4719;1986.
21. Lala DS, Rice DA, Parker KL. Steroidogenic factor I, a key regulator of steroidogenic enzyme expression, is the mouse homolog of fushi tarazu-factor I. Mol Endocrinol 6:1249-1258;1992.
22. Lewohl JM, Dodd PR, Mayfield RD, Harris RA. Application of DNA microarrays to study human alcoholism. J Biomed Sci 8:28-36;2001.
23. Liu Z, Simpson ER. Molecular mechanism for cooperation between Sp1 and steroidogenic factor-1 (SF-1) to regulate bovine CYP11A gene expression. Mol Cell Endocrinol 153:183-196;1999.
24. Miller WL. Disorders of androgen biosynthesis. Semin Reprod Med 20:205-216;2002.
25. Miller WL. Molecular biology of steroid hormone synthesis. Endocr Rev 9:295-318;1988.
26. Moore CC, Brentano ST, Miller WL. Human P450scc gene transcription is induced by cyclic AMP and repressed by 12-O-tetradecanoylphorbol-13-acetate and A23187 through independent cis elements. Mol Cell Biol 10:6013-6023;1990.
27. Nelson DR, Kamataki T, Waxman DJ, Guengerich FP, Estabrook RW, Feyereisen R, Gonzalez FJ, Coon MJ, Gunsalus IC, Gotoh O, et al. The P450 superfamily: update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature. DNA Cell Biol 12:1-51;1993.
28. Orly J, Clemens JW, Singer O, Richards JS. Effects of hormones and protein kinase inhibitors on expression of steroidogenic enzyme promoters in electroporated primary rat granulosa cells. Biol Reprod 54:208-218;1996.
29. Pereira LA, Churchill MJ, Elefanty AG, Gouskos T, Lambert PF, Ramsay RG, Deacon NJ. Characterization of interactions between transcription factors and a regulatory region spanning nt -320 to -281 of the HIV-1 LTR in T-lymphoid and non-T-lymphoid cells. J Biomed Sci 9:68-81;2002.
30. Rice DA, Kirkman MS, Aitken LD, Mouw AR, Schimmer BP, Parker KL. Analysis of the promoter region of the gene encoding mouse cholesterol side-chain cleavage enzyme. J Biol Chem 265:11713-11720;1990.
31. Richards JS, Hedin L. Molecular aspects of hormone action in ovarian follicular development, ovulation, and luteinization. Annu Rev Physiol 50:441-463;1988.
32. Richards JS, Jahnsen T, Hedin L, Lifka J, Ratoosh S, Durica JM, Goldring NB. Ovarian follicular development: From physiology to molecular biology. Recent Prog Horm Res 43:231-276;1987.
33. Rodriguez H, Hum DW, Staels B, Miller WL. Transcription of the human genes for cytochrome P450scc and P450c17 is regulated differently in human adrenal NCI-H295 cells than in mouse adrenal Y1 cells. J Clin Endocrinol Metab 82:365-371;1997.
34. Shaheduzzaman S, Krishnan V, Petrovic A, Bittner M, Meltzer P, Trent J, Venkatesan S, Zeichner S. Effects of HIV-1 Nef on cellular gene expression profiles. J Biomed Sci 9:82-96;2002.
35. Simpson ER, McCarthy JL, Peterson JA. Evidence that the cycloheximide-sensitive site of adrenocorticotropic hormone action is in the mitochondrion. Changes in pregnenolone formation, cholesterol content, and the electron paramagnetic resonance spectra of cytochrome P-450. J Biol Chem 253:3135-3139;1978.
36. Simpson ER, Waterman MR. Regulation of the synthesis of steroidogenic enzymes in adrenal cortical cells by ACTH. Annu Rev Physiol 50:427-440;1988.
37. Stocco DM. A StAR search: Implications in controlling steroidgenesis. Biol Reprod 56:328-336;1997.
38. Tabakoff B, Nelson E, Yoshimura M, Hellevuo K, Hoffman PL. Phosphorylation cascades control the actions of ethanol on cell cAMP signalling. J Biomed Sci 8:44-51;2001.
39. Takayama K, Morohashi K, Honda S, Hara N, Omura T. Contribution of Ad4BP, a steroidogenic cell-specific transcription factor, to regulation of the human CYP11A and bovine CYP11B genes through their distal promoters. J Biochem (Tokyo) 116:193-203;1994.
40. Watanabe N, Inoue H, Fujii-Kuriyama Y. Regulatory mechanisms of cAMP-dependent and cell-specific expression of human steroidogenic cytochrome P450scc (CYP11A1) gene. Eur J Biochem 222:825-834;1994.
41. Waterman MR. A rising StAR: an essential role in cholesterol transport. Science 267:1780-1781;1995.
42. Ye SQ, Usher DC, Zhang LQ. Gene expression profiling of human diseases by serial analysis of gene expression. J Biomed Sci 9:384-394;2002.
43. Yeh JR, Hsu LC, Chung B. Sp1-like proteins function in the transcription of human ferredoxin genes. J Biomed Sci 7:144-151;2000.